(Q1920577)

English

menin

mammalian protein found in Homo sapiens

MEN1
uniprot:O00255
menin 1

In more languages

Statements

1 reference

13 November 2019

UniProt protein ID

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O00255

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00255

determination method

protein-macromolecule adaptor activity

determination method

1 reference

8 April 2019

c-Myb, Menin, GATA-3, and MLL form a dynamic transcription complex that plays a pivotal role in human T helper type 2 cell development

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00255

determination method

determination method

1 reference

8 April 2019

Inactivation of menin, a Smad3-interacting protein, blocks transforming growth factor type beta signaling

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00255

determination method

protein N-terminus binding

determination method

1 reference

8 April 2019

The tumor suppressor protein menin interacts with NF-kappaB proteins and inhibits NF-kappaB-mediated transactivation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00255

determination method

histone-lysine N-methyltransferase activity

determination method

1 reference

27 February 2018

Menin associates with a trithorax family histone methyltransferase complex and with the hoxc8 locus

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=O00255&geneProductId=UniProtKB:O00255

determination method

protein binding

determination method

14 references

8 April 2019

The 32-kilodalton subunit of replication protein A interacts with menin, the product of the MEN1 tumor suppressor gene

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00255

determination method

8 April 2019

c-Myb, Menin, GATA-3, and MLL form a dynamic transcription complex that plays a pivotal role in human T helper type 2 cell development

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00255

determination method

8 April 2019

Menin interacts directly with the homeobox-containing protein Pem

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00255

determination method

8 April 2019

Menin associates with FANCD2, a protein involved in repair of DNA damage

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00255

determination method

8 April 2019

Menin interacts with the AP1 transcription factor JunD and represses JunD-activated transcription

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00255

determination method

8 April 2019

Multiple endocrine neoplasia type 1 interacts with forkhead transcription factor CHES1 in DNA damage response

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00255

determination method

8 April 2019

Leukemia proto-oncoprotein MLL forms a SET1-like histone methyltransferase complex with menin to regulate Hox gene expression

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00255

determination method

8 April 2019

Menin associates with a trithorax family histone methyltransferase complex and with the hoxc8 locus

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00255

determination method

8 April 2019

Menin, a tumor suppressor, associates with nonmuscle myosin II-A heavy chain

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00255

determination method

8 April 2019

Menin, a tumor suppressor, associates with nonmuscle myosin II-A heavy chain

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00255

determination method

8 April 2019

Menin associates with FANCD2, a protein involved in repair of DNA damage

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00255

determination method

8 April 2019

Menin stimulates homology-directed DNA repair

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00255

determination method

8 April 2019

The tumor suppressor protein menin interacts with NF-kappaB proteins and inhibits NF-kappaB-mediated transactivation

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00255

determination method

8 April 2019

HTLV-1 bZIP factor impedes the menin tumor suppressor and upregulates JunD-mediated transcription of the hTERT gene

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00255

determination method

four-way junction DNA binding

determination method

1 reference

8 April 2019

Direct binding of DNA by tumor suppressor menin

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00255

determination method

Y-form DNA binding

determination method

1 reference

27 February 2018

Direct binding of DNA by tumor suppressor menin

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=O00255&geneProductId=UniProtKB:O00255

determination method

double-stranded DNA binding

determination method

1 reference

27 February 2018

Direct binding of DNA by tumor suppressor menin

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=O00255&geneProductId=UniProtKB:O00255

determination method

determination method

1 reference

8 April 2019

Menin interacts directly with the homeobox-containing protein Pem

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00255

determination method

determination method

determination method

1 reference

8 April 2019

Menin associates with FANCD2, a protein involved in repair of DNA damage

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00255

determination method

determination method

2 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00255

determination method

8 April 2019

Human Protein Atlas

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00255

determination method

determination method

1 reference

27 February 2018

Menin associates with FANCD2, a protein involved in repair of DNA damage

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=O00255&geneProductId=UniProtKB:O00255

determination method

cleavage furrow

determination method

1 reference

8 April 2019

Menin, a tumor suppressor, associates with nonmuscle myosin II-A heavy chain

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00255

determination method

determination method

8 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00255

determination method

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00255

determination method

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00255

determination method

8 April 2019

Menin, the product of the MEN1 gene, is a nuclear protein

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00255

determination method

8 April 2019

Leukemia proto-oncoprotein MLL forms a SET1-like histone methyltransferase complex with menin to regulate Hox gene expression

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00255

determination method

8 April 2019

Menin, a tumor suppressor, associates with nonmuscle myosin II-A heavy chain

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00255

determination method

8 April 2019

Menin and MLL cooperatively regulate expression of cyclin-dependent kinase inhibitors

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00255

determination method

8 April 2019

PTIP associates with MLL3- and MLL4-containing histone H3 lysine 4 methyltransferase complex

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00255

determination method

histone methyltransferase complex

determination method

endoplasmic reticulum lumen

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00255

determination method

protein-containing complex

determination method

1 reference

8 April 2019

Leukemia proto-oncoprotein MLL forms a SET1-like histone methyltransferase complex with menin to regulate Hox gene expression

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00255

determination method

histone methyltransferase complex

determination method

3 references

8 April 2019

Menin associates with a trithorax family histone methyltransferase complex and with the hoxc8 locus

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00255

determination method

8 April 2019

PTIP associates with MLL3- and MLL4-containing histone H3 lysine 4 methyltransferase complex

