(Q14904616)

Cystine-knot cytokine

1 reference

Transforming growth factor-beta, C-terminal domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

TGF-beta, propeptide family

1 reference

based on heuristic

inferred from protein domain or family

Transforming growth factor beta, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

25 May 2022

1 reference

25 May 2022

type II transforming growth factor beta receptor binding

4 references

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04202&geneProductId=UniProtKB:P04202

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04202&geneProductId=UniProtKB:P04202

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04202&geneProductId=UniProtKB:P04202

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04202&geneProductId=UniProtKB:P04202

type III transforming growth factor beta receptor binding

1 reference

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04202&geneProductId=UniProtKB:P04202

transforming growth factor beta receptor binding

3 references

21 June 2018

Targeted disruption of the mouse transforming growth factor-beta 1 gene results in multifocal inflammatory disease

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04202&geneProductId=UniProtKB:P04202

21 June 2018

Cholesterol suppresses cellular TGF-beta responsiveness: implications in atherogenesis

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04202&geneProductId=UniProtKB:P04202

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04202&geneProductId=UniProtKB:P04202

type I transforming growth factor beta receptor binding

protein serine/threonine kinase activator activity

1 reference

21 June 2018

Galectin-9-CD44 interaction enhances stability and function of adaptive regulatory T cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04202&geneProductId=UniProtKB:P04202

5 references

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04202&geneProductId=UniProtKB:P04202

21 June 2018

Developmentally regulated expression of mouse HtrA3 and its role as an inhibitor of TGF-beta signaling

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04202&geneProductId=UniProtKB:P04202

21 June 2018

The NH2-terminal propeptide of type I procollagen acts intracellularly to modulate cell function

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04202&geneProductId=UniProtKB:P04202

21 June 2018

P311 binds to the latency associated protein and downregulates the expression of TGF-beta1 and TGF-beta2

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04202&geneProductId=UniProtKB:P04202

21 June 2018

Heart and liver defects and reduced transforming growth factor beta2 sensitivity in transforming growth factor beta type III receptor-deficient embryos

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04202&geneProductId=UniProtKB:P04202

1 reference

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04202&geneProductId=UniProtKB:P04202

5 references

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04202&geneProductId=UniProtKB:P04202

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04202&geneProductId=UniProtKB:P04202

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04202&geneProductId=UniProtKB:P04202

21 June 2018

Murine pregnancy-specific glycoprotein 23 induces the proangiogenic factors transforming-growth factor beta 1 and vascular endothelial growth factor a in cell types involved in vascular remodeling in pregnancy

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04202&geneProductId=UniProtKB:P04202

21 June 2018

Mesenchymal stem cells produce Wnt isoforms and TGF-beta1 that mediate proliferation and procollagen expression by lung fibroblasts

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04202&geneProductId=UniProtKB:P04202

1 reference

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04202&geneProductId=UniProtKB:P04202

5 references

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04202&geneProductId=UniProtKB:P04202

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04202&geneProductId=UniProtKB:P04202

21 June 2018

Disruption of the gene encoding the latent transforming growth factor-beta binding protein 4 (LTBP-4) causes abnormal lung development, cardiomyopathy, and colorectal cancer

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04202&geneProductId=UniProtKB:P04202

21 June 2018

Colocalization of TGF-beta 1 and collagen I and III, fibronectin and glycosaminoglycans during lung branching morphogenesis

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04202&geneProductId=UniProtKB:P04202

21 June 2018

Extracellular fibrillar structure of latent TGF beta binding protein-1: role in TGF beta-dependent endothelial-mesenchymal transformation during endocardial cushion tissue formation in mouse embryonic heart

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04202&geneProductId=UniProtKB:P04202

positive regulation of histone deacetylation

biological process

2 references

21 June 2018

A direct intersection between p53 and transforming growth factor beta pathways targets chromatin modification and transcription repression of the alpha-fetoprotein gene

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04202&geneProductId=UniProtKB:P04202

21 June 2018

Repression of Runx2 function by TGF-beta through recruitment of class II histone deacetylases by Smad3.

