Wikidata

(Q14865884)

English

Amyloid beta (A4) precursor protein

mammalian protein found in Mus musculus

  • AG
  • App
  • alzheimer disease amyloid protein
  • amyloid beta A4 protein
  • amyloid precursor protein
  • protease nexin II
  • amyloid-beta A4 protein
  • amyloid-beta precursor protein
  • beta-amyloid precursor protein
  • alzheimer disease amyloid A4 protein homolog
  • amyloidogenic glycoprotein
  • appican
  • ABPP
In more languages

Statements

part of
molecular function
protein binding
determination method
IPI
23 references
retrieved
9 May 2019
stated in
Megalin interacts with APP and the intracellular adapter protein FE65 in neurons
GOA
curator
UniProt
UniProt protein ID
P12023
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12023
determination method
IPI
retrieved
9 May 2019
stated in
Essential roles for Fe65, Alzheimer amyloid precursor-binding protein, in the cellular response to DNA damage
GOA
curator
UniProt
UniProt protein ID
P12023
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12023
determination method
IPI
retrieved
9 May 2019
stated in
Down syndrome cell adhesion molecule (DSCAM) associates with uncoordinated-5C (UNC5C) in netrin-1-mediated growth cone collapse
GOA
curator
UniProt
UniProt protein ID
P12023
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12023
determination method
IPI
retrieved
9 May 2019
stated in
Identification of NEEP21 as a ß-amyloid precursor protein-interacting protein in vivo that modulates amyloidogenic processing in vitro
GOA
curator
UniProt
UniProt protein ID
P12023
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12023
determination method
IPI
retrieved
9 May 2019
stated in
Transforming growth factor beta2 is a neuronal death-inducing ligand for amyloid-beta precursor protein
GOA
curator
UniProt
UniProt protein ID
P12023
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12023
determination method
IPI
retrieved
9 May 2019
stated in
VPS35 regulates cell surface recycling and signaling of dopamine receptor D1
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12023
determination method
IPI
retrieved
9 May 2019
stated in
Amyloid precursor proteins anchor CPEB to membranes and promote polyadenylation-induced translation
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12023
determination method
IPI
retrieved
9 May 2019
stated in
Interaction of a novel mitochondrial protein, 4-nitrophenylphosphatase domain and non-neuronal SNAP25-like protein homolog 1 (NIPSNAP1), with the amyloid precursor protein family
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12023
determination method
IPI
retrieved
9 May 2019
stated in
F-spondin interaction with the apolipoprotein E receptor ApoEr2 affects processing of amyloid precursor protein
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12023
determination method
IPI
retrieved
9 May 2019
stated in
LRAD3, a novel low-density lipoprotein receptor family member that modulates amyloid precursor protein trafficking
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12023
determination method
IPI
retrieved
9 May 2019
stated in
A TAG1-APP signalling pathway through Fe65 negatively modulates neurogenesis
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12023
determination method
IPI
retrieved
9 May 2019
stated in
The in vivo brain interactome of the amyloid precursor protein
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12023
determination method
IPI
retrieved
9 May 2019
stated in
Disabled-1 binds to the cytoplasmic domain of amyloid precursor-like protein 1
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12023
determination method
IPI
retrieved
9 May 2019
stated in
Progressive accumulation of amyloid-beta oligomers in Alzheimer's disease and in amyloid precursor protein transgenic mice is accompanied by selective alterations in synaptic scaffold proteins
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12023
determination method
IPI
retrieved
9 May 2019
stated in
c-Jun N-terminal kinase (JNK)-interacting protein-1b/islet-brain-1 scaffolds Alzheimer's amyloid precursor protein with JNK
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12023
determination method
IPI
retrieved
9 May 2019
stated in
Homo- and heterodimerization of APP family members promotes intercellular adhesion
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12023
determination method
IPI
retrieved
9 May 2019
stated in
Crystal structures of the Dab homology domains of mouse disabled 1 and 2
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12023
determination method
IPI
retrieved
9 May 2019
stated in
Tyrosine phosphorylation of the beta-amyloid precursor protein cytoplasmic tail promotes interaction with Shc
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12023
determination method
IPI
retrieved
9 May 2019
stated in
Yeast Two-Hybrid Screening for Proteins that Interact with the Extracellular Domain of Amyloid Precursor Protein
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12023
determination method
IPI
retrieved
9 May 2019
stated in
Molecular characterization of a trafficking organelle: dissecting the axonal paths of calsyntenin-1 transport vesicles
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12023
determination method
IPI
retrieved
9 May 2019
stated in
Iron-export ferroxidase activity of β-amyloid precursor protein is inhibited by zinc in Alzheimer's disease
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12023
determination method
IPI
retrieved
9 May 2019
stated in
Generation of amyloid-β is reduced by the interaction of calreticulin with amyloid precursor protein, presenilin and nicastrin
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12023
determination method
IPI
retrieved
9 May 2019
stated in
Characterization of the adaptor protein ARH expression in the brain and ARH molecular interactions
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12023
determination method
IPI
cell component
membrane
determination method
IDA
TAS
IEA
6 references
retrieved
9 May 2019
stated in
Tyrosine phosphorylation of the beta-amyloid precursor protein cytoplasmic tail promotes interaction with Shc
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12023
determination method
TAS
retrieved
9 May 2019
stated in
GOA
curator
UniProt
UniProt protein ID
P12023
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12023
determination method
IEA
retrieved
9 May 2019
stated in
Profiles of amyloid precursor and presenilin 2-like proteins are correlated during development of the mouse hypothalamus
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12023
determination method
IDA
retrieved
9 May 2019
stated in
Spatial segregation of gamma-secretase and substrates in distinct membrane domains
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12023
determination method
IDA
retrieved
9 May 2019
stated in
Developmental regulation of amyloid precursor protein at the neuromuscular junction in mouse skeletal muscle
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12023
determination method
IDA
retrieved
9 May 2019
stated in
Both raft- and non-raft proteins associate with CHAPS-insoluble complexes: some APP in large complexes
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12023
determination method
IDA
biological process
has part(s)

Identifiers

 
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