Wikidata

(Q21101484)

English

Forkhead box O3

mammalian protein found in Homo sapiens

  • forkhead, Drosophila, homolog of, in rhabdomyosarcoma-like 1
  • FOXO3
  • forkhead in rhabdomyosarcoma-like 1
  • forkhead box protein O3
  • forkhead homolog (rhabdomyosarcoma) like 1
  • forkhead box O3A
  • AF6q21 protein
In more languages

Statements

molecular function
protein binding
determination method
IPI
18 references
retrieved
8 April 2019
stated in
A novel AMPK-dependent FoxO3A-SIRT3 intramitochondrial complex sensing glucose levels.
GOA
curator
UniProt
UniProt protein ID
O43524
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43524
determination method
IPI
retrieved
8 April 2019
stated in
Uncoupling FoxO3A mitochondrial and nuclear functions in cancer cells undergoing metabolic stress and chemotherapy.
GOA
curator
UniProt
UniProt protein ID
O43524
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43524
determination method
IPI
retrieved
8 April 2019
stated in
Deficiency of the transcriptional regulator p8 results in increased autophagy and apoptosis, and causes impaired heart function
GOA
curator
UniProt
UniProt protein ID
O43524
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43524
determination method
IPI
retrieved
8 April 2019
stated in
CHOP potentially co-operates with FOXO3a in neuronal cells to regulate PUMA and BIM expression in response to ER stress
GOA
curator
UniProt
UniProt protein ID
O43524
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43524
determination method
IPI
retrieved
8 April 2019
stated in
IkappaB kinase promotes tumorigenesis through inhibition of forkhead FOXO3a
GOA
curator
UniProt
UniProt protein ID
O43524
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43524
determination method
IPI
retrieved
8 April 2019
stated in
Bimodal regulation of FoxO3 by AKT and 14-3-3
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43524
determination method
IPI
retrieved
8 April 2019
stated in
Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43524
determination method
IPI
retrieved
8 April 2019
stated in
The evolutionarily conserved longevity determinants HCF-1 and SIR-2.1/SIRT1 collaborate to regulate DAF-16/FOXO
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43524
determination method
IPI
retrieved
8 April 2019
stated in
FOXO4 is acetylated upon peroxide stress and deacetylated by the longevity protein hSir2(SIRT1)
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43524
determination method
IPI
retrieved
8 April 2019
stated in
Integration of Smad and forkhead pathways in the control of neuroepithelial and glioblastoma cell proliferation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43524
determination method
IPI
retrieved
8 April 2019
stated in
Nodal enhances the activity of FoxO3a and its synergistic interaction with Smads to regulate cyclin G2 transcription in ovarian cancer cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43524
determination method
IPI
retrieved
8 April 2019
stated in
Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43524
determination method
IPI
retrieved
8 April 2019
stated in
14-3-3 transits to the nucleus and participates in dynamic nucleocytoplasmic transport
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43524
determination method
IPI
retrieved
8 April 2019
stated in
Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43524
determination method
IPI
retrieved
8 April 2019
stated in
The Forkhead box M1 protein regulates the transcription of the estrogen receptor alpha in breast cancer cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43524
determination method
IPI
retrieved
8 April 2019
stated in
Pim kinases promote cell cycle progression by phosphorylating and down-regulating p27Kip1 at the transcriptional and posttranscriptional levels
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43524
determination method
IPI
retrieved
8 April 2019
stated in
c-Myc represses FOXO3a-mediated transcription of the gene encoding the p27(Kip1) cyclin dependent kinase inhibitor
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43524
determination method
IPI
retrieved
8 April 2019
stated in
Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43524
determination method
IPI
cell component
cytoplasm
determination method
IEA
IDA
8 references
retrieved
21 June 2018
stated in
GOA
curator
UniProt
UniProt protein ID
O43524
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O43524&geneProductId=UniProtKB:O43524
determination method
IEA
retrieved
21 June 2018
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O43524&geneProductId=UniProtKB:O43524