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04202&geneProductId=UniProtKB:P04202

positive regulation of transcription regulatory region DNA binding

skeletal system development

tolerance induction to self antigen

1 reference

21 June 2018

T cell-produced transforming growth factor-beta1 controls T cell tolerance and regulates Th1- and Th17-cell differentiation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04202&geneProductId=UniProtKB:P04202

positive regulation of protein phosphorylation

1 reference

21 June 2018

Identification of two distinct functions for TGF-beta in early mouse development

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04202&geneProductId=UniProtKB:P04202

Smad expression during kidney development

response to cholesterol

ureteric bud development

1 reference

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04202&geneProductId=UniProtKB:P04202

positive regulation of MAP kinase activity

IEP

regulation of sodium ion transport

1 reference

21 June 2018

Inhibition of prostasin-induced ENaC activities by PN-1 and regulation of PN-1 expression by TGF-beta1 and aldosterone

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04202&geneProductId=UniProtKB:P04202

negative regulation of cell cycle

response to progesterone

mammary gland development

1 reference

21 June 2018

Regulated expression and growth inhibitory effects of transforming growth factor-beta isoforms in mouse mammary gland development

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04202&geneProductId=UniProtKB:P04202

1 reference

21 June 2018

T cell-produced transforming growth factor-beta1 controls T cell tolerance and regulates Th1- and Th17-cell differentiation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04202&geneProductId=UniProtKB:P04202

negative regulation of ossification

1 reference

21 June 2018

Ubiquitin ligase Smurf1 controls osteoblast activity and bone homeostasis by targeting MEKK2 for degradation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04202&geneProductId=UniProtKB:P04202

negative regulation of hyaluronan biosynthetic process

T cell differentiation

1 reference

21 June 2018

T cell-produced transforming growth factor-beta1 controls T cell tolerance and regulates Th1- and Th17-cell differentiation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04202&geneProductId=UniProtKB:P04202

positive regulation of blood vessel endothelial cell migration

negative regulation of epithelial cell proliferation

regulation of binding

1 reference

21 June 2018

Induction of vascular smooth muscle alpha-actin gene transcription in transforming growth factor beta1-activated myofibroblasts mediated by dynamic interplay between the Pur repressor proteins and Sp1/Smad coactivators

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04202&geneProductId=UniProtKB:P04202

animal organ morphogenesis

1 reference

21 June 2018

Transforming growth factor beta 1 null mutation in mice causes excessive inflammatory response and early death

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04202&geneProductId=UniProtKB:P04202

inner ear development

1 reference

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04202&geneProductId=UniProtKB:P04202

negative regulation of macrophage cytokine production

cell population proliferation

3 references

21 June 2018

Transforming growth factor beta 1 null mutation in mice causes excessive inflammatory response and early death

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04202&geneProductId=UniProtKB:P04202

21 June 2018

Targeted disruption of the mouse transforming growth factor-beta 1 gene results in multifocal inflammatory disease

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04202&geneProductId=UniProtKB:P04202

21 June 2018

Disruption of the gene encoding the latent transforming growth factor-beta binding protein 4 (LTBP-4) causes abnormal lung development, cardiomyopathy, and colorectal cancer

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04202&geneProductId=UniProtKB:P04202

transforming growth factor beta receptor signaling pathway

5 references

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04202&geneProductId=UniProtKB:P04202

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04202&geneProductId=UniProtKB:P04202

21 June 2018

Disruption of the gene encoding the latent transforming growth factor-beta binding protein 4 (LTBP-4) causes abnormal lung development, cardiomyopathy, and colorectal cancer

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04202&geneProductId=UniProtKB:P04202

21 June 2018

LRG1 promotes angiogenesis by modulating endothelial TGF-β signalling.

