(Q14911713)

Ribosomal protein S5 domain 2-type fold, subgroup

1 reference

Histidine kinase/HSP90-like ATPase superfamily

1 reference

DNA mismatch repair protein Mlh1, C-terminal domain, protein family

1 reference

Histidine kinase/HSP90-like ATPase family

1 reference

DNA mismatch repair protein family, N-terminal domain, protein family

1 reference

DNA mismatch repair protein, S5 domain 2-like, protein family

1 reference

DNA mismatch repair, conserved site, protein family

1 reference

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK91

1 reference

25 May 2022

1 reference

25 May 2022

mismatched DNA binding

1 reference

14 February 2019

1 reference

16 July 2018

Altered somatic hypermutation and reduced class-switch recombination in exonuclease 1-mutant mice

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9JK91&geneProductId=UniProtKB:Q9JK91

single-stranded DNA binding

3 references

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9JK91&geneProductId=UniProtKB:Q9JK91

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9JK91&geneProductId=UniProtKB:Q9JK91

10 September 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9JK91&geneProductId=UniProtKB:Q9JK91

2 references

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK91

1 reference

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9JK91&geneProductId=UniProtKB:Q9JK91

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK91

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK91

14 February 2019

Altered somatic hypermutation and reduced class-switch recombination in exonuclease 1-mutant mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK91

2 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK91

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK91

3 references

16 July 2018

The cohesin subunit RAD21L functions in meiotic synapsis and exhibits sexual dimorphism in fertility

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9JK91&geneProductId=UniProtKB:Q9JK91

16 July 2018

Mouse pachytene checkpoint 2 (trip13) is required for completing meiotic recombination but not synapsis

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9JK91&geneProductId=UniProtKB:Q9JK91

16 July 2018

The Mre11 complex influences DNA repair, synapsis, and crossing over in murine meiosis

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9JK91&geneProductId=UniProtKB:Q9JK91

Mouse pachytene checkpoint 2 (trip13) is required for completing meiotic recombination but not synapsis

male germ cell nucleus

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK91

1 reference

10 September 2018

Genomic instability in mice lacking histone H2AX

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9JK91&geneProductId=UniProtKB:Q9JK91

3 references

condensed nuclear chromosome

3 references

14 February 2019

Meiotic failure in male mice lacking an X-linked factor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK91

14 February 2019

Mammalian CNTD1 is critical for meiotic crossover maturation and deselection of excess precrossover sites

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK91

14 February 2019

Mouse HFM1/Mer3 is required for crossover formation and complete synapsis of homologous chromosomes during meiosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK91

3 references

14 February 2019

Characterization of a novel meiosis-specific protein within the central element of the synaptonemal complex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK91

14 February 2019

Novel and diverse functions of the DNA mismatch repair family in mammalian meiosis and recombination

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK91

14 February 2019

Localization of MMR proteins on meiotic chromosomes in mice indicates distinct functions during prophase I

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK91

3 references

14 February 2019

Involvement of mouse Mlh1 in DNA mismatch repair and meiotic crossing over

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK91

14 February 2019

Targeted disruption of exons 1 to 6 of the Fanconi Anemia group A gene leads to growth retardation, strain-specific microphthalmia, meiotic defects and primordial germ cell hypoplasia

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK91

14 February 2019

Meiotic arrest and aneuploidy in MLH3-deficient mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK91

late recombination nodule

1 reference

14 February 2019

Alignment of Homologous Chromosomes and Effective Repair of Programmed DNA Double-Strand Breaks during Mouse Meiosis Require the Minichromosome Maintenance Domain Containing 2 (MCMDC2) Protein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK91

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9JK91&geneProductId=UniProtKB:Q9JK91

mismatch repair complex

1 reference

16 July 2018

3 references

4 references

10 September 2018

Characterization of a novel meiosis-specific protein within the central element of the synaptonemal complex

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9JK91&geneProductId=UniProtKB:Q9JK91

10 September 2018

Novel and diverse functions of the DNA mismatch repair family in mammalian meiosis and recombination

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9JK91&geneProductId=UniProtKB:Q9JK91

10 September 2018

Localization of MMR proteins on meiotic chromosomes in mice indicates distinct functions during prophase I

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9JK91&geneProductId=UniProtKB:Q9JK91

10 September 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9JK91&geneProductId=UniProtKB:Q9JK91

4 references

14 February 2019

The Mre11 complex influences DNA repair, synapsis, and crossing over in murine meiosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK91

14 February 2019

The cohesin subunit RAD21L functions in meiotic synapsis and exhibits sexual dimorphism in fertility

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK91

14 February 2019

Mouse pachytene checkpoint 2 (trip13) is required for completing meiotic recombination but not synapsis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK91

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK91

3 references

14 February 2019

ATR kinase activation mediated by MutSalpha and MutLalpha in response to cytotoxic O6-methylguanine adducts

