(Q14866248)

English

Toll-like receptor 3

mammalian protein found in Mus musculus

toll-like receptor 3
Tlr3
uniprot:Q99MB1

In more languages

Statements

1 reference

25 May 2022

UniProt protein ID

Toll/interleukin-1 receptor homology (TIR) domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q99MB1

Leucine-rich repeat domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q99MB1

toll-like receptor 3

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q99MB1

membrane proteins

1 reference

based on heuristic

inferred from GOA cell component → membrane

Toll/interleukin-1 receptor homology (TIR) domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Cysteine-rich flanking region, C-terminal domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Leucine-rich repeat, typical subtype, protein family

1 reference

based on heuristic

inferred from protein domain or family

Leucine-rich repeat, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

25 May 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

molecular function

determination method

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99MB1

determination method

transmembrane signaling receptor activity

determination method

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99MB1

determination method

double-stranded RNA binding

determination method

5 references

24 April 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99MB1&geneProductId=UniProtKB:Q99MB1

determination method

24 April 2018

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99MB1&geneProductId=UniProtKB:Q99MB1

determination method

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99MB1&geneProductId=UniProtKB:Q99MB1

determination method

24 April 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99MB1&geneProductId=UniProtKB:Q99MB1

determination method

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99MB1&geneProductId=UniProtKB:Q99MB1

determination method

double-stranded RNA binding

determination method

4 references

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99MB1

determination method

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99MB1

determination method

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99MB1

determination method

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99MB1

determination method

determination method

2 references

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99MB1

determination method

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99MB1

determination method

integral component of membrane

determination method

2 references

determination method

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99MB1

determination method

determination method

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99MB1

determination method

endoplasmic reticulum membrane

determination method

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99MB1

determination method

determination method

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99MB1

determination method

endoplasmic reticulum

determination method

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99MB1

determination method

endosome membrane

determination method

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99MB1

determination method

integral component of plasma membrane

determination method

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99MB1

determination method

determination method

2 references

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99MB1

determination method

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99MB1

determination method

biological process

defense response

determination method

1 reference

14 February 2019

Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99MB1

determination method

positive regulation of inflammatory response

determination method

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99MB1

determination method

male gonad development

determination method

1 reference

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99MB1

determination method

positive regulation of interleukin-12 production

determination method

1 reference

14 February 2019

Microglia initiate central nervous system innate and adaptive immune responses through multiple TLRs

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99MB1

determination method

positive regulation of type III interferon production

determination method

1 reference

14 February 2019

TNF superfamily member TWEAK exacerbates inflammation and demyelination in the cuprizone-induced model

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99MB1

determination method

positive regulation of cytokine production

determination method

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99MB1

determination method

response to exogenous dsRNA

determination method

4 references

14 February 2019

Raftlin is involved in the nucleocapture complex to induce poly(I:C)-mediated TLR3 activation

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99MB1

determination method

14 February 2019

Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling pathway

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99MB1

determination method

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99MB1

determination method

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99MB1

determination method

immune system process

determination method

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99MB1

determination method

cellular response to interferon-beta

determination method

1 reference

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99MB1

determination method

positive regulation of JNK cascade

determination method

1 reference

14 February 2019

TAK1, but not TAB1 or TAB2, plays an essential role in multiple signaling pathways in vivo

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99MB1

determination method

cellular response to dsRNA

determination method

1 reference

10 September 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99MB1&geneProductId=UniProtKB:Q99MB1

determination method

regulation of dendritic cell cytokine production

determination method

1 reference

14 February 2019

Phosphoinositide 3-kinase-dependent inhibition of dendritic cell interleukin-12 production by Giardia lamblia

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99MB1

determination method

cellular response to mechanical stimulus

determination method

1 reference

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99MB1

determination method

positive regulation of NF-kappaB transcription factor activity

determination method

1 reference

14 February 2019

Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling pathway

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99MB1

determination method

defense response to virus

determination method

3 references

14 February 2019

Microglia initiate central nervous system innate and adaptive immune responses through multiple TLRs

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99MB1

determination method

14 February 2019

An important role for type III interferon (IFN-lambda/IL-28) in TLR-induced antiviral activity

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99MB1

determination method

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99MB1

determination method

positive regulation of interleukin-6 production

determination method

5 references

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99MB1

determination method

14 February 2019

Critical role for Cryopyrin/Nalp3 in activation of caspase-1 in response to viral infection and double-stranded RNA

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99MB1

determination method

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99MB1

determination method

14 February 2019

The cytosolic sensors Nod1 and Nod2 are critical for bacterial recognition and host defense after exposure to Toll-like receptor ligands

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99MB1

determination method

14 February 2019

Microglia initiate central nervous system innate and adaptive immune responses through multiple TLRs

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99MB1

determination method

positive regulation of tumor necrosis factor production

determination method

positive regulation of I-kappaB kinase/NF-kappaB signaling

determination method

4 references

14 February 2019

Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling pathway

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99MB1

determination method

14 February 2019

TAK1, but not TAB1 or TAB2, plays an essential role in multiple signaling pathways in vivo

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99MB1

determination method

14 February 2019

TAK1, but not TAB1 or TAB2, plays an essential role in multiple signaling pathways in vivo

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99MB1

determination method

14 February 2019

Peli1 facilitates TRIF-dependent Toll-like receptor signaling and proinflammatory cytokine production

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99MB1

determination method

positive regulation of chemokine production

determination method

3 references

positive regulation of apoptotic process

determination method

1 reference

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99MB1

determination method

cellular response to interferon-gamma

determination method

1 reference

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99MB1

determination method

innate immune response

determination method

3 references

14 February 2019

Microglia initiate central nervous system innate and adaptive immune responses through multiple TLRs

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99MB1

determination method

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99MB1

determination method

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99MB1

determination method

inflammatory response

determination method

1 reference

24 April 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99MB1&geneProductId=UniProtKB:Q99MB1

determination method

toll-like receptor 3 signaling pathway

determination method

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99MB1

determination method

positive regulation of type I interferon production

determination method

1 reference

14 February 2019

TNF superfamily member TWEAK exacerbates inflammation and demyelination in the cuprizone-induced model

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99MB1

determination method

signal transduction

determination method

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99MB1

determination method

MyD88-independent toll-like receptor signaling pathway

determination method

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99MB1

determination method

positive regulation of interferon-beta production

determination method

1 reference

14 February 2019

Microglia initiate central nervous system innate and adaptive immune responses through multiple TLRs

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99MB1

determination method

positive regulation of angiogenesis

determination method

1 reference

14 February 2019

miR-126-3p Promotes Matrix-Dependent Perivascular Cell Attachment, Migration and Intercellular Interaction.

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99MB1

determination method

positive regulation of transcription by RNA polymerase II

determination method

1 reference

14 February 2019

Microglia initiate central nervous system innate and adaptive immune responses through multiple TLRs

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99MB1

determination method

toll-like receptor signaling pathway

determination method

3 references

response to dsRNA

determination method

2 references

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99MB1

determination method

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99MB1

determination method

Identifiers

RefSeq protein ID

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

Ensembl protein ID

ENSMUSP00000034056

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000034056

ENSMUSP00000126556

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000126556

ENSMUSP00000147738

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000147738

ENSMUSP00000147783

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000147783

ENSMUSP00000147961

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000147961

ENSMUSP00000148127

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000148127

ENSMUSP00000148263

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000148263

PDB structure ID

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

Retrieved from "https://www.wikidata.org/w/index.php?title=Q14866248&oldid=2023063030"