(Q90929094)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30104700%20AND%20SRC:MED&resulttype=core&format=json

17 April 2020

title

Mechanisms of signalling and biased agonism in G protein-coupled receptors (English)

1 reference

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17 April 2020

3

1 reference

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17 April 2020

Mohan Madan Babu

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30104700%20AND%20SRC:MED&resulttype=core&format=json

17 April 2020

Patrick M. Sexton

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30104700%20AND%20SRC:MED&resulttype=core&format=json

17 April 2020

author name string

Denise Wootten

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30104700%20AND%20SRC:MED&resulttype=core&format=json

17 April 2020

Arthur Christopoulos

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30104700%20AND%20SRC:MED&resulttype=core&format=json

17 April 2020

publication date

1 October 2018

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30104700%20AND%20SRC:MED&resulttype=core&format=json

Nature Reviews Molecular Cell Biology

17 April 2020

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30104700%20AND%20SRC:MED&resulttype=core&format=json

17 April 2020

volume

19

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30104700%20AND%20SRC:MED&resulttype=core&format=json

17 April 2020

issue

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30104700%20AND%20SRC:MED&resulttype=core&format=json

17 April 2020

page(s)

638-653

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30104700%20AND%20SRC:MED&resulttype=core&format=json

Structured and disordered facets of the GPCR fold

17 April 2020

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7 January 2021

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7 January 2021

Trends in GPCR drug discovery: new agents, targets and indications.

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7 January 2021

Pharmacogenomics of GPCR Drug Targets

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7 January 2021

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7 January 2021

GPCR Dynamics: Structures in Motion

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7 January 2021

The role of kinetic context in apparent biased agonism at GPCRs

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7 January 2021

Functional selectivity of GPCR-directed drug action through location bias

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7 January 2021

Plasma membrane localization of the μ-opioid receptor controls spatiotemporal signaling

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7 January 2021

Theoretical Aspects of GPCR-Ligand Complex Pharmacology

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7 January 2021

Structural biology. Structural basis for chemokine recognition and activation of a viral G protein-coupled receptor

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7 January 2021

Constitutive activities and inverse agonism in dopamine receptors

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7 January 2021

The activity of the serotonin receptor 2C is regulated by alternative splicing

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7 January 2021

Agonist-bound structures of G protein-coupled receptors

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7 January 2021

The GPRC6A receptor displays constitutive internalization and sorting to the slow recycling pathway.

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7 January 2021

Lipid stress inhibits endocytosis of melanocortin-4 receptor from modified clathrin-enriched sites and impairs receptor desensitization

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7 January 2021

GPCRs globally coevolved with receptor activity-modifying proteins, RAMPs

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7 January 2021

Receptor Activity-Modifying Proteins (RAMPs): New Insights and Roles

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7 January 2021

Melanocortin Receptor Accessory Proteins (MRAPs): Functions in the melanocortin system and beyond.

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7 January 2021

Virus-encoded 7 transmembrane receptors

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7 January 2021

PTH receptor-1 signalling-mechanistic insights and therapeutic prospects

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7 January 2021

Calcimimetic and calcilytic therapies for inherited disorders of the calcium-sensing receptor signalling pathway

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7 January 2021

Convergent evidence for mGluR5 in synaptic and neuroinflammatory pathways implicated in ASD.

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7 January 2021

Recent advances in biophysical studies of rhodopsins - Oligomerization, folding, and structure.

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7 January 2021

Fluorescence resonance energy transfer analysis of alpha 2a-adrenergic receptor activation reveals distinct agonist-specific conformational changes.

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7 January 2021

A fluorescence resonance energy transfer-based M2 muscarinic receptor sensor reveals rapid kinetics of allosteric modulation

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7 January 2021

Conformational Profiling of the AT1 Angiotensin II Receptor Reflects Biased Agonism, G Protein Coupling, and Cellular Context

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7 January 2021

Phase-plate cryo-EM structure of a biased agonist-bound human GLP-1 receptor-Gs complex.

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7 January 2021

The conformational signature of β-arrestin2 predicts its trafficking and signalling functions.

