(Q100152373)

English

ERBB2 KD mutants bind TKIs

An instance of the biological reaction in Homo sapiens with Reactome ID (R-HSA-9665121)

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1 reference

8 July 2022

Signaling by ERBB2 KD Mutants

1 reference

8 July 2022

1 reference

8 July 2022

https://identifiers.org/reactome:R-HSA-9665121

1 reference

8 July 2022

ERBB2 KD mutants (TKI sensitive):ERBIN:HSP90:CDC37 [plasma membrane]

quantity

1

object of statement has role

1 reference

8 July 2022

TKIs (ERBB2) [cytosol]

quantity

1

object of statement has role

1 reference

8 July 2022

ERBB2 KD mutants:TKIs:ERBIN:HSP90:CDC37 [plasma membrane]

quantity

1

object of statement has role

1 reference

8 July 2022

Activating HER2 mutations in HER2 gene amplification negative breast cancer

1 reference

8 July 2022

Differential sensitivity of ERBB2 kinase domain mutations towards lapatinib

1 reference

8 July 2022

High-Throughput Functional Evaluation of Variants of Unknown Significance in

1 reference

8 July 2022

EXEL-7647 inhibits mutant forms of ErbB2 associated with lapatinib resistance and neoplastic transformation

1 reference

8 July 2022

An Acquired HER2T798I Gatekeeper Mutation Induces Resistance to Neratinib in a Patient with HER2 Mutant-Driven Breast Cancer.

1 reference

8 July 2022

Phosphorylation of mutationally introduced tyrosine in the activation loop of HER2 confers gain-of-function activity

1 reference

8 July 2022

Tumor driven by gain-of-function HER2 H878Y mutant is highly sensitive to HER2 inhibitor

1 reference

8 July 2022

Anti-tumor effect of neratinib against lung cancer cells harboring oncogene alterations

1 reference

8 July 2022

Antitumor effect of afatinib, as a human epidermal growth factor receptor 2-targeted therapy, in lung cancers harboring HER2 oncogene alterations

1 reference

8 July 2022

The major lung cancer-derived mutants of ERBB2 are oncogenic and are associated with sensitivity to the irreversible EGFR/ERBB2 inhibitor HKI-272.

1 reference

8 July 2022

Identifiers

1 reference

8 July 2022

(Q100152373)

ERBB2 KD mutants bind TKIs

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