(Q14916414)

English

Interleukin 1 beta

mammalian protein found in Mus musculus

Il1b
IL-1 beta
interleukin-1 beta
uniprot:P10749

In more languages

Statements

1 reference

25 May 2022

UniProt protein ID

1 reference

19 January 2017

UniProt protein ID

interleukin-1 beta

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P10749

Cytokine IL1/FGF

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P10749

Interleukin-1 propeptide family

1 reference

based on heuristic

inferred from protein domain or family

Interleukin-1 conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

25 May 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

molecular function

cytokine activity

determination method

6 references

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10749

determination method

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10749

determination method

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10749

determination method

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10749

determination method

9 May 2019

The role of interleukin 1 receptor-associated kinase-4 (IRAK-4) kinase activity in IRAK-4-mediated signaling

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10749

determination method

9 May 2019

Interplay between IFN-gamma and IL-6 signaling governs neutrophil trafficking and apoptosis during acute inflammation

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10749

determination method

cytokine activity

determination method

7 references

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10749

determination method

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10749

determination method

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10749

determination method

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10749

determination method

14 February 2019

The role of interleukin 1 receptor-associated kinase-4 (IRAK-4) kinase activity in IRAK-4-mediated signaling

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10749

determination method

14 February 2019

Interplay between IFN-gamma and IL-6 signaling governs neutrophil trafficking and apoptosis during acute inflammation

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10749

determination method

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10749

determination method

integrin binding

determination method

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10749

determination method

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10749

determination method

extracellular region

determination method

4 references

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10749

determination method

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10749

determination method

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10749

determination method

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10749

determination method

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10749

determination method

extracellular exosome

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10749

determination method

secretory granule

determination method

1 reference

16 September 2017

Tissue kallikrein mK13 is a candidate processing enzyme for the precursor of interleukin-1beta in the submandibular gland of mice

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10749&geneProductId=UniProtKB:P10749

determination method

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10749

determination method

determination method

1 reference

9 May 2019

Astrocyte-derived ATP induces vesicle shedding and IL-1 beta release from microglia

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10749

determination method

cytoplasmic vesicle

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10749

determination method

extracellular space

determination method

10 references

16 September 2017

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10749&geneProductId=UniProtKB:P10749

determination method

16 September 2017

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10749&geneProductId=UniProtKB:P10749

determination method

16 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10749&geneProductId=UniProtKB:P10749

determination method

16 September 2017

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10749&geneProductId=UniProtKB:P10749

determination method

16 September 2017

Tissue kallikrein mK13 is a candidate processing enzyme for the precursor of interleukin-1beta in the submandibular gland of mice

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10749&geneProductId=UniProtKB:P10749

determination method

16 September 2017

Mice lacking tartrate-resistant acid phosphatase (Acp 5) have disordered macrophage inflammatory responses and reduced clearance of the pathogen, Staphylococcus aureus

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10749&geneProductId=UniProtKB:P10749

determination method

16 September 2017

Altered cytokine production in mice lacking P2X(7) receptors

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10749&geneProductId=UniProtKB:P10749

determination method

16 September 2017

Astrocyte-derived ATP induces vesicle shedding and IL-1 beta release from microglia

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10749&geneProductId=UniProtKB:P10749

determination method

16 September 2017

Pellino3 ubiquitinates RIP2 and mediates Nod2-induced signaling and protective effects in colitis

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10749&geneProductId=UniProtKB:P10749

determination method

16 September 2017

A new transcriptional role for matrix metalloproteinase-12 in antiviral immunity

Critical Assessment of Protein Function Annotation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10749&geneProductId=UniProtKB:P10749

determination method

extracellular space

determination method

11 references

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10749

determination method

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10749

determination method

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10749

determination method

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10749

determination method

9 May 2019

Astrocyte-derived ATP induces vesicle shedding and IL-1 beta release from microglia

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10749

determination method

9 May 2019

Pellino3 ubiquitinates RIP2 and mediates Nod2-induced signaling and protective effects in colitis

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10749

determination method

9 May 2019

Mice lacking tartrate-resistant acid phosphatase (Acp 5) have disordered macrophage inflammatory responses and reduced clearance of the pathogen, Staphylococcus aureus

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10749

determination method

9 May 2019

Tissue kallikrein mK13 is a candidate processing enzyme for the precursor of interleukin-1beta in the submandibular gland of mice

