(Q14331165)

English

Reelin

mammalian protein found in Mus musculus

Reln
reelin
Reeler protein
extracellular matrix serine protease

In more languages

Statements

1 reference

25 May 2022

UniProt protein ID

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q60841

Sialidase superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q60841

Galactose-binding-like domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q60841

membrane proteins

1 reference

based on heuristic

inferred from GOA cell component → membrane

Reeler domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

EGF-like domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

EGF-like, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

25 May 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

molecular function

metal ion binding

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60841

determination method

very-low-density lipoprotein particle receptor binding

determination method

1 reference

9 May 2019

Reelin is a ligand for lipoprotein receptors

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60841

determination method

peptidase activity

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60841

determination method

serine-type peptidase activity

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60841

determination method

hydrolase activity

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60841

determination method

protein binding

determination method

3 references

9 May 2019

Structure of a receptor-binding fragment of reelin and mutational analysis reveal a recognition mechanism similar to endocytic receptors

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60841

determination method

9 May 2019

Structural basis for specific recognition of reelin by its receptors

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60841

determination method

9 May 2019

Direct binding of Reelin to VLDL receptor and ApoE receptor 2 induces tyrosine phosphorylation of disabled-1 and modulates tau phosphorylation

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60841

determination method

extracellular matrix structural constituent

determination method

1 reference

1 January 2018

Quantitative proteomic profiling of the extracellular matrix of pancreatic islets during the angiogenic switch and insulinoma progression.

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q60841&geneProductId=UniProtKB:Q60841

determination method

extracellular matrix structural constituent

determination method

extracellular matrix structural constituent

determination method

1 reference

9 May 2019

Quantitative proteomic profiling of the extracellular matrix of pancreatic islets during the angiogenic switch and insulinoma progression.

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60841

determination method

lipoprotein particle receptor binding

determination method

3 references

extracellular region

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60841

determination method

plasma membrane

determination method

1 reference

9 May 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60841

determination method

determination method

1 reference

14 February 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60841

determination method

extracellular space

determination method

3 references

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60841

determination method

14 February 2019

Lack of Reelin causes malpositioning of nigral dopaminergic neurons: Evidence from comparison of normal and Relnrl mutant mice

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60841

determination method

14 February 2019

Reelin activates SRC family tyrosine kinases in neurons

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60841

determination method

determination method

3 references

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60841

determination method

9 May 2019

The transcriptional repressor RP58 is crucial for cell-division patterning and neuronal survival in the developing cortex

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60841

determination method

9 May 2019

Developmental roles of p73 in Cajal-Retzius cells and cortical patterning

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60841

determination method

determination method

1 reference

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60841

determination method

neuron projection

determination method

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60841

determination method

neuronal cell body

determination method

1 reference

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60841

determination method

determination method

1 reference

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60841

determination method

collagen-containing extracellular matrix

determination method

1 reference

9 May 2019

Quantitative proteomic profiling of the extracellular matrix of pancreatic islets during the angiogenic switch and insulinoma progression.

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60841

determination method

extracellular space

determination method

4 references

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60841

determination method

9 May 2019

Reelin activates SRC family tyrosine kinases in neurons

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60841

determination method

9 May 2019

Lack of Reelin causes malpositioning of nigral dopaminergic neurons: Evidence from comparison of normal and Relnrl mutant mice

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60841

determination method

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60841

determination method

biological process

receptor localization to synapse

determination method

regulation of behavior

determination method

1 reference

9 May 2019

Reelin regulates postnatal neurogenesis and enhances spine hypertrophy and long-term potentiation

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60841

determination method

positive regulation of small GTPase mediated signal transduction

determination method

1 reference

9 May 2019

Activation of a Dab1/CrkL/C3G/Rap1 pathway in Reelin-stimulated neurons

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60841

determination method

cerebral cortex tangential migration

determination method

1 reference

9 May 2019

A novel mode of tangential migration of cortical projection neurons

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60841

determination method

positive regulation of long-term synaptic potentiation

determination method

1 reference

9 May 2019

Reelin supplementation enhances cognitive ability, synaptic plasticity, and dendritic spine density

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60841

determination method

NMDA glutamate receptor clustering

determination method

spinal cord patterning

determination method

1 reference

9 May 2019

Absence of Reelin results in altered nociception and aberrant neuronal positioning in the dorsal spinal cord

