Wikidata

(Q128861)

English

angiotensin I converting enzyme

mammalian protein found in Homo sapiens

  • dipeptidyl carboxypeptidase 1
  • angiotensin I converting enzyme (peptidyl-dipeptidase A) 1
  • angiotensin-converting enzyme
  • ACE
  • carboxycathepsin
  • CD143 antigen
  • dipeptidyl carboxypeptidase I
  • angiotensin converting enzyme, somatic isoform
  • kininase II
  • peptidase P
  • Peptidyl-Dipeptidase A
In more languages

Statements

molecular function
metallopeptidase activity
determination method
IDA
IEA
ISS
TAS
9 references
retrieved
26 September 2017
stated in
Molecular cloning of human testicular angiotensin-converting enzyme: the testis isozyme is identical to the C-terminal half of endothelial angiotensin-converting enzyme
GOA
curator
UniProt
UniProt protein ID
P12821
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P12821&geneProductId=UniProtKB:P12821
determination method
TAS
retrieved
26 September 2017
stated in
GOA
curator
UniProt
UniProt protein ID
P12821
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P12821&geneProductId=UniProtKB:P12821
determination method
ISS
retrieved
26 September 2017
stated in
GOA
curator
UniProt
UniProt protein ID
P12821
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P12821&geneProductId=UniProtKB:P12821
determination method
IEA
retrieved
26 September 2017
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P12821&geneProductId=UniProtKB:P12821
determination method
IEA
retrieved
26 September 2017
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P12821&geneProductId=UniProtKB:P12821
determination method
IEA
retrieved
26 September 2017
stated in
Human ACE and bradykinin B2 receptors form a complex at the plasma membrane
GOA
curator
UniProt
UniProt protein ID
P12821
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P12821&geneProductId=UniProtKB:P12821
determination method
IDA
retrieved
26 September 2017
stated in
Two putative active centers in human angiotensin I-converting enzyme revealed by molecular cloning
GOA
curator
UniProt
UniProt protein ID
P12821
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P12821&geneProductId=UniProtKB:P12821
determination method
IDA
retrieved
26 September 2017
stated in
Purification and characterization of recombinant human testis angiotensin-converting enzyme expressed in chinese hamster ovary cells
GOA
curator
UniProt
UniProt protein ID
P12821
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P12821&geneProductId=UniProtKB:P12821
determination method
IDA
retrieved
26 September 2017
stated in
The two homologous domains of human angiotensin I-converting enzyme interact differently with competitive inhibitors
GOA
curator
UniProt
UniProt protein ID
P12821
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P12821&geneProductId=UniProtKB:P12821
determination method
IDA
peptidyl-dipeptidase activity
determination method
IDA
IEA
ISS
TAS
14 references
retrieved
26 September 2017
stated in
Molecular cloning of human testicular angiotensin-converting enzyme: the testis isozyme is identical to the C-terminal half of endothelial angiotensin-converting enzyme
GOA
curator
UniProt
UniProt protein ID
P12821
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P12821&geneProductId=UniProtKB:P12821
determination method
TAS
retrieved
26 September 2017
stated in
RXP 407, a selective inhibitor of the N-domain of angiotensin I-converting enzyme, blocks in vivo the degradation of hemoregulatory peptide acetyl-Ser-Asp-Lys-Pro with no effect on angiotensin I hydrolysis
GOA
curator
UniProt
UniProt protein ID
P12821
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P12821&geneProductId=UniProtKB:P12821
determination method
ISS
retrieved
26 September 2017
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P12821&geneProductId=UniProtKB:P12821
determination method
IEA
retrieved
26 September 2017
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P12821&geneProductId=UniProtKB:P12821
determination method
IEA
retrieved
26 September 2017
stated in
Human ACE and bradykinin B2 receptors form a complex at the plasma membrane
GOA
curator
UniProt
UniProt protein ID
P12821
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P12821&geneProductId=UniProtKB:P12821
determination method
IDA
retrieved
26 September 2017
stated in
Two putative active centers in human angiotensin I-converting enzyme revealed by molecular cloning
GOA
curator
UniProt
UniProt protein ID
P12821
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P12821&geneProductId=UniProtKB:P12821
determination method
IDA
retrieved
26 September 2017
stated in
Purification and characterization of recombinant human testis angiotensin-converting enzyme expressed in chinese hamster ovary cells
GOA
curator
UniProt
UniProt protein ID
P12821
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P12821&geneProductId=UniProtKB:P12821