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK91

14 February 2019

Meiosis in mice without a synaptonemal complex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK91

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK91

nuclear-transcribed mRNA poly(A) tail shortening

IBA

biological process

1 reference

14 February 2019

Stepwise deletions of polyA sequences in mismatch repair-deficient colorectal cancers

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK91

resolution of meiotic recombination intermediates

somatic hypermutation of immunoglobulin genes

reciprocal meiotic recombination

3 references

14 February 2019

Involvement of mouse Mlh1 in DNA mismatch repair and meiotic crossing over

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK91

14 February 2019

Chromosomal influence on meiotic spindle assembly: abnormal meiosis I in female Mlh1 mutant mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK91

14 February 2019

Crossover and noncrossover pathways in mouse meiosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK91

male meiotic nuclear division

1 reference

14 February 2019

Novel and diverse functions of the DNA mismatch repair family in mammalian meiosis and recombination

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK91

meiotic telomere clustering

1 reference

14 February 2019

Mutations that affect meiosis in male mice influence the dynamics of the mid-preleptotene and bouquet stages

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK91

meiotic metaphase I plate congression

1 reference

14 February 2019

Chromosomal influence on meiotic spindle assembly: abnormal meiosis I in female Mlh1 mutant mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK91

homologous chromosome segregation

1 reference

14 February 2019

Meikin is a conserved regulator of meiosis-I-specific kinetochore function

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK91

cellular response to DNA damage stimulus

5 references

14 February 2019

MBD4 deficiency reduces the apoptotic response to DNA-damaging agents in the murine small intestine

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK91

14 February 2019

Contributions by MutL homologues Mlh3 and Pms2 to DNA mismatch repair and tumor suppression in the mouse

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK91

14 February 2019

A defect in a single allele of the Mlh1 gene causes dissociation of the killing and tumorigenic actions of an alkylating carcinogen in methyltransferase-deficient mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK91

14 February 2019

Separation of killing and tumorigenic effects of an alkylating agent in mice defective in two of the DNA repair genes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK91

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK91

meiotic chromosome segregation

IEA

1 reference

14 February 2019

Meiotic prophase abnormalities and metaphase cell death in MLH1-deficient mouse spermatocytes: insights into regulation of spermatogenic progress

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK91

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK91

homologous chromosome pairing at meiosis

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK91

somatic recombination of immunoglobulin gene segments

1 reference

14 February 2019

Role for mismatch repair proteins Msh2, Mlh1, and Pms2 in immunoglobulin class switching shown by sequence analysis of recombination junctions

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK91

intrinsic apoptotic signaling pathway in response to DNA damage

1 reference

14 February 2019

MBD4 deficiency reduces the apoptotic response to DNA-damaging agents in the murine small intestine

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK91

1 reference

14 February 2019

Mlh1 Can Function in Antibody Class Switch Recombination Independently of Msh2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK91

negative regulation of mitotic recombination

1 reference

14 February 2019

Mlh1 mediates tissue-specific regulation of mitotic recombination

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK91

somatic recombination of immunoglobulin genes involved in immune response

1 reference

14 February 2019

Mlh1 Can Function in Antibody Class Switch Recombination Independently of Msh2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK91

meiotic spindle midzone assembly

IGI

1 reference

14 February 2019

Chromosomal influence on meiotic spindle assembly: abnormal meiosis I in female Mlh1 mutant mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK91

16 references

16 July 2018

Ribonucleotides misincorporated into DNA act as strand-discrimination signals in eukaryotic mismatch repair

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9JK91&geneProductId=UniProtKB:Q9JK91

16 July 2018

Functional analysis of human MLH1 and MSH2 missense variants and hybrid human-yeast MLH1 proteins in Saccharomyces cerevisiae

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9JK91&geneProductId=UniProtKB:Q9JK91

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9JK91&geneProductId=UniProtKB:Q9JK91

16 July 2018

Mlh1 deficiency enhances several phenotypes of Apc(Min)/+ mice

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9JK91&geneProductId=UniProtKB:Q9JK91

16 July 2018

Differing patterns of genetic instability in mice deficient in the mismatch repair genes Pms2, Mlh1, Msh2, Msh3 and Msh6

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9JK91&geneProductId=UniProtKB:Q9JK91

16 July 2018

Elevated mutant frequencies and increased C : G-->T : A transitions in Mlh1-/- versus Pms2-/- murine small intestinal epithelial cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9JK91&geneProductId=UniProtKB:Q9JK91

16 July 2018

Different mismatch repair deficiencies all have the same effects on somatic hypermutation: intact primary mechanism accompanied by secondary modifications

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9JK91&geneProductId=UniProtKB:Q9JK91

16 July 2018

Contributions by MutL homologues Mlh3 and Pms2 to DNA mismatch repair and tumor suppression in the mouse

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9JK91&geneProductId=UniProtKB:Q9JK91

