(Q14911994)

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O60934

SMAD/FHA domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O60934

nibrin

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O60934

Forkhead-associated (FHA) domain, protein family

1 reference

DNA repair Nbs1, C-terminal domain, protein family

1 reference

Nibrin, second BRCT domain, protein family

1 reference

BRCT domain, protein family

1 reference

protein N-terminus binding

1 reference

13 November 2019

1 reference

13 November 2019

1 reference

8 April 2019

The hMre11/hRad50 protein complex and Nijmegen breakage syndrome: linkage of double-strand break repair to the cellular DNA damage response

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60934

ATM activation by DNA double-strand breaks through the Mre11-Rad50-Nbs1 complex

IPI

DNA helicase activity

1 reference

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=O60934&geneProductId=UniProtKB:O60934

transcription factor binding

1 reference

8 April 2019

Mre11 complex and DNA replication: linkage to E2F and sites of DNA synthesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60934

29 references

8 April 2019

Recruitment of NBS1 into PML oncogenic domains via interaction with SP100 protein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60934

8 April 2019

N terminus of CtIP is critical for homologous recombination-mediated double-strand break repair

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60934

8 April 2019

MRNIP/C5orf45 Interacts with the MRN Complex and Contributes to the DNA Damage Response

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60934

8 April 2019

ATRX dysfunction induces replication defects in primary mouse cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60934

8 April 2019

ATM-dependent phosphorylation of ATF2 is required for the DNA damage response

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60934

8 April 2019

SOSS complexes participate in the maintenance of genomic stability

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60934

8 April 2019

PTIP associates with MLL3- and MLL4-containing histone H3 lysine 4 methyltransferase complex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60934

8 April 2019

A supramodular FHA/BRCT-repeat architecture mediates Nbs1 adaptor function in response to DNA damage

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60934

8 April 2019

RNF8 transduces the DNA-damage signal via histone ubiquitylation and checkpoint protein assembly

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60934

8 April 2019

Acetyltransferase p300 regulates NBS1-mediated DNA damage response

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60934

8 April 2019

MDC1 directly binds phosphorylated histone H2AX to regulate cellular responses to DNA double-strand breaks

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60934

8 April 2019

A divalent FHA/BRCT-binding mechanism couples the MRE11-RAD50-NBS1 complex to damaged chromatin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60934

8 April 2019

MDC1 regulates intra-S-phase checkpoint by targeting NBS1 to DNA double-strand breaks

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60934

8 April 2019

MDC1 is a mediator of the mammalian DNA damage checkpoint

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60934

8 April 2019

DNA Repair Network Analysis Reveals Shieldin as a Key Regulator of NHEJ and PARP Inhibitor Sensitivity.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60934

8 April 2019

Crystal structure of human Mre11: understanding tumorigenic mutations

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60934

8 April 2019

The NBS1-Treacle complex controls ribosomal RNA transcription in response to DNA damage

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60934

8 April 2019

CtIP tetramer assembly is required for DNA-end resection and repair

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60934

8 April 2019

MRE11-RAD50-NBS1 is a critical regulator of FANCD2 stability and function during DNA double-strand break repair

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60934

8 April 2019

Rad17 recruits the MRE11-RAD50-NBS1 complex to regulate the cellular response to DNA double-strand breaks

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60934

8 April 2019

Five dysfunctional telomeres predict onset of senescence in human cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60934

8 April 2019

Notch is a direct negative regulator of the DNA-damage response

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60934

8 April 2019

VRK1 phosphorylates and protects NBS1 from ubiquitination and proteasomal degradation in response to DNA damage

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60934

8 April 2019

RNF8 ubiquitylates histones at DNA double-strand breaks and promotes assembly of repair proteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60934

8 April 2019

CDK targeting of NBS1 promotes DNA-end resection, replication restart and homologous recombination

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60934

8 April 2019

SOSS complexes participate in the maintenance of genomic stability

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60934

8 April 2019

Phospho-dependent interactions between NBS1 and MDC1 mediate chromatin retention of the MRN complex at sites of DNA damage

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60934

8 April 2019

SIRT1 regulates the function of the Nijmegen breakage syndrome protein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60934

8 April 2019

NBS1 localizes to gamma-H2AX foci through interaction with the FHA/BRCT domain

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60934

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60934

8 April 2019

Nibrin, a novel DNA double-strand break repair protein, is mutated in Nijmegen breakage syndrome

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60934

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60934

site of double-strand break

cell component

1 reference

8 April 2019

ATM-dependent phosphorylation of ATF2 is required for the DNA damage response

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60934

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60934

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60934

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60934

8 April 2019

Recruitment of NBS1 into PML oncogenic domains via interaction with SP100 protein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60934

8 April 2019

Nijmegen breakage syndrome disease protein and MRE11 at PML nuclear bodies and meiotic telomeres

