(Q21497067)

http://www.ebi.ac.uk/interpro/protein/Q99ML1

1 reference

25 May 2022

1 reference

25 May 2022

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99ML1

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99ML1

PUMA induces the rapid apoptosis of colorectal cancer cells

mitochondrial envelope

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99ML1

4 references

24 April 2018

PUMA induces the rapid apoptosis of colorectal cancer cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99ML1&geneProductId=UniProtKB:Q99ML1

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99ML1&geneProductId=UniProtKB:Q99ML1

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99ML1&geneProductId=UniProtKB:Q99ML1

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99ML1&geneProductId=UniProtKB:Q99ML1

IEA

endoplasmic reticulum

1 reference

14 February 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99ML1

5 references

14 February 2019

PUMA induces the rapid apoptosis of colorectal cancer cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99ML1

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99ML1

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99ML1

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99ML1

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99ML1

positive regulation of cysteine-type endopeptidase activity

biological process

intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator

2 references

1 reference

14 February 2019

PUMA couples the nuclear and cytoplasmic proapoptotic function of p53

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99ML1

determination of adult lifespan

1 reference

14 February 2019

Puma is required for p53-induced depletion of adult stem cells

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99ML1

1 reference

14 February 2019

CCT chaperonin complex is required for efficient delivery of anthrax toxin into the cytosol of host cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99ML1

cellular response to DNA damage stimulus

1 reference

14 February 2019

Puma is required for p53-induced depletion of adult stem cells

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99ML1

intrinsic apoptotic signaling pathway

IGI

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99ML1

positive regulation of neuron apoptotic process

IEA

negative regulation of cell growth

1 reference

14 February 2019

PUMA induces the rapid apoptosis of colorectal cancer cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99ML1

intrinsic apoptotic signaling pathway by p53 class mediator

1 reference

14 February 2019

PUMA induces the rapid apoptosis of colorectal cancer cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99ML1

positive regulation of apoptotic process

3 references

24 April 2018

The NF-kappaB regulator Bcl-3 and the BH3-only proteins Bim and Puma control the death of activated T cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99ML1&geneProductId=UniProtKB:Q99ML1

24 April 2018

p53- and drug-induced apoptotic responses mediated by BH3-only proteins puma and noxa

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99ML1&geneProductId=UniProtKB:Q99ML1

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99ML1&geneProductId=UniProtKB:Q99ML1

cellular response to ionizing radiation

IEA

1 reference

14 February 2019

Slug antagonizes p53-mediated apoptosis of hematopoietic progenitors by repressing puma

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99ML1

apoptotic signaling pathway

IGI

1 reference

14 February 2019

Expression of bbc3, a pro-apoptotic BH3-only gene, is regulated by diverse cell death and survival signals

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99ML1

positive regulation of thymocyte apoptotic process

1 reference

14 February 2019

Puma is required for p53-induced depletion of adult stem cells

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99ML1

2 references

positive regulation of protein homooligomerization

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99ML1

negative regulation of endoplasmic reticulum calcium ion concentration

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99ML1

release of sequestered calcium ion into cytosol

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99ML1

intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress

4 references

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99ML1&geneProductId=UniProtKB:Q99ML1

24 April 2018

Neuronal apoptosis induced by endoplasmic reticulum stress is regulated by ATF4-CHOP-mediated induction of the Bcl-2 homology 3-only member PUMA

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99ML1&geneProductId=UniProtKB:Q99ML1

24 April 2018

CHOP potentially co-operates with FOXO3a in neuronal cells to regulate PUMA and BIM expression in response to ER stress

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99ML1&geneProductId=UniProtKB:Q99ML1

24 April 2018

Endoplasmic reticulum stress-induced apoptosis: multiple pathways and activation of p53-up-regulated modulator of apoptosis (PUMA) and NOXA by p53

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99ML1&geneProductId=UniProtKB:Q99ML1

positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway

2 references

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99ML1&geneProductId=UniProtKB:Q99ML1

24 April 2018

Cell death provoked by loss of interleukin-3 signaling is independent of Bad, Bim, and PI3 kinase, but depends in part on Puma

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99ML1&geneProductId=UniProtKB:Q99ML1

positive regulation of intrinsic apoptotic signaling pathway

1 reference

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99ML1&geneProductId=UniProtKB:Q99ML1

release of cytochrome c from mitochondria

3 references

14 February 2019

PUMA induces the rapid apoptosis of colorectal cancer cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99ML1

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99ML1

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99ML1

activation of cysteine-type endopeptidase activity involved in apoptotic process

3 references

14 February 2019

PUMA induces the rapid apoptosis of colorectal cancer cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99ML1

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99ML1

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99ML1

positive regulation of apoptotic process

4 references

14 February 2019

p53- and drug-induced apoptotic responses mediated by BH3-only proteins puma and noxa

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99ML1

14 February 2019

The NF-kappaB regulator Bcl-3 and the BH3-only proteins Bim and Puma control the death of activated T cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99ML1

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99ML1

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99ML1

intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress

5 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99ML1

14 February 2019

Neuronal apoptosis induced by endoplasmic reticulum stress is regulated by ATF4-CHOP-mediated induction of the Bcl-2 homology 3-only member PUMA

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99ML1

14 February 2019

CHOP potentially co-operates with FOXO3a in neuronal cells to regulate PUMA and BIM expression in response to ER stress

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99ML1

14 February 2019

Endoplasmic reticulum stress-induced apoptosis: multiple pathways and activation of p53-up-regulated modulator of apoptosis (PUMA) and NOXA by p53

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99ML1

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99ML1

positive regulation of release of cytochrome c from mitochondria

execution phase of apoptosis

3 references

14 February 2019

PUMA induces the rapid apoptosis of colorectal cancer cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99ML1

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99ML1

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99ML1

positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99ML1

14 February 2019

Cell death provoked by loss of interleukin-3 signaling is independent of Bad, Bim, and PI3 kinase, but depends in part on Puma

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99ML1

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99ML1

positive regulation of cysteine-type endopeptidase activity

3 references

14 February 2019

Neuronal apoptosis induced by endoplasmic reticulum stress is regulated by ATF4-CHOP-mediated induction of the Bcl-2 homology 3-only member PUMA

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99ML1

14 February 2019

CHOP potentially co-operates with FOXO3a in neuronal cells to regulate PUMA and BIM expression in response to ER stress

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99ML1

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99ML1