(Q14878408)

http://www.ebi.ac.uk/interpro/protein/O08586

Bifunctional phosphatidylinositol trisphosphate phosphatase/dual specificity phosphatase PTEN

1 reference

stated in

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O08586

Tensin phosphatase, C2 domain, protein family

1 reference

Tensin-type phosphatase domain, protein family

1 reference

Protein-tyrosine phosphatase, catalytic domain, protein family

1 reference

Protein-tyrosine phosphatase, active site, protein family

1 reference

Dual specificity phosphatase

1 reference

phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity

1 reference

25 May 2022

1 reference

25 May 2022

4 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08586

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08586

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08586

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08586

Regulation of PTEN stability and activity by Plk3

protein kinase binding

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08586

phosphoprotein phosphatase activity

IPI

protein serine/threonine phosphatase activity

ISO

protein tyrosine/serine/threonine phosphatase activity

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08586

phosphatidylinositol-3-phosphatase activity

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08586

protein tyrosine phosphatase activity

5 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08586

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08586

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08586

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08586

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08586

inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity

4 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08586

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08586

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08586

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08586

phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity

6 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08586

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08586

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08586

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08586

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08586

9 May 2019

Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08586

9 references

9 May 2019

Na+/H+ exchanger regulatory factor 1 inhibits platelet-derived growth factor signaling in breast cancer cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08586

9 May 2019

PTEN tumor suppressor associates with NHERF proteins to attenuate PDGF receptor signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08586

9 May 2019

Dlg1-PTEN interaction regulates myelin thickness to prevent damaging peripheral nerve overmyelination

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08586

9 May 2019

PTEN nuclear localization is regulated by oxidative stress and mediates p53-dependent tumor suppression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08586

9 May 2019

Involvement of PTEN in TPA-mediated p53-activation in mouse skin epidermal JB6 cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08586

9 May 2019

Essential role for nuclear PTEN in maintaining chromosomal integrity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08586

9 May 2019

The deubiquitinylation and localization of PTEN are regulated by a HAUSP-PML network

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08586

9 May 2019

PTEN tumor suppressor associates with NHERF proteins to attenuate PDGF receptor signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08586

9 May 2019

Deubiquitylase OTUD3 regulates PTEN stability and suppresses tumorigenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08586

6 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08586

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08586

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08586

9 May 2019

The ubiquitin ligase Nedd4-1 is dispensable for the regulation of PTEN stability and localization

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08586

9 May 2019

Prostate-specific deletion of the murine Pten tumor suppressor gene leads to metastatic prostate cancer

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08586

9 May 2019

PTEN nuclear localization is regulated by oxidative stress and mediates p53-dependent tumor suppression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08586

6 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08586

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08586

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08586

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08586

9 May 2019

The ubiquitin ligase Nedd4-1 is dispensable for the regulation of PTEN stability and localization

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08586

9 May 2019

Prostate-specific deletion of the murine Pten tumor suppressor gene leads to metastatic prostate cancer

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08586

myelin sheath adaxonal region

1 reference

9 May 2019

Pals1 is a major regulator of the epithelial-like polarization and the extension of the myelin sheath in peripheral nerves

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08586

Schmidt-Lanterman incisure

1 reference

9 May 2019

Pals1 is a major regulator of the epithelial-like polarization and the extension of the myelin sheath in peripheral nerves

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08586

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08586

4 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08586

9 May 2019

Reelin deficiency causes specific defects in the molecular composition of the synapses in the adult brain

Community Assessment of Community Annotation with Ontologies

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08586

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08586

9 May 2019

Reelin deficiency causes specific defects in the molecular composition of the synapses in the adult brain

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08586

1 reference

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O08586&geneProductId=UniProtKB:O08586

negative regulation of cell population proliferation

biological process

6 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08586

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08586

9 May 2019

Feedback inhibition of Akt signaling limits the growth of tumors lacking Tsc2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08586

9 May 2019

Genetic analysis of Pten and Tsc2 functional interactions in the mouse reveals asymmetrical haploinsufficiency in tumor suppression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08586

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08586

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08586

dendritic spine morphogenesis

4 references

9 May 2019

Phosphatase and tensin homolog, deleted on chromosome 10 deficiency in brain causes defects in synaptic structure, transmission and plasticity, and myelination abnormalities

