Wikidata

(Q21097342)

English

Parkinsonism associated deglycase

mammalian protein found in Homo sapiens

  • epididymis secretory sperm binding protein Li 67p
  • protein DJ-1
  • protein/nucleic acid deglycase DJ-1
  • maillard deglycase
  • Parkinson disease (autosomal recessive, early onset) 7
  • oncogene DJ1
  • protein deglycase DJ-1
  • PARK7
  • parkinson protein 7
  • Parkinson disease protein 7
In more languages

Statements

molecular function
protein binding
determination method
IPI
18 references
retrieved
9 May 2019
stated in
DJ-1 positively regulates the androgen receptor by impairing the binding of PIASx alpha to the receptor
GOA
curator
UniProt
UniProt protein ID
Q99497
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99497
determination method
IPI
retrieved
9 May 2019
stated in
Parkin, PINK1, and DJ-1 form a ubiquitin E3 ligase complex promoting unfolded protein degradation
GOA
curator
UniProt
UniProt protein ID
Q99497
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99497
determination method
IPI
retrieved
9 May 2019
stated in
Regulation of the VHL/HIF-1 pathway by DJ-1
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99497
determination method
IPI
retrieved
9 May 2019
stated in
DJ-1 binds to mitochondrial complex I and maintains its activity
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99497
determination method
IPI
retrieved
9 May 2019
stated in
DJ-1 enhances cell survival through the binding of Cezanne, a negative regulator of NF-kappaB
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99497
determination method
IPI
retrieved
9 May 2019
stated in
Interaction of DJ-1 with Daxx inhibits apoptosis signal-regulating kinase 1 activity and cell death
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99497
determination method
IPI
retrieved
9 May 2019
stated in
Nuclear translocation of DJ-1 during oxidative stress-induced neuronal cell death
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99497
determination method
IPI
retrieved
9 May 2019
stated in
The Parkinson's disease-associated DJ-1 protein is a transcriptional co-activator that protects against neuronal apoptosis
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99497
determination method
IPI
retrieved
9 May 2019
stated in
DJ-1 interacts with RACK1 and protects neurons from oxidative-stress-induced apoptosis
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99497
determination method
IPI
retrieved
9 May 2019
stated in
Association of PINK1 and DJ-1 confers digenic inheritance of early-onset Parkinson's disease
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99497
determination method
IPI
retrieved
9 May 2019
stated in
DJ-1 interacts with RACK1 and protects neurons from oxidative-stress-induced apoptosis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99497
determination method
IPI
retrieved
9 May 2019
stated in
DJ-1 inhibits TRAIL-induced apoptosis by blocking pro-caspase-8 recruitment to FADD
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99497
determination method
IPI
retrieved
9 May 2019
stated in
DJ-1 enhances cell survival through the binding of Cezanne, a negative regulator of NF-kappaB
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99497
determination method
IPI
retrieved
9 May 2019
stated in
Interaction of DJ-1 with Daxx inhibits apoptosis signal-regulating kinase 1 activity and cell death
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99497
determination method
IPI
retrieved
9 May 2019
stated in
DJ-1 cooperates with PYCR1 in cell protection against oxidative stress
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99497
determination method
IPI
retrieved
9 May 2019
stated in
DJ-1 binds androgen receptor directly and mediates its activity in hormonally treated prostate cancer cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99497
determination method
IPI
retrieved
9 May 2019
stated in
A proteome-scale map of the human interactome network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99497
determination method
IPI
retrieved
9 May 2019
stated in
Increased interaction between DJ-1 and the Mi-2/ nucleosome remodelling and deacetylase complex during cellular stress
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99497
determination method
IPI
cell component
cytoplasm
determination method
IDA
IEA
6 references
retrieved
9 May 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q99497
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99497
determination method
IEA
retrieved
9 May 2019
stated in
Mitochondrial localization of DJ-1 leads to enhanced neuroprotection
GOA
curator
UniProt
UniProt protein ID
Q99497
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99497
determination method
IDA
retrieved
9 May 2019
stated in
DJ-1 binds to mitochondrial complex I and maintains its activity
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99497
determination method
IDA
retrieved
9 May 2019
stated in
Interaction of DJ-1 with Daxx inhibits apoptosis signal-regulating kinase 1 activity and cell death
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99497
determination method
IDA
retrieved
9 May 2019
stated in
DJ-1 binds androgen receptor directly and mediates its activity in hormonally treated prostate cancer cells
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99497
determination method
IDA
retrieved
9 May 2019
stated in
Mutations in the DJ-1 gene associated with autosomal recessive early-onset parkinsonism
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99497