16 July 2018

A defect in a single allele of the Mlh1 gene causes dissociation of the killing and tumorigenic actions of an alkylating carcinogen in methyltransferase-deficient mice

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9JK91&geneProductId=UniProtKB:Q9JK91

16 July 2018

Tumour susceptibility and spontaneous mutation in mice deficient in Mlh1, Pms1 and Pms2 DNA mismatch repair

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9JK91&geneProductId=UniProtKB:Q9JK91

16 July 2018

Separation of killing and tumorigenic effects of an alkylating agent in mice defective in two of the DNA repair genes

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9JK91&geneProductId=UniProtKB:Q9JK91

16 July 2018

Different mutator phenotypes in Mlh1- versus Pms2-deficient mice

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9JK91&geneProductId=UniProtKB:Q9JK91

16 July 2018

Tumorigenesis in Mlh1 and Mlh1/Apc1638N mutant mice

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9JK91&geneProductId=UniProtKB:Q9JK91

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9JK91&geneProductId=UniProtKB:Q9JK91

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9JK91&geneProductId=UniProtKB:Q9JK91

16 July 2018

Efficient repair of A/C mismatches in mouse cells deficient in long-patch mismatch repair

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9JK91&geneProductId=UniProtKB:Q9JK91

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK91

double-strand break repair via nonhomologous end joining

IEA

1 reference

14 February 2019

Modulation of error-prone double-strand break repair in mammalian chromosomes by DNA mismatch repair protein Mlh1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK91

3 references

14 February 2019

Roles of MGMT and MLH1 proteins in alkylation-induced apoptosis and mutagenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK91

14 February 2019

Mlh1 mediates tissue-specific regulation of mitotic recombination

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK91

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK91

female meiosis chromosome segregation

IEA

1 reference

14 February 2019

Meikin is a conserved regulator of meiosis-I-specific kinetochore function

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK91

positive regulation of isotype switching to IgA isotypes

1 reference

14 February 2019

Reduced isotype switching in splenic B cells from mice deficient in mismatch repair enzymes

Critical Assessment of Protein Function Annotation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK91

positive regulation of isotype switching to IgG isotypes

1 reference

14 February 2019

Reduced isotype switching in splenic B cells from mice deficient in mismatch repair enzymes

Critical Assessment of Protein Function Annotation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK91

Impact of lactobacilli on orally acquired listeriosis

response to bacterium

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK91

17 references

14 February 2019

Ribonucleotides misincorporated into DNA act as strand-discrimination signals in eukaryotic mismatch repair

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK91

14 February 2019

Functional analysis of human MLH1 and MSH2 missense variants and hybrid human-yeast MLH1 proteins in Saccharomyces cerevisiae

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK91

14 February 2019

Separation of killing and tumorigenic effects of an alkylating agent in mice defective in two of the DNA repair genes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK91

14 February 2019

Different mismatch repair deficiencies all have the same effects on somatic hypermutation: intact primary mechanism accompanied by secondary modifications

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK91

14 February 2019

Tumour susceptibility and spontaneous mutation in mice deficient in Mlh1, Pms1 and Pms2 DNA mismatch repair

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK91

14 February 2019

Different mutator phenotypes in Mlh1- versus Pms2-deficient mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK91

14 February 2019

Differing patterns of genetic instability in mice deficient in the mismatch repair genes Pms2, Mlh1, Msh2, Msh3 and Msh6

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK91

14 February 2019

Elevated mutant frequencies and increased C : G-->T : A transitions in Mlh1-/- versus Pms2-/- murine small intestinal epithelial cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK91

14 February 2019

Tumorigenesis in Mlh1 and Mlh1/Apc1638N mutant mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK91

14 February 2019

A defect in a single allele of the Mlh1 gene causes dissociation of the killing and tumorigenic actions of an alkylating carcinogen in methyltransferase-deficient mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK91

14 February 2019

Mlh1 deficiency enhances several phenotypes of Apc(Min)/+ mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK91

14 February 2019

Contributions by MutL homologues Mlh3 and Pms2 to DNA mismatch repair and tumor suppression in the mouse

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK91

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK91

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK91

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK91

14 February 2019

Efficient repair of A/C mismatches in mouse cells deficient in long-patch mismatch repair

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK91

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK91

somatic hypermutation of immunoglobulin genes

IBA

3 references

14 February 2019

Different mismatch repair deficiencies all have the same effects on somatic hypermutation: intact primary mechanism accompanied by secondary modifications

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK91

14 February 2019

Hypermutation in Ig V genes from mice deficient in the MLH1 mismatch repair protein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK91

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK91

DNA mismatch repair, conserved site

IBA

has part(s)

1 reference

DNA mismatch repair protein, S5 domain 2-like

1 reference

DNA mismatch repair protein Mlh1, C-terminal

1 reference

Histidine kinase/HSP90-like ATPase domain

1 reference

DNA mismatch repair protein family, N-terminal

1 reference