(Q14914500)

English

Janus kinase 3

mammalian protein found in Mus musculus

tyrosine-protein kinase JAK3
JAK-3
Jak3

In more languages

Statements

1 reference

25 May 2022

UniProt protein ID

Protein kinase-like domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q62137

tyrosine-protein kinase, non-receptor Jak3

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q62137

SH2 domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q62137

membrane proteins

1 reference

based on heuristic

inferred from GOA cell component → membrane

Serine-threonine/tyrosine-protein kinase, catalytic domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

SH2 domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Band 4.1 domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

FERM domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Protein kinase domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Protein kinase, ATP binding site, protein family

1 reference

based on heuristic

inferred from protein domain or family

Tyrosine-protein kinase, catalytic domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Tyrosine-protein kinase, active site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

25 May 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

molecular function

transferase activity

determination method

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62137

determination method

nucleotide binding

determination method

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62137

determination method

protein kinase activity

determination method

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62137

determination method

non-membrane spanning protein tyrosine kinase activity

determination method

kinase activity

determination method

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62137

determination method

protein binding

determination method

1 reference

14 February 2019

Molecular cloning of the mouse APS as a member of the Lnk family adaptor proteins

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62137

determination method

protein phosphatase binding

determination method

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62137

determination method

signaling receptor binding

determination method

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q62137&geneProductId=UniProtKB:Q62137

determination method

determination method

2 references

protein tyrosine kinase activity

determination method

4 references

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62137

determination method

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62137

determination method

14 February 2019

Molecular cloning of the mouse APS as a member of the Lnk family adaptor proteins

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62137

determination method

14 February 2019

Involvement of the Jak-3 Janus kinase in signalling by interleukins 2 and 4 in lymphoid and myeloid cells

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62137

determination method

determination method

2 references

extrinsic component of cytoplasmic side of plasma membrane

determination method

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q62137&geneProductId=UniProtKB:Q62137

determination method

intracellular anatomical structure

determination method

1 reference

24 April 2018

Molecular cloning of the mouse APS as a member of the Lnk family adaptor proteins

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q62137&geneProductId=UniProtKB:Q62137

determination method

determination method

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62137

determination method

endomembrane system

determination method

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62137

determination method

determination method

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62137

determination method

determination method

3 references

biological process

negative regulation of FasL production

determination method

1 reference

14 February 2019

Requirement for Jak3 in mature T cells: its role in regulation of T cell homeostasis

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62137

determination method

negative regulation of interleukin-10 production

determination method

1 reference

14 February 2019

Jak3 negatively regulates dendritic-cell cytokine production and survival

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62137

determination method

response to interleukin-15

determination method

1 reference

14 February 2019

Regulation of JAK3 expression and activation in human B cells and B cell malignancies

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62137

determination method

adaptive immune response

determination method

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62137

determination method

response to interleukin-4

determination method

3 references

phosphorylation

determination method

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62137

determination method

interleukin-4-mediated signaling pathway

determination method

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62137

determination method

transmembrane receptor protein tyrosine kinase signaling pathway

determination method

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q62137&geneProductId=UniProtKB:Q62137

determination method

immune system process

determination method

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62137

determination method

response to interleukin-2

determination method

1 reference

14 February 2019

Distinct effects of Jak3 signaling on alphabeta and gammadelta thymocyte development

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62137

determination method

negative regulation of thymocyte apoptotic process

determination method

1 reference

14 February 2019

Distinct effects of Jak3 signaling on alphabeta and gammadelta thymocyte development

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62137

determination method

cellular response to cytokine stimulus

determination method

1 reference

14 February 2019

JANEX-1, a JAK3 inhibitor, protects pancreatic islets from cytokine toxicity through downregulation of NF-kappaB activation and the JAK/STAT pathway

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62137

determination method

T cell homeostasis

determination method

1 reference

24 April 2018

Requirement for Jak3 in mature T cells: its role in regulation of T cell homeostasis