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7 January 2021

β-Arrestin biosensors reveal a rapid, receptor-dependent activation/deactivation cycle

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7 January 2021

Site-specific phosphorylation of CXCR4 is dynamically regulated by multiple kinases and results in differential modulation of CXCR4 signaling

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7 January 2021

Functional antagonism of different G protein-coupled receptor kinases for beta-arrestin-mediated angiotensin II receptor signaling

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7 January 2021

Selective engagement of G protein coupled receptor kinases (GRKs) encodes distinct functions of biased ligands

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7 January 2021

Distinct conformations of GPCR-β-arrestin complexes mediate desensitization, signaling, and endocytosis

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7 January 2021

Differential G-protein-coupled receptor phosphorylation provides evidence for a signaling bar code.

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7 January 2021

Distinct phosphorylation sites on the β(2)-adrenergic receptor establish a barcode that encodes differential functions of β-arrestin.

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7 January 2021

Phosphorylation-induced conformation of β2-adrenoceptor related to arrestin recruitment revealed by NMR.

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7 January 2021

Diversity and modularity of G protein-coupled receptor structures

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7 January 2021

Molecular signatures of G-protein-coupled receptors

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7 January 2021

Allosteric coupling from G protein to the agonist-binding pocket in GPCRs

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7 January 2021

Activation mechanism of the β2-adrenergic receptor

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7 January 2021

The dynamic process of β(2)-adrenergic receptor activation

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7 January 2021

Structural Insights into the Dynamic Process of β2-Adrenergic Receptor Signaling

1 reference

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7 January 2021

Priming GPCR signaling through the synergistic effect of two G proteins.

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7 January 2021

Universal allosteric mechanism for Gα activation by GPCRs

1 reference

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7 January 2021

SIGNAL TRANSDUCTION. Structural basis for nucleotide exchange in heterotrimeric G proteins

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7 January 2021

5-HT2C Receptor Structures Reveal the Structural Basis of GPCR Polypharmacology.

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7 January 2021

Evolutionary action and structural basis of the allosteric switch controlling β2AR functional selectivity.

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7 January 2021

Biased signaling pathways in β2-adrenergic receptor characterized by 19F-NMR.

1 reference

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7 January 2021

Structure of the Nanobody-Stabilized Active State of the Kappa Opioid Receptor.

1 reference

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7 January 2021

Crystal Structure of an LSD-Bound Human Serotonin Receptor

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7 January 2021

How Ligands Illuminate GPCR Molecular Pharmacology

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7 January 2021

Structure-inspired design of β-arrestin-biased ligands for aminergic GPCRs.

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7 January 2021

Visualization of arrestin recruitment by a G-protein-coupled receptor

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7 January 2021

Sortase ligation enables homogeneous GPCR phosphorylation to reveal diversity in β-arrestin coupling.

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7 January 2021

Identification of Phosphorylation Codes for Arrestin Recruitment by G Protein-Coupled Receptors.

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7 January 2021

GPCR-G Protein-β-Arrestin Super-Complex Mediates Sustained G Protein Signaling

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7 January 2021

Phase-plate cryo-EM structure of a class B GPCR-G-protein complex

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7 January 2021

Cryo-EM structure of the activated GLP-1 receptor in complex with a G protein

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7 January 2021

Allostery and Biased Agonism at Class B G Protein-Coupled Receptors

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7 January 2021

Structure of the human glucagon class B G-protein-coupled receptor

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7 January 2021

Structure of class B GPCR corticotropin-releasing factor receptor 1

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7 January 2021

Extra-helical binding site of a glucagon receptor antagonist

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7 January 2021

Human GLP-1 receptor transmembrane domain structure in complex with allosteric modulators

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7 January 2021

Molecular basis for negative regulation of the glucagon receptor

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7 January 2021

Inhibitory Mechanism of an Allosteric Antibody Targeting the Glucagon Receptor

1 reference

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7 January 2021

Structure of the full-length glucagon class B G-protein-coupled receptor

1 reference

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7 January 2021

Structure of the glucagon receptor in complex with a glucagon analogue

1 reference

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7 January 2021

Crystal structure of the GLP-1 receptor bound to a peptide agonist.

