(Q21498746)

Rho GTPase activation protein

1 reference

SH2 domain superfamily

1 reference

membrane protein

1 reference

inferred from GOA cell component → membrane

PI3K p85 subunit, inter-SH2 domain, protein family

1 reference

SH2 domain, protein family

1 reference

Phosphatidylinositol 3-kinase regulatory subunit alpha, SH3 domain, protein family

1 reference

Rho GTPase-activating protein domain family

1 reference

PI3K p85 subunit, C-terminal SH2 domain, protein family

1 reference

PI3K p85 subunit, N-terminal SH2 domain, protein family

1 reference

SH3 domain, protein family

1 reference

ErbB-3 class receptor binding

1 reference

25 May 2022

1 reference

25 May 2022

3 references

phosphatidylinositol 3-kinase regulator activity

ISS

insulin-like growth factor receptor binding

2 references

3 references

insulin receptor binding

3 references

phosphatidylinositol 3-kinase regulatory subunit binding

1 reference

14 February 2019

The regulatory subunits of PI3K, p85alpha and p85beta, interact with XBP-1 and increase its nuclear translocation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26450

transcription factor binding

IPI

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26450

14 February 2019

The regulatory subunits of PI3K, p85alpha and p85beta, interact with XBP-1 and increase its nuclear translocation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26450

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26450

2 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26450

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26450

21 references

14 February 2019

Absence of Appl2 sensitizes endotoxin shock through activation of PI3K/Akt pathway.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26450

14 February 2019

PSM, a mediator of PDGF-BB-, IGF-I-, and insulin-stimulated mitogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26450

14 February 2019

Serine phosphorylation sites on IRS2 activated by angiotensin II and protein kinase C to induce selective insulin resistance in endothelial cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26450

14 February 2019

Enkurin is a novel calmodulin and TRPC channel binding protein in sperm

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26450

14 February 2019

PS1 activates PI3K thus inhibiting GSK-3 activity and tau overphosphorylation: effects of FAD mutations

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26450

14 February 2019

LIME acts as a transmembrane adapter mediating BCR-dependent B-cell activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26450

14 February 2019

Phosphoinositide 3-kinase p85beta regulates invadopodium formation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26450

14 February 2019

BCAP: the tyrosine kinase substrate that connects B cell receptor to phosphoinositide 3-kinase activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26450

14 February 2019

Nuclear receptor corepressor is a novel regulator of phosphatidylinositol 3-kinase signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26450

14 February 2019

CDK4 is an essential insulin effector in adipocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26450

14 February 2019

SOCS-6 binds to insulin receptor substrate 4, and mice lacking the SOCS-6 gene exhibit mild growth retardation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26450

14 February 2019

Protein-protein interaction panel using mouse full-length cDNAs

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26450

14 February 2019

NYAP: a phosphoprotein family that links PI3K to WAVE1 signalling in neurons

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26450

14 February 2019

Angiogenesis selectively requires the p110alpha isoform of PI3K to control endothelial cell migration.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26450

14 February 2019

Abi1/Hssh3bp1 pY213 links Abl kinase signaling to p85 regulatory subunit of PI-3 kinase in regulation of macropinocytosis in LNCaP cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26450

14 February 2019

A TRAF-like motif of the inducible costimulator ICOS controls development of germinal center TFH cells via the kinase TBK1.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26450

14 February 2019

Overexpression of the dual-specificity phosphatase MKP-4/DUSP-9 protects against stress-induced insulin resistance

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26450

14 February 2019

p37δ is a new isoform of PI3K p110δ that increases cell proliferation and is overexpressed in tumors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26450

14 February 2019

Impaired liver regeneration in Nrf2 knockout mice: role of ROS-mediated insulin/IGF-1 resistance

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26450

14 February 2019

Bioinformatics and cellular signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26450

14 February 2019

The density of extracellular matrix proteins regulates inflammation and insulin signaling in adipocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26450

protein heterodimerization activity

IPI

1 reference

14 February 2019

The regulatory subunits of PI3K, p85alpha and p85beta, interact with XBP-1 and increase its nuclear translocation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26450

signaling receptor binding

IPI

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26450

platelet-derived growth factor receptor binding

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26450

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26450

protein C-terminus binding

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26450

protein kinase binding

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26450

protein domain specific binding

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26450

estrogen receptor binding

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26450

receptor tyrosine kinase binding

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26450

ubiquitin protein ligase binding

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26450

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26450

phosphoprotein binding

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26450

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26450

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26450

14 February 2019

The p85 regulatory subunit of phosphoinositide 3-kinase down-regulates IRS-1 signaling via the formation of a sequestration complex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26450

phosphatidylinositol 3-kinase complex, class IA

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26450

1 reference

14 February 2019

The lymphoid lineage-specific actin-uncapping protein Rltpr is essential for costimulation via CD28 and the development of regulatory T cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26450

1 reference

14 February 2019

Phosphoinositide 3-kinase p85beta regulates invadopodium formation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26450

perinuclear endoplasmic reticulum membrane

1 reference

14 February 2019

Phosphoinositide 3-kinase p85beta regulates invadopodium formation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26450

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26450

phosphatidylinositol 3-kinase complex

3 references

24 April 2018

Increased insulin sensitivity and hypoglycaemia in mice lacking the p85 alpha subunit of phosphoinositide 3-kinase

http://www.ebi.ac.uk/QuickGO/annotations?protein=P26450&geneProductId=UniProtKB:P26450