determination method
IDA
cytosol
determination method
IDA
IEA
IMP
7 references
retrieved
17 October 2017
stated in
DJ-1 inhibits TRAIL-induced apoptosis by blocking pro-caspase-8 recruitment to FADD
GOA
curator
UniProt
UniProt protein ID
Q99497
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99497&geneProductId=UniProtKB:Q99497
determination method
IMP
retrieved
17 October 2017
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99497&geneProductId=UniProtKB:Q99497
determination method
IEA
retrieved
17 October 2017
stated in
Parkin, PINK1, and DJ-1 form a ubiquitin E3 ligase complex promoting unfolded protein degradation
GOA
curator
UniProt
UniProt protein ID
Q99497
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99497&geneProductId=UniProtKB:Q99497
determination method
IDA
retrieved
17 October 2017
stated in
Mitochondrial localization of the Parkinson's disease related protein DJ-1: implications for pathogenesis
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99497&geneProductId=UniProtKB:Q99497
determination method
IDA
retrieved
17 October 2017
stated in
Nuclear translocation of DJ-1 during oxidative stress-induced neuronal cell death
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99497&geneProductId=UniProtKB:Q99497
determination method
IDA
retrieved
17 October 2017
stated in
The expression of DJ-1 (PARK7) in normal human CNS and idiopathic Parkinson's disease
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99497&geneProductId=UniProtKB:Q99497
determination method
IDA
retrieved
17 October 2017
stated in
GOA
curator
Human Protein Atlas
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99497&geneProductId=UniProtKB:Q99497
determination method
IDA
mitochondrion
determination method
IDA
IEA
IMP
9 references
retrieved
9 May 2019
stated in
DJ-1 inhibits TRAIL-induced apoptosis by blocking pro-caspase-8 recruitment to FADD
GOA
curator
UniProt
UniProt protein ID
Q99497
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99497
determination method
IMP
retrieved
9 May 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q99497
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99497
determination method
IEA
retrieved
9 May 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99497
determination method
IEA
retrieved
9 May 2019
stated in
Parkin, PINK1, and DJ-1 form a ubiquitin E3 ligase complex promoting unfolded protein degradation
GOA
curator
UniProt
UniProt protein ID
Q99497
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99497
determination method
IDA
retrieved
9 May 2019
stated in
Mitochondrial localization of DJ-1 leads to enhanced neuroprotection
GOA
curator
UniProt
UniProt protein ID
Q99497
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99497
determination method
IDA
retrieved
9 May 2019
stated in
DJ-1 binds to mitochondrial complex I and maintains its activity
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99497
determination method
IDA
retrieved
9 May 2019
stated in
The Parkinson's disease-associated DJ-1 protein is a transcriptional co-activator that protects against neuronal apoptosis
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99497
determination method
IDA
retrieved
9 May 2019
stated in
DJ-1 cooperates with PYCR1 in cell protection against oxidative stress
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99497
determination method
IDA
retrieved
9 May 2019
stated in
Mitochondrial localization of the Parkinson's disease related protein DJ-1: implications for pathogenesis
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99497
determination method
IDA
nucleus
determination method
IDA
IEA
12 references
retrieved
17 October 2017
stated in
GOA
curator
UniProt
UniProt protein ID
Q99497
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99497&geneProductId=UniProtKB:Q99497
determination method
IEA
retrieved
17 October 2017
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99497&geneProductId=UniProtKB:Q99497
determination method
IEA
retrieved
17 October 2017
stated in
DJ-1 positively regulates the androgen receptor by impairing the binding of PIASx alpha to the receptor
GOA
curator
UniProt
UniProt protein ID
Q99497
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99497&geneProductId=UniProtKB:Q99497
determination method
IDA
retrieved
17 October 2017
stated in
Proteomic characterization of the human sperm nucleus
GOA
curator
UniProt
UniProt protein ID
Q99497
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99497&geneProductId=UniProtKB:Q99497
determination method
IDA
retrieved
17 October 2017
stated in
Mitochondrial localization of DJ-1 leads to enhanced neuroprotection
GOA
curator
UniProt
UniProt protein ID
Q99497
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99497&geneProductId=UniProtKB:Q99497
determination method
IDA
retrieved
17 October 2017
stated in
Nuclear translocation of DJ-1 during oxidative stress-induced neuronal cell death
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99497&geneProductId=UniProtKB:Q99497
determination method
IDA
retrieved
17 October 2017
stated in
Interaction of DJ-1 with Daxx inhibits apoptosis signal-regulating kinase 1 activity and cell death
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99497&geneProductId=UniProtKB:Q99497
determination method
IDA
retrieved
17 October 2017
stated in
DJ-1 binds to mitochondrial complex I and maintains its activity
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99497&geneProductId=UniProtKB:Q99497
determination method
IDA
retrieved
