(Q1622348)

Immunoglobulin-like domain superfamily

1 reference

T cell antigen CD28

1 reference

Immunoglobulin V-set domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

1 reference

13 November 2019

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10747

1 reference

8 April 2019

Catalytic activity of ADAM8, ADAM15, and MDC-L (ADAM28) on synthetic peptide substrates and in ectodomain cleavage of CD23

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10747

12 references

8 April 2019

Mechanism for down-regulation of CD28 by Nef.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10747

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10747

8 April 2019

Characterization of Lck-binding elements in the herpesviral regulatory Tip protein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10747

8 April 2019

The modulation of CD40 ligand signaling by transmembrane CD28 splice variant in human T cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10747

8 April 2019

CTLA-4 binding to the lipid kinase phosphatidylinositol 3-kinase in T cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10747

8 April 2019

Binding of phosphatidylinositol-3-OH kinase to CD28 is required for T-cell signalling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10747

8 April 2019

ICOS ligation recruits the p50alpha PI3K regulatory subunit to the immunological synapse.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10747

8 April 2019

Growth factor receptor-bound protein 2 SH2/SH3 domain binding to CD28 and its role in co-signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10747

8 April 2019

T-cell antigen CD28 interacts with the lipid kinase phosphatidylinositol 3-kinase by a cytoplasmic Tyr(P)-Met-Xaa-Met motif

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10747

8 April 2019

p56Lck and p59Fyn regulate CD28 binding to phosphatidylinositol 3-kinase, growth factor receptor-bound protein GRB-2, and T cell-specific protein-tyrosine kinase ITK: implications for T-cell costimulation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10747

8 April 2019

GRID: a novel Grb-2-related adapter protein that interacts with the activated T cell costimulatory receptor CD28

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10747

8 April 2019

Selective CD28pYMNM mutations implicate phosphatidylinositol 3-kinase in CD86-CD28-mediated costimulation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10747

identical protein binding

IPI

1 reference

8 April 2019

Human T cell activation. II. A new activation pathway used by a major T cell population via a disulfide-bonded dimer of a 44 kilodalton polypeptide (9.3 antigen)

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10747

NAS

protein kinase binding

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10747

phosphatidylinositol-4,5-bisphosphate 3-kinase activity

1 reference

7 November 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10747&geneProductId=UniProtKB:P10747

integral component of membrane

cell component

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10747

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10747

2 references

integral component of plasma membrane

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10747

immunological synapse

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10747

protein complex involved in cell adhesion

1 reference

8 April 2019

Identification of residues in the V domain of CD80 (B7-1) implicated in functional interactions with CD28 and CTLA4

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10747

external side of plasma membrane

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10747

8 April 2019

The transmembrane adaptor protein TRIM regulates T cell receptor (TCR) expression and TCR-mediated signaling via an association with the TCR zeta chain

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10747

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10747

regulatory T cell differentiation

IBA

biological process

1 reference

8 April 2019

Acquisition of suppressive function by activated human CD4+ CD25- T cells is associated with the expression of CTLA-4 not FoxP3

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10747

regulation of regulatory T cell differentiation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10747

3 references

1 January 2018

Cross-linking of the CD40 ligand on human CD4+ T lymphocytes generates a costimulatory signal that up-regulates IL-4 synthesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10747

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10747

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10747

mitigation of host defenses by virus

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10747

positive regulation of translation

1 reference

8 April 2019

The regulation of protein synthesis and translation factors by CD3 and CD28 in human primary T lymphocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10747

negative regulation of gene expression

NAS

1 reference

8 April 2019

Proinflammatory stimuli induce galectin-9 in human mesenchymal stromal cells to suppress T-cell proliferation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10747

negative thymic T cell selection

IMP

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10747

cell surface receptor signaling pathway

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10747

positive regulation of gene expression

1 reference

8 April 2019

Proinflammatory stimuli induce galectin-9 in human mesenchymal stromal cells to suppress T-cell proliferation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10747

CD28/B7 system of T cell costimulation

IMP

humoral immune response

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10747

positive regulation of T cell proliferation

5 references

7 November 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10747&geneProductId=UniProtKB:P10747

7 November 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10747&geneProductId=UniProtKB:P10747

7 November 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10747&geneProductId=UniProtKB:P10747

7 November 2018

Human T cell activation. II. A new activation pathway used by a major T cell population via a disulfide-bonded dimer of a 44 kilodalton polypeptide (9.3 antigen)

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10747&geneProductId=UniProtKB:P10747

7 November 2018

Cross-linking of the CD40 ligand on human CD4+ T lymphocytes generates a costimulatory signal that up-regulates IL-4 synthesis

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10747&geneProductId=UniProtKB:P10747

positive regulation of alpha-beta T cell proliferation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10747

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10747

apoptotic signaling pathway

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10747

positive regulation of phosphatidylinositol 3-kinase signaling

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10747

positive regulation of isotype switching to IgG isotypes

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10747

positive regulation of viral genome replication

1 reference

8 April 2019

Costimulation of CD4+ T cells via CD28 modulates human immunodeficiency virus type 1 infection and replication in vitro

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10747

T cell receptor signaling pathway

NAS

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10747

positive regulation of mitotic nuclear division

positive regulation of inflammatory response to antigenic stimulus

ISS

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10747

positive regulation of transcription by RNA polymerase II

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10747

positive regulation of interleukin-10 production

1 reference

8 April 2019

Cross-linking of the CD40 ligand on human CD4+ T lymphocytes generates a costimulatory signal that up-regulates IL-4 synthesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10747

phosphatidylinositol phosphate biosynthetic process

1 reference

7 November 2018

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10747&geneProductId=UniProtKB:P10747

positive regulation of interleukin-4 production

1 reference

8 April 2019

Cross-linking of the CD40 ligand on human CD4+ T lymphocytes generates a costimulatory signal that up-regulates IL-4 synthesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10747

1 reference

1 January 2018

CCL5-mediated T-cell chemotaxis involves the initiation of mRNA translation through mTOR/4E-BP1

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10747

negative regulation of apoptotic process

IGI

1 reference

8 April 2019

CD28/B7 system of T cell costimulation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10747

regulation of T cell proliferation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10747

positive regulation of T cell proliferation

4 references

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10747

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10747

1 January 2018

Cross-linking of the CD40 ligand on human CD4+ T lymphocytes generates a costimulatory signal that up-regulates IL-4 synthesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10747

1 January 2018

Human T cell activation. II. A new activation pathway used by a major T cell population via a disulfide-bonded dimer of a 44 kilodalton polypeptide (9.3 antigen)

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10747

positive regulation of mitotic nuclear division

1 reference

8 April 2019

Human T cell activation. II. A new activation pathway used by a major T cell population via a disulfide-bonded dimer of a 44 kilodalton polypeptide (9.3 antigen)

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10747

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

immune system process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10747

4 references

8 April 2019

Cross-linking of the CD40 ligand on human CD4+ T lymphocytes generates a costimulatory signal that up-regulates IL-4 synthesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10747

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10747

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10747

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10747

positive regulation of T cell proliferation

IBA

5 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10747

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10747

8 April 2019

Cross-linking of the CD40 ligand on human CD4+ T lymphocytes generates a costimulatory signal that up-regulates IL-4 synthesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10747

8 April 2019

Human T cell activation. II. A new activation pathway used by a major T cell population via a disulfide-bonded dimer of a 44 kilodalton polypeptide (9.3 antigen)

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10747

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10747

immunoglobulin V-set domain

IBA

Gene Atlas image

PBB GE CD28 211856 x at fs.png
732 × 530; 11 KB

0 references

has part(s)

1 reference