Wikidata

(Q15331171)

English

Leucine-rich repeat kinase 2

mammalian protein found in Mus musculus

  • leucine-rich repeat serine/threonine-protein kinase 2
  • Lrrk2
  • uniprot:Q5S006
In more languages

Statements

part of
molecular function
protein binding
determination method
IPI
16 references
retrieved
14 February 2019
stated in
Phosphorylation of amyloid precursor protein by mutant LRRK2 promotes AICD activity and neurotoxicity in Parkinson's disease.
GOA
curator
UniProt
UniProt protein ID
Q5S006
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5S006
determination method
IPI
retrieved
14 February 2019
stated in
Leucine-rich repeat kinase 2 regulates Sec16A at ER exit sites to allow ER-Golgi export
GOA
curator
UniProt
UniProt protein ID
Q5S006
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5S006
determination method
IPI
retrieved
14 February 2019
stated in
RAB7L1 interacts with LRRK2 to modify intraneuronal protein sorting and Parkinson's disease risk
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5S006
determination method
IPI
retrieved
14 February 2019
stated in
LRRK2 functions as a Wnt signaling scaffold, bridging cytosolic proteins and membrane-localized LRP6
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5S006
determination method
IPI
retrieved
14 February 2019
stated in
Unbiased screen for interactors of leucine-rich repeat kinase 2 supports a common pathway for sporadic and familial Parkinson disease
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5S006
determination method
IPI
retrieved
14 February 2019
stated in
ArfGAP1 is a GTPase activating protein for LRRK2: reciprocal regulation of ArfGAP1 by LRRK2
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5S006
determination method
IPI
retrieved
14 February 2019
stated in
Leucine-rich repeat kinase 2 exacerbates neuronal cytotoxicity through phosphorylation of histone deacetylase 3 and histone deacetylation
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5S006
determination method
IPI
retrieved
14 February 2019
stated in
GTPase activity and neuronal toxicity of Parkinson's disease-associated LRRK2 is regulated by ArfGAP1
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5S006
determination method
IPI
retrieved
14 February 2019
stated in
Leucine-rich repeat kinase 2 binds to neuronal vesicles through protein interactions mediated by its C-terminal WD40 domain
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5S006
determination method
IPI
retrieved
14 February 2019
stated in
LRRK2 regulates synaptogenesis and dopamine receptor activation through modulation of PKA activity
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5S006
determination method
IPI
retrieved
14 February 2019
stated in
Leucine-rich repeat kinase 2 disturbs mitochondrial dynamics via Dynamin-like protein
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5S006
determination method
IPI
retrieved
14 February 2019
stated in
Phosphorylation-dependent 14-3-3 binding to LRRK2 is impaired by common mutations of familial Parkinson's disease
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5S006
determination method
IPI
retrieved
14 February 2019
stated in
LRRK2 controls synaptic vesicle storage and mobilization within the recycling pool
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5S006
determination method
IPI
retrieved
14 February 2019
stated in
Functional interaction of Parkinson's disease-associated LRRK2 with members of the dynamin GTPase superfamily
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5S006
determination method
IPI
retrieved
14 February 2019
stated in
A Parkinson's disease gene regulatory network identifies the signaling protein RGS2 as a modulator of LRRK2 activity and neuronal toxicity
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5S006
determination method
IPI
retrieved
14 February 2019
stated in
ARHGEF7 (Beta-PIX) acts as guanine nucleotide exchange factor for leucine-rich repeat kinase 2
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5S006
determination method
IPI
protein serine/threonine kinase activity
determination method
IBA
IDA
IEA
IMP
ISO
6 references
retrieved
24 April 2018
stated in
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q5S006&geneProductId=UniProtKB:Q5S006
determination method
ISO
retrieved
24 April 2018
stated in
Leucine-rich repeat kinase 2 exacerbates neuronal cytotoxicity through phosphorylation of histone deacetylase 3 and histone deacetylation
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q5S006&geneProductId=UniProtKB:Q5S006
determination method
IMP
retrieved
24 April 2018
stated in
GOA
curator
UniProt
UniProt protein ID
Q5S006
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q5S006&geneProductId=UniProtKB:Q5S006
determination method
IEA
retrieved
24 April 2018
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q5S006&geneProductId=UniProtKB:Q5S006
determination method
IEA
retrieved
24 April 2018
stated in
Leucine-rich repeat kinase 2 exacerbates neuronal cytotoxicity through phosphorylation of histone deacetylase 3 and histone deacetylation
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q5S006&geneProductId=UniProtKB:Q5S006
determination method
IDA
retrieved
24 April 2018
stated in
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q5S006&geneProductId=UniProtKB:Q5S006
determination method
IBA
protein serine/threonine kinase activity
determination method
IDA
IEA
IMP
ISO
6 references
retrieved
14 February 2019
stated in
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5S006
determination method
ISO
retrieved
14 February 2019
stated in
Phosphorylation of amyloid precursor protein by mutant LRRK2 promotes AICD activity and neurotoxicity in Parkinson's disease.
GOA
curator
UniProt
UniProt protein ID
Q5S006
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5S006
determination method
IMP
retrieved
14 February 2019
stated in
Leucine-rich repeat kinase 2 exacerbates neuronal cytotoxicity through phosphorylation of histone deacetylase 3 and histone deacetylation
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5S006
determination method
IMP
retrieved
14 February 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q5S006
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5S006
determination method
IEA
retrieved
14 February 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5S006
determination method
IEA
retrieved
14 February 2019
stated in
Leucine-rich repeat kinase 2 exacerbates neuronal cytotoxicity through phosphorylation of histone deacetylase 3 and histone deacetylation
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5S006
determination method
IDA
cell component
biological process
protein phosphorylation
determination method
IDA
IEA
IMP
ISO
6 references
retrieved
14 February 2019
stated in
Kinase activity of mutant LRRK2 mediates neuronal toxicity
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5S006
determination method
ISO
retrieved
14 February 2019
stated in
Phosphorylation of amyloid precursor protein by mutant LRRK2 promotes AICD activity and neurotoxicity in Parkinson's disease.
GOA
curator
UniProt
UniProt protein ID
Q5S006
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5S006
determination method
IMP
retrieved
14 February 2019
stated in
Leucine-rich repeat kinase 2 exacerbates neuronal cytotoxicity through phosphorylation of histone deacetylase 3 and histone deacetylation
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5S006
determination method
IMP
retrieved
14 February 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5S006
determination method
IEA
retrieved
14 February 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5S006
determination method
IEA
retrieved
14 February 2019
stated in
Leucine-rich repeat kinase 2 exacerbates neuronal cytotoxicity through phosphorylation of histone deacetylase 3 and histone deacetylation
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5S006
determination method
IDA

Identifiers

 
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