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04202&geneProductId=UniProtKB:P04202

21 June 2018

Nodal is a novel TGF-beta-like gene expressed in the mouse node during gastrulation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04202&geneProductId=UniProtKB:P04202

1 reference

21 June 2018

The role of transforming growth factor-beta signalling in the patterning of the proximal processes of the murine dentary

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04202&geneProductId=UniProtKB:P04202

negative regulation of cell population proliferation

IEP

5 references

21 June 2018

Transforming growth factor beta 1 null mutation in mice causes excessive inflammatory response and early death

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04202&geneProductId=UniProtKB:P04202

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04202&geneProductId=UniProtKB:P04202

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04202&geneProductId=UniProtKB:P04202

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04202&geneProductId=UniProtKB:P04202

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04202&geneProductId=UniProtKB:P04202

positive regulation of receptor clustering

1 reference

21 June 2018

Galectin-9-CD44 interaction enhances stability and function of adaptive regulatory T cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04202&geneProductId=UniProtKB:P04202

regulation of apoptotic process

1 reference

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04202&geneProductId=UniProtKB:P04202

positive regulation of collagen biosynthetic process

3 references

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04202&geneProductId=UniProtKB:P04202

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04202&geneProductId=UniProtKB:P04202

21 June 2018

Mesenchymal stem cells produce Wnt isoforms and TGF-beta1 that mediate proliferation and procollagen expression by lung fibroblasts

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04202&geneProductId=UniProtKB:P04202

cellular response to transforming growth factor beta stimulus

3 references

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04202&geneProductId=UniProtKB:P04202

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04202&geneProductId=UniProtKB:P04202

21 June 2018

Loss of Usp9x disrupts cortical architecture, hippocampal development and TGFβ-mediated axonogenesis

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04202&geneProductId=UniProtKB:P04202

pathway-restricted SMAD protein phosphorylation

3 references

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04202&geneProductId=UniProtKB:P04202

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04202&geneProductId=UniProtKB:P04202

21 June 2018

Heart and liver defects and reduced transforming growth factor beta2 sensitivity in transforming growth factor beta type III receptor-deficient embryos

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04202&geneProductId=UniProtKB:P04202

regulation of DNA binding

1 reference

21 June 2018

Induction of vascular smooth muscle alpha-actin gene transcription in transforming growth factor beta1-activated myofibroblasts mediated by dynamic interplay between the Pur repressor proteins and Sp1/Smad coactivators

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04202&geneProductId=UniProtKB:P04202

regulation of actin cytoskeleton reorganization

1 reference

21 June 2018

CD2AP in mouse and human podocytes controls a proteolytic program that regulates cytoskeletal structure and cellular survival

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04202&geneProductId=UniProtKB:P04202

negative regulation of fat cell differentiation

IGI

positive regulation of protein metabolic process

cell-cell junction organization

negative regulation of myoblast differentiation

positive regulation of protein kinase B signaling

common-partner SMAD protein phosphorylation

regulation of MAPK cascade

1 reference

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04202&geneProductId=UniProtKB:P04202

SMAD protein signal transduction

1 reference

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04202&geneProductId=UniProtKB:P04202

epidermal growth factor receptor signaling pathway

negative regulation of blood vessel endothelial cell migration

positive regulation of protein dephosphorylation

extrinsic apoptotic signaling pathway

mitotic cell cycle checkpoint signaling

positive regulation of fibroblast proliferation

1 reference

21 June 2018

The small GTPase N-Ras regulates extracellular matrix synthesis, proliferation and migration in fibroblasts

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04202&geneProductId=UniProtKB:P04202

negative regulation of cell differentiation

1 reference

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04202&geneProductId=UniProtKB:P04202

regulation of branching involved in mammary gland duct morphogenesis

1 reference

21 June 2018

Wnt5a is required for proper mammary gland development and TGF-beta-mediated inhibition of ductal growth

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04202&geneProductId=UniProtKB:P04202

1 reference

21 June 2018

mSmile is necessary for bronchial smooth muscle and alveolar myofibroblast development

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04202&geneProductId=UniProtKB:P04202

positive regulation of peptidyl-serine phosphorylation

negative regulation of T cell proliferation

1 reference

21 June 2018

T cell-produced transforming growth factor-beta1 controls T cell tolerance and regulates Th1- and Th17-cell differentiation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04202&geneProductId=UniProtKB:P04202