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10749

determination method

9 May 2019

Altered cytokine production in mice lacking P2X(7) receptors

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10749

determination method

9 May 2019

A new transcriptional role for matrix metalloproteinase-12 in antiviral immunity

Critical Assessment of Protein Function Annotation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10749

determination method

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10749

determination method

biological process

negative regulation of insulin receptor signaling pathway

determination method

1 reference

9 May 2019

Long-term treatment with interleukin-1beta induces insulin resistance in murine and human adipocytes

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10749

determination method

cellular response to mechanical stimulus

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10749

determination method

response to carbohydrate

determination method

1 reference

9 May 2019

Inhibitory effects of chloride on the activation of caspase-1, IL-1beta secretion, and cytolysis by the P2X7 receptor

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10749

determination method

cytokine-mediated signaling pathway

determination method

neutrophil chemotaxis

determination method

1 reference

23 May 2017

Interplay between IFN-gamma and IL-6 signaling governs neutrophil trafficking and apoptosis during acute inflammation

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P10749

determination method

positive regulation of prostaglandin secretion

determination method

1 reference

9 May 2019

Central control of fever and female body temperature by RANKL/RANK

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10749

determination method

negative regulation of MAP kinase activity

determination method

1 reference

9 May 2019

Long-term treatment with interleukin-1beta induces insulin resistance in murine and human adipocytes

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10749

determination method

inflammatory response

determination method

4 references

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10749

determination method

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10749

determination method

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10749

determination method

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10749

determination method

negative regulation of lipid metabolic process

determination method

1 reference

9 May 2019

Long-term treatment with interleukin-1beta induces insulin resistance in murine and human adipocytes

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10749

determination method

positive regulation of lipid catabolic process

determination method

1 reference

9 May 2019

Long-term treatment with interleukin-1beta induces insulin resistance in murine and human adipocytes

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10749

determination method

positive regulation of fever generation

determination method

1 reference

9 May 2019

Central control of fever and female body temperature by RANKL/RANK

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10749

determination method

positive regulation of angiogenesis

determination method

1 reference

23 May 2017

IL-1 is required for tumor invasiveness and angiogenesis

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P10749

determination method

immune response

determination method

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10749

determination method

ectopic germ cell programmed cell death

determination method

1 reference

9 May 2019

Caspase-2 deficiency prevents programmed germ cell death resulting from cytokine insufficiency but not meiotic defects caused by loss of ataxia telangiectasia-mutated (Atm) gene function

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10749

determination method

leukocyte migration

determination method

1 reference

9 May 2019

Neutrophil elastase (NE)-deficient mice demonstrate a nonredundant role for NE in neutrophil migration, generation of proinflammatory mediators, and phagocytosis in response to zymosan particles in vivo

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10749

determination method

response to ATP

determination method

4 references

9 May 2019

P2X7 receptor differentially couples to distinct release pathways for IL-1beta in mouse macrophage

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10749

determination method

9 May 2019

P2X7 receptor differentially couples to distinct release pathways for IL-1beta in mouse macrophage

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10749

determination method

9 May 2019

Astrocyte-derived ATP induces vesicle shedding and IL-1 beta release from microglia

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10749

determination method

9 May 2019

Inhibitory effects of chloride on the activation of caspase-1, IL-1beta secretion, and cytolysis by the P2X7 receptor

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10749

determination method

positive regulation of gene expression

determination method

negative regulation of glucose transmembrane transport

determination method

1 reference

9 May 2019

Long-term treatment with interleukin-1beta induces insulin resistance in murine and human adipocytes

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10749

determination method

interleukin-1 beta production

determination method

1 reference

9 May 2019

An orthogonal proteomic-genomic screen identifies AIM2 as a cytoplasmic DNA sensor for the inflammasome

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10749

determination method

extrinsic apoptotic signaling pathway in absence of ligand

determination method

1 reference

9 May 2019

Caspase-2 deficiency prevents programmed germ cell death resulting from cytokine insufficiency but not meiotic defects caused by loss of ataxia telangiectasia-mutated (Atm) gene function

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10749

determination method

positive regulation of vascular endothelial growth factor production

determination method

negative regulation of adiponectin secretion

determination method

1 reference

9 May 2019

Long-term treatment with interleukin-1beta induces insulin resistance in murine and human adipocytes

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10749

determination method

positive regulation of cell division

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10749

determination method

fever generation

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10749

determination method

regulation of nitric-oxide synthase activity

determination method

3 references

23 May 2017

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P10749

determination method

23 May 2017

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P10749

determination method

23 May 2017

Signalling pathway involved in nitric oxide synthase type II activation in chondrocytes: synergistic effect of leptin with interleukin-1

