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Myelin protein zero
mammalian protein found in Homo sapiens
myelin protein P0
Charcot-Marie-Tooth neuropathy 1B
MPZ
myelin peripheral protein
MPP
In more languages
edit
Statements
instance of
protein
1 reference
stated in
UniProt
retrieved
13 November 2019
UniProt protein ID
P25189
part of
Immunoglobulin-like fold
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/P25189
Immunoglobulin-like domain superfamily
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/P25189
Myelin protein P0
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/P25189
Myelin-PO, C-terminal domain, protein family
1 reference
based on heuristic
inferred from protein domain or family
Immunoglobulin subtype, protein family
1 reference
based on heuristic
inferred from protein domain or family
Immunoglobulin V-set domain, protein family
1 reference
based on heuristic
inferred from protein domain or family
immunoglobulin-like domain, protein family
1 reference
based on heuristic
inferred from protein domain or family
Myelin P0 protein, conserved site, protein family
1 reference
based on heuristic
inferred from protein domain or family
found in taxon
Homo sapiens
1 reference
stated in
UniProt
retrieved
13 November 2019
UniProt protein ID
P25189
encoded by
MPZ
1 reference
stated in
UniProt
retrieved
13 November 2019
UniProt protein ID
P25189
molecular function
structural molecule activity
determination method
NAS
1 reference
retrieved
8 April 2019
stated in
Charcot-Marie-Tooth neuropathy type 1B is associated with mutations of the myelin P0 gene
GOA
curator
Proteome Inc.
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25189
determination method
NAS
cell component
integral component of membrane
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
P25189
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25189
determination method
IEA
myelin sheath
determination method
IEA
2 references
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
P25189
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25189
determination method
IEA
retrieved
8 April 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25189
determination method
IEA
rough endoplasmic reticulum
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25189
determination method
IEA
lysosome
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25189
determination method
IEA
basolateral plasma membrane
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25189
determination method
IEA
integral component of plasma membrane
determination method
IEA
TAS
2 references
retrieved
8 April 2019
stated in
De novo mutation of the myelin P0 gene in Dejerine-Sottas disease (hereditary motor and sensory neuropathy type III)
GOA
curator
Proteome Inc.
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25189
determination method
TAS
retrieved
8 April 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25189
determination method
IEA
membrane
determination method
IEA
2 references
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
P25189
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25189
determination method
IEA
retrieved
8 April 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25189
determination method
IEA
plasma membrane
determination method
IDA
IEA
NAS
4 references
retrieved
8 April 2019
stated in
Deletion of the serine 34 codon from the major peripheral myelin protein P0 gene in Charcot-Marie-Tooth disease type 1B
GOA
curator
Proteome Inc.
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25189
determination method
NAS
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
P25189
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25189
determination method
IEA
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25189
determination method
IEA
retrieved
8 April 2019
stated in
Different cellular and molecular mechanisms for early and late-onset myelin protein zero mutations
GOA
curator
UniProt
UniProt protein ID
P25189
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25189
determination method
IDA
biological process
negative regulation of apoptotic process
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25189
determination method
IEA
chemical synaptic transmission
determination method
TAS
1 reference
retrieved
8 April 2019
stated in
Charcot-Marie-Tooth neuropathy type 1B is associated with mutations of the myelin P0 gene
GOA
curator
Proteome Inc.
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25189
determination method
TAS
myelination
determination method
IMP
1 reference
retrieved
8 April 2019
stated in
Peripheral myelin modification in CMT1B correlates with MPZ gene mutations
GOA
curator
UniProt
UniProt protein ID
P25189
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25189
determination method
IMP
cell-cell adhesion via plasma-membrane adhesion molecules
determination method
IMP
1 reference
retrieved
8 April 2019
stated in
Different cellular and molecular mechanisms for early and late-onset myelin protein zero mutations
GOA
curator
UniProt
UniProt protein ID
P25189
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25189
determination method
IMP
cell aggregation
determination method
IMP
1 reference
retrieved
8 April 2019
stated in
Different cellular and molecular mechanisms for early and late-onset myelin protein zero mutations
GOA
curator
UniProt
UniProt protein ID
P25189
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25189
determination method
IMP
Gene Atlas image
PBB GE MPZ 210280 at fs.png
732 × 530; 8 KB
0 references
has part(s)
myelin P0 protein, conserved site
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/P25189
myelin-PO, C-terminal
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/P25189
immunoglobulin-like domain
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/P25189
immunoglobulin V-set domain
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/P25189
immunoglobulin subtype
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/P25189
Identifiers
RefSeq protein ID
NP_000521
1 reference
stated in
NCBI Gene
retrieved
30 May 2020
Entrez Gene ID
4359
NP_001302420
1 reference
stated in
NCBI Gene
retrieved
30 May 2020
Entrez Gene ID
4359
XP_016856810
1 reference
stated in
NCBI Gene
retrieved
30 May 2020
Entrez Gene ID
4359
UniProt protein ID
P25189
1 reference
stated in
UniProt
retrieved
13 November 2019
UniProt protein ID
P25189
Ensembl protein ID
ENSP00000431538
1 reference
stated in
Ensembl Release 99
Ensembl protein ID
ENSP00000431538
ENSP00000432943
1 reference
stated in
Ensembl Release 99
Ensembl protein ID
ENSP00000432943
ENSP00000431441
1 reference
stated in
Ensembl Release 99
Ensembl protein ID
ENSP00000431441
ENSP00000488104
1 reference
stated in
Ensembl Release 99
Ensembl protein ID
ENSP00000488104
ENSP00000500814
1 reference
stated in
Ensembl Release 99
Ensembl protein ID
ENSP00000500814
ENSP00000499818
1 reference
stated in
Ensembl Release 99
Ensembl protein ID
ENSP00000499818
PDB structure ID
3OAI
1 reference
stated in
UniProt
UniProt protein ID
P25189
retrieved
20 March 2016
language of work or name
English
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