determination method
IEA
retrieved
21 June 2018
stated in
IkappaB kinase promotes tumorigenesis through inhibition of forkhead FOXO3a
GOA
curator
UniProt
UniProt protein ID
O43524
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O43524&geneProductId=UniProtKB:O43524
determination method
IDA
retrieved
21 June 2018
stated in
A conserved MST-FOXO signaling pathway mediates oxidative-stress responses and extends life span
GOA
curator
UniProt
UniProt protein ID
O43524
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O43524&geneProductId=UniProtKB:O43524
determination method
IDA
retrieved
21 June 2018
stated in
A novel AMPK-dependent FoxO3A-SIRT3 intramitochondrial complex sensing glucose levels.
GOA
curator
UniProt
UniProt protein ID
O43524
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O43524&geneProductId=UniProtKB:O43524
determination method
IDA
retrieved
21 June 2018
stated in
Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor
GOA
curator
UniProt
UniProt protein ID
O43524
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O43524&geneProductId=UniProtKB:O43524
determination method
IDA
retrieved
21 June 2018
stated in
The MK5/PRAK kinase and Myc form a negative feedback loop that is disrupted during colorectal tumorigenesis
GOA
curator
UniProt
UniProt protein ID
O43524
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O43524&geneProductId=UniProtKB:O43524
determination method
IDA
retrieved
21 June 2018
stated in
Foxo3a regulates apoptosis by negatively targeting miR-21
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O43524&geneProductId=UniProtKB:O43524
determination method
IDA
nucleus
determination method
IDA
IEA
IMP
11 references
retrieved
21 June 2018
stated in
Uncoupling FoxO3A mitochondrial and nuclear functions in cancer cells undergoing metabolic stress and chemotherapy.
GOA
curator
UniProt
UniProt protein ID
O43524
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O43524&geneProductId=UniProtKB:O43524
determination method
IMP
retrieved
21 June 2018
stated in
GOA
curator
UniProt
UniProt protein ID
O43524
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O43524&geneProductId=UniProtKB:O43524
determination method
IEA
retrieved
21 June 2018
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O43524&geneProductId=UniProtKB:O43524
determination method
IEA
retrieved
21 June 2018
stated in
A novel AMPK-dependent FoxO3A-SIRT3 intramitochondrial complex sensing glucose levels.
GOA
curator
UniProt
UniProt protein ID
O43524
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O43524&geneProductId=UniProtKB:O43524
determination method
IDA
retrieved
21 June 2018
stated in
A conserved MST-FOXO signaling pathway mediates oxidative-stress responses and extends life span
GOA
curator
UniProt
UniProt protein ID
O43524
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O43524&geneProductId=UniProtKB:O43524
determination method
IDA
retrieved
21 June 2018
stated in
CHOP potentially co-operates with FOXO3a in neuronal cells to regulate PUMA and BIM expression in response to ER stress
GOA
curator
UniProt
UniProt protein ID
O43524
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O43524&geneProductId=UniProtKB:O43524
determination method
IDA
retrieved
21 June 2018
stated in
IkappaB kinase promotes tumorigenesis through inhibition of forkhead FOXO3a
GOA
curator
UniProt
UniProt protein ID
O43524
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O43524&geneProductId=UniProtKB:O43524
determination method
IDA
retrieved
21 June 2018
stated in
Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor
GOA
curator
UniProt
UniProt protein ID
O43524
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O43524&geneProductId=UniProtKB:O43524
determination method
IDA
retrieved
21 June 2018
stated in
The MK5/PRAK kinase and Myc form a negative feedback loop that is disrupted during colorectal tumorigenesis
GOA
curator
UniProt
UniProt protein ID
O43524
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O43524&geneProductId=UniProtKB:O43524
determination method
IDA
retrieved
21 June 2018
stated in
Selective VPS34 inhibitor blocks autophagy and uncovers a role for NCOA4 in ferritin degradation and iron homeostasis in vivo
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O43524&geneProductId=UniProtKB:O43524
determination method
IDA
retrieved
21 June 2018
stated in
Lacritin rescues stressed epithelia via rapid forkhead box O3 (FOXO3)-associated autophagy that restores metabolism
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O43524&geneProductId=UniProtKB:O43524
determination method
IDA
nucleus
determination method
