(Q21111348)

English

Axin 2

mammalian protein found in Homo sapiens

axin-2
AXIN2
axin-like protein
conductin
axis inhibition protein 2
Axil

In more languages

Statements

1 reference

13 November 2019

UniProt protein ID

Ubiquitin-like domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9Y2T1

RGS domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9Y2T1

RGS, subdomain 1/3

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9Y2T1

DIX domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9Y2T1

DIX domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Axin beta-catenin binding domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Axin-1/2, tankyrase-binding domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Regulator of G protein signalling

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y2T1

determination method

GTPase activator activity

determination method

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y2T1&geneProductId=UniProtKB:Q9Y2T1

determination method

protein binding

determination method

6 references

8 April 2019

Nuclear PKM2 regulates β-catenin transactivation upon EGFR activation

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y2T1

determination method

8 April 2019

Adenomatous polyposis coli (APC) membrane recruitment 3, a member of the APC membrane recruitment family of APC-binding proteins, is a positive regulator of Wnt-β-catenin signalling

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y2T1

determination method

8 April 2019

Wilms tumor suppressor WTX negatively regulates WNT/beta-catenin signaling

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y2T1

determination method

8 April 2019

GSK-3beta-dependent phosphorylation of adenomatous polyposis coli gene product can be modulated by beta-catenin and protein phosphatase 2A complexed with Axin

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y2T1

determination method

8 April 2019

TGIF governs a feed-forward network that empowers Wnt signaling to drive mammary tumorigenesis

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y2T1

determination method

8 April 2019

Aberrant Wnt/beta-catenin signaling can induce chromosomal instability in colon cancer

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y2T1

determination method

determination method

3 references

8 April 2019

Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y2T1

determination method

8 April 2019

The ubiquitin-specific protease USP34 regulates axin stability and Wnt/β-catenin signaling

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y2T1

determination method

8 April 2019

RNF146 is a poly(ADP-ribose)-directed E3 ligase that regulates axin degradation and Wnt signalling

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y2T1

determination method

beta-catenin binding

determination method

1 reference

8 April 2019

Mutations in AXIN2 cause colorectal cancer with defective mismatch repair by activating beta-catenin/TCF signalling

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y2T1

determination method

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y2T1

determination method

plasma membrane

determination method

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y2T1&geneProductId=UniProtKB:Q9Y2T1

determination method

determination method

3 references

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y2T1

determination method

8 April 2019

The ubiquitin-specific protease USP34 regulates axin stability and Wnt/β-catenin signaling

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y2T1

determination method

8 April 2019

Subcellular distribution of Wnt pathway proteins in normal and neoplastic colon

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y2T1

determination method

beta-catenin destruction complex

determination method

1 reference

8 April 2019

Mutations in AXIN2 cause colorectal cancer with defective mismatch repair by activating beta-catenin/TCF signalling

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y2T1

determination method

biological process

regulation of mismatch repair

determination method

1 reference

8 April 2019

Mutations in AXIN2 cause colorectal cancer with defective mismatch repair by activating beta-catenin/TCF signalling

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y2T1

determination method

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y2T1

determination method

bone mineralization

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y2T1

determination method

positive regulation of protein phosphorylation

determination method

1 reference

8 April 2019

Conductin/axin2 and Wnt signalling regulates centrosome cohesion

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y2T1

determination method

positive regulation of cell death

determination method

1 reference

8 April 2019

Epigenetic silencing of AXIN2 in colorectal carcinoma with microsatellite instability

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y2T1

determination method

positive regulation of canonical Wnt signaling pathway

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y2T1

determination method

positive regulation of epithelial to mesenchymal transition

determination method

1 reference

8 April 2019

A Wnt-Axin2-GSK3beta cascade regulates Snail1 activity in breast cancer cells

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y2T1

determination method

multicellular organism development

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y2T1

determination method

mRNA stabilization

determination method

1 reference

8 April 2019

A Wnt-Axin2-GSK3beta cascade regulates Snail1 activity in breast cancer cells

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y2T1

determination method

maintenance of DNA repeat elements

determination method

1 reference

8 April 2019

Frameshift mutations of Wnt pathway genes AXIN2 and TCF7L2 in gastric carcinomas with high microsatellite instability

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y2T1

determination method

regulation of Wnt signaling pathway

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y2T1

determination method

chondrocyte differentiation involved in endochondral bone morphogenesis

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y2T1

determination method

regulation of chondrocyte development

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y2T1

determination method

secondary heart field specification

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y2T1

determination method

cell population proliferation

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y2T1

determination method

negative regulation of canonical Wnt signaling pathway

determination method

3 references

8 April 2019

Mutations in AXIN2 cause colorectal cancer with defective mismatch repair by activating beta-catenin/TCF signalling

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y2T1

determination method

8 April 2019

Epigenetic silencing of AXIN2 in colorectal carcinoma with microsatellite instability

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y2T1

determination method

8 April 2019

Activation of AXIN2 expression by beta-catenin-T cell factor. A feedback repressor pathway regulating Wnt signaling

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y2T1

determination method

positive regulation of GTPase activity

determination method

1 reference

24 April 2018

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y2T1&geneProductId=UniProtKB:Q9Y2T1

determination method

beta-catenin-TCF complex assembly

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y2T1

determination method

Wnt signaling pathway

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y2T1

determination method

intramembranous ossification

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y2T1

determination method

negative regulation of osteoblast differentiation

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y2T1

determination method

Identifiers

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000302625

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000302625

ENSP00000364854

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000364854

ENSP00000441151

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000441151

ENSP00000463192

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000463192

ENSP00000463761

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000463761

ENSP00000464264

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000464264

ENSP00000478916

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000478916

ENSP00000481191

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000481191

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