(Q100152561)

English

KIT mutants bind type II TKIs

An instance of the biological reaction in Homo sapiens with Reactome ID (R-HSA-9669900)

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8 July 2022

KIT mutants bind TKIs

1 reference

8 July 2022

1 reference

8 July 2022

https://identifiers.org/reactome:R-HSA-9669900

1 reference

8 July 2022

type II KIT binding TKIs [cytosol]

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1

object of statement has role

1 reference

8 July 2022

type II TKI sensitive KIT mutants [plasma membrane]

quantity

1

object of statement has role

1 reference

8 July 2022

type II sensitive KIT mutants:type II TKIs [plasma membrane]

quantity

1

object of statement has role

1 reference

8 July 2022

Rational design of inhibitors that bind to inactive kinase conformations

1 reference

8 July 2022

Targeting cancer with small molecule kinase inhibitors

1 reference

8 July 2022

The role of small molecule Kit protein-tyrosine kinase inhibitors in the treatment of neoplastic disorders.

1 reference

8 July 2022

Structural and clinical consequences of activation loop mutations in class III receptor tyrosine kinases

1 reference

8 July 2022

Ponatinib inhibits polyclonal drug-resistant KIT oncoproteins and shows therapeutic potential in heavily pretreated gastrointestinal stromal tumor (GIST) patients.

1 reference

8 July 2022

Complementary activity of tyrosine kinase inhibitors against secondary kit mutations in imatinib-resistant gastrointestinal stromal tumours

1 reference

8 July 2022

Novel Insights into the Treatment of Imatinib-Resistant Gastrointestinal Stromal Tumors

1 reference

8 July 2022

Use of c-KIT/PDGFRA mutational analysis to predict the clinical response to imatinib in patients with advanced gastrointestinal stromal tumours entered on phase I and II studies of the EORTC Soft Tissue and Bone Sarcoma Group

1 reference

8 July 2022

Gastrointestinal stromal tumours: origin and molecular oncology.

1 reference

8 July 2022

Identifiers

1 reference

8 July 2022

(Q100152561)

KIT mutants bind type II TKIs

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