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60934

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60934

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60934

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60934

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60934

1 reference

8 April 2019

Cell-cycle-regulated association of RAD50/MRE11/NBS1 with TRF2 and human telomeres

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60934

The mismatch repair system is required for S-phase checkpoint activation

nuclear inclusion body

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60934

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60934

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60934

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60934

8 April 2019

Cell-cycle-regulated association of RAD50/MRE11/NBS1 with TRF2 and human telomeres

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60934

4 references

17 October 2017

A balance between elongation and trimming regulates telomere stability in stem cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=O60934&geneProductId=UniProtKB:O60934

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=O60934&geneProductId=UniProtKB:O60934

17 October 2017

The hMre11/hRad50 protein complex and Nijmegen breakage syndrome: linkage of double-strand break repair to the cellular DNA damage response

http://www.ebi.ac.uk/QuickGO/annotations?protein=O60934&geneProductId=UniProtKB:O60934

17 October 2017

RAD50 and NBS1 form a stable complex functional in DNA binding and tethering

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=O60934&geneProductId=UniProtKB:O60934

5 references

8 April 2019

A balance between elongation and trimming regulates telomere stability in stem cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60934

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60934

8 April 2019

The hMre11/hRad50 protein complex and Nijmegen breakage syndrome: linkage of double-strand break repair to the cellular DNA damage response

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60934

8 April 2019

RAD50 and NBS1 form a stable complex functional in DNA binding and tethering

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60934

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60934

regulation of DNA-dependent DNA replication initiation

biological process

1 reference

8 April 2019

The hMre11/hRad50 protein complex and Nijmegen breakage syndrome: linkage of double-strand break repair to the cellular DNA damage response

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60934

neuromuscular process controlling balance

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60934

positive regulation of kinase activity

1 reference

8 April 2019

ATM activation by DNA double-strand breaks through the Mre11-Rad50-Nbs1 complex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60934

telomeric 3' overhang formation

1 reference

8 April 2019

The involvement of the Mre11/Rad50/Nbs1 complex in the generation of G-overhangs at human telomeres

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60934

DNA damage checkpoint signaling

1 reference

8 April 2019

Critical role for mouse Hus1 in an S-phase DNA damage cell cycle checkpoint

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60934

DNA damage response, signal transduction by p53 class mediator

1 reference

8 April 2019

The hMre11/hRad50 protein complex and Nijmegen breakage syndrome: linkage of double-strand break repair to the cellular DNA damage response

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60934

in utero embryonic development

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60934

intrinsic apoptotic signaling pathway

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60934

positive regulation of telomere maintenance

1 reference

8 April 2019

The involvement of the Mre11/Rad50/Nbs1 complex in the generation of G-overhangs at human telomeres

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60934

negative regulation of telomere capping

1 reference

8 April 2019

MRE11-RAD50-NBS1 and ATM function as co-mediators of TRF1 in telomere length control

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60934

1 reference

17 October 2017

ATM activation by DNA double-strand breaks through the Mre11-Rad50-Nbs1 complex

http://www.ebi.ac.uk/QuickGO/annotations?protein=O60934&geneProductId=UniProtKB:O60934

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60934

positive regulation of protein autophosphorylation

1 reference

8 April 2019

ATM activation by DNA double-strand breaks through the Mre11-Rad50-Nbs1 complex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60934

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60934

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60934

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60934

cell population proliferation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60934

double-strand break repair via nonhomologous end joining

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60934

DNA synthesis involved in DNA repair

1 reference

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=O60934&geneProductId=UniProtKB:O60934

2 references

regulation of signal transduction by p53 class mediator

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60934

1 reference

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=O60934&geneProductId=UniProtKB:O60934

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60934

double-strand break repair

1 reference

17 October 2017

The hMre11/hRad50 protein complex and Nijmegen breakage syndrome: linkage of double-strand break repair to the cellular DNA damage response

http://www.ebi.ac.uk/QuickGO/annotations?protein=O60934&geneProductId=UniProtKB:O60934

DNA double-strand break processing

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60934

1 reference

8 April 2019

A balance between elongation and trimming regulates telomere stability in stem cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60934

telomere maintenance via telomere trimming

1 reference

8 April 2019

A balance between elongation and trimming regulates telomere stability in stem cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60934

mitotic G2 DNA damage checkpoint signaling

IGI

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60934

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60934

8 April 2019

Chk2 activation dependence on Nbs1 after DNA damage

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60934

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60934

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60934

signal transduction in response to DNA damage

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60934

inferred by common MeSH mappings on source and on Wikidata

Gene Atlas image

PBB GE NBN 202907 s at fs.png
732 × 530; 11 KB

0 references

Identifiers

MeSH descriptor ID

C112156

subject named as

NBN protein, human

0 references

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

13 November 2019

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference