(Q18031866)

English

TBX3

protein-coding gene in the species Homo sapiens

TBX3-ISO
UMS
XHL
T-box 3
T-box transcription factor 3

In more languages

Statements

1 reference

ensembl Release 106

Ensembl gene ID

ENSG00000135111

protein-coding gene

1 reference

Ensembl Release 87

Ensembl gene ID

ENSG00000135111

Protein TBX3 PDB 1h6f.png
996 × 633; 434 KB

0 references

1 reference

ensembl Release 106

Ensembl gene ID

ENSG00000135111

T-box transcription factor 3

1 reference

6 July 2017

UniProt protein ID

genetic association

colorectal cancer

determination method

genome-wide association study

1 reference

https://gemma.msl.ubc.ca/phenotypes.html?phenotypeUrlId=DOID_9256&ncbiId=6926

http://www.genome.gov/gwastudies/index.cfm?gene=TBX3

Identification of Genetic Susceptibility Loci for Colorectal Tumors in a Genome-Wide Meta-analysis

25 May 2020

ulnar-mammary syndrome

2 references

UniProt protein ID

13 August 2019

Open Targets Platform

24 August 2023

https://platform.opentargets.org/evidence/ENSG00000135111/MONDO_0008411

based on heuristic

inferred from an Open Targets association score over 0.7

human chromosome 12

genomic assembly

genome assembly GRCh38

Genome assembly GRCh37

1 reference

ensembl Release 106

Ensembl gene ID

ENSG00000135111

strand orientation

genomic assembly

genome assembly GRCh38

Genome assembly GRCh37

1 reference

ensembl Release 106

Ensembl gene ID

ENSG00000135111

115108059

human chromosome 12

genomic assembly

Genome assembly GRCh37

1 reference

ensembl Release 106

Ensembl gene ID

ENSG00000135111

114670255

human chromosome 12

genomic assembly

genome assembly GRCh38

1 reference

ensembl Release 106

Ensembl gene ID

ENSG00000135111

115121969

human chromosome 12

genomic assembly

Genome assembly GRCh37

1 reference

ensembl Release 106

Ensembl gene ID

ENSG00000135111

114684175

human chromosome 12

genomic assembly

genome assembly GRCh38

1 reference

ensembl Release 106

Ensembl gene ID

ENSG00000135111

cytogenetic location

12q24.21

1 reference

15 May 2022

decreased expression in

determination method

disease susceptibility

2 references

Functional identity of hypothalamic melanocortin neurons depends on Tbx3

type of reference

The roles and regulation of TBX3 in development and disease.

gene deletion association with

ulnar-mammary syndrome

determination method

2 references

Mutations in human TBX3 alter limb, apocrine and genital development in ulnar-mammary syndrome

type of reference

The roles and regulation of TBX3 in development and disease.

altered regulation leads to

determination method

disease susceptibility

2 references

A new PKCα/β/TBX3/E-cadherin pathway is involved in PLCε-regulated invasion and migration in human bladder cancer cells

type of reference

The roles and regulation of TBX3 in development and disease.

4371

1 reference

15 May 2022

Gene Atlas image

PBB GE TBX3 219682 s at fs.png
732 × 530; 11 KB

0 references

increased expression in

protective factor

determination method

2 references

The T-box transcription factor 3 is a promising biomarker and a key regulator of the oncogenic phenotype of a diverse range of sarcoma subtypes

type of reference

The roles and regulation of TBX3 in development and disease.

determination method

disease susceptibility

2 references

TBX3 is overexpressed in breast cancer and represses p14 ARF by interacting with histone deacetylases

type of reference

The roles and regulation of TBX3 in development and disease.

determination method

disease susceptibility

2 references

The T-box transcription factor 3 is a promising biomarker and a key regulator of the oncogenic phenotype of a diverse range of sarcoma subtypes

type of reference

The roles and regulation of TBX3 in development and disease.

stomach carcinoma

determination method

disease susceptibility

2 references

Tbx3 overexpression in human gastric cancer is correlated with advanced tumor stage and nodal status and promotes cancer cell growth and invasion

type of reference

The roles and regulation of TBX3 in development and disease.

head and neck cancer

determination method

disease susceptibility

3 references

Tbx3 represses PTEN and is over-expressed in head and neck squamous cell carcinoma

type of reference

The roles and regulation of TBX3 in development and disease.