CD4-positive, CD25-positive, alpha-beta regulatory T cell lineage commitment

1 reference

21 June 2018

TGF-beta-induced Foxp3 inhibits T(H)17 cell differentiation by antagonizing RORgammat function

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04202&geneProductId=UniProtKB:P04202

negative regulation of cell growth

3 references

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04202&geneProductId=UniProtKB:P04202

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04202&geneProductId=UniProtKB:P04202

21 June 2018

Heart and liver defects and reduced transforming growth factor beta2 sensitivity in transforming growth factor beta type III receptor-deficient embryos

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04202&geneProductId=UniProtKB:P04202

positive regulation of chemotaxis

protein export from nucleus

regulation of protein import into nucleus

1 reference

21 June 2018

The non-ankyrin C terminus of Ikappa Balpha physically interacts with p53 in vivo and dissociates in response to apoptotic stress, hypoxia, DNA damage, and transforming growth factor-beta 1-mediated growth suppression

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04202&geneProductId=UniProtKB:P04202

positive regulation of protein import into nucleus

oligodendrocyte development

1 reference

21 June 2018

Mutation of pescadillo disrupts oligodendrocyte formation in zebrafish

Community Assessment of Community Annotation with Ontologies

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04202&geneProductId=UniProtKB:P04202

positive regulation of interleukin-17 production

3 references

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04202&geneProductId=UniProtKB:P04202

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04202&geneProductId=UniProtKB:P04202

21 June 2018

TGF-beta is necessary for induction of IL-23R and Th17 differentiation by IL-6 and IL-23

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04202&geneProductId=UniProtKB:P04202

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04202&geneProductId=UniProtKB:P04202

inflammatory response

5 references

21 June 2018

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04202&geneProductId=UniProtKB:P04202

21 June 2018

Transforming growth factor beta 1 null mutation in mice causes excessive inflammatory response and early death

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04202&geneProductId=UniProtKB:P04202

21 June 2018

Targeted disruption of the mouse transforming growth factor-beta 1 gene results in multifocal inflammatory disease

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04202&geneProductId=UniProtKB:P04202

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04202&geneProductId=UniProtKB:P04202

negative regulation of interleukin-17 production

1 reference

21 June 2018

TGF-beta-induced Foxp3 inhibits T(H)17 cell differentiation by antagonizing RORgammat function

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04202&geneProductId=UniProtKB:P04202

Targeted disruption of the mouse transforming growth factor-beta 1 gene results in multifocal inflammatory disease

lymph node development

1 reference

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04202&geneProductId=UniProtKB:P04202

Notch signaling pathway

1 reference

21 June 2018

Hepatic Notch2 deficiency leads to bile duct agenesis perinatally and secondary bile duct formation after weaning

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04202&geneProductId=UniProtKB:P04202

negative regulation of protein phosphorylation

SMAD protein complex assembly

regulation of striated muscle tissue development

1 reference

21 June 2018

TGF-beta inhibits muscle differentiation through functional repression of myogenic transcription factors by Smad3

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04202&geneProductId=UniProtKB:P04202

response to vitamin D

1 reference

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04202&geneProductId=UniProtKB:P04202

chondrocyte differentiation

regulatory T cell differentiation

regulation of cartilage development

1 reference

21 June 2018

Regulation of BMP-dependent chondrogenesis in early limb mesenchyme by TGFbeta signals

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04202&geneProductId=UniProtKB:P04202

branch elongation involved in mammary gland duct branching

1 reference

21 June 2018

Mammary gland development in transforming growth factor beta1 null mutant mice: systemic and epithelial effects

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04202&geneProductId=UniProtKB:P04202

1 reference

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04202&geneProductId=UniProtKB:P04202

cellular response to organic cyclic compound

cellular calcium ion homeostasis

1 reference

21 June 2018

TGF beta 1 inhibits Ca2+-calcineurin-mediated activation in thymocytes

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04202&geneProductId=UniProtKB:P04202

negative regulation of transcription by RNA polymerase II

3 references

21 June 2018

Repression of Runx2 function by TGF-beta through recruitment of class II histone deacetylases by Smad3.