17 October 2017
stated in
The Parkinson's disease-associated DJ-1 protein is a transcriptional co-activator that protects against neuronal apoptosis
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99497&geneProductId=UniProtKB:Q99497
determination method
IDA
retrieved
17 October 2017
stated in
The expression of DJ-1 (PARK7) in normal human CNS and idiopathic Parkinson's disease
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99497&geneProductId=UniProtKB:Q99497
determination method
IDA
retrieved
17 October 2017
stated in
Mutations in the DJ-1 gene associated with autosomal recessive early-onset parkinsonism
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99497&geneProductId=UniProtKB:Q99497
determination method
IDA
retrieved
17 October 2017
stated in
GOA
curator
Human Protein Atlas
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99497&geneProductId=UniProtKB:Q99497
determination method
IDA
extracellular exosome
determination method
IDA
5 references
retrieved
17 October 2017
stated in
Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT)
GOA
curator
UniProt
UniProt protein ID
Q99497
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99497&geneProductId=UniProtKB:Q99497
determination method
IDA
retrieved
17 October 2017
stated in
Large-scale proteomics and phosphoproteomics of urinary exosomes
GOA
curator
UniProt
UniProt protein ID
Q99497
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99497&geneProductId=UniProtKB:Q99497
determination method
IDA
retrieved
17 October 2017
stated in
MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis
GOA
curator
UniProt
UniProt protein ID
Q99497
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99497&geneProductId=UniProtKB:Q99497
determination method
IDA
retrieved
17 October 2017
stated in
In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine
GOA
curator
UniProt
UniProt protein ID
Q99497
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99497&geneProductId=UniProtKB:Q99497
determination method
IDA
retrieved
17 October 2017
stated in
Proteomic analysis of podocyte exosome-enriched fraction from normal human urine
GOA
curator
UniProt
UniProt protein ID
Q99497
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99497&geneProductId=UniProtKB:Q99497
determination method
IDA
nucleus
determination method
HDA
IBA
IDA
IEA
13 references
retrieved
9 May 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q99497
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99497
determination method
IEA
retrieved
9 May 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99497
determination method
IEA
retrieved
9 May 2019
stated in
DJ-1 positively regulates the androgen receptor by impairing the binding of PIASx alpha to the receptor
GOA
curator
UniProt
UniProt protein ID
Q99497
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99497
determination method
IDA
retrieved
9 May 2019
stated in
Mitochondrial localization of DJ-1 leads to enhanced neuroprotection
GOA
curator
UniProt
UniProt protein ID
Q99497
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99497
determination method
IDA
retrieved
9 May 2019
stated in
The expression of DJ-1 (PARK7) in normal human CNS and idiopathic Parkinson's disease
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99497
determination method
IDA
retrieved
9 May 2019
stated in
DJ-1 binds to mitochondrial complex I and maintains its activity
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99497
determination method
IDA
retrieved
9 May 2019
stated in
Interaction of DJ-1 with Daxx inhibits apoptosis signal-regulating kinase 1 activity and cell death
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99497
determination method
IDA
retrieved
9 May 2019
stated in
Nuclear translocation of DJ-1 during oxidative stress-induced neuronal cell death
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99497
determination method
IDA
retrieved
9 May 2019
stated in
The Parkinson's disease-associated DJ-1 protein is a transcriptional co-activator that protects against neuronal apoptosis
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99497
determination method
IDA
retrieved
9 May 2019
stated in
Mutations in the DJ-1 gene associated with autosomal recessive early-onset parkinsonism
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99497
determination method
IDA
retrieved
9 May 2019
stated in
GOA
curator
Human Protein Atlas
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99497
determination method
IDA
retrieved
9 May 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99497
determination method
IBA
retrieved
9 May 2019
stated in
Proteomic characterization of the human sperm nucleus
GOA
curator
UniProt
UniProt protein ID
Q99497
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99497
determination method
HDA
cytosol
determination method
IBA
IDA
IEA
IMP
8 references
retrieved
9 May 2019
stated in
DJ-1 inhibits TRAIL-induced apoptosis by blocking pro-caspase-8 recruitment to FADD
GOA
curator
UniProt
UniProt protein ID
Q99497
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99497
determination method
IMP
retrieved
9 May 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99497
determination method
IEA
retrieved
9 May 2019
stated in
Parkin, PINK1, and DJ-1 form a ubiquitin E3 ligase complex promoting unfolded protein degradation
GOA
curator
UniProt
UniProt protein ID
Q99497
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99497
determination method
IDA
retrieved
9 May 2019
stated in
