(Q14878193)

English

Interleukin 1 alpha

mammalian protein found in Homo sapiens

pro-interleukin-1-alpha
preinterleukin 1 alpha
hematopoietin-1
IL1A
IL-1 alpha
interleukin-1 alpha

In more languages

Statements

1 reference

13 November 2019

UniProt protein ID

Cytokine IL1/FGF

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P01583

interleukin-1 family

2 references

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P01583

Transporter Classification Database ID

2 October 2019

based on heuristic

hierarchical database ID heuristic

Interleukin-1 alpha

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P01583

Interleukin-1 propeptide family

1 reference

based on heuristic

inferred from protein domain or family

Interleukin-1 conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

Interleukin 1-alpha

1 reference

13 November 2019

UniProt protein ID

molecular function

cytokine activity

determination method

5 references

8 April 2019

Rebound from nitric oxide inhibition triggers enhanced monocyte activation and chemotaxis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01583

determination method

8 April 2019

Cloning, sequence and expression of two distinct human interleukin-1 complementary DNAs

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01583

determination method

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01583

determination method

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01583

determination method

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01583

determination method

protein binding

determination method

6 references

8 April 2019

S100A13 mediates the copper-dependent stress-induced release of IL-1α from both human U937 and murine NIH 3T3 cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01583

determination method

8 April 2019

Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01583

determination method

8 April 2019

Active caspase-1 is a regulator of unconventional protein secretion

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01583

determination method

8 April 2019

A proteome-scale map of the human interactome network

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01583

determination method

8 April 2019

Widespread macromolecular interaction perturbations in human genetic disorders

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01583

determination method

8 April 2019

Intracellular IL-1alpha-binding proteins contribute to biological functions of endogenous IL-1alpha in systemic sclerosis fibroblasts

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01583

determination method

copper ion binding

determination method

1 reference

8 April 2019

S100A13 mediates the copper-dependent stress-induced release of IL-1α from both human U937 and murine NIH 3T3 cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01583

determination method

interleukin-1 receptor binding

determination method

interleukin-1 receptor binding

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01583

determination method

determination method

1 reference

8 April 2019

S100A13 mediates the copper-dependent stress-induced release of IL-1α from both human U937 and murine NIH 3T3 cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01583

determination method

determination method

1 reference

31 January 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01583&geneProductId=UniProtKB:P01583

determination method

extracellular space

determination method

6 references

8 April 2019

Interleukin 1 is processed and released during apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01583

determination method

8 April 2019

cDNA cloning of IL-1 alpha and IL-1 beta from mRNA of U937 cell line

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01583

determination method

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01583

determination method

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01583

determination method

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01583

determination method

8 April 2019

S100A13 mediates the copper-dependent stress-induced release of IL-1α from both human U937 and murine NIH 3T3 cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01583

determination method

biological process

cellular response to heat

determination method

1 reference

8 April 2019

S100A13 mediates the copper-dependent stress-induced release of IL-1α from both human U937 and murine NIH 3T3 cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01583

determination method

response to copper ion

determination method

1 reference

8 April 2019

S100A13 mediates the copper-dependent stress-induced release of IL-1α from both human U937 and murine NIH 3T3 cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01583

determination method

positive regulation of gene expression

determination method

1 reference

8 April 2019

Proinflammatory stimuli induce galectin-9 in human mesenchymal stromal cells to suppress T-cell proliferation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01583

determination method

immune response

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01583

determination method

connective tissue replacement involved in inflammatory response wound healing

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01583

determination method

positive regulation of protein secretion

determination method

1 reference

8 April 2019

Regulation of insulin-like growth factor-binding protein-5 by insulin-like growth factor I and interleukin-1alpha in ovine articular chondrocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01583

determination method

extrinsic apoptotic signaling pathway in absence of ligand

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01583

determination method

ectopic germ cell programmed cell death

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01583

determination method

cell population proliferation

determination method

1 reference

1 January 2018

Cloning and expression of murine interleukin-1 cDNA in Escherichia coli

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01583

determination method

inflammatory response

determination method

negative regulation of extrinsic apoptotic signaling pathway in absence of ligand

determination method

1 reference

8 April 2019

A phosphatidylinositol 3-kinase/Akt pathway, activated by tumor necrosis factor or interleukin-1, inhibits apoptosis but does not activate NFkappaB in human endothelial cells

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01583

determination method

positive regulation of mitotic nuclear division

determination method

1 reference

8 April 2019

Cloning, sequence and expression of two distinct human interleukin-1 complementary DNAs

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01583

determination method

positive regulation of cell division

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01583

determination method

positive regulation of transcription by RNA polymerase II

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01583

determination method

negative regulation of cell population proliferation

determination method

1 reference

8 April 2019

cDNA cloning of IL-1 alpha and IL-1 beta from mRNA of U937 cell line

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01583

determination method

apoptotic process

determination method

1 reference

8 April 2019

Interleukin 1 is processed and released during apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01583

determination method

positive regulation of interleukin-6 production

determination method

1 reference

31 January 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01583&geneProductId=UniProtKB:P01583

determination method

positive regulation of neutrophil extravasation

determination method

1 reference

31 January 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01583&geneProductId=UniProtKB:P01583

determination method

fever generation

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01583

determination method

positive regulation of monocyte chemotactic protein-1 production

determination method

1 reference

31 January 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01583&geneProductId=UniProtKB:P01583

determination method

regulation of signaling receptor activity

determination method

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01583

determination method

interleukin-1-mediated signaling pathway

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01583

determination method

Gene Atlas image

PBB GE IL1A 210118 s at fs.png
732 × 530; 10 KB

0 references

Interleukin-1 conserved site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P01583

Interleukin-1 propeptide

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P01583

Identifiers

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000263339

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000263339

PDB structure ID

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

Transporter Classification Database ID

2 references

Transporter Classification database

13 March 2020

Transporter Classification database

29 April 2020

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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