Wikidata

(Q21102206)

English

Lysine methyltransferase 2A

mammalian protein found in Homo sapiens

  • CXXC-type zinc finger protein 7
  • KMT2A
  • histone-lysine N-methyltransferase 2A
  • zinc finger protein HRX
  • myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila)
  • mixed lineage leukemia 1
  • Myeloid/lymphoid or mixed-lineage leukemia protein 1
  • trithorax-like protein
  • Myeloid/lymphoid or mixed-lineage leukemia
  • ALL-1
  • lysine (K)-specific methyltransferase 2A
  • lysine N-methyltransferase 2A
  • Myeloid-Lymphoid Leukemia Protein
In more languages

Statements

part of
molecular function
protein binding
determination method
IPI
23 references
retrieved
9 May 2019
stated in
Physical association and coordinate function of the H3 K4 methyltransferase MLL1 and the H4 K16 acetyltransferase MOF
GOA
curator
UniProt
UniProt protein ID
Q03164
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03164
determination method
IPI
retrieved
9 May 2019
stated in
Protein interactions of the MLL PHD fingers modulate MLL target gene regulation in human cells
GOA
curator
UniProt
UniProt protein ID
Q03164
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03164
determination method
IPI
retrieved
9 May 2019
stated in
Leukemia proto-oncoprotein MLL forms a SET1-like histone methyltransferase complex with menin to regulate Hox gene expression
GOA
curator
UniProt
UniProt protein ID
Q03164
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03164
determination method
IPI
retrieved
9 May 2019
stated in
Structural basis for the requirement of additional factors for MLL1 SET domain activity and recognition of epigenetic marks
GOA
curator
UniProt
UniProt protein ID
Q03164
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03164
determination method
IPI
retrieved
9 May 2019
stated in
On the mechanism of multiple lysine methylation by the human mixed lineage leukemia protein-1 (MLL1) core complex
GOA
curator
UniProt
UniProt protein ID
Q03164
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03164
determination method
IPI
retrieved
9 May 2019
stated in
The histone methyltransferase MLL1 permits the oscillation of circadian gene expression
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03164
determination method
IPI
retrieved
9 May 2019
stated in
Structural basis for activity regulation of MLL family methyltransferases
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03164
determination method
IPI
retrieved
9 May 2019
stated in
Physical association and coordinate function of the H3 K4 methyltransferase MLL1 and the H4 K16 acetyltransferase MOF
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03164
determination method
IPI
retrieved
9 May 2019
stated in
Protein interactions of the MLL PHD fingers modulate MLL target gene regulation in human cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03164
determination method
IPI
retrieved
9 May 2019
stated in
The mutational landscape of lethal castration-resistant prostate cancer
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03164
determination method
IPI
retrieved
9 May 2019
stated in
Leu628 of the KIX domain of CBP is a key residue for the interaction with the MLL transactivation domain
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03164
determination method
IPI
retrieved
9 May 2019
stated in
Crosstalk between leukemia-associated proteins MOZ and MLL regulates HOX gene expression in human cord blood CD34+ cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03164
determination method
IPI
retrieved
9 May 2019
stated in
WDR5 interacts with mixed lineage leukemia (MLL) protein via the histone H3-binding pocket
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03164
determination method
IPI
retrieved
9 May 2019
stated in
Pro isomerization in MLL1 PHD3-bromo cassette connects H3K4me readout to CyP33 and HDAC-mediated repression
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03164
determination method
IPI
retrieved
9 May 2019
stated in
Leukemia proto-oncoprotein MLL forms a SET1-like histone methyltransferase complex with menin to regulate Hox gene expression
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03164
determination method
IPI
retrieved
9 May 2019
stated in
A High-Density Map for Navigating the Human Polycomb Complexome
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03164
determination method
IPI
retrieved
9 May 2019
stated in
NAD(+)-SIRT1 control of H3K4 trimethylation through circadian deacetylation of MLL1.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03164
determination method
IPI
retrieved
9 May 2019
stated in
SET1 and p300 act synergistically, through coupled histone modifications, in transcriptional activation by p53
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03164
determination method
IPI
retrieved
9 May 2019
stated in
The PAF complex synergizes with MLL fusion proteins at HOX loci to promote leukemogenesis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03164
determination method
IPI
retrieved
9 May 2019
stated in
The same pocket in menin binds both MLL and JUND but has opposite effects on transcription
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03164
determination method
IPI
retrieved
9 May 2019
stated in
Phosphorylation of MLL by ATR is required for execution of mammalian S-phase checkpoint
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03164
determination method
IPI
retrieved
9 May 2019
stated in
Structural and biochemical insights into MLL1 core complex assembly
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03164
determination method
IPI
retrieved
9 May 2019
stated in
On the mechanism of multiple lysine methylation by the human mixed lineage leukemia protein-1 (MLL1) core complex
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03164
determination method
IPI
histone methyltransferase activity (H3-K4 specific)
determination method
EXP
IBA
IDA
IEA
IMP
6 references
retrieved
9 May 2019
stated in
Physical association and coordinate function of the H3 K4 methyltransferase MLL1 and the H4 K16 acetyltransferase MOF
GOA
curator
UniProt
UniProt protein ID
Q03164
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03164
determination method
IMP
retrieved
9 May 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03164
determination method
IEA
retrieved
9 May 2019
stated in
Structural basis for the requirement of additional factors for MLL1 SET domain activity and recognition of epigenetic marks
GOA
curator
UniProt
UniProt protein ID
Q03164
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03164
determination method
IDA
retrieved
9 May 2019
stated in
On the mechanism of multiple lysine methylation by the human mixed lineage leukemia protein-1 (MLL1) core complex
GOA
curator
UniProt
UniProt protein ID
Q03164
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03164
determination method
IDA
retrieved
9 May 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03164
determination method
IBA
retrieved
9 May 2019
stated in
The ability of MLL to bind RUNX1 and methylate H3K4 at PU.1 regulatory regions is impaired by MDS/AML-associated RUNX1/AML1 mutations.
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03164
determination method
EXP
cell component
nucleus
determination method
NAS
IDA
IEA
6 references
retrieved
9 May 2019
stated in
Involvement of a homolog of Drosophila trithorax by 11q23 chromosomal translocations in acute leukemias
GOA
curator
UniProt
UniProt protein ID
Q03164
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03164
determination method
NAS
retrieved
9 May 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q03164
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03164
determination method
IEA
retrieved
9 May 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03164
determination method
IEA
retrieved
9 May 2019
stated in
Protein interactions of the MLL PHD fingers modulate MLL target gene regulation in human cells
GOA
curator
UniProt
UniProt protein ID
Q03164
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03164
determination method
IDA
retrieved
9 May 2019
stated in
Menin and MLL cooperatively regulate expression of cyclin-dependent kinase inhibitors
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03164
determination method
IDA
retrieved
9 May 2019
stated in
Human RNA polymerase II-association factor 1 (hPaf1/PD2) regulates histone methylation and chromatin remodeling in pancreatic cancer
GOA
curator
Community Assessment of Community Annotation with Ontologies
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03164
determination method
IDA
biological process

Identifiers

MeSH descriptor ID
D051788
subject named as
Myeloid-Lymphoid Leukemia Protein
0 references
PDB structure ID
 
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