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P10749

determination method

response to lipopolysaccharide

determination method

3 references

14 January 2019

P2X7 receptor differentially couples to distinct release pathways for IL-1beta in mouse macrophage

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10749&geneProductId=UniProtKB:P10749

determination method

14 January 2019

P2X7 receptor differentially couples to distinct release pathways for IL-1beta in mouse macrophage

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10749&geneProductId=UniProtKB:P10749

determination method

14 January 2019

Tissue kallikrein mK13 is a candidate processing enzyme for the precursor of interleukin-1beta in the submandibular gland of mice

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10749&geneProductId=UniProtKB:P10749

determination method

positive regulation of interleukin-6 production

determination method

3 references

23 May 2017

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P10749

determination method

23 May 2017

Peli1 facilitates TRIF-dependent Toll-like receptor signaling and proinflammatory cytokine production

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P10749

determination method

23 May 2017

The role of interleukin 1 receptor-associated kinase-4 (IRAK-4) kinase activity in IRAK-4-mediated signaling

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P10749

determination method

regulation of defense response to virus by host

determination method

1 reference

9 May 2019

A new transcriptional role for matrix metalloproteinase-12 in antiviral immunity

Critical Assessment of Protein Function Annotation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10749

determination method

negative regulation of transcription by RNA polymerase II

determination method

1 reference

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10749

determination method

positive regulation of cytosolic calcium ion concentration

determination method

1 reference

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10749

determination method

determination method

1 reference

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10749

determination method

regulation of signaling receptor activity

determination method

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10749

determination method

positive regulation of vascular endothelial growth factor production

determination method

4 references

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10749

determination method

9 May 2019

IL-1 is required for tumor invasiveness and angiogenesis

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10749

determination method

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10749

determination method

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10749

determination method

positive regulation of gene expression

determination method

4 references

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10749

determination method

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10749

determination method

9 May 2019

IL-1 family members and STAT activators induce cytokine production by Th2, Th17, and Th1 cells

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10749

determination method

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10749

determination method

negative regulation of gene expression

determination method

1 reference

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10749

determination method

positive regulation of cell death

determination method

1 reference

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10749

determination method

negative regulation of glutamate secretion

determination method

1 reference

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10749

determination method

interleukin-6 production

determination method

1 reference

9 May 2019

Accessory protein-like is essential for IL-18-mediated signaling

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10749

determination method

positive regulation of interferon-gamma production

determination method

positive regulation of interleukin-6 production

determination method

4 references

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10749

determination method

14 February 2019

The role of interleukin 1 receptor-associated kinase-4 (IRAK-4) kinase activity in IRAK-4-mediated signaling

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10749

determination method

14 February 2019

Peli1 facilitates TRIF-dependent Toll-like receptor signaling and proinflammatory cytokine production

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10749

determination method

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10749

determination method

positive regulation of stress-activated MAPK cascade

determination method

1 reference

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10749

determination method

positive regulation of immature T cell proliferation in thymus

determination method

1 reference

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10749

determination method

social behavior

determination method

1 reference

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10749

determination method

positive regulation of apoptotic process

determination method

1 reference

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10749

determination method

positive regulation of I-kappaB kinase/NF-kappaB signaling

determination method

4 references

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10749

determination method

9 May 2019

TAK1, but not TAB1 or TAB2, plays an essential role in multiple signaling pathways in vivo

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10749

determination method

9 May 2019

TAK1, but not TAB1 or TAB2, plays an essential role in multiple signaling pathways in vivo

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10749

determination method

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10749

determination method

positive regulation of JUN kinase activity

determination method

1 reference

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10749

determination method

positive regulation of neuron apoptotic process

determination method

1 reference

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10749

determination method

negative regulation of neuron differentiation

determination method

1 reference

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10749

determination method

positive regulation of glial cell differentiation

determination method

1 reference

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10749

determination method

positive regulation of angiogenesis

determination method

4 references

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10749

determination method

9 May 2019

IL-1 is required for tumor invasiveness and angiogenesis

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10749

determination method

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10749

determination method

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10749

determination method

positive regulation of transcription by RNA polymerase II

determination method

4 references

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10749

determination method

9 May 2019

IL-1 family members and STAT activators induce cytokine production by Th2, Th17, and Th1 cells

