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Vav guanine nucleotide exchange factor 3
mammalian protein found in Homo sapiens
vav 3 oncogene
guanine nucleotide exchange factor VAV3
VAV-3
VAV3
vav 3 guanine nucleotide exchange factor
In more languages
edit
Statements
instance of
protein
1 reference
stated in
UniProt
retrieved
13 November 2019
UniProt protein ID
Q9UKW4
part of
SH3-like domain superfamily
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/Q9UKW4
CH domain superfamily
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/Q9UKW4
SH2 domain superfamily
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/Q9UKW4
Dbl homology (DH) domain superfamily
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/Q9UKW4
PH-like domain superfamily
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/Q9UKW4
smooth muscle protein/calponin
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/Q9UKW4
pleckstrin homology domain, protein family
1 reference
based on heuristic
inferred from protein domain or family
SH2 domain, protein family
1 reference
based on heuristic
inferred from protein domain or family
Protein kinase C-like, phorbol ester/diacylglycerol-binding domain, protein family
1 reference
based on heuristic
inferred from protein domain or family
VAV3 protein, second SH3 domain, protein family
1 reference
based on heuristic
inferred from protein domain or family
Vav, PH domain, protein family
1 reference
based on heuristic
inferred from protein domain or family
Calmodulin-regulated spectrin-associated protein, CH domain, protein family
1 reference
based on heuristic
inferred from protein domain or family
Calponin homology domain, protein family
1 reference
based on heuristic
inferred from protein domain or family
VAV3, SH2 domain, protein family
1 reference
based on heuristic
inferred from protein domain or family
Dbl homology (DH) domain, protein family
1 reference
based on heuristic
inferred from protein domain or family
SH3 domain, protein family
1 reference
based on heuristic
inferred from protein domain or family
Guanine-nucleotide dissociation stimulator, CDC24, conserved site, protein family
1 reference
based on heuristic
inferred from protein domain or family
found in taxon
Homo sapiens
1 reference
stated in
UniProt
retrieved
13 November 2019
UniProt protein ID
Q9UKW4
encoded by
VAV3
1 reference
stated in
UniProt
retrieved
13 November 2019
UniProt protein ID
Q9UKW4
molecular function
protein binding
determination method
IPI
6 references
retrieved
8 April 2019
stated in
A proteomics strategy to elucidate functional protein-protein interactions applied to EGF signaling
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKW4
determination method
IPI
retrieved
8 April 2019
stated in
Identification of multi-SH3 domain-containing protein interactome in pancreatic cancer: a yeast two-hybrid approach
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKW4
determination method
IPI
retrieved
8 April 2019
stated in
Selected reaction monitoring mass spectrometry reveals the dynamics of signaling through the GRB2 adaptor
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKW4
determination method
IPI
retrieved
8 April 2019
stated in
Enhanced prediction of Src homology 2 (SH2) domain binding potentials using a fluorescence polarization-derived c-Met, c-Kit, ErbB, and androgen receptor interactome
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKW4
determination method
IPI
retrieved
8 April 2019
stated in
A human MAP kinase interactome
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKW4
determination method
IPI
retrieved
8 April 2019
stated in
Constitutive c-jun N-terminal kinase activity in acute myeloid leukemia derives from Flt3 and affects survival and proliferation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKW4
determination method
IPI
metal ion binding
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q9UKW4
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKW4
determination method
IEA
epidermal growth factor receptor binding
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKW4
determination method
IEA
GTPase activator activity
determination method
TAS
1 reference
retrieved
8 April 2019
stated in
Biological and regulatory properties of Vav-3, a new member of the Vav family of oncoproteins
GOA
curator
Proteome Inc.
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKW4
determination method
TAS
guanyl-nucleotide exchange factor activity
determination method
EXP
TAS
IEA
5 references
retrieved
8 April 2019
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKW4
determination method
TAS
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q9UKW4
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKW4
determination method
IEA
retrieved
8 April 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKW4
determination method
IEA
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKW4
determination method
IEA
retrieved
8 April 2019
stated in
Phosphotyrosine-dependent activation of Rac-1 GDP/GTP exchange by the vav proto-oncogene product
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKW4
determination method
EXP
cell component
cytoplasm
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKW4
determination method
IEA
cytosol
determination method
TAS
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKW4
determination method
TAS
plasma membrane
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKW4
determination method
IEA
biological process
angiogenesis
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q9UKW4
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKW4
determination method
IEA
Fc-gamma receptor signaling pathway involved in phagocytosis
determination method
TAS
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKW4
determination method
TAS
intracellular signal transduction
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKW4
determination method
IEA
ephrin receptor signaling pathway
determination method
TAS
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKW4
determination method
TAS
lamellipodium assembly
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKW4
determination method
IEA
regulation of Rho protein signal transduction
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKW4
determination method
IEA
positive regulation of phosphatidylinositol 3-kinase activity
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKW4
determination method
IEA
vascular endothelial growth factor receptor signaling pathway
determination method
TAS
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKW4
determination method
TAS
small GTPase mediated signal transduction
determination method
TAS
IEA
2 references
retrieved
8 April 2019
stated in
Biological and regulatory properties of Vav-3, a new member of the Vav family of oncoproteins
GOA
curator
Proteome Inc.