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q62137&geneProductId=UniProtKB:Q62137

determination method

protein phosphorylation

determination method

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62137

determination method

positive regulation of extrinsic apoptotic signaling pathway in absence of ligand

determination method

1 reference

14 February 2019

Jak3 negatively regulates dendritic-cell cytokine production and survival

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62137

determination method

negative regulation of T-helper 1 cell differentiation

determination method

1 reference

14 February 2019

Jak3 negatively regulates dendritic-cell cytokine production and survival

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62137

determination method

negative regulation of dendritic cell cytokine production

determination method

1 reference

14 February 2019

Jak3 negatively regulates dendritic-cell cytokine production and survival

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62137

determination method

regulation of T cell apoptotic process

determination method

1 reference

14 February 2019

Requirement for Jak3 in mature T cells: its role in regulation of T cell homeostasis

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62137

determination method

positive regulation of dendritic cell apoptotic process

determination method

1 reference

14 February 2019

Jak3 negatively regulates dendritic-cell cytokine production and survival

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62137

determination method

peptidyl-tyrosine autophosphorylation

determination method

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q62137&geneProductId=UniProtKB:Q62137

determination method

peptidyl-tyrosine phosphorylation

determination method

1 reference

14 February 2019

Molecular cloning of the mouse APS as a member of the Lnk family adaptor proteins

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62137

determination method

B cell differentiation

determination method

1 reference

24 April 2018

Requirement for Jak3 in mature T cells: its role in regulation of T cell homeostasis

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q62137&geneProductId=UniProtKB:Q62137

determination method

lymph node development

determination method

1 reference

14 February 2019

Role of TNF ligand and receptor family in the lymphoid organogenesis defined by gene targeting

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62137

determination method

negative regulation of T cell activation

determination method

1 reference

14 February 2019

Requirement for Jak3 in mature T cells: its role in regulation of T cell homeostasis

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62137

determination method

enzyme linked receptor protein signaling pathway

determination method

1 reference

14 February 2019

Involvement of the Jak-3 Janus kinase in signalling by interleukins 2 and 4 in lymphoid and myeloid cells

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62137

determination method

determination method

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q62137&geneProductId=UniProtKB:Q62137

determination method

response to interleukin-9

determination method

1 reference

14 February 2019

Regulation of JAK3 expression and activation in human B cells and B cell malignancies

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62137

determination method

positive regulation of transcription by RNA polymerase II

determination method

1 reference

14 February 2019

Stat5 activation is uniquely associated with cytokine signaling in peripheral T cells

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62137

determination method

negative regulation of interleukin-12 production

determination method

1 reference

14 February 2019

Jak3 negatively regulates dendritic-cell cytokine production and survival

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62137

determination method

inflammatory response

determination method

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q62137&geneProductId=UniProtKB:Q62137

determination method

erythrocyte differentiation

determination method

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62137

determination method

tyrosine phosphorylation of STAT protein

determination method

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62137

determination method

positive regulation of T cell proliferation

determination method

positive regulation of nitric-oxide synthase biosynthetic process

determination method

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62137

determination method

cytokine-mediated signaling pathway

determination method

3 references

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62137

determination method

14 February 2019

Involvement of the Jak-3 Janus kinase in signalling by interleukins 2 and 4 in lymphoid and myeloid cells

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62137

determination method

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62137

determination method

innate immune response

determination method

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62137

determination method

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q62137

tyrosine-protein kinase, catalytic domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q62137

tyrosine-protein kinase, active site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q62137

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q62137

serine-threonine/tyrosine-protein kinase, catalytic domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q62137

protein kinase, ATP binding site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q62137

Band 4.1 domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q62137

protein kinase domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q62137

Identifiers

RefSeq protein ID

1 reference

20 March 2022

1 reference

20 March 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

Ensembl protein ID

ENSMUSP00000060073

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000060073

ENSMUSP00000105639

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000105639

ENSMUSP00000105640

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000105640

Sitelinks

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Wiktionary(0 entries)

Multilingual sites(0 entries)

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