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00255

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00255

determination method

biological process

negative regulation of cell-substrate adhesion

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00255

determination method

negative regulation of protein phosphorylation

determination method

1 reference

8 April 2019

Menin uncouples Elk-1, JunD and c-Jun phosphorylation from MAP kinase activation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00255

determination method

positive regulation of transforming growth factor beta receptor signaling pathway

determination method

1 reference

8 April 2019

Inactivation of menin, a Smad3-interacting protein, blocks transforming growth factor type beta signaling

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00255

determination method

regulation of transcription, DNA-templated

determination method

1 reference

27 February 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=O00255&geneProductId=UniProtKB:O00255

determination method

negative regulation of cyclin-dependent protein serine/threonine kinase activity

determination method

1 reference

8 April 2019

Menin and MLL cooperatively regulate expression of cyclin-dependent kinase inhibitors

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00255

determination method

negative regulation of telomerase activity

determination method

1 reference

8 April 2019

Multiple tumor suppressor pathways negatively regulate telomerase

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00255

determination method

negative regulation of cell cycle

determination method

1 reference

27 February 2018

Direct binding of DNA by tumor suppressor menin

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=O00255&geneProductId=UniProtKB:O00255

determination method

regulation of activin receptor signaling pathway

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00255

determination method

negative regulation of transcription by RNA polymerase II

determination method

4 references

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00255

determination method

8 April 2019

Menin interacts with the AP1 transcription factor JunD and represses JunD-activated transcription

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00255

determination method

8 April 2019

Multiple tumor suppressor pathways negatively regulate telomerase

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00255

determination method

8 April 2019

HTLV-1 bZIP factor impedes the menin tumor suppressor and upregulates JunD-mediated transcription of the hTERT gene

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00255

determination method

negative regulation of DNA-binding transcription factor activity

determination method

negative regulation of osteoblast differentiation

determination method

1 reference

8 April 2019

Menin suppresses osteoblast differentiation by antagonizing the AP-1 factor, JunD

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00255

determination method

negative regulation of cell cycle G1/S phase transition

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00255

determination method

determination method

1 reference

8 April 2019

Menin uncouples Elk-1, JunD and c-Jun phosphorylation from MAP kinase activation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00255

determination method

cellular response to DNA damage stimulus

determination method

1 reference

8 April 2019

Menin localizes to chromatin through an ATR-CHK1 mediated pathway after UV-induced DNA damage

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00255

determination method

negative regulation of JNK cascade

determination method

1 reference

8 April 2019

Menin uncouples Elk-1, JunD and c-Jun phosphorylation from MAP kinase activation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00255

determination method

brain development

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00255

determination method

cellular response to peptide hormone stimulus

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00255

determination method

decidualization

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00255

determination method

negative regulation of epithelial cell proliferation

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00255

determination method

mitotic cell cycle

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00255

determination method

osteoblast development

determination method

1 reference

8 April 2019

Menin suppresses osteoblast differentiation by antagonizing the AP-1 factor, JunD

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00255

determination method

positive regulation of protein binding

determination method

1 reference

8 April 2019

c-Myb, Menin, GATA-3, and MLL form a dynamic transcription complex that plays a pivotal role in human T helper type 2 cell development

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00255

determination method

negative regulation of transcription, DNA-templated

determination method

1 reference

8 April 2019

Menin uncouples Elk-1, JunD and c-Jun phosphorylation from MAP kinase activation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00255

determination method

response to gamma radiation

determination method

1 reference

8 April 2019

Menin associates with FANCD2, a protein involved in repair of DNA damage

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00255

determination method

determination method

1 reference

8 April 2019

Menin localizes to chromatin through an ATR-CHK1 mediated pathway after UV-induced DNA damage

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00255

determination method

type B pancreatic cell differentiation

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00255

determination method

determination method

1 reference

8 April 2019

Menin associates with FANCD2, a protein involved in repair of DNA damage

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00255

determination method

regulation of type B pancreatic cell proliferation

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00255

determination method

cellular response to glucose stimulus

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00255

determination method

negative regulation of cell population proliferation

determination method

1 reference

27 February 2018

Direct binding of DNA by tumor suppressor menin

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=O00255&geneProductId=UniProtKB:O00255

determination method

response to transforming growth factor beta

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00255

determination method

histone lysine methylation

determination method

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00255

determination method

beta-catenin-TCF complex assembly

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00255

determination method

transcription, DNA-templated

determination method

1 reference

27 February 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=O00255&geneProductId=UniProtKB:O00255

determination method

post-translational protein modification

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00255

determination method

chromatin organization

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00255

determination method

Gene Atlas image

PBB GE MEN1 202645 s at fs.png
732 × 530; 12 KB

0 references

Identifiers

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000308975

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000308975

ENSP00000323747

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000323747

ENSP00000337088

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000337088

ENSP00000366530

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000366530

ENSP00000366538

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000366538

ENSP00000366543

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000366543

ENSP00000377899

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000377899

ENSP00000377901

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000377901

ENSP00000366533

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000366533

ENSP00000388016

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000388016

ENSP00000394933

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000394933

ENSP00000402752

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000402752

ENSP00000411218

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000411218

ENSP00000413944

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000413944

ENSP00000500905

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000500905

ENSP00000500585

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000500585

1 reference

Freebase Data Dumps

publication date

28 October 2013

Microsoft Academic ID

0 references

1 reference

26 January 2022

https://docs.openalex.org/download-snapshot/snapshot-data-format

PDB structure ID

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

Sitelinks

Wikipedia(7 entries)

arwiki MEN1
bswiki MEN1
cywiki MEN1
dewiki Menin
enwiki MEN1
eswiki Menina
ukwiki Менін

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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