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04202&geneProductId=UniProtKB:P04202

21 June 2018

Chromatin-bound p53 anchors activated Smads and the mSin3A corepressor to confer transforming-growth-factor-beta-mediated transcription repression

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04202&geneProductId=UniProtKB:P04202

21 June 2018

A direct intersection between p53 and transforming growth factor beta pathways targets chromatin modification and transcription repression of the alpha-fetoprotein gene

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04202&geneProductId=UniProtKB:P04202

1 reference

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04202&geneProductId=UniProtKB:P04202

positive regulation of epithelial to mesenchymal transition

3 references

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04202&geneProductId=UniProtKB:P04202

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04202&geneProductId=UniProtKB:P04202

21 June 2018

EPB41L5 functions to post-transcriptionally regulate cadherin and integrin during epithelial-mesenchymal transition

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04202&geneProductId=UniProtKB:P04202

mitigation of host defenses by virus

lens fiber cell differentiation

1 reference

21 June 2018

The anaphase-promoting complex coordinates initiation of lens differentiation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04202&geneProductId=UniProtKB:P04202

extracellular matrix assembly

3 references

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04202&geneProductId=UniProtKB:P04202

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04202&geneProductId=UniProtKB:P04202

21 June 2018

Mesenchymal stem cells produce Wnt isoforms and TGF-beta1 that mediate proliferation and procollagen expression by lung fibroblasts

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04202&geneProductId=UniProtKB:P04202

hematopoietic progenitor cell differentiation

ATP biosynthetic process

regulation of interleukin-23 production

1 reference

21 June 2018

TGF-beta-induced Foxp3 inhibits T(H)17 cell differentiation by antagonizing RORgammat function

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04202&geneProductId=UniProtKB:P04202

positive regulation of protein secretion

frontal suture morphogenesis

1 reference

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04202&geneProductId=UniProtKB:P04202

epithelial to mesenchymal transition

phosphate-containing compound metabolic process

regulation of gene expression

1 reference

21 June 2018

The small GTPase N-Ras regulates extracellular matrix synthesis, proliferation and migration in fibroblasts

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04202&geneProductId=UniProtKB:P04202

adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains

1 reference

21 June 2018

TGF-beta is necessary for induction of IL-23R and Th17 differentiation by IL-6 and IL-23

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04202&geneProductId=UniProtKB:P04202

response to radiation

1 reference

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04202&geneProductId=UniProtKB:P04202

mononuclear cell proliferation

1 reference

21 June 2018

T cell-produced transforming growth factor-beta1 controls T cell tolerance and regulates Th1- and Th17-cell differentiation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04202&geneProductId=UniProtKB:P04202

negative regulation of transcription, DNA-templated

negative regulation of T cell activation

1 reference

21 June 2018

TGF beta 1 inhibits Ca2+-calcineurin-mediated activation in thymocytes

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04202&geneProductId=UniProtKB:P04202

positive regulation of odontogenesis

1 reference

21 June 2018

Comparative analysis of TGF beta s, BMPs, IGF1, msxs, fibronectin, osteonectin and bone sialoprotein gene expression during normal and in vitro-induced odontoblast differentiation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04202&geneProductId=UniProtKB:P04202

lipopolysaccharide-mediated signaling pathway

positive regulation of protein localization to nucleus

1 reference

24 April 2018

CD2AP in mouse and human podocytes controls a proteolytic program that regulates cytoskeletal structure and cellular survival

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04202&geneProductId=UniProtKB:P04202

1 reference

21 June 2018

Transforming growth factor beta 1 null mutation in mice causes excessive inflammatory response and early death

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04202&geneProductId=UniProtKB:P04202

response to estradiol

1 reference

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04202&geneProductId=UniProtKB:P04202

hyaluronan catabolic process

regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation

1 reference

21 June 2018

TGF-beta-induced Foxp3 inhibits T(H)17 cell differentiation by antagonizing RORgammat function

