(Q100152394)

English

RAS activation by SOS1 bound to phosphorylated heterodimers of ERBB2 ECD mutants and EGFR through GRB2

An instance of the biological reaction in Homo sapiens with Reactome ID (R-HSA-9665408)

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Statements

1 reference

8 July 2022

Signaling by ERBB2 ECD mutants

1 reference

13 July 2022

1 reference

8 July 2022

https://identifiers.org/reactome:R-HSA-9665408

1 reference

8 July 2022

p21 RAS:GDP [plasma membrane]

quantity

1

object of statement has role

1 reference

8 July 2022

p21 RAS:GTP [plasma membrane]

quantity

1

object of statement has role

1 reference

8 July 2022

p-6Y-ERBB2 ECD mutants:EGF:p-6Y-EGFR:GRB2:SOS1 [plasma membrane]

quantity

1

object of statement has role

1 reference

8 July 2022

1

object of statement has role

1 reference

8 July 2022

1

object of statement has role

1 reference

8 July 2022

Activating HER2 mutations in HER2 gene amplification negative breast cancer

1 reference

8 July 2022

Functional analysis of receptor tyrosine kinase mutations in lung cancer identifies oncogenic extracellular domain mutations of ERBB2.

1 reference

8 July 2022

Identifiers

1 reference

8 July 2022

(Q100152394)

RAS activation by SOS1 bound to phosphorylated heterodimers of ERBB2 ECD mutants and EGFR through GRB2

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