(Q37738658)

22 August 2017

ATRX loss promotes tumor growth and impairs nonhomologous end joining DNA repair in glioma (English)

1 reference

22 August 2017

0 references

Anda-Alexandra Calinescu

2

0 references

Maria G. Castro

24

0 references

Chris Jones

object named as

Chris Jones

22

0 references

Vera Gorbunova

object named as

Vera Gorbunova

20

0 references

author name string

Carl Koschmann

1

1 reference

22 August 2017

Felipe J Nunez

3

1 reference

22 August 2017

Alan Mackay

4

1 reference

22 August 2017

Janet Fazal-Salom

5

1 reference

22 August 2017

Daniel Thomas

6

1 reference

22 August 2017

Flor Mendez

7

1 reference

22 August 2017

Neha Kamran

8

1 reference

22 August 2017

Marta Dzaman

9

1 reference

22 August 2017

Lakshman Mulpuri

10

1 reference

22 August 2017

Johnathon Krasinkiewicz

11

1 reference

22 August 2017

Rosemary Lemons

13

1 reference

22 August 2017

Jacqueline A Brosnan-Cashman

14

1 reference

22 August 2017

Youping Li

15

1 reference

22 August 2017

Soyeon Roh

16

1 reference

22 August 2017

Lili Zhao

17

1 reference

22 August 2017

Henry Appelman

18

1 reference

22 August 2017

David Ferguson

19

1 reference

22 August 2017

Alan Meeker

21

1 reference

22 August 2017

Pedro R Lowenstein

23

1 reference

22 August 2017

language of work or name

English

0 references

publication date

1 March 2016

1 reference

Science Translational Medicine

22 August 2017

1 reference

22 August 2017

8

1 reference

22 August 2017

328

1 reference

22 August 2017

328ra28

1 reference

Loss of ATRX Suppresses Resolution of Telomere Cohesion to Control Recombination in ALT Cancer Cells

22 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5381643

Glioma Groups Based on 1p/19q, IDH, and TERT Promoter Mutations in Tumors

22 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5381643

Comprehensive, Integrative Genomic Analysis of Diffuse Lower-Grade Gliomas

22 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5381643

Transposon mediated integration of plasmid DNA into the subventricular zone of neonatal mice to generate novel models of glioblastoma

22 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5381643

Integrative analysis of complex cancer genomics and clinical profiles using the cBioPortal

22 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5381643

Alpha thalassemia/mental retardation syndrome X-linked gene product ATRX is required for proper replication restart and cellular resistance to replication stress

22 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5381643

Frequent ATRX, CIC, FUBP1 and IDH1 mutations refine the classification of malignant gliomas

22 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5381643

Loss of ATRX, genome instability, and an altered DNA damage response are hallmarks of the alternative lengthening of telomeres pathway

22 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5381643

The cBio cancer genomics portal: an open platform for exploring multidimensional cancer genomics data

22 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5381643

Driver mutations in histone H3.3 and chromatin remodelling genes in paediatric glioblastoma

22 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5381643

Review: insights gained from modelling high-grade glioma in the mouse

22 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5381643

Altered telomeres in tumors with ATRX and DAXX mutations

22 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5381643

Microsatellite instability in pediatric high grade glioma is associated with genomic profile and differential target gene inactivation

22 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5381643

Regulation of cell differentiation by the DNA damage response

22 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5381643

MRE11 deficiency increases sensitivity to poly(ADP-ribose) polymerase inhibition in microsatellite unstable colorectal cancers

22 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5381643

A genome-wide RNA interference screen reveals an essential CREB3L2-ATF5-MCL1 survival pathway in malignant glioma with therapeutic implications

22 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5381643

Integrated molecular genetic profiling of pediatric high-grade gliomas reveals key differences with the adult disease

22 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5381643

Genomic instability--an evolving hallmark of cancer

22 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5381643

DNA repair by homologous recombination, but not by nonhomologous end joining, is elevated in breast cancer cells.

22 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5381643

Expression of mutant p53 proteins implicates a lineage relationship between neural stem cells and malignant astrocytic glioma in a murine model

22 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5381643

De novo induction of genetically engineered brain tumors in mice using plasmid DNA

22 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5381643

Cells of adult brain germinal zone have properties akin to hair cells and can be used to replace inner ear sensory cells after damage

22 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5381643

Comprehensive genomic characterization defines human glioblastoma genes and core pathways

22 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5381643

ATP-dependent chromatin remodeling factors and DNA damage repair

22 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5381643

DNA damage-induced cell death by apoptosis.

22 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5381643

The chromatin-remodeling protein ATRX is critical for neuronal survival during corticogenesis

22 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5381643

Role of DNA-PK in the cellular response to DNA double-strand breaks

22 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5381643

The ATRX syndrome protein forms a chromatin-remodeling complex with Daxx and localizes in promyelocytic leukemia nuclear bodies

22 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5381643

Molecular-clinical spectrum of the ATR-X syndrome

22 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5381643

The nonhomologous end-joining pathway of DNA repair is required for genomic stability and the suppression of translocations

22 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5381643

Is non-homologous end-joining really an inherently error-prone process?

22 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5381643

The DNA damage response and cancer therapy

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5381643

Inhibition of DNA-dependent protein kinase induces accelerated senescence in irradiated human cancer cells

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5381643

Microsatellite instability in radiation-induced murine tumours; influence of tumour type and radiation quality

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5381643

Mutational landscape and clonal architecture in grade II and III gliomas

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5381643

DNA damage in mammalian neural stem cells leads to astrocytic differentiation mediated by BMP2 signaling through JAK-STAT

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5381643

Potent topoisomerase I inhibition by novel silatecans eliminates glioma proliferation in vitro and in vivo.

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5381643

Malignant astrocytomas originate from neural stem/progenitor cells in a somatic tumor suppressor mouse model

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5381643

Use of an orthotopic xenograft model for assessing the effect of epidermal growth factor receptor amplification on glioblastoma radiation response.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5381643

Chemosensitivity of glioma cells in vitro: a meta analysis.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5381643

Preclinical antitumor activity of temozolomide in mice: efficacy against human brain tumor xenografts and synergism with 1,3-bis(2-chloroethyl)-1-nitrosourea.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5381643

Real-time PCR assay for measurement of mouse telomeres

1 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26936505

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

DNA C-circles are specific and quantifiable markers of alternative-lengthening-of-telomeres activity

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26936505

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Use of mononucleotide repeat markers for detection of microsatellite instability in mouse tumors

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26936505

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1126/SCITRANSLMED.AAC8228

1 reference

22 August 2017

1 reference

22 August 2017

1 reference