(Q21989859)

English

Protocadherin 15

mammalian protein found in Mus musculus

protocadherin 15 CD3 isoform
Pcdh15
protocadherin 15 CD2
Ames waltzer
protocadherin-15

In more languages

Statements

1 reference

25 May 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

molecular function

calcium ion binding

determination method

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99PJ1

determination method

protein binding

determination method

12 references

14 February 2019

Tip-link protein protocadherin 15 interacts with transmembrane channel-like proteins TMC1 and TMC2

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99PJ1

determination method

14 February 2019

The murine catecholamine methyltransferase mTOMT is essential for mechanotransduction by cochlear hair cells.

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99PJ1

determination method

14 February 2019

Interactions in the network of Usher syndrome type 1 proteins

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99PJ1

determination method

14 February 2019

TMHS is an integral component of the mechanotransduction machinery of cochlear hair cells

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99PJ1

determination method

14 February 2019

Physical and functional interaction between protocadherin 15 and myosin VIIa in mechanosensory hair cells

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99PJ1

determination method

14 February 2019

Scaffold protein harmonin (USH1C) provides molecular links between Usher syndrome type 1 and type 2

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99PJ1

determination method

14 February 2019

Cadherin 23 and protocadherin 15 interact to form tip-link filaments in sensory hair cells

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99PJ1

determination method

14 February 2019

Interactions in the network of Usher syndrome type 1 proteins

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99PJ1

determination method

14 February 2019

Photoreceptor expression of the Usher syndrome type 1 protein protocadherin 15 (USH1F) and its interaction with the scaffold protein harmonin (USH1C)

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99PJ1

determination method

14 February 2019

Structure of the N terminus of cadherin 23 reveals a new adhesion mechanism for a subset of cadherin superfamily members

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99PJ1

determination method

14 February 2019

A mouse model for nonsyndromic deafness (DFNB12) links hearing loss to defects in tip links of mechanosensory hair cells

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99PJ1

determination method

14 February 2019

Structure of a force-conveying cadherin bond essential for inner-ear mechanotransduction

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99PJ1

determination method

protein-containing complex binding

determination method

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99PJ1

determination method

protein N-terminus binding

determination method

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99PJ1

determination method

determination method

1 reference

14 February 2019

Physical and functional interaction between protocadherin 15 and myosin VIIa in mechanosensory hair cells

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99PJ1

determination method

stereocilium bundle

determination method

1 reference

21 June 2018

Regulation of PCDH15 function in mechanosensory hair cells by alternative splicing of the cytoplasmic domain

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99PJ1&geneProductId=UniProtKB:Q99PJ1

determination method

determination method

2 references

plasma membrane

determination method

3 references

determination method

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99PJ1

determination method

extracellular region

determination method

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99PJ1

determination method

extracellular space

determination method

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99PJ1

determination method

integral component of plasma membrane

determination method

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99PJ1

determination method

determination method

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99PJ1

determination method

14 February 2019

PCDH15 is expressed in the neurosensory epithelium of the eye and ear and mutant alleles are responsible for both USH1F and DFNB23

HUGO Gene Nomenclature Committee

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99PJ1

determination method

14 February 2019

Class III myosins shape the auditory hair bundles by limiting microvilli and stereocilia growth

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99PJ1

determination method

biological process

inner ear receptor cell stereocilium organization

determination method

1 reference

14 February 2019

A core cochlear phenotype in USH1 mouse mutants implicates fibrous links of the hair bundle in its cohesion, orientation and differential growth

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99PJ1

determination method

startle response

determination method

1 reference

14 February 2019

Characterization of a new allele of Ames waltzer generated by ENU mutagenesis

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99PJ1

determination method

locomotory behavior

determination method

4 references

14 February 2019

Characterization of a new allele of Ames waltzer generated by ENU mutagenesis

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99PJ1

determination method

14 February 2019

Cochlear developmental defect and background-dependent hearing thresholds in the Jackson circler (jc) mutant mouse

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99PJ1

determination method

14 February 2019

Neuroepithelial defects of the inner ear in a new allele of the mouse mutation Ames waltzer

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99PJ1

determination method

14 February 2019

A new mouse insertional mutation that causes sensorineural deafness and vestibular defects

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99PJ1

determination method

multicellular organism growth

determination method

1 reference

14 February 2019

Neuroepithelial defects of the inner ear in a new allele of the mouse mutation Ames waltzer

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99PJ1

determination method

actin filament organization

determination method

1 reference

14 February 2019

Severe vestibular and auditory impairment in three alleles of Ames waltzer (av) mice

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99PJ1

determination method

sensory perception of light stimulus

determination method

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99PJ1

determination method

determination method

11 references

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99PJ1

determination method

14 February 2019

Severe vestibular and auditory impairment in three alleles of Ames waltzer (av) mice

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99PJ1

determination method

14 February 2019

Physical and functional interaction between protocadherin 15 and myosin VIIa in mechanosensory hair cells

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99PJ1

determination method

14 February 2019

Electron Microscopic Studies of Capillary Permeability in Normal and Ames Waltzer Deaf Mice

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99PJ1

determination method

14 February 2019

Fine genetic and comparative mapping of the deafness mutation Ames waltzer on mouse chromosome 10