1 reference

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7 January 2021

Polar transmembrane interactions drive formation of ligand-specific and signal pathway-biased family B G protein-coupled receptor conformations

1 reference

https://api.crossref.org/works/10.1038%2FS41580-018-0049-3

7 January 2021

The Extracellular Surface of the GLP-1 Receptor Is a Molecular Trigger for Biased Agonism

1 reference

https://api.crossref.org/works/10.1038%2FS41580-018-0049-3

7 January 2021

Extracellular loops 2 and 3 of the calcitonin receptor selectively modify agonist binding and efficacy.

1 reference

https://api.crossref.org/works/10.1038%2FS41580-018-0049-3

7 January 2021

A Hydrogen-Bonded Polar Network in the Core of the Glucagon-Like Peptide-1 Receptor Is a Fulcrum for Biased Agonism: Lessons from Class B Crystal Structures

1 reference

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7 January 2021

Key interactions by conserved polar amino acids located at the transmembrane helical boundaries in Class B GPCRs modulate activation, effector specificity and biased signalling in the glucagon-like peptide-1 receptor

1 reference

https://api.crossref.org/works/10.1038%2FS41580-018-0049-3

7 January 2021

Extending the Structural View of Class B GPCRs.

1 reference

https://api.crossref.org/works/10.1038%2FS41580-018-0049-3

7 January 2021

Glucagon-like peptide-1 receptor dimerization differentially regulates agonist signaling but does not affect small molecule allostery.

1 reference

https://api.crossref.org/works/10.1038%2FS41580-018-0049-3

7 January 2021

Coexpressed Class B G Protein-Coupled Secretin and GLP-1 Receptors Self- and Cross-Associate: Impact on Pancreatic Islets.

1 reference

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7 January 2021

Lateral allosterism in the glucagon receptor family: glucagon-like peptide 1 induces G-protein-coupled receptor heteromer formation

1 reference

https://api.crossref.org/works/10.1038%2FS41580-018-0049-3

7 January 2021

Spatial Intensity Distribution Analysis: Studies of G Protein-Coupled Receptor Oligomerisation

1 reference

https://api.crossref.org/works/10.1038%2FS41580-018-0049-3

7 January 2021

Class C G protein-coupled receptors: reviving old couples with new partners

1 reference

https://api.crossref.org/works/10.1038%2FS41580-018-0049-3

7 January 2021

Structural mechanism of ligand activation in human calcium-sensing receptor.

1 reference

https://api.crossref.org/works/10.1038%2FS41580-018-0049-3

7 January 2021

Structural mechanism of ligand activation in human GABAB receptor

1 reference

https://api.crossref.org/works/10.1038%2FS41580-018-0049-3

7 January 2021

Structural biology of GABAB receptor

1 reference

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7 January 2021

Major ligand-induced rearrangement of the heptahelical domain interface in a GPCR dimer.

1 reference

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7 January 2021

Molecular insights into allosteric modulation of Class C G protein-coupled receptors.

1 reference

https://api.crossref.org/works/10.1038%2FS41580-018-0049-3

7 January 2021

Biased allosteric modulation at the CaS receptor engendered by structurally diverse calcimimetics

1 reference

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7 January 2021

Allosteric Modulation of GPCRs: New Insights and Potential Utility for Treatment of Schizophrenia and Other CNS Disorders

1 reference

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7 January 2021

Cholecystokinin responsiveness varies across the population dependent on metabolic phenotype.

1 reference

https://api.crossref.org/works/10.1038%2FS41580-018-0049-3

7 January 2021

Beneficial effects of β-sitosterol on type 1 cholecystokinin receptor dysfunction induced by elevated membrane cholesterol

1 reference

https://api.crossref.org/works/10.1038%2FS41580-018-0049-3

7 January 2021

Cholesterol increases kinetic, energetic, and mechanical stability of the human β2-adrenergic receptor.

