(Q15326513)

Zinc finger, NHR/GATA-type

1 reference

nuclear receptor ROR

1 reference

Nuclear hormone receptor, ligand-binding domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Zinc finger, nuclear hormone receptor-type, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

25 May 2022

1 reference

25 May 2022

7 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51448

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51448

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51448

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51448

14 February 2019

T helper 17 lineage differentiation is programmed by orphan nuclear receptors ROR alpha and ROR gamma

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51448

14 February 2019

Cross-talk among ROR alpha 1 and the Rev-erb family of orphan nuclear receptors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51448

14 February 2019

RORalpha regulates the expression of genes involved in lipid homeostasis in skeletal muscle cells: caveolin-3 and CPT-1 are direct targets of ROR

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51448

sequence-specific DNA binding

6 references

14 February 2019

Transcriptional regulation of apolipoprotein C-III gene expression by the orphan nuclear receptor RORalpha

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51448

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51448

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51448

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51448

14 February 2019

Identification of oxysterol 7alpha-hydroxylase (Cyp7b1) as a novel retinoid-related orphan receptor alpha (RORalpha) (NR1F1) target gene and a functional cross-talk between RORalpha and liver X receptor (NR1H3)

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51448

14 February 2019

T helper 17 lineage differentiation is programmed by orphan nuclear receptors ROR alpha and ROR gamma

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51448

1 reference

14 February 2019

RORalpha coordinates reciprocal signaling in cerebellar development through sonic hedgehog and calcium-dependent pathways

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51448

ligand-activated transcription factor activity

IPI

3 references

DNA-binding transcription factor activity

5 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51448

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51448

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51448

14 February 2019

RORγ directly regulates the circadian expression of clock genes and downstream targets in vivo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51448

14 February 2019

Identification of RVR, a novel orphan nuclear receptor that acts as a negative transcriptional regulator

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51448

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51448

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51448

steroid hormone receptor activity

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51448

nuclear receptor activity

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51448

5 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51448

14 February 2019

The orphan nuclear receptor RORalpha restrains adipocyte differentiation through a reduction of C/EBPbeta activity and perilipin gene expression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51448

14 February 2019

Modulation of clock gene expression by the transcriptional coregulator receptor interacting protein 140 (RIP140)

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51448

14 February 2019

Interaction of MAGED1 with nuclear receptors affects circadian clock function

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51448

14 February 2019

RORalpha-mediated Purkinje cell development determines disease severity in adult SCA1 mice

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51448

transcription coactivator binding

IPI

4 references

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51448&geneProductId=UniProtKB:P51448

16 July 2018

Transcriptional coactivator PGC-1alpha integrates the mammalian clock and energy metabolism

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51448&geneProductId=UniProtKB:P51448

16 July 2018

Absence of the SRC-2 coactivator results in a glycogenopathy resembling Von Gierke's disease

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51448&geneProductId=UniProtKB:P51448

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51448&geneProductId=UniProtKB:P51448

RNA polymerase II cis-regulatory region sequence-specific DNA binding

1 reference

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51448&geneProductId=UniProtKB:P51448

core promoter sequence-specific DNA binding

1 reference

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51448&geneProductId=UniProtKB:P51448

transcription coactivator binding

ISO

5 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51448

14 February 2019

Absence of the SRC-2 coactivator results in a glycogenopathy resembling Von Gierke's disease

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51448

14 February 2019

Transcriptional coactivator PGC-1alpha integrates the mammalian clock and energy metabolism

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51448

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51448

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51448

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51448

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51448

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51448

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51448

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51448

8 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51448

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51448

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51448

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51448

14 February 2019

Identification of oxysterol 7alpha-hydroxylase (Cyp7b1) as a novel retinoid-related orphan receptor alpha (RORalpha) (NR1F1) target gene and a functional cross-talk between RORalpha and liver X receptor (NR1H3)

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51448

14 February 2019

RORγ directly regulates the circadian expression of clock genes and downstream targets in vivo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51448

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51448

14 February 2019

The nuclear receptor ROR(alpha) exerts a bi-directional regulation of IL-6 in resting and reactive astrocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51448

negative regulation of fat cell differentiation

biological process

1 reference

14 February 2019

The orphan nuclear receptor RORalpha restrains adipocyte differentiation through a reduction of C/EBPbeta activity and perilipin gene expression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51448

nitric oxide biosynthetic process

1 reference

14 February 2019

Cerebellar nitric oxide synthase, cGMP and motor function in two lines of cerebellar mutant mice, Staggerer and Wriggle Mouse Sagami

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51448

regulation of transcription, DNA-templated

5 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51448

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51448

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51448

14 February 2019

Identification of oxysterol 7alpha-hydroxylase (Cyp7b1) as a novel retinoid-related orphan receptor alpha (RORalpha) (NR1F1) target gene and a functional cross-talk between RORalpha and liver X receptor (NR1H3)

