(Q21090654)

English

Clobazam and its active metabolite N-desmethylclobazam display significantly greater affinities for α₂- versus α₁-GABA(A)-receptor complexes

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scholarly article

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Clobazam and its active metabolite N-desmethylclobazam display significantly greater affinities for α₂- versus α₁-GABA(A)-receptor complexes (English)

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author name string

Henrik Sindal Jensen

1

author given names

Henrik Sindal

author last names

Jensen

1 reference

15 August 2022

Kathryn Nichol

2

author given names

Kathryn

author last names

Nichol

1 reference

15 August 2022

Deborah Lee

3

author given names

Deborah

author last names

Lee

1 reference

15 August 2022

Bjarke Ebert

4

author given names

Bjarke

author last names

Ebert

1 reference

15 August 2022

language of work or name

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publication date

2014

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0 references

9

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2

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e88456

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copyright license

Creative Commons Attribution 4.0 International

12 February 2014

1 reference

April 2022 Public Data File from Crossref

copyright status

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Respiratory and sedative effects of clobazam and clonazepam in volunteers

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3922815

19 March 2017

Pharmacophore/receptor models for GABA(A)/BzR subtypes (alpha1beta3gamma2, alpha5beta3gamma2, and alpha6beta3gamma2) via a comprehensive ligand-mapping approach

2 references

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3922815

19 March 2017

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0088456

21 January 2018

Type I and type II GABAA-benzodiazepine receptors produced in transfected cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3922815

19 March 2017

Clobazam in treatment of refractory epilepsy: the Canadian experience. A retrospective study. Canadian Clobazam Cooperative Group

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3922815

19 March 2017

Evaluation of anti-hyperalgesic and analgesic effects of two benzodiazepines in human experimental pain: a randomized placebo-controlled study

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3922815

12 September 2017

GABA(A) receptor physiology and its relationship to the mechanism of action of the 1,5-benzodiazepine clobazam

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3922815

12 September 2017

Beyond classical benzodiazepines: novel therapeutic potential of GABAA receptor subtypes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3922815

12 September 2017

Searching for perfect sleep: the continuing evolution of GABAA receptor modulators as hypnotics

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3922815

12 September 2017

Lennox-Gastaut syndrome: a consensus approach on diagnosis, assessment, management, and trial methodology

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3922815

12 September 2017

Differential contribution of GABA(A) receptor subtypes to the anticonvulsant efficacy of benzodiazepine site ligands.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3922815

12 September 2017

TPA023 [7-(1,1-dimethylethyl)-6-(2-ethyl-2H-1,2,4-triazol-3-ylmethoxy)-3-(2-fluorophenyl)-1,2,4-triazolo[4,3-b]pyridazine], an agonist selective for alpha2- and alpha3-containing GABAA receptors, is a nonsedating anxiolytic in rodents and primates.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3922815

12 September 2017

Different GABAA receptor subtypes mediate the anxiolytic, abuse-related, and motor effects of benzodiazepine-like drugs in primates

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3922815

12 September 2017

Specific GABA(A) circuits in brain development and therapy.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3922815

12 September 2017

Sedative but not anxiolytic properties of benzodiazepines are mediated by the GABA(A) receptor alpha1 subtype.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3922815

12 September 2017

N-desmethylclobazam: a possible alternative to clobazam in the treatment of refractory epilepsy?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3922815

12 September 2017

Recent developments in the behavioral pharmacology of benzodiazepine (omega) receptors: evidence for the functional significance of receptor subtypes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3922815

27 September 2017

Determinants of benzodiazepine brain uptake: lipophilicity versus binding affinity.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3922815

30 May 2018

Effects of clobazam and clonazepam on saccadic eye movements and other parameters of psychomotor performance

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3922815

30 May 2018

Benzodiazepine actions mediated by specific gamma-aminobutyric acid(A) receptor subtypes.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0088456

21 January 2018

Molecular and neuronal substrate for the selective attenuation of anxiety.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0088456

21 January 2018

Reversal of pathological pain through specific spinal GABAA receptor subtypes.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0088456

21 January 2018

Requirement of alpha5-GABAA receptors for the development of tolerance to the sedative action of diazepam in mice.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0088456

21 January 2018

A major influence of CYP2C19 genotype on the steady-state concentration of N-desmethylclobazam

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0088456

21 January 2018

Influence of CYP2C19 polymorphism and concomitant antiepileptic drugs on serum clobazam and N-desmethyl clobazam concentrations in patients with epilepsy.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0088456

21 January 2018

Pharmacokinetic drug interactions between clobazam and drugs metabolized by cytochrome P450 isoenzymes

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0088456

21 January 2018

Clobazam shows a different antiepileptic action profile from clonazepam and zonisamide in Ihara epileptic rats

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0088456

21 January 2018

Clobazam in Treatment of Refractory Epilepsy: The Canadian Experience. A Retrospecti

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0088456

21 January 2018

Randomized, phase III study results of clobazam in Lennox-Gastaut syndrome

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0088456

21 January 2018

Comparative study in mice of ten 1,4-benzodiazepines and of clobazam: anticonvulsant, anxiolytic, sedative, and myorelaxant effects

1 reference

https://pubmed.ncbi.nlm.nih.gov/24533090

12 December 2020

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Identifiers

10.1371/JOURNAL.PONE.0088456

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

2014PLoSO...988456J

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release_vewem3dxi5ho5pf4qfi73nmzaa

1 reference

https://api.fatcat.wiki/v0/release/vewem3dxi5ho5pf4qfi73nmzaa

24 November 2022

based on heuristic

mapped directly with Wikidata item

OpenCitations bibliographic resource ID

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

ResearchGate publication ID

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