(Q27684635)

10

0 references

Vadim Cherezov

11

0 references

Huixian Wu

Huixian Wu

2

0 references

Xi-Ping Huang

Xi-Ping Huang

6

0 references

Raymond C. Stevens

Raymond C Stevens

14

0 references

Marc Caron

12

Marc G Caron

0 references

Bryan L. Roth

13

Bryan L Roth

0 references

Gye Won Han

5

Gye Won Han

0 references

Eyal Vardy

4

Eyal Vardy

0 references

author name string

Chong Wang

1

0 references

Tama Evron

3

0 references

Sandy J Hufeisen

7

0 references

Thomas J Mangano

8

0 references

Dan J Urban

Lipidic cubic phase injector facilitates membrane protein serial femtosecond crystallography

9

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language of work or name

English

0 references

publication date

10 July 2014

0 references

published in

Nature Communications

0 references

volume

5

0 references

page(s)

4355

0 references

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4198951

Structural insights into the role of the Smoothened cysteine-rich domain in Hedgehog signalling

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4198951

Structure and function of the Smoothened extracellular domain in vertebrate Hedgehog signaling

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4198951

Structure of the human smoothened receptor bound to an antitumour agent

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4198951

Structural Features for Functional Selectivity at Serotonin Receptors

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4198951

Structure of the agonist-bound neurotensin receptor

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4198951

Crystal structure of the µ-opioid receptor bound to a morphinan antagonist

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4198951

Diversity and modularity of G protein-coupled receptor structures

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4198951

Crystal structure of the β2 adrenergic receptor-Gs protein complex

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4198951

Structure of an agonist-bound human A2A adenosine receptor

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4198951

The structural basis for agonist and partial agonist action on a β(1)-adrenergic receptor

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4198951

Evidence for allosteric interactions of antagonist binding to the smoothened receptor

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4198951

The 2.6 angstrom crystal structure of a human A2A adenosine receptor bound to an antagonist

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4198951

A Specific Cholesterol Binding Site Is Established by the 2.8 Å Structure of the Human β2-Adrenergic Receptor

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4198951

Small-molecule modulators of Hedgehog signaling: identification and characterization of Smoothened agonists and antagonists

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4198951

Inhibition of Hedgehog signaling by direct binding of cyclopamine to Smoothened

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4198951

Small molecule modulation of Smoothened activity

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4198951

Activating Smoothened mutations in sporadic basal-cell carcinoma

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4198951

Smoothened mutation confers resistance to a Hedgehog pathway inhibitor in medulloblastoma.

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4198951

Features and development of Coot

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4198951

Phasercrystallographic software

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4198951

Refinement of macromolecular structures by the maximum-likelihood method

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4198951

Vertebrate Smoothened functions at the primary cilium

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4198951

Hedgehog signaling in animal development: paradigms and principles

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4198951

Effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamine

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4198951

Crystallizing membrane proteins using lipidic mesophases

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4198951

Discovery of NVP-LEQ506, a second-generation inhibitor of smoothened

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4198951

Structure-function of the G protein-coupled receptor superfamily

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4198951

The Hedgehog signal transduction network

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4198951

Hedgehog partial agonism drives Warburg-like metabolism in muscle and brown fat.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4198951

Small molecule antagonists in distinct binding modes inhibit drug-resistant mutant of smoothened.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4198951

Small molecule inhibition of GDC-0449 refractory smoothened mutants and downstream mechanisms of drug resistance

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4198951

Inhibition of the hedgehog pathway in advanced basal-cell carcinoma

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4198951

GDC-0449-a potent inhibitor of the hedgehog pathway

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4198951

Rastering strategy for screening and centring of microcrystal samples of human membrane proteins with a sub-10 microm size X-ray synchrotron beam.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4198951

The effect of ligand efficacy on the formation and stability of a GPCR-G protein complex

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4198951

Converse conformational control of smoothened activity by structurally related small molecules

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4198951

Hedgehog-Gli signaling pathway inhibitors as anticancer agents.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4198951

Hedgehog signal transduction by Smoothened: pharmacologic evidence for a 2-step activation process

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4198951

Activation of heterotrimeric G proteins by Smoothened

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4198951

Hedgehog signalling in cancer formation and maintenance

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4198951

Oxysterol binding to the extracellular domain of Smoothened in Hedgehog signaling

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4198951

Flexible protein-ligand docking by global energy optimization in internal coordinates.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4198951

1-amino-4-benzylphthalazines as orally bioavailable smoothened antagonists with antitumor activity

2 June 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS5355

Influence of calculation level and effect of methylation on axial/equatorial equilibria in piperidines

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS5355

Hedgehog pathway modulation by multiple lipid binding sites on the smoothened effector of signal response.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS5355

Structural Basis for Molecular Recognition at Serotonin Receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS5355

A robotic system for crystallizing membrane and soluble proteins in lipidic mesophases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS5355

Processing of X-ray diffraction data collected in oscillation mode

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS5355

Serotonin inhibits apoptosis of pulmonary artery smooth muscle cell by pERK1/2 and PDK through 5-HT1B receptors and 5-HT transporters.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4198951

27 November 2018

Identifiers

DOI

10.1038/NCOMMS5355

1 reference

Dimensions Publication ID

3138030

ADS bibcode

2014NatCo...5.4355W

0 references

1045497145

0 references

3138030

1 reference

1 reference

1 reference