determination method
IDA
retrieved
26 September 2017
stated in
The two homologous domains of human angiotensin I-converting enzyme interact differently with competitive inhibitors
GOA
curator
UniProt
UniProt protein ID
P12821
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P12821&geneProductId=UniProtKB:P12821
determination method
IDA
retrieved
26 September 2017
stated in
The hemoregulatory peptide N-acetyl-Ser-Asp-Lys-Pro is a natural and specific substrate of the N-terminal active site of human angiotensin-converting enzyme
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P12821&geneProductId=UniProtKB:P12821
determination method
IDA
retrieved
26 September 2017
stated in
The two homologous domains of human angiotensin I-converting enzyme are both catalytically active
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P12821&geneProductId=UniProtKB:P12821
determination method
IDA
retrieved
26 September 2017
stated in
Evaluation of angiotensin-converting enzyme (ACE), its homologue ACE2 and neprilysin in angiotensin peptide metabolism
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P12821&geneProductId=UniProtKB:P12821
determination method
IDA
retrieved
26 September 2017
stated in
Differences in the properties and enzymatic specificities of the two active sites of angiotensin I-converting enzyme (kininase II). Studies with bradykinin and other natural peptides
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P12821&geneProductId=UniProtKB:P12821
determination method
IDA
retrieved
26 September 2017
stated in
Abeta42-to-Abeta40- and angiotensin-converting activities in different domains of angiotensin-converting enzyme
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P12821&geneProductId=UniProtKB:P12821
determination method
IDA
retrieved
26 September 2017
stated in
Hydrolysis of substance P and neurotensin by converting enzyme and neutral endopeptidase
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P12821&geneProductId=UniProtKB:P12821
determination method
IDA
metallopeptidase activity
determination method
IBA
IDA
IEA
ISS
TAS
10 references
retrieved
8 April 2019
stated in
Molecular cloning of human testicular angiotensin-converting enzyme: the testis isozyme is identical to the C-terminal half of endothelial angiotensin-converting enzyme
GOA
curator
UniProt
UniProt protein ID
P12821
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12821
determination method
TAS
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
P12821
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12821
determination method
ISS
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
P12821
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12821
determination method
IEA
retrieved
8 April 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12821
determination method
IEA
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12821
determination method
IEA
retrieved
8 April 2019
stated in
The two homologous domains of human angiotensin I-converting enzyme interact differently with competitive inhibitors
GOA
curator
UniProt
UniProt protein ID
P12821
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12821
determination method
IDA
retrieved
8 April 2019
stated in
Purification and characterization of recombinant human testis angiotensin-converting enzyme expressed in chinese hamster ovary cells
GOA
curator
UniProt
UniProt protein ID
P12821
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12821
determination method
IDA
retrieved
8 April 2019
stated in
Human ACE and bradykinin B2 receptors form a complex at the plasma membrane
GOA
curator
UniProt
UniProt protein ID
P12821
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12821
determination method
IDA
retrieved
8 April 2019
stated in
Two putative active centers in human angiotensin I-converting enzyme revealed by molecular cloning
GOA
curator
UniProt
UniProt protein ID
P12821
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12821
determination method
IDA
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12821
determination method
IBA
peptidyl-dipeptidase activity
determination method
IBA
IDA
IEA
ISS
TAS
15 references
retrieved
8 April 2019
stated in
Molecular cloning of human testicular angiotensin-converting enzyme: the testis isozyme is identical to the C-terminal half of endothelial angiotensin-converting enzyme
GOA
curator
UniProt
UniProt protein ID
P12821
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12821
determination method
TAS
retrieved
8 April 2019
stated in
RXP 407, a selective inhibitor of the N-domain of angiotensin I-converting enzyme, blocks in vivo the degradation of hemoregulatory peptide acetyl-Ser-Asp-Lys-Pro with no effect on angiotensin I hydrolysis
GOA
curator
UniProt
UniProt protein ID
P12821
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12821
determination method
ISS
retrieved