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99PJ1

determination method

14 February 2019

A new mouse insertional mutation that causes sensorineural deafness and vestibular defects

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99PJ1

determination method

14 February 2019

PCDH15 is expressed in the neurosensory epithelium of the eye and ear and mutant alleles are responsible for both USH1F and DFNB23

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99PJ1

determination method

14 February 2019

Neuroepithelial defects of the inner ear in a new allele of the mouse mutation Ames waltzer

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99PJ1

determination method

14 February 2019

Digenic inheritance of deafness caused by mutations in genes encoding cadherin 23 and protocadherin 15 in mice and humans

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99PJ1

determination method

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99PJ1

determination method

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99PJ1

determination method

detection of mechanical stimulus involved in equilibrioception

determination method

1 reference

14 February 2019

Physical and functional interaction between protocadherin 15 and myosin VIIa in mechanosensory hair cells

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99PJ1

determination method

actin filament bundle assembly

determination method

1 reference

21 June 2018

Regulation of PCDH15 function in mechanosensory hair cells by alternative splicing of the cytoplasmic domain

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99PJ1&geneProductId=UniProtKB:Q99PJ1

determination method

detection of mechanical stimulus involved in sensory perception of sound

determination method

1 reference

14 February 2019

Physical and functional interaction between protocadherin 15 and myosin VIIa in mechanosensory hair cells

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99PJ1

determination method

morphogenesis of an epithelium

determination method

1 reference

14 February 2019

The mouse Ames waltzer hearing-loss mutant is caused by mutation of Pcdh15, a novel protocadherin gene

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99PJ1

determination method

auditory receptor cell stereocilium organization

determination method

5 references

14 February 2019

A new spontaneous mutation in the mouse protocadherin 15 gene

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99PJ1

determination method

14 February 2019

Severe vestibular and auditory impairment in three alleles of Ames waltzer (av) mice

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99PJ1

determination method

14 February 2019

TMHS is an integral component of the mechanotransduction machinery of cochlear hair cells

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99PJ1

determination method

14 February 2019

Neuroepithelial defects of the inner ear in a new allele of the mouse mutation Ames waltzer

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99PJ1

determination method

14 February 2019

Digenic inheritance of deafness caused by mutations in genes encoding cadherin 23 and protocadherin 15 in mice and humans

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99PJ1

determination method

inner ear auditory receptor cell differentiation

determination method

1 reference

14 February 2019

Physical and functional interaction between protocadherin 15 and myosin VIIa in mechanosensory hair cells

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99PJ1

determination method

equilibrioception

determination method

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99PJ1

determination method

inner ear development

determination method

3 references

14 February 2019

Characterization of a new allele of Ames waltzer generated by ENU mutagenesis

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99PJ1

determination method

14 February 2019

Neuroepithelial defects of the inner ear in a new allele of the mouse mutation Ames waltzer

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99PJ1

determination method

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99PJ1

determination method

photoreceptor cell maintenance

determination method

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99PJ1

determination method

visual perception

determination method

1 reference

14 February 2019

Ames Waltzer deaf mice have reduced electroretinogram amplitudes and complex alternative splicing of Pcdh15 transcripts

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99PJ1

determination method

homophilic cell adhesion via plasma membrane adhesion molecules

determination method

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99PJ1

determination method

adult walking behavior

determination method

1 reference

14 February 2019

Severe vestibular and auditory impairment in three alleles of Ames waltzer (av) mice

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99PJ1

determination method

determination method

cell-cell signaling

determination method

1 reference

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99PJ1&geneProductId=UniProtKB:Q99PJ1

determination method

non-motile cilium assembly

determination method

1 reference

14 February 2019

Physical and functional interaction between protocadherin 15 and myosin VIIa in mechanosensory hair cells

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99PJ1

determination method

response to calcium ion

determination method

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99PJ1

determination method

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q99PJ1

Cadherin conserved site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q99PJ1

Identifiers

RefSeq protein ID

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

Ensembl protein ID

ENSMUSP00000090076

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000090076

ENSMUSP00000101064

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000101064

ENSMUSP00000101066

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000101066

ENSMUSP00000101069

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000101069

ENSMUSP00000114326

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000114326

ENSMUSP00000115399

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000115399

ENSMUSP00000117731

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000117731

ENSMUSP00000118201

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000118201

ENSMUSP00000119662

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000119662

ENSMUSP00000120056

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000120056

ENSMUSP00000120618

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000120618

ENSMUSP00000121130

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000121130

ENSMUSP00000121534

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000121534

ENSMUSP00000121939

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000121939

ENSMUSP00000122466

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000122466

ENSMUSP00000122606

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000122606

ENSMUSP00000122911

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000122911

ENSMUSP00000122940

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000122940

ENSMUSP00000123647

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000123647

ENSMUSP00000134863

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000134863

ENSMUSP00000135495

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000135495

ENSMUSP00000135501

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000135501

ENSMUSP00000135849

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000135849

ENSMUSP00000141792

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000141792

ENSMUSP00000141973

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000141973

ENSMUSP00000142173

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000142173

ENSMUSP00000142313

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000142313

ENSMUSP00000068561

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000068561

ENSMUSP00000118833

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000118833

ENSMUSP00000141594

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000141594

ENSMUSP00000141920

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000141920

ENSMUSP00000142238

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000142238

PDB structure ID

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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