Community Assessment of Community Annotation with Ontologies

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08586

9 May 2019

Pten knockdown in vivo increases excitatory drive onto dentate granule cells

Community Assessment of Community Annotation with Ontologies

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08586

9 May 2019

Phosphatase and tensin homolog, deleted on chromosome 10 deficiency in brain causes defects in synaptic structure, transmission and plasticity, and myelination abnormalities

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08586

9 May 2019

Pten knockdown in vivo increases excitatory drive onto dentate granule cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08586

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08586

response to organic cyclic compound

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08586

4 references

9 May 2019

Haploinsufficiency for Pten and Serotonin transporter cooperatively influences brain size and social behavior

Community Assessment of Community Annotation with Ontologies

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08586

9 May 2019

Pten regulates neuronal arborization and social interaction in mice

Community Assessment of Community Annotation with Ontologies

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08586

9 May 2019

Haploinsufficiency for Pten and Serotonin transporter cooperatively influences brain size and social behavior

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08586

9 May 2019

Pten regulates neuronal arborization and social interaction in mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08586

cellular response to hypoxia

1 reference

9 May 2019

PTEN degradation after ischemic stroke: a double-edged sword

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08586

regulation of myeloid cell apoptotic process

1 reference

9 May 2019

Mutation of Pten/Mmac1 in mice causes neoplasia in multiple organ systems

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08586

1 reference

9 May 2019

Analysis of mouse embryonic patterning and morphogenesis by forward genetics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08586

cellular response to decreased oxygen levels

1 reference

9 May 2019

PTEN degradation after ischemic stroke: a double-edged sword

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08586

Phosphatase and tensin homolog, deleted on chromosome 10 deficiency in brain causes defects in synaptic structure, transmission and plasticity, and myelination abnormalities

long-term potentiation

2 references

9 May 2019

Community Assessment of Community Annotation with Ontologies

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08586

9 May 2019

Phosphatase and tensin homolog, deleted on chromosome 10 deficiency in brain causes defects in synaptic structure, transmission and plasticity, and myelination abnormalities

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08586

negative regulation of protein kinase B signaling

7 references

9 May 2019

Deubiquitylase OTUD3 regulates PTEN stability and suppresses tumorigenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08586

9 May 2019

PTEN modulates cell cycle progression and cell survival by regulating phosphatidylinositol 3,4,5,-trisphosphate and Akt/protein kinase B signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08586

9 May 2019

Dlg1-PTEN interaction regulates myelin thickness to prevent damaging peripheral nerve overmyelination

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08586

9 May 2019

PTEN signaling through RAF1 proto-oncogene serine/threonine kinase (RAF1)/ERK in the epididymis is essential for male fertility

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08586

9 May 2019

Pten regulates neuronal arborization and social interaction in mice

Community Assessment of Community Annotation with Ontologies

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08586

9 May 2019

Pten regulates neuronal arborization and social interaction in mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08586

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08586

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08586

regulation of cellular component size

2 references

9 May 2019

Phosphatase and tensin homolog, deleted on chromosome 10 deficiency in brain causes defects in synaptic structure, transmission and plasticity, and myelination abnormalities

Community Assessment of Community Annotation with Ontologies

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08586

9 May 2019

Phosphatase and tensin homolog, deleted on chromosome 10 deficiency in brain causes defects in synaptic structure, transmission and plasticity, and myelination abnormalities

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08586

negative regulation of synaptic vesicle clustering

4 references

9 May 2019

Phosphatase and tensin homolog, deleted on chromosome 10 deficiency in brain causes defects in synaptic structure, transmission and plasticity, and myelination abnormalities

Community Assessment of Community Annotation with Ontologies

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08586

9 May 2019

Pten regulates neuronal arborization and social interaction in mice

Community Assessment of Community Annotation with Ontologies

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08586

9 May 2019

Phosphatase and tensin homolog, deleted on chromosome 10 deficiency in brain causes defects in synaptic structure, transmission and plasticity, and myelination abnormalities

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08586

9 May 2019

Pten regulates neuronal arborization and social interaction in mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08586

phosphatidylinositol dephosphorylation

4 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08586

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08586

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08586

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08586

regulation of synaptic transmission, GABAergic

1 reference

9 May 2019

PTEN degradation after ischemic stroke: a double-edged sword

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08586

response to organic substance

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08586

negative regulation of organ growth

nervous system development

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08586

negative regulation of axon regeneration

1 reference

9 May 2019

Gene-Silencing Screen for Mammalian Axon Regeneration Identifies Inpp5f (Sac2) as an Endogenous Suppressor of Repair after Spinal Cord Injury

