(Q1500000)

Toll/interleukin-1 receptor homology (TIR) domain superfamily

1 reference

Death-like domain superfamily

1 reference

Death domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

MyD88, death domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Toll/interleukin-1 receptor homology (TIR) domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

1 reference

13 November 2019

death receptor binding

1 reference

9 May 2019

IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL-1 signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99836

27 references

9 May 2019

Aspartate-glutamate-alanine-histidine box motif (DEAH)/RNA helicase A helicases sense microbial DNA in human plasmacytoid dendritic cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99836

9 May 2019

AIP1 functions as Arf6-GAP to negatively regulate TLR4 signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99836

9 May 2019

Functional assessment of the mutational effects of human IRAK4 and MyD88 genes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99836

9 May 2019

A proteome-scale map of the human interactome network

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99836

9 May 2019

Extracellular heat shock protein 70 mediates heat stress-induced epidermal growth factor receptor transactivation in A431 carcinoma cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99836

9 May 2019

Human TLR10 is a functional receptor, expressed by B cells and plasmacytoid dendritic cells, which activates gene transcription through MyD88

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99836

9 May 2019

The transmembrane activator TACI triggers immunoglobulin class switching by activating B cells through the adaptor MyD88

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99836

9 May 2019

The apoptotic signaling pathway activated by Toll-like receptor-2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99836

9 May 2019

Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99836

9 May 2019

Hepatitis C virus nonstructural protein 5A modulates the toll-like receptor-MyD88-dependent signaling pathway in macrophage cell lines

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99836

9 May 2019

Distinct roles of TIR and non-TIR regions in the subcellular localization and signaling properties of MyD88

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99836

9 May 2019

MAPPIT analysis of TLR adaptor complexes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99836

9 May 2019

Modulation of TLR4 signaling by a novel adaptor protein signal-transducing adaptor protein-2 in macrophages

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99836

9 May 2019

Selective disruption of TLR2-MyD88 interaction inhibits inflammation and attenuates Alzheimer's pathology

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99836

9 May 2019

The Brucella TIR-like protein TcpB interacts with the death domain of MyD88

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99836

9 May 2019

DOCK8 functions as an adaptor that links TLR-MyD88 signaling to B cell activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99836

9 May 2019

Localization of TLR2 and MyD88 to Chlamydia trachomatis inclusions. Evidence for signaling by intracellular TLR2 during infection with an obligate intracellular pathogen.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99836

9 May 2019

Widespread macromolecular interaction perturbations in human genetic disorders

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99836

9 May 2019

TIRAP, an adaptor protein for TLR2/4, transduces a signal from RAGE phosphorylated upon ligand binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99836

9 May 2019

Characterization of Pellino2, a substrate of IRAK1 and IRAK4

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99836

9 May 2019

SARM modulates MyD88-mediated TLR activation through BB-loop dependent TIR-TIR interactions

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99836

9 May 2019

Toward an understanding of the protein interaction network of the human liver

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99836

9 May 2019

The hepatitis B e antigen (HBeAg) targets and suppresses activation of the toll-like receptor signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99836

9 May 2019

Towards a proteome-scale map of the human protein–protein interaction network

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99836

9 May 2019

Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99836

9 May 2019

The Brucella TIR-like protein TcpB interacts with the death domain of MyD88

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99836

9 May 2019

Hepatitis C virus nonstructural protein 5A modulates the toll-like receptor-MyD88-dependent signaling pathway in macrophage cell lines

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99836

identical protein binding

IPI

8 references

9 May 2019

Widespread macromolecular interaction perturbations in human genetic disorders

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99836

9 May 2019

Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99836

9 May 2019

Toward an understanding of the protein interaction network of the human liver

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99836

9 May 2019

Pooled-matrix protein interaction screens using Barcode Fusion Genetics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99836

9 May 2019

A proteome-scale map of the human interactome network

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99836

9 May 2019

MAPPIT analysis of TLR adaptor complexes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99836

9 May 2019

Next-generation sequencing to generate interactome datasets

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99836

9 May 2019

The Brucella TIR-like protein TcpB interacts with the death domain of MyD88

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99836

The Brucella TIR-like protein TcpB interacts with the death domain of MyD88

IPI

protein self-association

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99836

Toll-like receptor binding

IDA

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99836

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99836

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99836

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99836

1 reference

4 April 2017

The Brucella TIR-like protein TcpB interacts with the death domain of MyD88

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q99836

response to interleukin-1

IDA

biological process

1 reference

9 May 2019

Activation of ROS/NF-kappaB and Ca2+/CaM kinase II are necessary for VCAM-1 induction in IL-1beta-treated human tracheal smooth muscle cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99836

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99836

immune system process

1 reference

9 May 2019

negative regulation of apoptotic process

IEA

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99836

toll-like receptor signaling pathway

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99836

cell surface receptor signaling pathway

1 reference

9 May 2019

IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL-1 signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99836

cellular response to mechanical stimulus

1 reference

9 May 2019

Expression of the Bcl-2 protein BAD promotes prostate cancer growth

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99836

regulation of inflammatory response

IEP

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99836

positive regulation of interleukin-6 production

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99836

toll-like receptor 9 signaling pathway

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99836

positive regulation of interleukin-17 production

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99836

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99836

inflammatory response

1 reference

9 May 2019

3'-UTR-mediated mRNA stabilization

IEA

1 reference

9 May 2019

Toll IL-1 receptors differ in their ability to promote the stabilization of adenosine and uridine-rich elements containing mRNA

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99836

positive regulation of interleukin-23 production

IDA

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99836

defense response to Gram-positive bacterium

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99836

positive regulation of NF-kappaB transcription factor activity

1 reference

9 May 2019

The Brucella TIR-like protein TcpB interacts with the death domain of MyD88

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99836

1 reference

9 May 2019

The Brucella TIR-like protein TcpB interacts with the death domain of MyD88

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99836

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99836

innate immune response

1 reference

8 April 2019

type I interferon signaling pathway

IEA

1 reference

9 May 2019

HCV-induced miR-21 contributes to evasion of host immune system by targeting MyD88 and IRAK1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99836

positive regulation of gene expression

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99836

positive regulation of interleukin-8 production

1 reference

9 May 2019

Identification of MyD88 as a novel target of miR-155, involved in negative regulation of Helicobacter pylori-induced inflammation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99836

defense response to bacterium

1 reference

9 May 2019

Identification of MyD88 as a novel target of miR-155, involved in negative regulation of Helicobacter pylori-induced inflammation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99836

interleukin-1-mediated signaling pathway

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99836

cellular response to oxidised low-density lipoprotein particle stimulus

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99836

1 reference

9 May 2019

The TLR4 adaptor TRAM controls the phagocytosis of Gram-negative bacteria by interacting with the Rab11-family interacting protein 2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99836

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

Toll signaling pathway

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99836

http://purl.uniprot.org/uniprot/Q99836

IBA

Gene Atlas image

PBB GE MYD88 209124 at fs.png
732 × 530; 11 KB

0 references

exact match

1 reference

1 reference

Toll/interleukin-1 receptor homology (TIR) domain

1 reference

MyD88, death domain

1 reference

Identifiers

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

13 November 2019

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016