1 reference

https://api.crossref.org/works/10.1038%2FS41580-018-0049-3

7 January 2021

Modulation of the interaction between neurotensin receptor NTS1 and Gq protein by lipid

1 reference

https://api.crossref.org/works/10.1038%2FS41580-018-0049-3

7 January 2021

Newly synthesized cAMP is integrated at a membrane protein complex signalosome to ensure receptor response specificity.

1 reference

https://api.crossref.org/works/10.1038%2FS41580-018-0049-3

7 January 2021

Understanding the diversity of membrane lipid composition.

1 reference

https://api.crossref.org/works/10.1038%2FS41580-018-0049-3

7 January 2021

Caveolae as plasma membrane sensors, protectors and organizers.

1 reference

https://api.crossref.org/works/10.1038%2FS41580-018-0049-3

7 January 2021

Membrane curvature regulates ligand-specific membrane sorting of GPCRs in living cells.

1 reference

https://api.crossref.org/works/10.1038%2FS41580-018-0049-3

7 January 2021

Barcoding of GPCR trafficking and signaling through the various trafficking roadmaps by compartmentalized signaling networks

1 reference

https://api.crossref.org/works/10.1038%2FS41580-018-0049-3

7 January 2021

Effects of endocytosis on receptor-mediated signaling

1 reference

https://api.crossref.org/works/10.1038%2FS41580-018-0049-3

7 January 2021

An update on the physiological and therapeutic relevance of GPCR oligomers

1 reference

https://api.crossref.org/works/10.1038%2FS41580-018-0049-3

7 January 2021

Basic Pharmacological and Structural Evidence for Class A G-Protein-Coupled Receptor Heteromerization

1 reference

https://api.crossref.org/works/10.1038%2FS41580-018-0049-3

7 January 2021

G Protein-Coupled Receptor Heteromers.

1 reference

https://api.crossref.org/works/10.1038%2FS41580-018-0049-3

7 January 2021

Assembly and architecture of the Wnt/β-catenin signalosome at the membrane

1 reference

https://api.crossref.org/works/10.1038%2FS41580-018-0049-3

7 January 2021

RAMPs regulate the transport and ligand specificity of the calcitonin-receptor-like receptor

1 reference

https://api.crossref.org/works/10.1038%2FS41580-018-0049-3

7 January 2021

Beta2-adrenergic receptor redistribution in heart failure changes cAMP compartmentation.

1 reference

https://api.crossref.org/works/10.1038%2FS41580-018-0049-3

7 January 2021

Plasticity of surface structures and β(2)-adrenergic receptor localization in failing ventricular cardiomyocytes during recovery from heart failure

1 reference

https://api.crossref.org/works/10.1038%2FS41580-018-0049-3

7 January 2021

Endothelin-converting enzyme 1 and β-arrestins exert spatiotemporal control of substance P-induced inflammatory signals

1 reference

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7 January 2021

Adenylyl cyclase AC8 directly controls its micro-environment by recruiting the actin cytoskeleton in a cholesterol-rich milieu.

1 reference

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7 January 2021

Sub-picomolar relaxin signalling by a pre-assembled RXFP1, AKAP79, AC2, beta-arrestin 2, PDE4D3 complex

1 reference

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7 January 2021

Subcellular localization of MC4R with ADCY3 at neuronal primary cilia underlies a common pathway for genetic predisposition to obesity

1 reference

https://api.crossref.org/works/10.1038%2FS41580-018-0049-3

7 January 2021

Evidence for functional pre-coupled complexes of receptor heteromers and adenylyl cyclase.

1 reference

https://api.crossref.org/works/10.1038%2FS41580-018-0049-3

7 January 2021

Noncanonical GPCR signaling arising from a PTH receptor-arrestin-Gβγ complex

1 reference

https://api.crossref.org/works/10.1038%2FS41580-018-0049-3

7 January 2021

Dual role of mitochondria in producing melatonin and driving GPCR signaling to block cytochrome c release.

1 reference

https://api.crossref.org/works/10.1038%2FS41580-018-0049-3

7 January 2021

Intracellular Angiotensin-II Interacts With Nuclear Angiotensin Receptors in Cardiac Fibroblasts and Regulates RNA Synthesis, Cell Proliferation, and Collagen Secretion

1 reference

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7 January 2021

Regulation of cardiac nitric oxide signaling by nuclear β-adrenergic and endothelin receptors.

