(Q21120800)

Immunoglobulin-like domain superfamily

1 reference

Immunoglobulin subtype, protein family

1 reference

based on heuristic

inferred from protein domain or family

Immunoglobulin subtype 2, protein family

1 reference

based on heuristic

inferred from protein domain or family

immunoglobulin-like domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

17 September 2016

1 reference

21 March 2016

inhibitory MHC class I receptor activity

English

molecular function

3 references

8 April 2019

Interleukin 10 regulates cell surface and soluble LIR-2 (CD85d) expression on dendritic cells resulting in T cell hyporesponsiveness in vitro

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N423

8 April 2019

HLA-B*35-Px-mediated acceleration of HIV-1 infection by increased inhibitory immunoregulatory impulses

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N423

8 April 2019

Soluble HLA-G inhibits myeloid dendritic cell function in HIV-1 infection by interacting with leukocyte immunoglobulin-like receptor B2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N423

MHC class Ib protein binding

1 reference

1 January 2018

HLA-B*35-Px-mediated acceleration of HIV-1 infection by increased inhibitory immunoregulatory impulses

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8N423&geneProductId=UniProtKB:Q8N423

protein phosphatase 1 binding

1 reference

8 April 2019

The MHC class I binding proteins LIR-1 and LIR-2 inhibit Fc receptor-mediated signaling in monocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N423

14 references

8 April 2019

Inhibitory immunoglobulin-like receptors LILRB and PIR-B negatively regulate osteoclast development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N423

8 April 2019

Functional characterization of HLA-F and binding of HLA-F tetramers to ILT2 and ILT4 receptors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N423

8 April 2019

Human inhibitory receptors Ig-like transcript 2 (ILT2) and ILT4 compete with CD8 for MHC class I binding and bind preferentially to HLA-G

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N423

8 April 2019

Multimeric structures of HLA-G isoforms function through differential binding to LILRB receptors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N423

8 April 2019

Inhibitory receptors bind ANGPTLs and support blood stem cells and leukaemia development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N423

8 April 2019

Inhibitory immunoglobulin-like receptors LILRB and PIR-B negatively regulate osteoclast development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N423

8 April 2019

Structural basis for recognition of the nonclassical MHC molecule HLA-G by the leukocyte Ig-like receptor B2 (LILRB2/LIR2/ILT4/CD85d)

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N423

8 April 2019

Efficient leukocyte Ig-like receptor signaling and crystal structure of disulfide-linked HLA-G dimer.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N423

8 April 2019

Real-Time Analysis of Binding Events between Different Aβ1-42 Species and Human Lilrb2 by Dual Polarization Interferometry.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N423

8 April 2019

A motif in LILRB2 critical for Angptl2 binding and activation.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N423

8 April 2019

Human LilrB2 is a β-amyloid receptor and its murine homolog PirB regulates synaptic plasticity in an Alzheimer's model

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N423

8 April 2019

Cutting Edge: Class II-like Structural Features and Strong Receptor Binding of the Nonclassical HLA-G2 Isoform Homodimer.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N423

8 April 2019

Angiopoietin-like proteins stimulate HSPC development through interaction with notch receptor signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N423

8 April 2019

HLA-F and MHC-I Open Conformers Bind Natural Killer Cell Ig-Like Receptor KIR3DS1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N423

MHC class I protein binding

6 references

8 April 2019

Multimeric structures of HLA-G isoforms function through differential binding to LILRB receptors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N423

8 April 2019

Ig-like transcript 4 inhibits lipid antigen presentation through direct CD1d interaction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N423

8 April 2019

Soluble HLA-G inhibits myeloid dendritic cell function in HIV-1 infection by interacting with leukocyte immunoglobulin-like receptor B2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N423

8 April 2019

Inhibitory immunoglobulin-like receptors LILRB and PIR-B negatively regulate osteoclast development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N423

8 April 2019

The MHC class I binding proteins LIR-1 and LIR-2 inhibit Fc receptor-mediated signaling in monocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N423

8 April 2019

Interleukin 10 regulates cell surface and soluble LIR-2 (CD85d) expression on dendritic cells resulting in T cell hyporesponsiveness in vitro

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N423

cell adhesion molecule binding

1 reference

8 April 2019

Ig-like transcript 4 inhibits lipid antigen presentation through direct CD1d interaction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N423

protein homodimerization activity

1 reference

8 April 2019

Human LilrB2 is a β-amyloid receptor and its murine homolog PirB regulates synaptic plasticity in an Alzheimer's model

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N423

protein-containing complex binding

1 reference

8 April 2019

Human LilrB2 is a β-amyloid receptor and its murine homolog PirB regulates synaptic plasticity in an Alzheimer's model

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N423

MHC class Ib protein complex binding

1 reference

8 April 2019

Structural basis for recognition of the nonclassical MHC molecule HLA-G by the leukocyte Ig-like receptor B2 (LILRB2/LIR2/ILT4/CD85d)

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N423

1 reference

8 April 2019

Ig-like transcript 4 inhibits lipid antigen presentation through direct CD1d interaction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N423

integral component of membrane

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N423

1 reference

3 January 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q8N423

integral component of plasma membrane

2 references

1 reference

8 April 2019

Interleukin 10 regulates cell surface and soluble LIR-2 (CD85d) expression on dendritic cells resulting in T cell hyporesponsiveness in vitro