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51448

14 February 2019

Identification of RVR, a novel orphan nuclear receptor that acts as a negative transcriptional regulator

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51448

Cerebellar nitric oxide synthase, cGMP and motor function in two lines of cerebellar mutant mice, Staggerer and Wriggle Mouse Sagami

cGMP metabolic process

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51448

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51448

cellular response to sterol

3 references

cellular response to tumor necrosis factor

1 reference

14 February 2019

The nuclear receptor ROR(alpha) exerts a bi-directional regulation of IL-6 in resting and reactive astrocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51448

cerebellar Purkinje cell differentiation

1 reference

14 February 2019

Altered gene expression of the N-methyl-D-aspartate receptor channel subunits in Purkinje cells of the staggerer mutant mouse

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51448

negative regulation of I-kappaB kinase/NF-kappaB signaling

3 references

circadian regulation of gene expression

1 reference

14 February 2019

RORγ directly regulates the circadian expression of clock genes and downstream targets in vivo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51448

transcription, DNA-templated

1 reference

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51448&geneProductId=UniProtKB:P51448

cerebellar granule cell precursor proliferation

1 reference

14 February 2019

RORalpha coordinates reciprocal signaling in cerebellar development through sonic hedgehog and calcium-dependent pathways

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51448

regulation of steroid metabolic process

1 reference

14 February 2019

Gene expression profiling reveals a regulatory role for ROR alpha and ROR gamma in phase I and phase II metabolism

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51448

positive regulation of transcription, DNA-templated

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51448

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51448

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51448

14 February 2019

Modulation of clock gene expression by the transcriptional coregulator receptor interacting protein 140 (RIP140)

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51448

regulation of smoothened signaling pathway

1 reference

14 February 2019

RORalpha coordinates reciprocal signaling in cerebellar development through sonic hedgehog and calcium-dependent pathways

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51448

muscle cell differentiation

3 references

intracellular receptor signaling pathway

3 references

regulation of glucose metabolic process

1 reference

14 February 2019

Modulation of retinoic acid receptor-related orphan receptor alpha and gamma activity by 7-oxygenated sterol ligands

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51448

regulation of circadian rhythm

1 reference

14 February 2019

Pivotal role of Rho-associated kinase 2 in generating the intrinsic circadian rhythm of vascular contractility

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51448

3 references

cellular response to interleukin-1

1 reference

14 February 2019

The nuclear receptor ROR(alpha) exerts a bi-directional regulation of IL-6 in resting and reactive astrocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51448

xenobiotic metabolic process

1 reference

14 February 2019

Gene expression profiling reveals a regulatory role for ROR alpha and ROR gamma in phase I and phase II metabolism

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51448

positive regulation of circadian rhythm

1 reference

14 February 2019

RORγ directly regulates the circadian expression of clock genes and downstream targets in vivo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51448

positive regulation of vascular endothelial growth factor production

3 references

T-helper 17 cell differentiation

1 reference

14 February 2019

T helper 17 lineage differentiation is programmed by orphan nuclear receptors ROR alpha and ROR gamma

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51448

negative regulation of inflammatory response

cellular response to hypoxia

3 references

triglyceride homeostasis

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51448

14 February 2019

Identification of oxysterol 7alpha-hydroxylase (Cyp7b1) as a novel retinoid-related orphan receptor alpha (RORalpha) (NR1F1) target gene and a functional cross-talk between RORalpha and liver X receptor (NR1H3)

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51448

14 February 2019

Transcriptional regulation of apolipoprotein C-III gene expression by the orphan nuclear receptor RORalpha

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51448

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51448

regulation of macrophage activation

1 reference

14 February 2019

Peripheral macrophage abnormalities in mutant mice with spinocerebellar degeneration

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51448

positive regulation of transcription by RNA polymerase II

4 references

14 February 2019

The nuclear receptor ROR(alpha) exerts a bi-directional regulation of IL-6 in resting and reactive astrocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51448

14 February 2019

RORalpha regulates the expression of genes involved in lipid homeostasis in skeletal muscle cells: caveolin-3 and CPT-1 are direct targets of ROR

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51448

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51448

14 February 2019

RORalpha regulates the expression of genes involved in lipid homeostasis in skeletal muscle cells: caveolin-3 and CPT-1 are direct targets of ROR

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51448

steroid hormone mediated signaling pathway

1 reference

14 February 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51448

Identification of oxysterol 7alpha-hydroxylase (Cyp7b1) as a novel retinoid-related orphan receptor alpha (RORalpha) (NR1F1) target gene and a functional cross-talk between RORalpha and liver X receptor (NR1H3)

cholesterol homeostasis

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51448

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51448

negative regulation of inflammatory response

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51448

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51448

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51448

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51448

multicellular organism development

IBA

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51448

Nuclear hormone receptor, ligand-binding domain

has part(s)

1 reference

nuclear hormone receptor-type zinc finger

1 reference