determination method

disease susceptibility

2 references

The T-box transcription factor 3 is a promising biomarker and a key regulator of the oncogenic phenotype of a diverse range of sarcoma subtypes

type of reference

The roles and regulation of TBX3 in development and disease.

determination method

disease susceptibility

2 references

Expression of TBX3 in Hepatocellular Carcinoma and Its Clinical Implication

type of reference

The roles and regulation of TBX3 in development and disease.

non-small-cell lung carcinoma

determination method

disease susceptibility

2 references

T-box 3 overexpression is associated with poor prognosis of non-small cell lung cancer

type of reference

The roles and regulation of TBX3 in development and disease.

determination method

disease susceptibility

2 references

The T-box transcription factor, TBX3, is sufficient to promote melanoma formation and invasion

type of reference

The roles and regulation of TBX3 in development and disease.

determination method

disease susceptibility

2 references

Increased expression of cSHMT, Tbx3 and utrophin in plasma of ovarian and breast cancer patients

type of reference

The roles and regulation of TBX3 in development and disease.

pancreatic cancer

determination method

disease susceptibility

2 references

Tbx3 fosters pancreatic cancer growth by increased angiogenesis and activin/nodal-dependent induction of stemness.

type of reference

The roles and regulation of TBX3 in development and disease.

rhabdomyosarcoma

determination method

disease susceptibility

2 references

The T-box transcription factor 3 is a promising biomarker and a key regulator of the oncogenic phenotype of a diverse range of sarcoma subtypes

type of reference

The roles and regulation of TBX3 in development and disease.

colorectal cancer

determination method

disease susceptibility

2 references

Overexpression of Tbx3 is correlated with Epithelial-Mesenchymal Transition phenotype and predicts poor prognosis of colorectal cancer

type of reference

The roles and regulation of TBX3 in development and disease.

1 reference

HomoloGene build68

4371

1 reference

HomoloGene build68

4371

1 reference

HomoloGene build68

4371

1

1 reference

20 April 2022

https://bgee.org/bgee15_0/gene/ENSG00000135111

stromal cell of endometrium

2

1 reference

20 April 2022

https://bgee.org/bgee15_0/gene/ENSG00000135111

seminal vesicula

3

1 reference

20 April 2022

https://bgee.org/bgee15_0/gene/ENSG00000135111

4

1 reference

20 April 2022

https://bgee.org/bgee15_0/gene/ENSG00000135111

right lobe of thyroid gland

5

1 reference

20 April 2022

https://bgee.org/bgee15_0/gene/ENSG00000135111

6

1 reference

20 April 2022

https://bgee.org/bgee15_0/gene/ENSG00000135111

left lobe of thyroid gland

7

1 reference

20 April 2022

https://bgee.org/bgee15_0/gene/ENSG00000135111

8

1 reference

20 April 2022

https://bgee.org/bgee15_0/gene/ENSG00000135111

9

1 reference

20 April 2022

https://bgee.org/bgee15_0/gene/ENSG00000135111

corpus epididymis

10

1 reference

20 April 2022

https://bgee.org/bgee15_0/gene/ENSG00000135111

http://identifiers.org/ncbigene/6926

1 reference

Identifiers.org

http://www.ebi.ac.uk/miriam/main/collections/MIR:00000069

Identifiers

1 reference

15 May 2022

1 reference

15 May 2022

1 reference

15 May 2022

Ensembl gene ID

ENSG00000135111

1 reference

ensembl Release 106

Ensembl gene ID

ENSG00000135111

Ensembl transcript ID

ENST00000257566

1 reference

ensembl Release 106

Ensembl gene ID

ENSG00000135111

ENST00000349155

1 reference

ensembl Release 106

Ensembl gene ID

ENSG00000135111

ENST00000548503

1 reference

ensembl Release 106

Ensembl gene ID

ENSG00000135111

ENST00000552054

1 reference

ensembl Release 106

Ensembl gene ID

ENSG00000135111

0 references

HGNC gene symbol

1 reference

15 May 2022

1 reference

15 May 2022

1 reference

Online Mendelian Inheritance in Man

19 August 2019

1 reference

based on heuristic

inferred by common HGNC mappings on source and on Wikidata

15 June 2023

Sitelinks

Wikipedia(7 entries)

arwiki TBX3
arzwiki TBX3
bswiki TBX3
cywiki TBX3
enwiki TBX3
eswiki TBX3
ukwiki TBX3

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

Retrieved from "https://www.wikidata.org/w/index.php?title=Q18031866&oldid=1971154986"