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N423

tertiary granule membrane

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N423

ficolin-1-rich granule membrane

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N423

2 references

adaptive immune response

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N423

Fc receptor mediated inhibitory signaling pathway

IEA

1 reference

8 April 2019

The MHC class I binding proteins LIR-1 and LIR-2 inhibit Fc receptor-mediated signaling in monocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N423

positive regulation of tolerance induction

1 reference

8 April 2019

Multimeric structures of HLA-G isoforms function through differential binding to LILRB receptors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N423

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N423

immune system process

1 reference

8 April 2019

positive regulation of regulatory T cell differentiation

IEA

1 reference

8 April 2019

Differentiation of type 1 T regulatory cells (Tr1) by tolerogenic DC-10 requires the IL-10-dependent ILT4/HLA-G pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N423

heterotypic cell-cell adhesion

1 reference

8 April 2019

Ig-like transcript 4 inhibits lipid antigen presentation through direct CD1d interaction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N423

1 reference

8 April 2019

A common inhibitory receptor for major histocompatibility complex class I molecules on human lymphoid and myelomonocytic cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N423

regulation of dendritic cell differentiation

1 reference

8 April 2019

HLA-B*35-Px-mediated acceleration of HIV-1 infection by increased inhibitory immunoregulatory impulses

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N423

positive regulation of T cell tolerance induction

IC

cellular defense response

1 reference

8 April 2019

A common inhibitory receptor for major histocompatibility complex class I molecules on human lymphoid and myelomonocytic cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N423

cell surface receptor signaling pathway

1 reference

8 April 2019

Cloning of novel immunoglobulin superfamily receptors expressed on human myeloid and lymphoid cells: structural evidence for new stimulatory and inhibitory pathways

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N423

negative regulation of T cell proliferation

3 references

8 April 2019

Interleukin 10 regulates cell surface and soluble LIR-2 (CD85d) expression on dendritic cells resulting in T cell hyporesponsiveness in vitro

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N423

8 April 2019

Ig-like transcript 4 inhibits lipid antigen presentation through direct CD1d interaction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N423

8 April 2019

Soluble HLA-G inhibits myeloid dendritic cell function in HIV-1 infection by interacting with leukocyte immunoglobulin-like receptor B2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N423

negative regulation of immune response

1 reference

3 January 2017

Multimeric structures of HLA-G isoforms function through differential binding to LILRB receptors

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q8N423

1 reference

8 April 2019

Cloning of novel immunoglobulin superfamily receptors expressed on human myeloid and lymphoid cells: structural evidence for new stimulatory and inhibitory pathways

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N423

positive regulation of T cell proliferation

1 reference

8 April 2019

Interleukin 10 regulates cell surface and soluble LIR-2 (CD85d) expression on dendritic cells resulting in T cell hyporesponsiveness in vitro

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N423

negative regulation of calcium ion transport

1 reference

8 April 2019

The MHC class I binding proteins LIR-1 and LIR-2 inhibit Fc receptor-mediated signaling in monocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N423

positive regulation of interleukin-6 production

1 reference

8 April 2019

Modulation of dendritic cell differentiation by HLA-G and ILT4 requires the IL-6--STAT3 signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N423

regulation of immune response

NAS

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N423

cellular response to lipopolysaccharide

1 reference

8 April 2019

Interleukin 10 regulates cell surface and soluble LIR-2 (CD85d) expression on dendritic cells resulting in T cell hyporesponsiveness in vitro

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N423

immune response-inhibiting cell surface receptor signaling pathway

negative regulation of antigen processing and presentation

1 reference

8 April 2019

Ig-like transcript 4 inhibits lipid antigen presentation through direct CD1d interaction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N423

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N423

neutrophil degranulation

1 reference

8 April 2019

1 reference

8 April 2019

Human LilrB2 is a β-amyloid receptor and its murine homolog PirB regulates synaptic plasticity in an Alzheimer's model

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N423

positive regulation of protein dephosphorylation

1 reference

8 April 2019

Human LilrB2 is a β-amyloid receptor and its murine homolog PirB regulates synaptic plasticity in an Alzheimer's model

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N423

negative regulation of protein metabolic process

1 reference

8 April 2019

Human LilrB2 is a β-amyloid receptor and its murine homolog PirB regulates synaptic plasticity in an Alzheimer's model

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N423

regulation of long-term synaptic potentiation

1 reference

8 April 2019

Human LilrB2 is a β-amyloid receptor and its murine homolog PirB regulates synaptic plasticity in an Alzheimer's model

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N423

positive regulation of long-term synaptic depression

1 reference

8 April 2019

Human LilrB2 is a β-amyloid receptor and its murine homolog PirB regulates synaptic plasticity in an Alzheimer's model

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N423

negative regulation of postsynaptic density organization

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N423

immunoglobulin-like domain

IC

has part(s)

1 reference

immunoglobulin subtype 2

1 reference

immunoglobulin subtype

1 reference

Identifiers

1 reference

21 March 2016

1 reference

21 March 2016

1 reference

21 March 2016

1 reference

21 March 2016