The expression of DJ-1 (PARK7) in normal human CNS and idiopathic Parkinson's disease
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99497
determination method
IDA
retrieved
9 May 2019
stated in
Mitochondrial localization of the Parkinson's disease related protein DJ-1: implications for pathogenesis
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99497
determination method
IDA
retrieved
9 May 2019
stated in
Nuclear translocation of DJ-1 during oxidative stress-induced neuronal cell death
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99497
determination method
IDA
retrieved
9 May 2019
stated in
GOA
curator
Human Protein Atlas
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99497
determination method
IDA
retrieved
9 May 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99497
determination method
IBA
biological process
negative regulation of protein binding
determination method
IDA
IGI
IMP
6 references
retrieved
9 May 2019
stated in
DJ-1 inhibits TRAIL-induced apoptosis by blocking pro-caspase-8 recruitment to FADD
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99497
determination method
IMP
retrieved
9 May 2019
stated in
Interaction of DJ-1 with Daxx inhibits apoptosis signal-regulating kinase 1 activity and cell death
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99497
determination method
IGI
retrieved
9 May 2019
stated in
DJ-1 positively regulates the androgen receptor by impairing the binding of PIASx alpha to the receptor
GOA
curator
UniProt
UniProt protein ID
Q99497
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99497
determination method
IDA
retrieved
9 May 2019
stated in
Regulation of the VHL/HIF-1 pathway by DJ-1
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99497
determination method
IDA
retrieved
9 May 2019
stated in
DJ-1 transcriptionally up-regulates the human tyrosine hydroxylase by inhibiting the sumoylation of pyrimidine tract-binding protein-associated splicing factor
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99497
determination method
IDA
retrieved
9 May 2019
stated in
DJ-1, a cancer- and Parkinson's disease-associated protein, stabilizes the antioxidant transcriptional master regulator Nrf2
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99497
determination method
IDA
cellular response to oxidative stress
determination method
IDA
IEA
IMP
6 references
retrieved
9 May 2019
stated in
Regulation of the VHL/HIF-1 pathway by DJ-1
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99497
determination method
IMP
retrieved
9 May 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99497
determination method
IEA
retrieved
9 May 2019
stated in
DJ-1 cleavage by matrix metalloproteinase 3 mediates oxidative stress-induced dopaminergic cell death
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99497
determination method
IDA
retrieved
9 May 2019
stated in
Interaction of DJ-1 with Daxx inhibits apoptosis signal-regulating kinase 1 activity and cell death
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99497
determination method
IDA
retrieved
9 May 2019
stated in
Oxidative status of DJ-1-dependent activation of dopamine synthesis through interaction of tyrosine hydroxylase and 4-dihydroxy-L-phenylalanine (L-DOPA) decarboxylase with DJ-1
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99497
determination method
IDA
retrieved
9 May 2019
stated in
Nuclear translocation of DJ-1 during oxidative stress-induced neuronal cell death
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99497
determination method
IDA
positive regulation of transcription by RNA polymerase II
determination method
IDA
IGI
IEA
IMP
7 references
retrieved
9 May 2019
stated in
DJ-1 induces thioredoxin 1 expression through the Nrf2 pathway
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99497
determination method
IMP
retrieved
9 May 2019
stated in
DJ-1 transcriptionally up-regulates the human tyrosine hydroxylase by inhibiting the sumoylation of pyrimidine tract-binding protein-associated splicing factor
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99497
determination method
IMP
retrieved
9 May 2019
stated in
Oxidative status of DJ-1-dependent activation of dopamine synthesis through interaction of tyrosine hydroxylase and 4-dihydroxy-L-phenylalanine (L-DOPA) decarboxylase with DJ-1
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99497
determination method
IMP
retrieved
9 May 2019
stated in
The Parkinson's disease-associated DJ-1 protein is a transcriptional co-activator that protects against neuronal apoptosis
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99497
determination method
IGI
retrieved
9 May 2019
stated in
DJ-1, a cancer- and Parkinson's disease-associated protein, stabilizes the antioxidant transcriptional master regulator Nrf2
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99497
determination method
IGI
retrieved
9 May 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99497
determination method
IEA
retrieved
9 May 2019
stated in
DJ-1 enhances cell survival through the binding of Cezanne, a negative regulator of NF-kappaB
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99497
determination method
IDA

Identifiers

MeSH descriptor ID
D000071617
subject named as
Protein Deglycase DJ-1
0 references
MeSH tree code
D08.811.277.785
0 references
D12.776.637.875
0 references
PDB structure ID
 
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                    Retrieved from "https://www.wikidata.org/w/index.php?title=Q21097342&oldid=2022912687"