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10749

determination method

9 May 2019

Peli1 facilitates TRIF-dependent Toll-like receptor signaling and proinflammatory cytokine production

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10749

determination method

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10749

determination method

positive regulation of JNK cascade

determination method

5 references

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10749

determination method

9 May 2019

TAK1, but not TAB1 or TAB2, plays an essential role in multiple signaling pathways in vivo

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10749

determination method

9 May 2019

Microglial receptor for advanced glycation end product-dependent signal pathway drives beta-amyloid-induced synaptic depression and long-term depression impairment in entorhinal cortex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10749

determination method

9 May 2019

TAK1, but not TAB1 or TAB2, plays an essential role in multiple signaling pathways in vivo

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10749

determination method

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10749

determination method

astrocyte activation

determination method

1 reference

9 May 2019

Astrocyte-shed extracellular vesicles regulate the peripheral leukocyte response to inflammatory brain lesions

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10749

determination method

positive regulation of astrocyte differentiation

determination method

1 reference

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10749

determination method

regulation of neurogenesis

determination method

1 reference

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10749

determination method

negative regulation of neurogenesis

determination method

1 reference

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10749

determination method

negative regulation of synaptic transmission

determination method

1 reference

9 May 2019

Microglial receptor for advanced glycation end product-dependent signal pathway drives beta-amyloid-induced synaptic depression and long-term depression impairment in entorhinal cortex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10749

determination method

regulation of nitric-oxide synthase activity

determination method

4 references

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10749

determination method

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10749

determination method

9 May 2019

Signalling pathway involved in nitric oxide synthase type II activation in chondrocytes: synergistic effect of leptin with interleukin-1

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10749

determination method

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10749

determination method

positive regulation of ERK1 and ERK2 cascade

determination method

1 reference

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10749

determination method

cellular response to lipopolysaccharide

determination method

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10749

determination method

positive regulation of neutrophil chemotaxis

determination method

1 reference

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10749

determination method

positive regulation of p38MAPK cascade

determination method

1 reference

9 May 2019

Microglial receptor for advanced glycation end product-dependent signal pathway drives beta-amyloid-induced synaptic depression and long-term depression impairment in entorhinal cortex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10749

determination method

negative regulation of branching morphogenesis of a nerve

determination method

1 reference

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10749

determination method

negative regulation of neural precursor cell proliferation

determination method

1 reference

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10749

determination method

positive regulation of T-helper 1 cell cytokine production

determination method

response to lipopolysaccharide

determination method

4 references

14 February 2019

P2X7 receptor differentially couples to distinct release pathways for IL-1beta in mouse macrophage

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10749

determination method

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10749

determination method

14 February 2019

Tissue kallikrein mK13 is a candidate processing enzyme for the precursor of interleukin-1beta in the submandibular gland of mice

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10749

determination method

14 February 2019

P2X7 receptor differentially couples to distinct release pathways for IL-1beta in mouse macrophage

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10749

determination method

positive regulation of prostaglandin biosynthetic process

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10749

determination method

response to lipopolysaccharide

determination method

5 references

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10749

determination method

9 May 2019

P2X7 receptor differentially couples to distinct release pathways for IL-1beta in mouse macrophage

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10749

determination method

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10749

determination method

9 May 2019

Tissue kallikrein mK13 is a candidate processing enzyme for the precursor of interleukin-1beta in the submandibular gland of mice

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10749

determination method

9 May 2019

P2X7 receptor differentially couples to distinct release pathways for IL-1beta in mouse macrophage

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10749

determination method

positive regulation of interleukin-6 production

determination method

5 references

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10749

determination method

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10749

determination method

9 May 2019

The role of interleukin 1 receptor-associated kinase-4 (IRAK-4) kinase activity in IRAK-4-mediated signaling

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10749

determination method

9 May 2019

Peli1 facilitates TRIF-dependent Toll-like receptor signaling and proinflammatory cytokine production

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10749

determination method

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10749

determination method

positive regulation of complement activation

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10749

determination method

positive regulation of inflammatory response

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10749

determination method

response to interleukin-1

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10749

determination method

positive regulation of RNA biosynthetic process

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10749

determination method

Interleukin-1 propeptide

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P10749

Interleukin-1 conserved site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P10749

Identifiers

RefSeq protein ID

1 reference

20 March 2022

1 reference

20 March 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

Ensembl protein ID

ENSMUSP00000028881

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000028881

PDB structure ID

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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