1 reference

https://api.crossref.org/works/10.1038%2FS41580-018-0049-3

7 January 2021

G protein-coupled receptor (GPCR) signaling via heterotrimeric G proteins from endosomes

1 reference

https://api.crossref.org/works/10.1038%2FS41580-018-0049-3

7 January 2021

Spatial encoding of cyclic AMP signaling specificity by GPCR endocytosis

1 reference

https://api.crossref.org/works/10.1038%2FS41580-018-0049-3

7 January 2021

Endosomal generation of cAMP in GPCR signaling

1 reference

https://api.crossref.org/works/10.1038%2FS41580-018-0049-3

7 January 2021

Neurokinin 1 receptor signaling in endosomes mediates sustained nociception and is a viable therapeutic target for prolonged pain relief

1 reference

https://api.crossref.org/works/10.1038%2FS41580-018-0049-3

7 January 2021

Endosomal signaling of the receptor for calcitonin gene-related peptide mediates pain transmission

1 reference

https://api.crossref.org/works/10.1038%2FS41580-018-0049-3

7 January 2021

β2-adrenergic receptor control of endosomal PTH receptor signaling via Gβγ.

1 reference

https://api.crossref.org/works/10.1038%2FS41580-018-0049-3

7 January 2021

Caveolin-3 regulates compartmentation of cardiomyocyte beta2-adrenergic receptor-mediated cAMP signaling.

1 reference

https://api.crossref.org/works/10.1038%2FS41580-018-0049-3

7 January 2021

A new inhibitor of the β-arrestin/AP2 endocytic complex reveals interplay between GPCR internalization and signalling

1 reference

https://api.crossref.org/works/10.1038%2FS41580-018-0049-3

7 January 2021

A kinetic view of GPCR allostery and biased agonism

1 reference

https://api.crossref.org/works/10.1038%2FS41580-018-0049-3

7 January 2021

Analyzing biased responses of GPCR ligands

1 reference

https://api.crossref.org/works/10.1038%2FS41580-018-0049-3

7 January 2021

The use of chemogenetic approaches to study the physiological roles of muscarinic acetylcholine receptors in the central nervous system

1 reference

https://api.crossref.org/works/10.1038%2FS41580-018-0049-3

7 January 2021

DREADDs for Neuroscientists

1 reference

https://api.crossref.org/works/10.1038%2FS41580-018-0049-3

7 January 2021

New Technologies for Elucidating Opioid Receptor Function

1 reference

https://api.crossref.org/works/10.1038%2FS41580-018-0049-3

7 January 2021

Optogenetic approaches for dissecting neuromodulation and GPCR signaling in neural circuits

1 reference

https://api.crossref.org/works/10.1038%2FS41580-018-0049-3

7 January 2021

TRV120027, a novel β-arrestin biased ligand at the angiotensin II type I receptor, unloads the heart and maintains renal function when added to furosemide in experimental heart failure

1 reference

https://api.crossref.org/works/10.1038%2FS41580-018-0049-3

7 January 2021

Cardiac myosin light chain phosphorylation and inotropic effects of a biased ligand, TRV120023, in a dilated cardiomyopathy model

1 reference

https://api.crossref.org/works/10.1038%2FS41580-018-0049-3

7 January 2021

Biased agonists of the kappa opioid receptor suppress pain and itch without causing sedation or dysphoria

1 reference

https://api.crossref.org/works/10.1038%2FS41580-018-0049-3

7 January 2021

A G protein-biased ligand at the μ-opioid receptor is potently analgesic with reduced gastrointestinal and respiratory dysfunction compared with morphine

1 reference

https://api.crossref.org/works/10.1038%2FS41580-018-0049-3

7 January 2021

Structure-based discovery of opioid analgesics with reduced side effects

1 reference

https://api.crossref.org/works/10.1038%2FS41580-018-0049-3

7 January 2021

Bias Factor and Therapeutic Window Correlate to Predict Safer Opioid Analgesics

1 reference

https://api.crossref.org/works/10.1038%2FS41580-018-0049-3

7 January 2021

Changes in the plasma membrane in metabolic disease: impact of the membrane environment on G protein-coupled receptor structure and function

1 reference

https://api.crossref.org/works/10.1038%2FS41580-018-0049-3

7 January 2021

White matter integrity in individuals at ultra-high risk for psychosis: a systematic review and discussion of the role of polyunsaturated fatty acids.