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60841

determination method

positive regulation of protein tyrosine kinase activity

determination method

postsynaptic density assembly

determination method

1 reference

9 May 2019

Reelin deficiency causes specific defects in the molecular composition of the synapses in the adult brain

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60841

determination method

modulation of chemical synaptic transmission

determination method

1 reference

9 May 2019

Functional consequences of hippocampal neuronal ectopia in the apolipoprotein E receptor-2 knockout mouse

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60841

determination method

postsynaptic density protein 95 clustering

determination method

glial cell differentiation

determination method

1 reference

9 May 2019

Reelin signaling directly affects radial glia morphology and biochemical maturation

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60841

determination method

regulation of NMDA receptor activity

determination method

determination method

1 reference

9 May 2019

Reelin supplementation enhances cognitive ability, synaptic plasticity, and dendritic spine density

Community Assessment of Community Annotation with Ontologies

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60841

determination method

lateral motor column neuron migration

determination method

1 reference

9 May 2019

Foxp1 and lhx1 coordinate motor neuron migration with axon trajectory choice by gating Reelin signalling

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60841

determination method

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60841

determination method

ventral spinal cord development

determination method

1 reference

9 May 2019

Foxp1 and lhx1 coordinate motor neuron migration with axon trajectory choice by gating Reelin signalling

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60841

determination method

determination method

1 reference

9 May 2019

Aberrant trajectory of thalamocortical axons associated with abnormal localization of neurocan immunoreactivity in the cerebral neocortex of reeler mutant mice

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60841

determination method

multicellular organism development

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60841

determination method

positive regulation of CREB transcription factor activity

determination method

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60841

determination method

positive regulation of synaptic transmission, glutamatergic

determination method

4 references

9 May 2019

Reelin signaling facilitates maturation of CA1 glutamatergic synapses

Community Assessment of Community Annotation with Ontologies

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60841

determination method

9 May 2019

Overexpression of Reelin prevents the manifestation of behavioral phenotypes related to schizophrenia and bipolar disorder.

Community Assessment of Community Annotation with Ontologies

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60841

determination method

9 May 2019

Reelin regulates postnatal neurogenesis and enhances spine hypertrophy and long-term potentiation

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60841

determination method

9 May 2019

Reelin signaling facilitates maturation of CA1 glutamatergic synapses

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60841

determination method

layer formation in cerebral cortex

determination method

1 reference

9 May 2019

Absence of layer-specific cadherin expression profiles in the neocortex of the reeler mutant mouse

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60841

determination method

response to pain

determination method

1 reference

9 May 2019

Absence of Reelin results in altered nociception and aberrant neuronal positioning in the dorsal spinal cord

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60841

determination method

positive regulation of lateral motor column neuron migration

determination method

1 reference

9 May 2019

Foxp1 and lhx1 coordinate motor neuron migration with axon trajectory choice by gating Reelin signalling

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60841

determination method

cerebral cortex development

determination method

1 reference

9 May 2019

Cell-type-specific consequences of Reelin deficiency in the mouse neocortex, hippocampus, and amygdala

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60841

determination method

regulation of gene expression

determination method

1 reference

9 May 2019

Identification of a novel brain-specific and Reelin-regulated gene that encodes a protein colocalized with synapsin

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60841

determination method

positive regulation of excitatory postsynaptic potential

determination method

4 references

9 May 2019

Reelin signaling facilitates maturation of CA1 glutamatergic synapses

Community Assessment of Community Annotation with Ontologies

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60841

determination method

9 May 2019

Overexpression of Reelin prevents the manifestation of behavioral phenotypes related to schizophrenia and bipolar disorder.

