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Sclerostin
mammalian protein found in Mus musculus
sclerostin
Sost
uniprot:Q99P68
In more languages
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Statements
instance of
protein
1 reference
stated in
UniProt
retrieved
25 May 2022
UniProt protein ID
Q99P68
subclass of
protein
1 reference
stated in
UniProt
retrieved
19 January 2017
UniProt protein ID
Q99P68
part of
Cystine-knot cytokine
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/Q99P68
Sclerostin
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/Q99P68
found in taxon
house mouse
1 reference
stated in
UniProt
retrieved
25 May 2022
UniProt protein ID
Q99P68
encoded by
Sost
1 reference
stated in
UniProt
retrieved
25 May 2022
UniProt protein ID
Q99P68
molecular function
transcription factor binding
determination method
ISO
1 reference
retrieved
14 February 2019
stated in
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99P68
determination method
ISO
heparin binding
determination method
IEA
1 reference
retrieved
14 February 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q99P68
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99P68
determination method
IEA
protein binding
determination method
IPI
2 references
retrieved
14 February 2019
stated in
Interferon regulatory factor 8 (IRF8) interacts with the B cell lymphoma 6 (BCL6) corepressor BCOR
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99P68
determination method
IPI
retrieved
14 February 2019
stated in
Bone density ligand, Sclerostin, directly interacts with LRP5 but not LRP5G171V to modulate Wnt activity
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99P68
determination method
IPI
cell component
extracellular region
determination method
IEA
1 reference
retrieved
14 February 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q99P68
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99P68
determination method
IEA
extracellular space
determination method
IEA
ISO
2 references
retrieved
14 February 2019
stated in
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99P68
determination method
ISO
retrieved
14 February 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99P68
determination method
IEA
Golgi apparatus
determination method
ISO
1 reference
retrieved
14 February 2019
stated in
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99P68
determination method
ISO
protein-containing complex
determination method
ISO
1 reference
retrieved
14 February 2019
stated in
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99P68
determination method
ISO
biological process
negative regulation of protein-containing complex assembly
determination method
ISO
1 reference
retrieved
14 February 2019
stated in
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99P68
determination method
ISO
negative regulation of Wnt signaling pathway
determination method
IDA
1 reference
retrieved
14 February 2019
stated in
Bone density ligand, Sclerostin, directly interacts with LRP5 but not LRP5G171V to modulate Wnt activity
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99P68
determination method
IDA
positive regulation of transcription, DNA-templated
determination method
ISO
1 reference
retrieved
14 February 2019
stated in
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99P68
determination method
ISO
cellular response to parathyroid hormone stimulus
determination method
ISO
1 reference
retrieved
14 February 2019
stated in
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99P68
determination method
ISO
negative regulation of Wnt signaling pathway involved in dorsal/ventral axis specification
determination method
ISO
1 reference
retrieved
24 April 2018
stated in
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99P68&geneProductId=UniProtKB:Q99P68
determination method
ISO
Wnt signaling pathway
determination method
IEA
1 reference
retrieved
14 February 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q99P68
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99P68
determination method
IEA
negative regulation of canonical Wnt signaling pathway
determination method
IGI
ISO
3 references
retrieved
14 February 2019
stated in
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99P68
determination method
ISO
retrieved
14 February 2019
stated in
FoxOs cooperatively regulate diverse pathways governing neural stem cell homeostasis
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99P68
determination method
IGI
retrieved
14 February 2019
stated in
Genetic evidence that SOST inhibits WNT signaling in the limb
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99P68
determination method
IGI
ossification
determination method
IDA
1 reference
retrieved
14 February 2019
stated in
Osteocyte control of bone formation via sclerostin, a novel BMP antagonist
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99P68
determination method
IDA
negative regulation of ossification
determination method
IEA
IMP
2 references
retrieved
14 February 2019
stated in
Conditionals by inversion provide a universal method for the generation of conditional alleles
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99P68
determination method
IMP
retrieved
14 February 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99P68
determination method
IEA
negative regulation of BMP signaling pathway
determination method
IDA
ISO
2 references
retrieved
14 February 2019
stated in
Osteocyte control of bone formation via sclerostin, a novel BMP antagonist
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99P68
determination method
ISO
retrieved
14 February 2019
stated in
Bone density ligand, Sclerostin, directly interacts with LRP5 but not LRP5G171V to modulate Wnt activity
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99P68
determination method
IDA
Identifiers
RefSeq protein ID
NP_077769
1 reference
stated in
NCBI Gene
retrieved
20 March 2022
Entrez Gene ID
74499
XP_006534439
1 reference
stated in
NCBI Gene
retrieved
20 March 2022
Entrez Gene ID
74499
UniProt protein ID
Q99P68
1 reference
stated in
UniProt
retrieved
25 May 2022
UniProt protein ID
Q99P68
Ensembl protein ID
ENSMUSP00000001534
1 reference
stated in
ensembl Release 106
Ensembl protein ID
ENSMUSP00000001534
PDB structure ID
2KD3
1 reference
stated in
UniProt
UniProt protein ID
Q99P68
retrieved
9 August 2016
language of work or name
English
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