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04202&geneProductId=UniProtKB:P04202

response to organic cyclic compound

1 reference

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04202&geneProductId=UniProtKB:P04202

positive regulation of protein-containing complex assembly

protein kinase B signaling

negative regulation of cell-cell adhesion

positive regulation of cell migration

positive regulation of regulatory T cell differentiation

1 reference

21 June 2018

Galectin-9-CD44 interaction enhances stability and function of adaptive regulatory T cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04202&geneProductId=UniProtKB:P04202

cellular response to growth factor stimulus

1 reference

21 June 2018

Comparative analysis of TGF beta s, BMPs, IGF1, msxs, fibronectin, osteonectin and bone sialoprotein gene expression during normal and in vitro-induced odontoblast differentiation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04202&geneProductId=UniProtKB:P04202

positive regulation of pathway-restricted SMAD protein phosphorylation

4 references

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04202&geneProductId=UniProtKB:P04202

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04202&geneProductId=UniProtKB:P04202

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04202&geneProductId=UniProtKB:P04202

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04202&geneProductId=UniProtKB:P04202

regulation of regulatory T cell differentiation

1 reference

21 June 2018

Strong CD28 costimulation suppresses induction of regulatory T cells from naive precursors through Lck signaling

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04202&geneProductId=UniProtKB:P04202

mammary gland branching involved in thelarche

IGI

1 reference

21 June 2018

Mammary gland development in transforming growth factor beta1 null mutant mice: systemic and epithelial effects

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04202&geneProductId=UniProtKB:P04202

1 reference

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04202&geneProductId=UniProtKB:P04202

response to laminar fluid shear stress

1 reference

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04202&geneProductId=UniProtKB:P04202

myeloid dendritic cell differentiation

1 reference

21 June 2018

Autocrine/paracrine TGFbeta1 is required for the development of epidermal Langerhans cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04202&geneProductId=UniProtKB:P04202

receptor catabolic process

T-helper 17 cell lineage commitment

1 reference

21 June 2018

TGF-beta-induced Foxp3 inhibits T(H)17 cell differentiation by antagonizing RORgammat function

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04202&geneProductId=UniProtKB:P04202

positive regulation of histone acetylation

1 reference

21 June 2018

Repression of Runx2 function by TGF-beta through recruitment of class II histone deacetylases by Smad3.

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04202&geneProductId=UniProtKB:P04202

regulation of transforming growth factor beta receptor signaling pathway

positive regulation of phosphatidylinositol 3-kinase activity

positive regulation of gene expression

4 references

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04202&geneProductId=UniProtKB:P04202

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04202&geneProductId=UniProtKB:P04202

24 April 2018

TGF-β-induced mesenchymal transition of MS-1 endothelial cells requires Smad-dependent cooperative activation of Rho signals and MRTF-A

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04202&geneProductId=UniProtKB:P04202

24 April 2018

Function, activity, and membrane targeting of cytosolic phospholipase A(2)zeta in mouse lung fibroblasts

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04202&geneProductId=UniProtKB:P04202

positive regulation of NAD+ ADP-ribosyltransferase activity

regulation of cell population proliferation

1 reference

21 June 2018

The non-ankyrin C terminus of Ikappa Balpha physically interacts with p53 in vivo and dissociates in response to apoptotic stress, hypoxia, DNA damage, and transforming growth factor-beta 1-mediated growth suppression

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04202&geneProductId=UniProtKB:P04202

negative regulation of skeletal muscle tissue development

positive regulation of peptidyl-threonine phosphorylation

positive regulation of isotype switching to IgA isotypes

positive regulation of cell population proliferation

3 references

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04202&geneProductId=UniProtKB:P04202

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04202&geneProductId=UniProtKB:P04202

21 June 2018

Coordination of trigeminal axon navigation and patterning with tooth organ formation: epithelial-mesenchymal interactions, and epithelial Wnt4 and Tgfbeta1 regulate semaphorin 3a expression in the dental mesenchyme

