Wikidata

(Q21106724)

English

Microtubule associated protein 1 light chain 3 alpha

mammalian protein found in Homo sapiens

  • microtubule-associated proteins 1A/1B light chain 3A
  • Autophagy-related protein LC3 A
  • autophagy-related ubiquitin-like modifier LC3 A
  • MAP1 light chain 3-like protein 1
  • microtubule-associated proteins 1A/1B light chain 3
  • MAP1A/MAP1B light chain 3 A
  • MAP1A/MAP1B LC3 A
  • MAP1LC3A
  • Microtubule-associated protein 1 light chain 3 alpha
  • MAP1A/1B light chain 3 A
  • MAP1LC3A protein, human
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No label defined

No description defined

Statements

molecular function
protein binding
determination method
IPI
18 references
retrieved
9 May 2019
stated in
Rab GTPase-activating proteins in autophagy: regulation of endocytic and autophagy pathways by direct binding to human ATG8 modifiers
GOA
curator
UniProt
UniProt protein ID
Q9H492
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H492
determination method
IPI
retrieved
9 May 2019
stated in
TRIM-mediated precision autophagy targets cytoplasmic regulators of innate immunity
GOA
curator
UniProt
UniProt protein ID
Q9H492
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H492
determination method
IPI
retrieved
9 May 2019
stated in
DOR/Tp53inp2 and Tp53inp1 constitute a metazoan gene family encoding dual regulators of autophagy and transcription
GOA
curator
UniProt
UniProt protein ID
Q9H492
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H492
determination method
IPI
retrieved
9 May 2019
stated in
The TP53INP2 protein is required for autophagy in mammalian cells
GOA
curator
UniProt
UniProt protein ID
Q9H492
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H492
determination method
IPI
retrieved
9 May 2019
stated in
TRIM proteins regulate autophagy and can target autophagic substrates by direct recognition
GOA
curator
UniProt
UniProt protein ID
Q9H492
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H492
determination method
IPI
retrieved
9 May 2019
stated in
Mitochondrial outer-membrane protein FUNDC1 mediates hypoxia-induced mitophagy in mammalian cells
GOA
curator
UniProt
UniProt protein ID
Q9H492
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H492
determination method
IPI
retrieved
9 May 2019
stated in
Ubiquilin4 is an adaptor protein that recruits Ubiquilin1 to the autophagy machinery
GOA
curator
UniProt
UniProt protein ID
Q9H492
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H492
determination method
IPI
retrieved
9 May 2019
stated in
The human homolog of Saccharomyces cerevisiae Apg7p is a Protein-activating enzyme for multiple substrates including human Apg12p, GATE-16, GABARAP, and MAP-LC3
GOA
curator
UniProt
UniProt protein ID
Q9H492
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H492
determination method
IPI
retrieved
9 May 2019
stated in
p62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy
GOA
curator
UniProt
UniProt protein ID
Q9H492
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H492
determination method
IPI
retrieved
9 May 2019
stated in
Phosphorylation of the autophagy receptor optineurin restricts Salmonella growth
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H492
determination method
IPI
retrieved
9 May 2019
stated in
Autophagic clearance of polyQ proteins mediated by ubiquitin-Atg8 adaptors of the conserved CUET protein family
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H492
determination method
IPI
retrieved
9 May 2019
stated in
A proteome-scale map of the human interactome network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H492
determination method
IPI
retrieved
9 May 2019
stated in
A role for NBR1 in autophagosomal degradation of ubiquitinated substrates
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H492
determination method
IPI
retrieved
9 May 2019
stated in
Network organization of the human autophagy system
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H492
determination method
IPI
retrieved
9 May 2019
stated in
Interactions with LC3 and polyubiquitin chains link nbr1 to autophagic protein turnover
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H492
determination method
IPI
retrieved
9 May 2019
stated in
Nix is a selective autophagy receptor for mitochondrial clearance
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H492
determination method
IPI
retrieved
9 May 2019
stated in
Ubiquilin4 is an adaptor protein that recruits Ubiquilin1 to the autophagy machinery
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H492
determination method
IPI
retrieved
9 May 2019
stated in
Regulation of endoplasmic reticulum turnover by selective autophagy
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H492