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08586

regulation of protein stability

presynaptic membrane assembly

2 references

9 May 2019

Phosphatase and tensin homolog, deleted on chromosome 10 deficiency in brain causes defects in synaptic structure, transmission and plasticity, and myelination abnormalities

Community Assessment of Community Annotation with Ontologies

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08586

9 May 2019

Phosphatase and tensin homolog, deleted on chromosome 10 deficiency in brain causes defects in synaptic structure, transmission and plasticity, and myelination abnormalities

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08586

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08586

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08586

central nervous system myelin maintenance

2 references

9 May 2019

Phosphatase and tensin homolog, deleted on chromosome 10 deficiency in brain causes defects in synaptic structure, transmission and plasticity, and myelination abnormalities

Community Assessment of Community Annotation with Ontologies

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08586

9 May 2019

Phosphatase and tensin homolog, deleted on chromosome 10 deficiency in brain causes defects in synaptic structure, transmission and plasticity, and myelination abnormalities

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08586

regulation of neuron projection development

1 reference

9 May 2019

DISC1 regulates new neuron development in the adult brain via modulation of AKT-mTOR signaling through KIAA1212

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08586

4 references

9 May 2019

Haploinsufficiency for Pten and Serotonin transporter cooperatively influences brain size and social behavior

Community Assessment of Community Annotation with Ontologies

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08586

9 May 2019

Pten regulates neuronal arborization and social interaction in mice

Community Assessment of Community Annotation with Ontologies

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08586

9 May 2019

Haploinsufficiency for Pten and Serotonin transporter cooperatively influences brain size and social behavior

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08586

9 May 2019

Pten regulates neuronal arborization and social interaction in mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08586

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08586

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08586

multicellular organismal response to stress

1 reference

9 May 2019

Pten regulates neuronal arborization and social interaction in mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08586

negative regulation of apoptotic process

1 reference

9 May 2019

PTEN modulates cell cycle progression and cell survival by regulating phosphatidylinositol 3,4,5,-trisphosphate and Akt/protein kinase B signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08586

negative regulation of cell size

3 references

9 May 2019

Pten knockdown in vivo increases excitatory drive onto dentate granule cells

Community Assessment of Community Annotation with Ontologies

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08586

9 May 2019

Pten knockdown in vivo increases excitatory drive onto dentate granule cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08586

9 May 2019

Pten regulates neuronal arborization and social interaction in mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08586

regulation of B cell apoptotic process

1 reference

9 May 2019

Mutation of Pten/Mmac1 in mice causes neoplasia in multiple organ systems

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08586

response to inorganic substance

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08586

response to arsenic-containing substance

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08586

central nervous system development

1 reference

9 May 2019

PTEN is essential for cell migration but not for fate determination and tumourigenesis in the cerebellum

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08586

positive regulation of apoptotic signaling pathway

1 reference

9 May 2019

Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08586

regulation of axon regeneration

1 reference

9 May 2019

B-RAF kinase drives developmental axon growth and promotes axon regeneration in the injured mature CNS

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08586

negative regulation of axonogenesis

IGI

1 reference

9 May 2019

Pten regulates neuronal arborization and social interaction in mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08586

postsynaptic density assembly

2 references

9 May 2019

Phosphatase and tensin homolog, deleted on chromosome 10 deficiency in brain causes defects in synaptic structure, transmission and plasticity, and myelination abnormalities

Community Assessment of Community Annotation with Ontologies

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08586

9 May 2019

Phosphatase and tensin homolog, deleted on chromosome 10 deficiency in brain causes defects in synaptic structure, transmission and plasticity, and myelination abnormalities

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08586

positive regulation of ERK1 and ERK2 cascade

1 reference

9 May 2019

PTEN signaling through RAF1 proto-oncogene serine/threonine kinase (RAF1)/ERK in the epididymis is essential for male fertility

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08586

neuron-neuron synaptic transmission

2 references

9 May 2019

Phosphatase and tensin homolog, deleted on chromosome 10 deficiency in brain causes defects in synaptic structure, transmission and plasticity, and myelination abnormalities

Community Assessment of Community Annotation with Ontologies

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08586

9 May 2019

Phosphatase and tensin homolog, deleted on chromosome 10 deficiency in brain causes defects in synaptic structure, transmission and plasticity, and myelination abnormalities