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04202&geneProductId=UniProtKB:P04202

positive regulation of superoxide anion generation

digestive tract development

1 reference

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04202&geneProductId=UniProtKB:P04202

skeletal muscle tissue development

1 reference

21 June 2018

Targeted disruption of the mouse transforming growth factor-beta 1 gene results in multifocal inflammatory disease

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04202&geneProductId=UniProtKB:P04202

positive regulation of fibroblast migration

4 references

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04202&geneProductId=UniProtKB:P04202

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04202&geneProductId=UniProtKB:P04202

21 June 2018

The small GTPase N-Ras regulates extracellular matrix synthesis, proliferation and migration in fibroblasts

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04202&geneProductId=UniProtKB:P04202

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04202&geneProductId=UniProtKB:P04202

positive regulation of cell division

1 reference

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04202&geneProductId=UniProtKB:P04202

1 reference

21 June 2018

Altered primordial germ cell migration in the absence of transforming growth factor beta signaling via ALK5

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04202&geneProductId=UniProtKB:P04202

positive regulation of transcription by RNA polymerase II

6 references

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04202&geneProductId=UniProtKB:P04202

21 June 2018

Foxh1 recruits Gsc to negatively regulate Mixl1 expression during early mouse development

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04202&geneProductId=UniProtKB:P04202

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04202&geneProductId=UniProtKB:P04202

21 June 2018

Repression of Runx2 function by TGF-beta through recruitment of class II histone deacetylases by Smad3.

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04202&geneProductId=UniProtKB:P04202

21 June 2018

Fgfr2b mediated epithelial-mesenchymal interactions coordinate tooth morphogenesis and dental trigeminal axon patterning

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04202&geneProductId=UniProtKB:P04202

21 June 2018

IL-4 inhibits TGF-beta-induced Foxp3+ T cells and, together with TGF-beta, generates IL-9+ IL-10+ Foxp3(-) effector T cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04202&geneProductId=UniProtKB:P04202

negative regulation of mitotic cell cycle

positive regulation of SMAD protein signal transduction

cellular response to insulin-like growth factor stimulus

1 reference

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04202&geneProductId=UniProtKB:P04202

1 reference

21 June 2018

Defective haematopoiesis and vasculogenesis in transforming growth factor-beta 1 knock out mice

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04202&geneProductId=UniProtKB:P04202

embryonic liver development

1 reference

21 June 2018

Defective haematopoiesis and vasculogenesis in transforming growth factor-beta 1 knock out mice

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04202&geneProductId=UniProtKB:P04202

cellular response to ionizing radiation

1 reference

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04202&geneProductId=UniProtKB:P04202

ventricular cardiac muscle tissue morphogenesis

1 reference

21 June 2018

Maternal rescue of transforming growth factor-beta 1 null mice

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04202&geneProductId=UniProtKB:P04202

heart valve morphogenesis

1 reference

21 June 2018

Maternal rescue of transforming growth factor-beta 1 null mice

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04202&geneProductId=UniProtKB:P04202

regulation of epithelial to mesenchymal transition involved in endocardial cushion formation

1 reference

21 June 2018

Ligand-specific function of transforming growth factor beta in epithelial-mesenchymal transition in heart development

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04202&geneProductId=UniProtKB:P04202

Defective haematopoiesis and vasculogenesis in transforming growth factor-beta 1 knock out mice

neural tube development

1 reference

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04202&geneProductId=UniProtKB:P04202

1 reference

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04202&geneProductId=UniProtKB:P04202

cellular response to mechanical stimulus

1 reference

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04202&geneProductId=UniProtKB:P04202

1 reference

21 June 2018

Defective haematopoiesis and vasculogenesis in transforming growth factor-beta 1 knock out mice

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04202&geneProductId=UniProtKB:P04202

regulation of SMAD protein signal transduction

1 reference

21 June 2018

Defective haematopoiesis and vasculogenesis in transforming growth factor-beta 1 knock out mice

