Wikidata

(Q1620739)

English

H2A.X variant histone

mammalian protein found in Homo sapiens

  • histone H2A.x
  • H2AX histone
  • H2A histone family member X
  • H2AX
  • histone H2AX
  • H2AFX
  • H2AFX protein, human
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No label defined

No description defined

Statements

molecular function
protein binding
determination method or standard
IPI
29 references
retrieved
8 April 2019
stated in
Novel function of beta-arrestin2 in the nucleus of mature spermatozoa
GOA
curator
UniProt
UniProt protein ID
P16104
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16104
determination method or standard
IPI
retrieved
8 April 2019
stated in
Werner syndrome helicase (WRN), nuclear DNA helicase II (NDH II) and histone gammaH2AX are localized to the centrosome
GOA
curator
UniProt
UniProt protein ID
P16104
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16104
determination method or standard
IPI
retrieved
8 April 2019
stated in
Phosphorylation of the Cajal body protein WRAP53β by ATM promotes its involvement in the DNA damage response
GOA
curator
UniProt
UniProt protein ID
P16104
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16104
determination method or standard
IPI
retrieved
8 April 2019
stated in
The proximity ligation assay reveals that at DNA double-strand breaks WRAP53β associates with γH2AX and controls interactions between RNF8 and MDC1.
GOA
curator
UniProt
UniProt protein ID
P16104
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16104
determination method or standard
IPI
retrieved
8 April 2019
stated in
Genome-wide YFP fluorescence complementation screen identifies new regulators for telomere signaling in human cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16104
determination method or standard
IPI
retrieved
8 April 2019
stated in
Tyrosine dephosphorylation of H2AX modulates apoptosis and survival decisions
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16104
determination method or standard
IPI
retrieved
8 April 2019
stated in
RNF8 transduces the DNA-damage signal via histone ubiquitylation and checkpoint protein assembly
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16104
determination method or standard
IPI
retrieved
8 April 2019
stated in
AIF promotes chromatinolysis and caspase-independent programmed necrosis by interacting with histone H2AX
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16104
determination method or standard
IPI
retrieved
8 April 2019
stated in
The phosphorylation status of PAS-B distinguishes HIF-1alpha from HIF-2alpha in NBS1 repression
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16104
determination method or standard
IPI
retrieved
8 April 2019
stated in
ChAM, a novel motif that mediates PALB2 intrinsic chromatin binding and facilitates DNA repair
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16104
determination method or standard
IPI
retrieved
8 April 2019
stated in
MDC1 directly binds phosphorylated histone H2AX to regulate cellular responses to DNA double-strand breaks
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16104
determination method or standard
IPI
retrieved
8 April 2019
stated in
A viral E3 ligase targets RNF8 and RNF168 to control histone ubiquitination and DNA damage responses
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16104
determination method or standard
IPI
retrieved
8 April 2019
stated in
Comparison of the structures and peptide binding specificities of the BRCT domains of MDC1 and BRCA1
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16104
determination method or standard
IPI
retrieved
8 April 2019
stated in
MDC1 is a mediator of the mammalian DNA damage checkpoint
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16104
determination method or standard
IPI
retrieved
8 April 2019
stated in
A-type lamins maintain the positional stability of DNA damage repair foci in mammalian nuclei
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16104
determination method or standard
IPI
retrieved
8 April 2019
stated in
Histone Interaction Landscapes Visualized by Crosslinking Mass Spectrometry in Intact Cell Nuclei
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16104
determination method or standard
IPI
retrieved
8 April 2019
stated in
Proteomic dissection of cell type-specific H2AX-interacting protein complex associated with hepatocellular carcinoma
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16104
determination method or standard
IPI
retrieved
8 April 2019
stated in
Five dysfunctional telomeres predict onset of senescence in human cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16104
determination method or standard
IPI
retrieved
8 April 2019
stated in
Factors determining DNA double-strand break repair pathway choice in G2 phase
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16104
determination method or standard
IPI
retrieved
8 April 2019
stated in
A cooperative activation loop among SWI/SNF, gamma-H2AX and H3 acetylation for DNA double-strand break repair
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16104
determination method or standard
IPI
retrieved
8 April 2019
stated in
Structural basis of γH2AX recognition by human PTIP BRCT5-BRCT6 domains in the DNA damage response pathway
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16104
determination method or standard
IPI
retrieved
8 April 2019
stated in
MMSET regulates histone H4K20 methylation and 53BP1 accumulation at DNA damage sites
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16104
determination method or standard
IPI
retrieved
8 April 2019
stated in
Wild-type p53-induced phosphatase 1 dephosphorylates histone variant gamma-H2AX and suppresses DNA double strand break repair
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16104
determination method or standard
IPI
retrieved
8 April 2019
stated in
Mutant telomerase RNAs induce DNA damage and apoptosis via the TRF2-ATM pathway in telomerase-overexpressing primary fibroblasts
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16104
determination method or standard
IPI
retrieved
8 April 2019
stated in
VRK1 chromatin kinase phosphorylates H2AX and is required for foci formation induced by DNA damage
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16104
determination method or standard
IPI
retrieved
8 April 2019
stated in
RNF8 ubiquitylates histones at DNA double-strand breaks and promotes assembly of repair proteins
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16104
determination method or standard
IPI
retrieved
