(Q14864142)

Hydroxymethylglutaryl-CoA reductase, class I/II, catalytic domain superfamily

1 reference

Hydroxymethylglutaryl-CoA reductase, class I/II, substrate-binding domain superfamily

1 reference

Hydroxymethylglutaryl-CoA reductase, N-terminal

1 reference

Hydroxymethylglutaryl-CoA reductase, class I/II, NAD/NADP-binding domain superfamily

1 reference

inferred from GOA cell component → membrane

membrane proteins

1 reference

based on heuristic

Sterol-sensing domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Hydroxymethylglutaryl-CoA reductase, class I/II, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

25 May 2022

1 reference

25 May 2022

oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01237

hydroxymethylglutaryl-CoA reductase (NADPH) activity

11 references

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q01237&geneProductId=UniProtKB:Q01237

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q01237&geneProductId=UniProtKB:Q01237

24 April 2018

Genetic and dietary interactions in the regulation of HMG-CoA reductase gene expression

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q01237&geneProductId=UniProtKB:Q01237

24 April 2018

Absence of functional peroxisomes does not lead to deficiency of enzymes involved in cholesterol biosynthesis

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q01237&geneProductId=UniProtKB:Q01237

24 April 2018

Apolipoprotein A-I is required for cholesteryl ester accumulation in steroidogenic cells and for normal adrenal steroid production

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q01237&geneProductId=UniProtKB:Q01237

24 April 2018

Leptin promotes biliary cholesterol elimination during weight loss in ob/ob mice by regulating the enterohepatic circulation of bile salts

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q01237&geneProductId=UniProtKB:Q01237

24 April 2018

Early embryonic lethality caused by targeted disruption of the 3-hydroxy-3-methylglutaryl-CoA reductase gene

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q01237&geneProductId=UniProtKB:Q01237

24 April 2018

Nerve regeneration and cholesterol reutilization occur in the absence of apolipoproteins E and A-I in mice

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q01237&geneProductId=UniProtKB:Q01237

24 April 2018

ApoA-I knockout mice: characterization of HDL metabolism in homozygotes and identification of a post-RNA mechanism of apoA-I up-regulation in heterozygotes

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q01237&geneProductId=UniProtKB:Q01237

24 April 2018

Schoenheimer effect explained--feedback regulation of cholesterol synthesis in mice mediated by Insig proteins

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q01237&geneProductId=UniProtKB:Q01237

24 April 2018

Altered hepatic cholesterol metabolism compensates for disruption of phosphatidylcholine transfer protein in mice

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q01237&geneProductId=UniProtKB:Q01237

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01237

2 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01237

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01237

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01237

oxidoreductase activity

1 reference

14 February 2019

hydroxymethylglutaryl-CoA reductase (NADPH) activity

12 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01237

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01237

14 February 2019

Absence of functional peroxisomes does not lead to deficiency of enzymes involved in cholesterol biosynthesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01237

14 February 2019

Altered hepatic cholesterol metabolism compensates for disruption of phosphatidylcholine transfer protein in mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01237

14 February 2019

ApoA-I knockout mice: characterization of HDL metabolism in homozygotes and identification of a post-RNA mechanism of apoA-I up-regulation in heterozygotes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01237

14 February 2019

Apolipoprotein A-I is required for cholesteryl ester accumulation in steroidogenic cells and for normal adrenal steroid production

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01237

14 February 2019

Schoenheimer effect explained--feedback regulation of cholesterol synthesis in mice mediated by Insig proteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01237

14 February 2019

Genetic and dietary interactions in the regulation of HMG-CoA reductase gene expression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01237

14 February 2019

Early embryonic lethality caused by targeted disruption of the 3-hydroxy-3-methylglutaryl-CoA reductase gene

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01237

14 February 2019

Nerve regeneration and cholesterol reutilization occur in the absence of apolipoproteins E and A-I in mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01237

14 February 2019

Leptin promotes biliary cholesterol elimination during weight loss in ob/ob mice by regulating the enterohepatic circulation of bile salts

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01237

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01237

integral component of membrane

IBA

cell component

endoplasmic reticulum membrane

2 references

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01237

3 references

endoplasmic reticulum

3 references

1 reference

14 February 2019

Glycogen stored in skeletal but not in cardiac muscle in acid alpha-glucosidase mutant (Pompe) mice is highly resistant to transgene-encoded human enzyme

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01237

steroid metabolic process

IGI

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01237

sterol biosynthetic process

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q01237&geneProductId=UniProtKB:Q01237

coenzyme A metabolic process

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01237

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01237

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01237

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01237

cholesterol metabolic process

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01237

negative regulation of MAP kinase activity

1 reference

14 February 2019

Glycogen stored in skeletal but not in cardiac muscle in acid alpha-glucosidase mutant (Pompe) mice is highly resistant to transgene-encoded human enzyme

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01237

cholesterol biosynthetic process

IGI

6 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01237

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01237

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01237

14 February 2019

Altered hepatic cholesterol metabolism compensates for disruption of phosphatidylcholine transfer protein in mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01237

14 February 2019

Nerve regeneration and cholesterol reutilization occur in the absence of apolipoproteins E and A-I in mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01237

14 February 2019

Apolipoprotein A-I is required for cholesteryl ester accumulation in steroidogenic cells and for normal adrenal steroid production

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01237

IDA

myoblast differentiation

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01237

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01237

steroid biosynthetic process

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01237

isoprenoid biosynthetic process

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01237

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01237

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01237

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01237

negative regulation of protein catabolic process

IBA

1 reference

14 February 2019

Statins promote the degradation of extracellular amyloid {beta}-peptide by microglia via stimulation of exosome-associated insulin-degrading enzyme (IDE) secretion

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01237

negative regulation of protein secretion

IMP

1 reference

14 February 2019

Statins promote the degradation of extracellular amyloid {beta}-peptide by microglia via stimulation of exosome-associated insulin-degrading enzyme (IDE) secretion

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01237

negative regulation of amyloid-beta clearance

IMP

1 reference

14 February 2019

Statins promote the degradation of extracellular amyloid {beta}-peptide by microglia via stimulation of exosome-associated insulin-degrading enzyme (IDE) secretion

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01237

physically interacts with

IMP

1 reference

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

2739

language of work or name

English

retrieved

17 August 2016

has part(s)

Hydroxymethylglutaryl-CoA reductase, class I/II, conserved site

1 reference

Sterol-sensing domain

1 reference