8 April 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12821
determination method
IEA
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12821
determination method
IEA
retrieved
8 April 2019
stated in
The two homologous domains of human angiotensin I-converting enzyme interact differently with competitive inhibitors
GOA
curator
UniProt
UniProt protein ID
P12821
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12821
determination method
IDA
retrieved
8 April 2019
stated in
Purification and characterization of recombinant human testis angiotensin-converting enzyme expressed in chinese hamster ovary cells
GOA
curator
UniProt
UniProt protein ID
P12821
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12821
determination method
IDA
retrieved
8 April 2019
stated in
Human ACE and bradykinin B2 receptors form a complex at the plasma membrane
GOA
curator
UniProt
UniProt protein ID
P12821
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12821
determination method
IDA
retrieved
8 April 2019
stated in
Two putative active centers in human angiotensin I-converting enzyme revealed by molecular cloning
GOA
curator
UniProt
UniProt protein ID
P12821
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12821
determination method
IDA
retrieved
8 April 2019
stated in
Abeta42-to-Abeta40- and angiotensin-converting activities in different domains of angiotensin-converting enzyme
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12821
determination method
IDA
retrieved
8 April 2019
stated in
Evaluation of angiotensin-converting enzyme (ACE), its homologue ACE2 and neprilysin in angiotensin peptide metabolism
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12821
determination method
IDA
retrieved
8 April 2019
stated in
Hydrolysis of substance P and neurotensin by converting enzyme and neutral endopeptidase
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12821
determination method
IDA
retrieved
8 April 2019
stated in
Differences in the properties and enzymatic specificities of the two active sites of angiotensin I-converting enzyme (kininase II). Studies with bradykinin and other natural peptides
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12821
determination method
IDA
retrieved
8 April 2019
stated in
The hemoregulatory peptide N-acetyl-Ser-Asp-Lys-Pro is a natural and specific substrate of the N-terminal active site of human angiotensin-converting enzyme
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12821
determination method
IDA
retrieved
8 April 2019
stated in
The two homologous domains of human angiotensin I-converting enzyme are both catalytically active
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12821
determination method
IDA
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12821
determination method
IBA
cell component
extracellular exosome
determination method
IDA
5 references
retrieved
26 September 2017
stated in
Proteomic analysis of podocyte exosome-enriched fraction from normal human urine
GOA
curator
UniProt
UniProt protein ID
P12821
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P12821&geneProductId=UniProtKB:P12821
determination method
IDA
retrieved
26 September 2017
stated in
Large-scale proteomics and phosphoproteomics of urinary exosomes
GOA
curator
UniProt
UniProt protein ID
P12821
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P12821&geneProductId=UniProtKB:P12821
determination method
IDA
retrieved
26 September 2017
stated in
Comprehensive analysis of low-abundance proteins in human urinary exosomes using peptide ligand library technology, peptide OFFGEL fractionation and nanoHPLC-chip-MS/MS
GOA
curator
UniProt
UniProt protein ID
P12821
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P12821&geneProductId=UniProtKB:P12821
determination method
IDA
retrieved
26 September 2017
stated in
In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine
GOA
curator
UniProt
UniProt protein ID
P12821
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P12821&geneProductId=UniProtKB:P12821
determination method
IDA
retrieved
26 September 2017
stated in
Identification and proteomic profiling of exosomes in human urine
GOA
curator
UniProt
UniProt protein ID
P12821
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P12821&geneProductId=UniProtKB:P12821
determination method
IDA
biological process
physically interacts with
Commons category
Angiotensin converting enzyme, ACE
0 references

Identifiers

NL CR AUT ID
ph250750
subject named as
angiotenzin konvertující enzym
0 references
MeSH descriptor ID
D007703
subject named as
Peptidyl-Dipeptidase A
0 references
PDB structure ID
Treccani's Dizionario di Medicina ID
ace
subject named as
ACE (Angiotensin Converting Enzyme)
publication date
2010
0 references
WordNet 3.1 Synset ID
14759821-n
1 reference
stated in
GF WordNet
 
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