(Q14864142)

Hydroxymethylglutaryl-CoA reductase, class I/II, catalytic domain superfamily

1 reference

Hydroxymethylglutaryl-CoA reductase, class I/II, substrate-binding domain superfamily

1 reference

Hydroxymethylglutaryl-CoA reductase, N-terminal

1 reference

Hydroxymethylglutaryl-CoA reductase, class I/II, NAD/NADP-binding domain superfamily

1 reference

inferred from GOA cell component → membrane

membrane protein

1 reference

based on heuristic

Sterol-sensing domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Hydroxymethylglutaryl-CoA reductase, class I/II, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

25 May 2022

1 reference

25 May 2022

oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01237

1 reference

14 February 2019

hydroxymethylglutaryl-CoA reductase (NADPH) activity

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q01237&geneProductId=UniProtKB:Q01237

11 references

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q01237&geneProductId=UniProtKB:Q01237

24 April 2018

24 April 2018

Genetic and dietary interactions in the regulation of HMG-CoA reductase gene expression

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q01237&geneProductId=UniProtKB:Q01237

24 April 2018

Absence of functional peroxisomes does not lead to deficiency of enzymes involved in cholesterol biosynthesis

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q01237&geneProductId=UniProtKB:Q01237

24 April 2018

Apolipoprotein A-I is required for cholesteryl ester accumulation in steroidogenic cells and for normal adrenal steroid production

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q01237&geneProductId=UniProtKB:Q01237

24 April 2018

Leptin promotes biliary cholesterol elimination during weight loss in ob/ob mice by regulating the enterohepatic circulation of bile salts

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q01237&geneProductId=UniProtKB:Q01237

24 April 2018

Early embryonic lethality caused by targeted disruption of the 3-hydroxy-3-methylglutaryl-CoA reductase gene

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q01237&geneProductId=UniProtKB:Q01237

24 April 2018

Nerve regeneration and cholesterol reutilization occur in the absence of apolipoproteins E and A-I in mice

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q01237&geneProductId=UniProtKB:Q01237

24 April 2018

ApoA-I knockout mice: characterization of HDL metabolism in homozygotes and identification of a post-RNA mechanism of apoA-I up-regulation in heterozygotes

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q01237&geneProductId=UniProtKB:Q01237

24 April 2018

Schoenheimer effect explained--feedback regulation of cholesterol synthesis in mice mediated by Insig proteins

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q01237&geneProductId=UniProtKB:Q01237

24 April 2018

Altered hepatic cholesterol metabolism compensates for disruption of phosphatidylcholine transfer protein in mice

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q01237&geneProductId=UniProtKB:Q01237

NADP binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01237

1 reference

14 February 2019

oxidoreductase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01237

1 reference

14 February 2019

hydroxymethylglutaryl-CoA reductase (NADPH) activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01237

12 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01237

14 February 2019

14 February 2019

Absence of functional peroxisomes does not lead to deficiency of enzymes involved in cholesterol biosynthesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01237

14 February 2019

Altered hepatic cholesterol metabolism compensates for disruption of phosphatidylcholine transfer protein in mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01237

14 February 2019

ApoA-I knockout mice: characterization of HDL metabolism in homozygotes and identification of a post-RNA mechanism of apoA-I up-regulation in heterozygotes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01237

14 February 2019

Apolipoprotein A-I is required for cholesteryl ester accumulation in steroidogenic cells and for normal adrenal steroid production

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01237

14 February 2019

Schoenheimer effect explained--feedback regulation of cholesterol synthesis in mice mediated by Insig proteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01237

14 February 2019

Genetic and dietary interactions in the regulation of HMG-CoA reductase gene expression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01237

14 February 2019

Early embryonic lethality caused by targeted disruption of the 3-hydroxy-3-methylglutaryl-CoA reductase gene

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01237

14 February 2019

Nerve regeneration and cholesterol reutilization occur in the absence of apolipoproteins E and A-I in mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01237

14 February 2019

Leptin promotes biliary cholesterol elimination during weight loss in ob/ob mice by regulating the enterohepatic circulation of bile salts

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01237

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01237

endoplasmic reticulum membrane

cell component

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01237

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01237

14 February 2019

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01237

membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01237

1 reference

14 February 2019

peroxisomal membrane

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01237

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01237

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01237

endoplasmic reticulum

1 reference

14 February 2019

Glycogen stored in skeletal but not in cardiac muscle in acid alpha-glucosidase mutant (Pompe) mice is highly resistant to transgene-encoded human enzyme

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01237

steroid metabolic process

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01237

1 reference

14 February 2019

sterol biosynthetic process

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q01237&geneProductId=UniProtKB:Q01237

1 reference

24 April 2018

coenzyme A metabolic process

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01237

1 reference

14 February 2019

lipid metabolism

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01237

1 reference

14 February 2019

response to nutrient

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01237

ageing

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01237

cholesterol metabolic process

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01237

1 reference

14 February 2019

negative regulation of MAP kinase activity

1 reference

14 February 2019

Glycogen stored in skeletal but not in cardiac muscle in acid alpha-glucosidase mutant (Pompe) mice is highly resistant to transgene-encoded human enzyme

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01237

cholesterol biosynthetic process

6 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01237

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01237

14 February 2019

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01237

14 February 2019

Altered hepatic cholesterol metabolism compensates for disruption of phosphatidylcholine transfer protein in mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01237

14 February 2019

Nerve regeneration and cholesterol reutilization occur in the absence of apolipoproteins E and A-I in mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01237

14 February 2019

Apolipoprotein A-I is required for cholesteryl ester accumulation in steroidogenic cells and for normal adrenal steroid production

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01237

myoblast differentiation

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01237

response to ethanol

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01237

steroid biosynthetic process

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01237

1 reference

14 February 2019

isoprenoid biosynthetic process

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01237

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01237

14 February 2019

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01237

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01237

negative regulation of protein catabolic process

1 reference

14 February 2019

Statins Promote the Degradation of Extracellular Amyloid β-Peptide by Microglia via Stimulation of Exosome-associated Insulin-degrading Enzyme (IDE) Secretion

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01237

negative regulation of protein secretion

1 reference

14 February 2019

Statins Promote the Degradation of Extracellular Amyloid β-Peptide by Microglia via Stimulation of Exosome-associated Insulin-degrading Enzyme (IDE) Secretion

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01237

negative regulation of amyloid-beta clearance

1 reference

14 February 2019

Statins Promote the Degradation of Extracellular Amyloid β-Peptide by Microglia via Stimulation of Exosome-associated Insulin-degrading Enzyme (IDE) Secretion

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01237

physically interacts with

1 reference

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

2739

language of work or name

English

Hydroxymethylglutaryl-CoA reductase, class I/II, conserved site

17 August 2016

has part(s)

1 reference

Sterol-sensing domain

1 reference