IBA
IDA
IEA
IMP
12 references
retrieved
8 April 2019
stated in
Uncoupling FoxO3A mitochondrial and nuclear functions in cancer cells undergoing metabolic stress and chemotherapy.
GOA
curator
UniProt
UniProt protein ID
O43524
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43524
determination method
IMP
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
O43524
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43524
determination method
IEA
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43524
determination method
IEA
retrieved
8 April 2019
stated in
A novel AMPK-dependent FoxO3A-SIRT3 intramitochondrial complex sensing glucose levels.
GOA
curator
UniProt
UniProt protein ID
O43524
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43524
determination method
IDA
retrieved
8 April 2019
stated in
The MK5/PRAK kinase and Myc form a negative feedback loop that is disrupted during colorectal tumorigenesis
GOA
curator
UniProt
UniProt protein ID
O43524
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43524
determination method
IDA
retrieved
8 April 2019
stated in
CHOP potentially co-operates with FOXO3a in neuronal cells to regulate PUMA and BIM expression in response to ER stress
GOA
curator
UniProt
UniProt protein ID
O43524
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43524
determination method
IDA
retrieved
8 April 2019
stated in
IkappaB kinase promotes tumorigenesis through inhibition of forkhead FOXO3a
GOA
curator
UniProt
UniProt protein ID
O43524
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43524
determination method
IDA
retrieved
8 April 2019
stated in
A conserved MST-FOXO signaling pathway mediates oxidative-stress responses and extends life span
GOA
curator
UniProt
UniProt protein ID
O43524
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43524
determination method
IDA
retrieved
8 April 2019
stated in
Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor
GOA
curator
UniProt
UniProt protein ID
O43524
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43524
determination method
IDA
retrieved
8 April 2019
stated in
Selective VPS34 inhibitor blocks autophagy and uncovers a role for NCOA4 in ferritin degradation and iron homeostasis in vivo
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43524
determination method
IDA
retrieved
8 April 2019
stated in
Lacritin rescues stressed epithelia via rapid forkhead box O3 (FOXO3)-associated autophagy that restores metabolism
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43524
determination method
IDA
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43524
determination method
IBA
cytoplasm
determination method
IBA
IDA
IEA
9 references
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
O43524
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43524
determination method
IEA
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43524
determination method
IEA
retrieved
8 April 2019
stated in
A novel AMPK-dependent FoxO3A-SIRT3 intramitochondrial complex sensing glucose levels.
GOA
curator
UniProt
UniProt protein ID
O43524
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43524
determination method
IDA
retrieved
8 April 2019
stated in
The MK5/PRAK kinase and Myc form a negative feedback loop that is disrupted during colorectal tumorigenesis
GOA
curator
UniProt
UniProt protein ID
O43524
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43524
determination method
IDA
retrieved
8 April 2019
stated in
IkappaB kinase promotes tumorigenesis through inhibition of forkhead FOXO3a
GOA
curator
UniProt
UniProt protein ID
O43524
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43524
determination method
IDA
retrieved
8 April 2019
stated in
A conserved MST-FOXO signaling pathway mediates oxidative-stress responses and extends life span
GOA
curator
UniProt
UniProt protein ID
O43524
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43524
determination method
IDA
retrieved
8 April 2019
stated in
Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor
GOA
curator
UniProt
UniProt protein ID
O43524
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43524
determination method
IDA
retrieved
8 April 2019
stated in
Foxo3a regulates apoptosis by negatively targeting miR-21
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43524
determination method
IDA
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43524
determination method
IBA
biological process

Identifiers

MeSH descriptor ID
D000071316
subject named as
Forkhead Box Protein O3
0 references
Freebase ID
/m/03cvkf5
0 references
 
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