determination method
IPI
cell component
autophagosome
determination method
IDA
IEA
9 references
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q9H492
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H492
determination method
IEA
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H492
determination method
IEA
retrieved
8 April 2019
stated in
Post-translational modifications of three members of the human MAP1LC3 family and detection of a novel type of modification for MAP1LC3B
GOA
curator
UniProt
UniProt protein ID
Q9H492
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H492
determination method
IDA
retrieved
8 April 2019
stated in
TP53INP1, a tumor suppressor, interacts with LC3 and ATG8-family proteins through the LC3-interacting region (LIR) and promotes autophagy-dependent cell death
GOA
curator
UniProt
UniProt protein ID
Q9H492
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H492
determination method
IDA
retrieved
8 April 2019
stated in
Human CLEC16A regulates autophagy through modulating mTOR activity
GOA
curator
UniProt
UniProt protein ID
Q9H492
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H492
determination method
IDA
retrieved
8 April 2019
stated in
HsAtg4B/HsApg4B/autophagin-1 cleaves the carboxyl termini of three human Atg8 homologues and delipidates microtubule-associated protein light chain 3- and GABAA receptor-associated protein-phospholipid conjugates
GOA
curator
UniProt
UniProt protein ID
Q9H492
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H492
determination method
IDA
retrieved
8 April 2019
stated in
The TP53INP2 protein is required for autophagy in mammalian cells
GOA
curator
UniProt
UniProt protein ID
Q9H492
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H492
determination method
IDA
retrieved
8 April 2019
stated in
Dynamic and transient interactions of Atg9 with autophagosomes, but not membrane integration, are required for autophagy.
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H492
determination method
IDA
retrieved
8 April 2019
stated in
WIPI2 links LC3 conjugation with PI3P, autophagosome formation, and pathogen clearance by recruiting Atg12-5-16L1.
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H492
determination method
IDA
autophagosome
determination method
IBA
IDA
IEA
10 references
retrieved
9 May 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q9H492
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H492
determination method
IEA
retrieved
9 May 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H492
determination method
IEA
retrieved
9 May 2019
stated in
TP53INP1, a tumor suppressor, interacts with LC3 and ATG8-family proteins through the LC3-interacting region (LIR) and promotes autophagy-dependent cell death
GOA
curator
UniProt
UniProt protein ID
Q9H492
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H492
determination method
IDA
retrieved
9 May 2019
stated in
HsAtg4B/HsApg4B/autophagin-1 cleaves the carboxyl termini of three human Atg8 homologues and delipidates microtubule-associated protein light chain 3- and GABAA receptor-associated protein-phospholipid conjugates
GOA
curator
UniProt
UniProt protein ID
Q9H492
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H492
determination method
IDA
retrieved
9 May 2019
stated in
Human CLEC16A regulates autophagy through modulating mTOR activity
GOA
curator
UniProt
UniProt protein ID
Q9H492
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H492
determination method
IDA
retrieved
9 May 2019
stated in
Post-translational modifications of three members of the human MAP1LC3 family and detection of a novel type of modification for MAP1LC3B
GOA
curator
UniProt
UniProt protein ID
Q9H492
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H492
determination method
IDA
retrieved
9 May 2019
stated in
The TP53INP2 protein is required for autophagy in mammalian cells
GOA
curator
UniProt
UniProt protein ID
Q9H492
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H492
determination method
IDA
retrieved
9 May 2019
stated in
Dynamic and transient interactions of Atg9 with autophagosomes, but not membrane integration, are required for autophagy.
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H492
determination method
IDA
retrieved
9 May 2019
stated in
WIPI2 links LC3 conjugation with PI3P, autophagosome formation, and pathogen clearance by recruiting Atg12-5-16L1.
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H492
determination method
IDA
retrieved
9 May 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H492
determination method
IBA
biological process

Identifiers

MeSH descriptor ID
C477012
subject named as
MAP1LC3A protein, human
0 references
 
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