Wikidata

(Q14874000)

English

C-abl oncogene 1, non-receptor tyrosine kinase

mammalian protein found in Mus musculus

  • p150
  • Abl1
  • v-abl Abelson murine leukemia oncogene 1
  • c-abl protein, type I
  • c-abl oncogene 1, receptor tyrosine kinase
  • proto-oncogene tyrosine-protein kinase ABL1
  • Abelson murine leukemia oncogene
  • proto-oncogene c-Abl
  • Abelson tyrosine-protein kinase 1
  • tyrosine-protein kinase ABL1
  • abelson murine leukemia viral oncogene homolog 1
  • c-abl protein, type II
  • c-abl protein, type III
In more languages

Statements

part of
molecular function
protein binding
determination method
IPI
8 references
retrieved
9 May 2019
stated in
c-Abl-mediated tyrosine phosphorylation of the T-bet DNA-binding domain regulates CD4+ T-cell differentiation and allergic lung inflammation
GOA
curator
UniProt
UniProt protein ID
P00520
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00520
determination method
IPI
retrieved
9 May 2019
stated in
Mena, a relative of VASP and Drosophila Enabled, is implicated in the control of microfilament dynamics
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00520
determination method
IPI
retrieved
9 May 2019
stated in
Characterization of a novel member of the DOK family that binds and modulates Abl signaling
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00520
determination method
IPI
retrieved
9 May 2019
stated in
c-Abl phosphorylates Dok1 to promote filopodia during cell spreading
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00520
determination method
IPI
retrieved
9 May 2019
stated in
Cytoskeletal protein PSTPIP1 directs the PEST-type protein tyrosine phosphatase to the c-Abl kinase to mediate Abl dephosphorylation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00520
determination method
IPI
retrieved
9 May 2019
stated in
Multiple signaling interactions of Abl and Arg kinases with the EphB2 receptor
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00520
determination method
IPI
retrieved
9 May 2019
stated in
Cdo binds Abl to promote p38alpha/beta mitogen-activated protein kinase activity and myogenic differentiation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00520
determination method
IPI
retrieved
9 May 2019
stated in
Cdk-inhibitory activity and stability of p27Kip1 are directly regulated by oncogenic tyrosine kinases
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00520
determination method
IPI
protein tyrosine kinase activity
determination method
IDA
IGI
IEA
IMP
ISO
19 references
retrieved
9 May 2019
stated in
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00520
determination method
ISO
retrieved
9 May 2019
stated in
Abl family tyrosine kinases are essential for basement membrane integrity and cortical lamination in the cerebellum
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00520
determination method
IMP
retrieved
9 May 2019
stated in
c-Abl promotes osteoblast expansion by differentially regulating canonical and non-canonical BMP pathways and p16INK4a expression
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00520
determination method
IMP
retrieved
9 May 2019
stated in
Phosphorylation of c-Crk II on the negative regulatory Tyr222 mediates nerve growth factor-induced cell spreading and morphogenesis
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00520
determination method
IMP
retrieved
9 May 2019
stated in
Cockayne syndrome protein B interacts with and is phosphorylated by c-Abl tyrosine kinase
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00520
determination method
IMP
retrieved
9 May 2019
stated in
Inactivation of NF-kappaB-dependent cell survival, a novel mechanism for the proapoptotic function of c-Abl
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00520
determination method
IMP
retrieved
9 May 2019
stated in
Phosphorylation by the c-Abl protein tyrosine kinase inhibits parkin's ubiquitination and protective function
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00520
determination method
IMP
retrieved
9 May 2019
stated in
SHP-2 is a novel target of Abl kinases during cell proliferation
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00520
determination method
IGI
retrieved
9 May 2019
stated in
Abelson family kinases regulate Frizzled planar cell polarity signaling via Dsh phosphorylation
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00520
determination method
IGI
retrieved
9 May 2019
stated in
GOA
curator
UniProt
UniProt protein ID
P00520
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00520
determination method
IEA
retrieved
9 May 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00520
determination method
IEA
retrieved
9 May 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00520
determination method
IEA
retrieved
9 May 2019
stated in
c-Abl tyrosine kinase regulates caspase-9 autocleavage in the apoptotic response to DNA damage
GOA
curator
UniProt
UniProt protein ID
P00520
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00520
determination method
IDA
retrieved
9 May 2019
stated in
Functional interaction between DNA-PK and c-Abl in response to DNA damage
GOA
curator
UniProt
UniProt protein ID
P00520
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00520
determination method
IDA
retrieved
9 May 2019
stated in
c-Abl tyrosine kinase binds and phosphorylates phospholipid scramblase 1
GOA
curator
UniProt
UniProt protein ID
P00520
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00520
determination method
IDA
retrieved
9 May 2019
stated in
c-Abl, Lamellipodin, and Ena/VASP proteins cooperate in dorsal ruffling of fibroblasts and axonal morphogenesis
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00520
determination method
IDA
retrieved
9 May 2019
stated in
SHP-2 is a novel target of Abl kinases during cell proliferation
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00520
determination method
IDA
retrieved
9 May 2019
stated in
Werner syndrome protein phosphorylation by abl tyrosine kinase regulates its activity and distribution
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00520
determination method
IDA
retrieved
9 May 2019
stated in
Abl family kinases regulate FcγR-mediated phagocytosis in murine macrophages
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00520
determination method
IDA
cell component
biological process

Identifiers

PDB structure ID
 
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