8 April 2019
stated in
CDK targeting of NBS1 promotes DNA-end resection, replication restart and homologous recombination
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16104
determination method or standard
IPI
retrieved
8 April 2019
stated in
Phospho-dependent interactions between NBS1 and MDC1 mediate chromatin retention of the MRN complex at sites of DNA damage
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16104
determination method or standard
IPI
retrieved
8 April 2019
stated in
NBS1 localizes to gamma-H2AX foci through interaction with the FHA/BRCT domain
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16104
determination method or standard
IPI
cell component
nucleus
determination method or standard
IDA
IEA
IMP
11 references
retrieved
17 October 2017
stated in
ERCC6L2 mutations link a distinct bone-marrow-failure syndrome to DNA repair and mitochondrial function
GOA
curator
UniProt
UniProt protein ID
P16104
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P16104&geneProductId=UniProtKB:P16104
determination method or standard
IMP
retrieved
17 October 2017
stated in
GOA
curator
UniProt
UniProt protein ID
P16104
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P16104&geneProductId=UniProtKB:P16104
determination method or standard
IEA
retrieved
17 October 2017
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P16104&geneProductId=UniProtKB:P16104
determination method or standard
IEA
retrieved
17 October 2017
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P16104&geneProductId=UniProtKB:P16104
determination method or standard
IEA
retrieved
17 October 2017
stated in
Proteomic characterization of the human sperm nucleus
GOA
curator
UniProt
UniProt protein ID
P16104
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P16104&geneProductId=UniProtKB:P16104
determination method or standard
IDA
retrieved
17 October 2017
stated in
Speckled-like pattern in the germinal center (SLIP-GC), a nuclear GTPase expressed in activation-induced deaminase-expressing lymphomas and germinal center B cells
GOA
curator
UniProt
UniProt protein ID
P16104
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P16104&geneProductId=UniProtKB:P16104
determination method or standard
IDA
retrieved
17 October 2017
stated in
Characterization of histone H2A and H2B variants and their post-translational modifications by mass spectrometry
GOA
curator
UniProt
UniProt protein ID
P16104
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P16104&geneProductId=UniProtKB:P16104
determination method or standard
IDA
retrieved
17 October 2017
stated in
Depletion of nuclear histone H2A variants is associated with chronic DNA damage signaling upon drug-evoked senescence of human somatic cells
GOA
curator
UniProt
UniProt protein ID
P16104
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P16104&geneProductId=UniProtKB:P16104
determination method or standard
IDA
retrieved
17 October 2017
stated in
The HiNF-P/p220NPAT cell cycle signaling pathway controls nonhistone target genes
GOA
curator
UniProt
UniProt protein ID
P16104
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P16104&geneProductId=UniProtKB:P16104
determination method or standard
IDA
retrieved
17 October 2017
stated in
NIMA-related protein kinase 1 is involved early in the ionizing radiation-induced DNA damage response
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P16104&geneProductId=UniProtKB:P16104
determination method or standard
IDA
retrieved
17 October 2017
stated in
Histone H2A variants and the inactive X chromosome: identification of a second macroH2A variant
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P16104&geneProductId=UniProtKB:P16104
determination method or standard
IDA
nucleus
determination method or standard
HDA
IDA
IEA
IMP
11 references
retrieved
8 April 2019
stated in
ERCC6L2 mutations link a distinct bone-marrow-failure syndrome to DNA repair and mitochondrial function
GOA
curator
UniProt
UniProt protein ID
P16104
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16104
determination method or standard
IMP
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
P16104
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16104
determination method or standard
IEA
retrieved
8 April 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16104
determination method or standard
IEA
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16104
determination method or standard
IEA
retrieved
8 April 2019
stated in
Characterization of histone H2A and H2B variants and their post-translational modifications by mass spectrometry
GOA
curator
UniProt
UniProt protein ID
P16104
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16104
determination method or standard
IDA
retrieved
8 April 2019
stated in
Speckled-like pattern in the germinal center (SLIP-GC), a nuclear GTPase expressed in activation-induced deaminase-expressing lymphomas and germinal center B cells
GOA
curator
UniProt
UniProt protein ID
P16104
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16104
determination method or standard
IDA
retrieved
8 April 2019
stated in
The HiNF-P/p220NPAT cell cycle signaling pathway controls nonhistone target genes
GOA
curator
UniProt
UniProt protein ID
P16104
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16104
determination method or standard
IDA
retrieved
8 April 2019
stated in
Depletion of nuclear histone H2A variants is associated with chronic DNA damage signaling upon drug-evoked senescence of human somatic cells
GOA
curator
UniProt
UniProt protein ID
P16104
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16104
determination method or standard
IDA
retrieved
8 April 2019
stated in
NIMA-related protein kinase 1 is involved early in the ionizing radiation-induced DNA damage response
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16104
determination method or standard
IDA
retrieved
8 April 2019
stated in
Histone H2A variants and the inactive X chromosome: identification of a second macroH2A variant
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16104
determination method or standard
IDA
retrieved
8 April 2019
stated in
Proteomic characterization of the human sperm nucleus
GOA
curator
UniProt
UniProt protein ID
P16104
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16104
determination method or standard
HDA
biological process
Gene Atlas image
PBB GE H2AFX 205436 s at fs.png
732 × 530; 12 KB
0 references

Identifiers

MeSH descriptor ID
C468783
subject named as
H2AFX protein, human
0 references
 
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