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04202&geneProductId=UniProtKB:P04202

response to immobilization stress

1 reference

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04202&geneProductId=UniProtKB:P04202

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04202&geneProductId=UniProtKB:P04202

BMP signaling pathway

1 reference

21 June 2018

membrane protein intracellular domain proteolysis

positive regulation of transcription, DNA-templated

4 references

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04202&geneProductId=UniProtKB:P04202

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04202&geneProductId=UniProtKB:P04202

21 June 2018

Induction of vascular smooth muscle alpha-actin gene transcription in transforming growth factor beta1-activated myofibroblasts mediated by dynamic interplay between the Pur repressor proteins and Sp1/Smad coactivators

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04202&geneProductId=UniProtKB:P04202

21 June 2018

Cutting edge: TGF-beta induces a regulatory phenotype in CD4+CD25- T cells through Foxp3 induction and down-regulation of Smad7

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04202&geneProductId=UniProtKB:P04202

positive regulation of ERK1 and ERK2 cascade

transforming growth factor beta receptor signaling pathway involved in heart development

1 reference

21 June 2018

Maternal rescue of transforming growth factor-beta 1 null mice

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04202&geneProductId=UniProtKB:P04202

regulation of signaling receptor activity

1 reference

21 June 2018

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04202&geneProductId=UniProtKB:P04202

1 reference

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04202&geneProductId=UniProtKB:P04202

osteoclast differentiation

IGI

protein phosphorylation

4 references

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04202&geneProductId=UniProtKB:P04202

21 June 2018

Wnt5a is required for proper mammary gland development and TGF-beta-mediated inhibition of ductal growth

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04202&geneProductId=UniProtKB:P04202

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04202&geneProductId=UniProtKB:P04202

21 June 2018

Disruption of the gene encoding the latent transforming growth factor-beta binding protein 4 (LTBP-4) causes abnormal lung development, cardiomyopathy, and colorectal cancer

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04202&geneProductId=UniProtKB:P04202

positive regulation of gene expression

5 references

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04202&geneProductId=UniProtKB:P04202

21 June 2018

Valve Endothelial Cell-Derived Tgfβ1 Signaling Promotes Nuclear Localization of Sox9 in Interstitial Cells Associated With Attenuated Calcification

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04202&geneProductId=UniProtKB:P04202

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04202&geneProductId=UniProtKB:P04202

21 June 2018

TGF-β-induced mesenchymal transition of MS-1 endothelial cells requires Smad-dependent cooperative activation of Rho signals and MRTF-A

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04202&geneProductId=UniProtKB:P04202

21 June 2018

Function, activity, and membrane targeting of cytosolic phospholipase A(2)zeta in mouse lung fibroblasts

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04202&geneProductId=UniProtKB:P04202

negative regulation of gene expression

3 references

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04202&geneProductId=UniProtKB:P04202

21 June 2018

Valve Endothelial Cell-Derived Tgfβ1 Signaling Promotes Nuclear Localization of Sox9 in Interstitial Cells Associated With Attenuated Calcification

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04202&geneProductId=UniProtKB:P04202

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04202&geneProductId=UniProtKB:P04202

negative regulation of biomineral tissue development

3 references

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04202&geneProductId=UniProtKB:P04202

21 June 2018

Valve Endothelial Cell-Derived Tgfβ1 Signaling Promotes Nuclear Localization of Sox9 in Interstitial Cells Associated With Attenuated Calcification

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04202&geneProductId=UniProtKB:P04202

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04202&geneProductId=UniProtKB:P04202

positive regulation of protein localization to nucleus

3 references

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04202&geneProductId=UniProtKB:P04202

21 June 2018

CD2AP in mouse and human podocytes controls a proteolytic program that regulates cytoskeletal structure and cellular survival

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04202&geneProductId=UniProtKB:P04202

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04202&geneProductId=UniProtKB:P04202

Transforming growth factor-beta, C-terminal

has part(s)

1 reference

Transforming growth factor beta, conserved site

1 reference

TGF-beta, propeptide

1 reference