1 reference

https://api.crossref.org/works/10.1038%2FS41580-018-0049-3

7 January 2021

Hypoxia sensing through β-adrenergic receptors

1 reference

https://api.crossref.org/works/10.1038%2FS41580-018-0049-3

7 January 2021

Amino acid metabolites that regulate G protein signaling during osmotic stress.

1 reference

https://api.crossref.org/works/10.1038%2FS41580-018-0049-3

7 January 2021

Oxidation inhibits PTH receptor signaling and trafficking.

1 reference

https://api.crossref.org/works/10.1038%2FS41580-018-0049-3

7 January 2021

The effect of pH on beta(2) adrenoceptor function. Evidence for protonation-dependent activation.

1 reference

https://api.crossref.org/works/10.1038%2FS41580-018-0049-3

7 January 2021

Membrane potentials regulating GPCRs: insights from experiments and molecular dynamics simulations

1 reference

https://api.crossref.org/works/10.1038%2FS41580-018-0049-3

7 January 2021

Buried ionizable networks are an ancient hallmark of G protein-coupled receptor activation

1 reference

https://api.crossref.org/works/10.1038%2FS41580-018-0049-3

7 January 2021

Sodium ion binding pocket mutations and adenosine A2A receptor function.

1 reference

https://api.crossref.org/works/10.1038%2FS41580-018-0049-3

7 January 2021

Pharmacogenetics of the G protein-coupled receptors

1 reference

https://api.crossref.org/works/10.1038%2FS41580-018-0049-3

7 January 2021

β1-adrenergic receptor polymorphisms confer differential function and predisposition to heart failure

1 reference

https://api.crossref.org/works/10.1038%2FS41580-018-0049-3

7 January 2021

A polymorphism within a conserved beta(1)-adrenergic receptor motif alters cardiac function and beta-blocker response in human heart failure

1 reference

https://api.crossref.org/works/10.1038%2FS41580-018-0049-3

7 January 2021

Lymphoid differentiation of hematopoietic stem cells requires efficient Cxcr4 desensitization

1 reference

https://api.crossref.org/works/10.1038%2FS41580-018-0049-3

7 January 2021

Biased agonism in drug discovery - is it too soon to choose a path?

1 reference

https://api.crossref.org/works/10.1038%2FS41580-018-0049-3

7 January 2021

Characterization of signal bias at the GLP-1 receptor induced by backbone modification of GLP-1.

1 reference

https://api.crossref.org/works/10.1038%2FS41580-018-0049-3

7 January 2021

Systematic analysis of factors influencing observations of biased agonism at the mu-opioid receptor.

1 reference

https://api.crossref.org/works/10.1038%2FS41580-018-0049-3

7 January 2021

Quantification of ligand bias for clinically relevant β2-adrenergic receptor ligands: implications for drug taxonomy.

1 reference

https://api.crossref.org/works/10.1038%2FS41580-018-0049-3

7 January 2021

The best of both worlds? Bitopic orthosteric/allosteric ligands of g protein-coupled receptors

1 reference

https://api.crossref.org/works/10.1038%2FS41580-018-0049-3

7 January 2021

Structural insights into G-protein-coupled receptor allostery

1 reference

https://api.crossref.org/works/10.1038%2FS41580-018-0049-3

7 January 2021

International Union of Basic and Clinical Pharmacology. XC. multisite pharmacology: recommendations for the nomenclature of receptor allosterism and allosteric ligands.

1 reference

https://api.crossref.org/works/10.1038%2FS41580-018-0049-3

7 January 2021

10.1038/S41580-018-0049-3

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30104700%20AND%20SRC:MED&resulttype=core&format=json

17 April 2020

1 reference