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P26450&geneProductId=UniProtKB:P26450

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P26450&geneProductId=UniProtKB:P26450

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26450

phosphatidylinositol 3-kinase complex

4 references

14 February 2019

Increased insulin sensitivity and hypoglycaemia in mice lacking the p85 alpha subunit of phosphoinositide 3-kinase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26450

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26450

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26450

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26450

negative regulation of cell adhesion

IBA

biological process

1 reference

14 February 2019

Phosphoinositide 3-kinase p85beta regulates invadopodium formation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26450

insulin-like growth factor receptor signaling pathway

3 references

positive regulation of endoplasmic reticulum unfolded protein response

3 references

negative regulation of osteoclast differentiation

1 reference

14 February 2019

Hyperactivation of p21ras and PI3K cooperate to alter murine and human neurofibromatosis type 1-haploinsufficient osteoclast functions

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26450

cellular glucose homeostasis

1 reference

14 February 2019

The regulatory subunits of PI3K, p85alpha and p85beta, interact with XBP-1 and increase its nuclear translocation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26450

negative regulation of apoptotic process

protein stabilization

3 references

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26450

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26450

14 February 2019

PS1 activates PI3K thus inhibiting GSK-3 activity and tau overphosphorylation: effects of FAD mutations

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26450

response to endoplasmic reticulum stress

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26450

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26450

14 February 2019

The regulatory subunits of PI3K, p85alpha and p85beta, interact with XBP-1 and increase its nuclear translocation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26450

regulation of stress fiber assembly

1 reference

14 February 2019

Phosphoinositide 3-kinase p85beta regulates invadopodium formation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26450

negative regulation of cell-matrix adhesion

1 reference

14 February 2019

Hyperactivation of p21ras and PI3K cooperate to alter murine and human neurofibromatosis type 1-haploinsufficient osteoclast functions

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26450

PS1 activates PI3K thus inhibiting GSK-3 activity and tau overphosphorylation: effects of FAD mutations

protein phosphorylation

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26450

phosphatidylinositol phosphate biosynthetic process

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P26450&geneProductId=UniProtKB:P26450

intrinsic apoptotic signaling pathway in response to DNA damage

ISS

positive regulation of tumor necrosis factor production

1 reference

14 February 2019

p85alpha acts as a novel signal transducer for mediation of cellular apoptotic response to UV radiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26450

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26450

positive regulation of RNA splicing

3 references

B cell differentiation

1 reference

14 February 2019

Increased insulin sensitivity and hypoglycaemia in mice lacking the p85 alpha subunit of phosphoinositide 3-kinase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26450

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26450

positive regulation of transcription by RNA polymerase II

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26450

14 February 2019

p85alpha acts as a novel signal transducer for mediation of cellular apoptotic response to UV radiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26450

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26450

14 February 2019

The regulatory subunits of PI3K, p85alpha and p85beta, interact with XBP-1 and increase its nuclear translocation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26450

regulation of insulin receptor signaling pathway

1 reference

14 February 2019

CDK4 is an essential insulin effector in adipocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26450

phosphatidylinositol-3-phosphate biosynthetic process

1 reference

14 February 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26450

regulation of protein localization to plasma membrane

1 reference

14 February 2019

Phosphoinositide 3-kinase p85beta regulates invadopodium formation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26450

protein import into nucleus

1 reference

14 February 2019

p85alpha acts as a novel signal transducer for mediation of cellular apoptotic response to UV radiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26450

positive regulation of protein phosphorylation

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26450

glucose metabolic process

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26450

insulin receptor signaling pathway

3 references

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P26450&geneProductId=UniProtKB:P26450

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P26450&geneProductId=UniProtKB:P26450

24 April 2018

The regulatory subunits of PI3K, p85alpha and p85beta, interact with XBP-1 and increase its nuclear translocation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P26450&geneProductId=UniProtKB:P26450

negative regulation of heart rate

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26450

positive regulation of gene expression

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26450

negative regulation of muscle cell apoptotic process

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26450

negative regulation of cell-cell adhesion

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26450

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26450

positive regulation of protein import into nucleus

5 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26450

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26450

14 February 2019

The regulatory subunits of PI3K, p85alpha and p85beta, interact with XBP-1 and increase its nuclear translocation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26450

14 February 2019

The regulatory subunits of PI3K, p85alpha and p85beta, interact with XBP-1 and increase its nuclear translocation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26450

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26450

positive regulation of myoblast differentiation

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26450

negative regulation of blood pressure

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26450

negative regulation of proteolysis

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26450

negative regulation of smooth muscle cell proliferation

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26450

response to glucocorticoid

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26450

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26450

insulin receptor signaling pathway

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26450

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26450

14 February 2019

The regulatory subunits of PI3K, p85alpha and p85beta, interact with XBP-1 and increase its nuclear translocation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26450

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26450

Rho GTPase-activating protein domain

IBA

has part(s)

1 reference

SH2 domain

1 reference

PI3K p85 subunit, inter-SH2 domain

1 reference

SH3 domain

1 reference

Phosphatidylinositol 3-kinase regulatory subunit alpha, SH3 domain

1 reference

PI3K p85 subunit, C-terminal SH2 domain

1 reference

PI3K p85 subunit, N-terminal SH2 domain

1 reference