Community Assessment of Community Annotation with Ontologies

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60841

determination method

9 May 2019

Reelin regulates postnatal neurogenesis and enhances spine hypertrophy and long-term potentiation

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60841

determination method

9 May 2019

Reelin signaling facilitates maturation of CA1 glutamatergic synapses

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60841

determination method

positive regulation of phosphatidylinositol 3-kinase signaling

determination method

peptidyl-tyrosine phosphorylation

determination method

1 reference

9 May 2019

Reelin activates SRC family tyrosine kinases in neurons

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60841

determination method

forebrain development

determination method

1 reference

9 May 2019

A stream of cells migrating from the caudal telencephalon reveals a link between the amygdala and neocortex

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60841

determination method

cell morphogenesis involved in differentiation

determination method

1 reference

9 May 2019

Reelin signaling directly affects radial glia morphology and biochemical maturation

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60841

determination method

determination method

1 reference

9 May 2019

A stream of cells migrating from the caudal telencephalon reveals a link between the amygdala and neocortex

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60841

determination method

hippocampus development

determination method

1 reference

9 May 2019

Reelin signaling facilitates maturation of CA1 glutamatergic synapses

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60841

determination method

positive regulation of dendritic spine morphogenesis

determination method

4 references

9 May 2019

Reelin supplementation enhances cognitive ability, synaptic plasticity, and dendritic spine density

Community Assessment of Community Annotation with Ontologies

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60841

determination method

9 May 2019

Reelin deficiency causes specific defects in the molecular composition of the synapses in the adult brain

Community Assessment of Community Annotation with Ontologies

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60841

determination method

9 May 2019

Reelin deficiency causes specific defects in the molecular composition of the synapses in the adult brain

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60841

determination method

9 May 2019

Reelin supplementation enhances cognitive ability, synaptic plasticity, and dendritic spine density

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60841

determination method

protein localization to synapse

determination method

positive regulation of TOR signaling

determination method

1 reference

9 May 2019

Reelin deficiency causes specific defects in the molecular composition of the synapses in the adult brain

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60841

determination method

long-term potentiation

determination method

1 reference

9 May 2019

Reelin supplementation enhances cognitive ability, synaptic plasticity, and dendritic spine density

Community Assessment of Community Annotation with Ontologies

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60841

determination method

neuron migration

determination method

7 references

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60841

determination method

14 February 2019

Reelin signaling is necessary for a specific step in the migration of hindbrain efferent neurons

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60841

determination method

14 February 2019

Lack of Reelin causes malpositioning of nigral dopaminergic neurons: Evidence from comparison of normal and Relnrl mutant mice

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60841

determination method

14 February 2019

Dissection of the cellular and molecular events that position cerebellar Purkinje cells: a study of the math1 null-mutant mouse

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60841

determination method

14 February 2019

Postnatal shifts of interneuron position in the neocortex of normal and reeler mice: evidence for inward radial migration

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60841

determination method

14 February 2019

Synergistic contributions of cyclin-dependant kinase 5/p35 and Reelin/Dab1 to the positioning of cortical neurons in the developing mouse brain

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60841

determination method

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60841

determination method

locomotory behavior

determination method

1 reference

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60841

determination method

dentate gyrus development

determination method

1 reference

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60841

determination method

neuron migration

determination method

8 references

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60841

determination method

9 May 2019

Dissection of the cellular and molecular events that position cerebellar Purkinje cells: a study of the math1 null-mutant mouse

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60841

determination method

9 May 2019

Reelin signaling is necessary for a specific step in the migration of hindbrain efferent neurons

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60841

determination method

9 May 2019

Postnatal shifts of interneuron position in the neocortex of normal and reeler mice: evidence for inward radial migration

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60841

determination method

9 May 2019

Lack of Reelin causes malpositioning of nigral dopaminergic neurons: Evidence from comparison of normal and Relnrl mutant mice

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60841

determination method

9 May 2019

Synergistic contributions of cyclin-dependant kinase 5/p35 and Reelin/Dab1 to the positioning of cortical neurons in the developing mouse brain

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60841

determination method

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60841

determination method

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60841

determination method

central nervous system development

determination method

3 references

9 May 2019

Evidence for a cell-specific action of Reelin in the spinal cord

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60841

determination method

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60841

determination method

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60841

determination method

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q60841

EGF-like, conserved site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q60841

EGF-like domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q60841

Identifiers

RefSeq protein ID

1 reference

20 March 2022

1 reference

20 March 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

Ensembl protein ID

ENSMUSP00000058025

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000058025

ENSMUSP00000124052

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000124052

ENSMUSP00000124077

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000124077

PDB structure ID

1 reference

UniProt protein ID

10 August 2016

language of work or name

1 reference

UniProt protein ID

10 August 2016

language of work or name

1 reference

UniProt protein ID

10 August 2016

language of work or name

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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