(Q53701648)

18 May 2018

title

Fragment-Based Approach to Targeting Inosine-5'-monophosphate Dehydrogenase (IMPDH) from Mycobacterium tuberculosis. (English)

1 reference

18 May 2018

Mycobacterium tuberculosis

main subject

1 reference

8

1 reference

18 May 2018

Valerie Mizrahi

Valerie Mizrahi

6

0 references

Ana Trapero

Ana Trapero

1

0 references

Vinayak Singh

Vinayak Singh

3

0 references

Anthony G Coyne

Anthony G Coyne

5

0 references

Tom Blundell

7

Tom L Blundell

1 reference

18 May 2018

author name string

Angela Pacitto

2

1 reference

18 May 2018

Mohamad Sabbah

4

1 reference

18 May 2018

Chris Abell

9

1 reference

18 May 2018

language of work or name

English

0 references

publication date

23 March 2018

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18 May 2018

Journal of Medicinal Chemistry

published in

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18 May 2018

volume

61

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18 May 2018

issue

7

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18 May 2018

page(s)

2806-2822

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18 May 2018

Opportunities and challenges in phenotypic drug discovery: an industry perspective

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19 May 2018

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Novel inhibitors of Mycobacterium tuberculosis GuaB2 identified by a target based high-throughput phenotypic screen

19 May 2018

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19 May 2018

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Fragment-based approaches to TB drugs

19 May 2018

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Targeting tuberculosis using structure-guided fragment-based drug design

19 May 2018

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The Inosine Monophosphate Dehydrogenase, GuaB2, Is a Vulnerable New Bactericidal Drug Target for Tuberculosis

19 May 2018

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Essential but not vulnerable: indazole sulfonamides targeting inosine monophosphate dehydrogenase as potential leads against Mycobacterium tuberculosis

19 May 2018

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Inhibition of Inosine-5'-monophosphate Dehydrogenase from Bacillus anthracis: Mechanism Revealed by Pre-Steady-State Kinetics

19 May 2018

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mCSM-lig: quantifying the effects of mutations on protein-small molecule affinity in genetic disease and emergence of drug resistance

19 May 2018

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CSM-lig: a web server for assessing and comparing protein-small molecule affinities.

19 May 2018

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Mycobacterium tuberculosis IMPDH in Complexes with Substrates, Products and Antitubercular Compounds

19 May 2018

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Inosine 5'-monophosphate dehydrogenase inhibitors as antimicrobial agents: recent progress and future perspectives.

19 May 2018

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pkCSM: Predicting Small-Molecule Pharmacokinetic and Toxicity Properties Using Graph-Based Signatures.

19 May 2018

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General and condition-specific essential functions of Pseudomonas aeruginosa

19 May 2018

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The complex mechanism of antimycobacterial action of 5-fluorouracil

19 May 2018

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Genes contributing to Staphylococcus aureus fitness in abscess- and infection-related ecologies

19 May 2018

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Promiscuity and selectivity in covalent enzyme inhibition: a systematic study of electrophilic fragments

19 May 2018

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Optimization of Benzoxazole-Based Inhibitors of Cryptosporidium parvum Inosine 5′-Monophosphate Dehydrogenase

19 May 2018

1 reference

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Novel inhibitors of inosine monophosphate dehydrogenase in patent literature of the last decade

19 May 2018

1 reference

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Bacillus anthracis Inosine 5′-Monophosphate Dehydrogenase in Action: The First Bacterial Series of Structures of Phosphate Ion-, Substrate-, and Product-Bound Complexes

19 May 2018

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Fragment-based approaches in drug discovery and chemical biology

19 May 2018

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Identification of novel Mt-Guab2 inhibitor series active against M. tuberculosis

19 May 2018

1 reference

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The antibiotic potential of prokaryotic IMP dehydrogenase inhibitors

19 May 2018

1 reference

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The challenge of new drug discovery for tuberculosis

19 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5900554

Identification of novel diphenyl urea inhibitors of Mt-GuaB2 active against Mycobacterium tuberculosis

19 May 2018

1 reference

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Triazole-linked inhibitors of inosine monophosphate dehydrogenase from human and Mycobacterium tuberculosis

19 May 2018

1 reference

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Synthesis, antiproliferative activity evaluation and structure-activity relationships of novel aromatic urea and amide analogues of N-phenyl-N'-(2-chloroethyl)ureas

19 May 2018

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PHENIX: a comprehensive Python-based system for macromolecular structure solution

19 May 2018

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19 May 2018

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IMP dehydrogenase: structure, mechanism, and inhibition

19 May 2018

1 reference

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Treatment outcomes among patients with multidrug-resistant tuberculosis: systematic review and meta-analysis

19 May 2018

1 reference

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Structure based development of phenylimidazole-derived inhibitors of indoleamine 2,3-dioxygenase

19 May 2018

1 reference

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Inosine monophosphate dehydrogenase as a probe in antiviral drug discovery

19 May 2018

1 reference

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Phenylimidazole derivatives of 4-pyridone as dual inhibitors of bacterial enoyl-acyl carrier protein reductases FabI and FabK.

19 May 2018

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Recent development of IMP dehydrogenase inhibitors for the treatment of cancer.

19 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5900554

Inosine monophosphate dehydrogenase (IMPDH) as a target in drug discovery

19 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5900554

Drugs for bad bugs: confronting the challenges of antibacterial discovery

19 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5900554

Inosine 5'-monophosphate dehydrogenase inhibitors for the treatment of autoimmune diseases

19 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5900554

Modulation of cancer pathways by inhibitors of guanylate metabolism

19 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5900554

Treatment of tuberculosis: present status and future prospects.

19 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5900554

Coot: model-building tools for molecular graphics

19 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5900554

Genes required for mycobacterial growth defined by high density mutagenesis

19 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5900554

IMP dehydrogenase, an enzyme linked with proliferation and malignancy

19 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5900554

Inosine 5'-monophosphate dehydrogenase of Escherichia coli. Purification by affinity chromatography, subunit structure and inhibition by guanosine 5'-monophosphate

19 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5900554

Virtual and experimental high-throughput screening (HTS) in search of novel inosine 5'-monophosphate dehydrogenase II (IMPDH II) inhibitors.

19 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5900554

Regulation of insulin-regulated membrane aminopeptidase activity by its C-terminal domain.

13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5900554

An efficient and expeditious synthesis of di- and monosubstituted 2-aminoimidazoles

13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5900554

10.1021/ACS.JMEDCHEM.7B01622

13 August 2018

Identifiers

DOI

1 reference

18 May 2018

PMCID

5900554

1 reference

18 May 2018

PubMed ID

29547284

1 reference

18 May 2018