(Q21134401)

protein homodimerization activity

1 reference

8 April 2019

Crystal structure of the human Hsmar1-derived transposase domain in the DNA repair enzyme Metnase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q53H47

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q53H47

histone methyltransferase activity (H3-K4 specific)

1 reference

8 April 2019

The SET domain protein Metnase mediates foreign DNA integration and links integration to nonhomologous end-joining repair

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q53H47

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q53H47

single-stranded DNA binding

1 reference

8 April 2019

The DDN catalytic motif is required for Metnase functions in non-homologous end joining (NHEJ) repair and replication restart

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q53H47

single-stranded DNA endodeoxyribonuclease activity

1 reference

8 April 2019

The DDN catalytic motif is required for Metnase functions in non-homologous end joining (NHEJ) repair and replication restart

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q53H47

4 references

8 April 2019

Metnase promotes restart and repair of stalled and collapsed replication forks

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q53H47

8 April 2019

Metnase mediates resistance to topoisomerase II inhibitors in breast cancer cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q53H47

8 April 2019

Crystal structure of the human Hsmar1-derived transposase domain in the DNA repair enzyme Metnase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q53H47

8 April 2019

The transposase domain protein Metnase/SETMAR suppresses chromosomal translocations

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q53H47

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q53H47

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q53H47

Chk1 phosphorylation of Metnase enhances DNA repair but inhibits replication fork restart

endonuclease activity

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q53H47

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q53H47

8 April 2019

Biochemical characterization of metnase's endonuclease activity and its role in NHEJ repair

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q53H47

8 April 2019

The transposase domain protein Metnase/SETMAR suppresses chromosomal translocations

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q53H47

histone methyltransferase activity (H3-K36 specific)

1 reference

8 April 2019

The SET domain protein Metnase mediates foreign DNA integration and links integration to nonhomologous end-joining repair

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q53H47

double-stranded DNA binding

1 reference

8 April 2019

The DDN catalytic motif is required for Metnase functions in non-homologous end joining (NHEJ) repair and replication restart

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q53H47

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q53H47

3 references

8 April 2019

Biochemical characterization of metnase's endonuclease activity and its role in NHEJ repair

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q53H47

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q53H47

8 April 2019

Crystal structure of the human Hsmar1-derived transposase domain in the DNA repair enzyme Metnase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q53H47

site of double-strand break

cell component

3 references

8 April 2019

Chk1 phosphorylation of Metnase enhances DNA repair but inhibits replication fork restart

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q53H47

8 April 2019

Human Pso4 is a metnase (SETMAR)-binding partner that regulates metnase function in DNA repair

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q53H47

8 April 2019

Methylation of histone H3 lysine 36 enhances DNA repair by nonhomologous end-joining

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q53H47

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q53H47

1 reference

8 April 2019

The SET and transposase domain protein Metnase enhances chromosome decatenation: regulation by automethylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q53H47

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q53H47

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q53H47

8 April 2019

Chk1 phosphorylation of Metnase enhances DNA repair but inhibits replication fork restart

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q53H47

8 April 2019

Biochemical characterization of metnase's endonuclease activity and its role in NHEJ repair

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q53H47

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q53H47

histone H3-K36 dimethylation

biological process

1 reference

8 April 2019

Methylation of histone H3 lysine 36 enhances DNA repair by nonhomologous end-joining

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q53H47

nucleic acid phosphodiester bond hydrolysis

1 reference

8 April 2019

Chk1 phosphorylation of Metnase enhances DNA repair but inhibits replication fork restart

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q53H47

positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity

DNA double-strand break processing

1 reference

8 April 2019

Biochemical characterization of metnase's endonuclease activity and its role in NHEJ repair

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q53H47

positive regulation of double-strand break repair via nonhomologous end joining

DNA catabolic process, endonucleolytic

3 references

8 April 2019

The DDN catalytic motif is required for Metnase functions in non-homologous end joining (NHEJ) repair and replication restart

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q53H47

8 April 2019

Biochemical characterization of metnase's endonuclease activity and its role in NHEJ repair

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q53H47

8 April 2019

Crystal structure of the human Hsmar1-derived transposase domain in the DNA repair enzyme Metnase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q53H47

cellular response to DNA damage stimulus

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q53H47

histone H3-K36 methylation

histone H3-K4 methylation

1 reference

8 April 2019

The SET domain protein Metnase mediates foreign DNA integration and links integration to nonhomologous end-joining repair

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q53H47

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q53H47

replication fork processing

3 references

8 April 2019

Metnase promotes restart and repair of stalled and collapsed replication forks

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q53H47

8 April 2019

Chk1 phosphorylation of Metnase enhances DNA repair but inhibits replication fork restart

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q53H47

8 April 2019

The DDN catalytic motif is required for Metnase functions in non-homologous end joining (NHEJ) repair and replication restart

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q53H47

histone lysine methylation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q53H47

mitotic DNA integrity checkpoint signaling

1 reference

8 April 2019

The SET and transposase domain protein Metnase enhances chromosome decatenation: regulation by automethylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q53H47

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q53H47

cell population proliferation

1 reference

8 April 2019

Metnase promotes restart and repair of stalled and collapsed replication forks

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q53H47

double-strand break repair via nonhomologous end joining

4 references

8 April 2019

Human Pso4 is a metnase (SETMAR)-binding partner that regulates metnase function in DNA repair

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q53H47

8 April 2019

Methylation of histone H3 lysine 36 enhances DNA repair by nonhomologous end-joining

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q53H47

8 April 2019

The DDN catalytic motif is required for Metnase functions in non-homologous end joining (NHEJ) repair and replication restart

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q53H47

8 April 2019

The SET domain protein Metnase mediates foreign DNA integration and links integration to nonhomologous end-joining repair

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q53H47

negative regulation of chromosome organization

1 reference

8 April 2019

The transposase domain protein Metnase/SETMAR suppresses chromosomal translocations

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q53H47

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q53H47

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q53H47

chromatin organization

1 reference

8 April 2019

1 reference

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/Q53H47

Pre-SET domain

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/Q53H47

Post-SET domain

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/Q53H47

Identifiers

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

13 November 2019

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016