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08586

protein dephosphorylation

positive regulation of cell population proliferation

1 reference

9 May 2019

Nuclear PTEN regulates the APC-CDH1 tumor-suppressive complex in a phosphatase-independent manner

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08586

negative regulation of focal adhesion assembly

negative regulation of epithelial cell proliferation

1 reference

9 May 2019

Targeted biallelic inactivation of Pten in the mouse prostate leads to prostate cancer accompanied by increased epithelial cell proliferation but not by reduced apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08586

endothelial cell migration

1 reference

9 May 2019

The PTEN/PI3K pathway governs normal vascular development and tumor angiogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08586

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08586

regulation of cellular localization

1 reference

9 May 2019

Rictor/mTORC2 is essential for maintaining a balance between beta-cell proliferation and cell size

Community Assessment of Community Annotation with Ontologies

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08586

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08586

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08586

PTEN nuclear localization is regulated by oxidative stress and mediates p53-dependent tumor suppression

regulation of cell cycle

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08586

positive regulation of excitatory postsynaptic potential

IGI

2 references

9 May 2019

Phosphatase and tensin homolog, deleted on chromosome 10 deficiency in brain causes defects in synaptic structure, transmission and plasticity, and myelination abnormalities

Community Assessment of Community Annotation with Ontologies

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08586

9 May 2019

Phosphatase and tensin homolog, deleted on chromosome 10 deficiency in brain causes defects in synaptic structure, transmission and plasticity, and myelination abnormalities

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08586

negative regulation of myelination

1 reference

9 May 2019

Dlg1-PTEN interaction regulates myelin thickness to prevent damaging peripheral nerve overmyelination

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08586

Targeted biallelic inactivation of Pten in the mouse prostate leads to prostate cancer accompanied by increased epithelial cell proliferation but not by reduced apoptosis

prostate gland growth

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08586

2 references

9 May 2019

Phosphatase and tensin homolog, deleted on chromosome 10 deficiency in brain causes defects in synaptic structure, transmission and plasticity, and myelination abnormalities

Community Assessment of Community Annotation with Ontologies

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08586

9 May 2019

Phosphatase and tensin homolog, deleted on chromosome 10 deficiency in brain causes defects in synaptic structure, transmission and plasticity, and myelination abnormalities

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08586

response to estradiol

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08586

1 reference

9 May 2019

Pten regulates neuronal arborization and social interaction in mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08586

cardiac muscle tissue development

1 reference

9 May 2019

The PTEN/PI3K pathway governs normal vascular development and tumor angiogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08586

1 reference

9 May 2019

The PTEN/PI3K pathway governs normal vascular development and tumor angiogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08586

Pten regulates neuronal arborization and social interaction in mice

forebrain morphogenesis

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08586

negative regulation of protein phosphorylation

3 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08586

9 May 2019

MicroRNA expression in response to murine myocardial infarction: miR-21 regulates fibroblast metalloprotease-2 via phosphatase and tensin homologue

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08586

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08586

1 reference

9 May 2019

PTEN is essential for cell migration but not for fate determination and tumourigenesis in the cerebellum

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08586

1 reference

9 May 2019

Pten regulates neuronal arborization and social interaction in mice

Community Assessment of Community Annotation with Ontologies

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08586

inositol phosphate dephosphorylation

4 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08586

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08586

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08586

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08586

negative regulation of ribosome biogenesis

2 references

9 May 2019

Phosphatase and tensin homolog, deleted on chromosome 10 deficiency in brain causes defects in synaptic structure, transmission and plasticity, and myelination abnormalities

Community Assessment of Community Annotation with Ontologies

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08586

9 May 2019

Phosphatase and tensin homolog, deleted on chromosome 10 deficiency in brain causes defects in synaptic structure, transmission and plasticity, and myelination abnormalities

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08586

negative regulation of cell migration

negative regulation of cardiac muscle cell proliferation

1 reference

9 May 2019

mir-17-92 cluster is required for and sufficient to induce cardiomyocyte proliferation in postnatal and adult hearts

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08586

positive regulation of ubiquitin protein ligase activity

3 references

peptidyl-tyrosine dephosphorylation

1 reference

9 May 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08586

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08586

cellular response to nerve growth factor stimulus

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08586

negative regulation of cyclin-dependent protein serine/threonine kinase activity

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O08586&geneProductId=UniProtKB:O08586

negative regulation of neuron projection development

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08586