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKW4
determination method
TAS
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKW4
determination method
IEA
B cell receptor signaling pathway
determination method
IMP
1 reference
retrieved
8 April 2019
stated in
ATM, CTLA4, MNDA, and HEM1 in high versus low CD38 expressing B-cell chronic lymphocytic leukemia
GOA
curator
UniProt
UniProt protein ID
Q9UKW4
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKW4
determination method
IMP
cell projection assembly
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKW4
determination method
IEA
Fc-epsilon receptor signaling pathway
determination method
TAS
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKW4
determination method
TAS
positive regulation of apoptotic process
determination method
TAS
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKW4
determination method
TAS
integrin-mediated signaling pathway
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKW4
determination method
IEA
cellular response to DNA damage stimulus
determination method
IMP
1 reference
retrieved
8 April 2019
stated in
ATM, CTLA4, MNDA, and HEM1 in high versus low CD38 expressing B-cell chronic lymphocytic leukemia
GOA
curator
UniProt
UniProt protein ID
Q9UKW4
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKW4
determination method
IMP
regulation of cell size
determination method
IGI
1 reference
retrieved
8 April 2019
stated in
Radixin regulates cell migration and cell-cell adhesion through Rac1
GOA
curator
UniProt
UniProt protein ID
Q9UKW4
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKW4
determination method
IGI
regulation of small GTPase mediated signal transduction
determination method
TAS
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKW4
determination method
TAS
cell migration
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKW4
determination method
IEA
platelet activation
determination method
TAS
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKW4
determination method
TAS
vesicle fusion
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKW4
determination method
IEA
positive regulation of cell adhesion
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKW4
determination method
IEA
positive regulation of B cell proliferation
determination method
IMP
1 reference
retrieved
8 April 2019
stated in
ATM, CTLA4, MNDA, and HEM1 in high versus low CD38 expressing B-cell chronic lymphocytic leukemia
GOA
curator
UniProt
UniProt protein ID
Q9UKW4
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKW4
determination method
IMP
neutrophil chemotaxis
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKW4
determination method
IEA
regulation of GTPase activity
determination method
IGI
IEA
2 references
retrieved
8 April 2019
stated in
Radixin regulates cell migration and cell-cell adhesion through Rac1
GOA
curator
UniProt
UniProt protein ID
Q9UKW4
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKW4
determination method
IGI
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKW4
determination method
IEA
positive regulation of signal transduction
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Gene Ontology Consortium
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKW4
determination method
IEA
positive regulation of GTPase activity
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Gene Ontology Consortium
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKW4
determination method
IEA
G protein-coupled receptor signaling pathway
determination method
TAS
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKW4
determination method
TAS
has part(s)
Dbl homology (DH) domain
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/Q9UKW4
SH3 domain
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/Q9UKW4
Calmodulin-regulated spectrin-associated protein, CH domain
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/Q9UKW4
pleckstrin homology domain
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/Q9UKW4
SH2 domain
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/Q9UKW4
protein kinase C-like, phorbol ester/diacylglycerol-binding domain
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/Q9UKW4
Guanine-nucleotide dissociation stimulator, CDC24, conserved site
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/Q9UKW4
Calponin homology domain
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/Q9UKW4
VAV3 protein, second SH3 domain
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/Q9UKW4
VAV3, SH2 domain
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/Q9UKW4
Vav, PH domain
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/Q9UKW4
Identifiers
RefSeq protein ID
NP_001073343
1 reference
stated in
NCBI Gene
retrieved
30 May 2020
Entrez Gene ID
10451
NP_006104
1 reference
stated in
NCBI Gene
retrieved
30 May 2020
Entrez Gene ID
10451
XP_005270417
1 reference
stated in
NCBI Gene
retrieved
30 May 2020
Entrez Gene ID
10451
XP_005270418
1 reference
stated in
NCBI Gene
retrieved
30 May 2020
Entrez Gene ID
10451
XP_016855542
1 reference
stated in
NCBI Gene
retrieved
30 May 2020
Entrez Gene ID
10451
XP_016855543
1 reference
stated in
NCBI Gene
retrieved
30 May 2020
Entrez Gene ID
10451
XP_016855544
1 reference
stated in
NCBI Gene
retrieved
30 May 2020
Entrez Gene ID
10451
XP_016855545
1 reference
stated in
NCBI Gene
retrieved
30 May 2020
Entrez Gene ID
10451
XP_024306087
1 reference
stated in
NCBI Gene
retrieved
30 May 2020
Entrez Gene ID
10451
UniProt protein ID
Q9UKW4
1 reference
stated in
UniProt
retrieved
13 November 2019
UniProt protein ID
Q9UKW4
Ensembl protein ID
ENSP00000359073
1 reference
stated in
Ensembl Release 99
Ensembl protein ID
ENSP00000359073
ENSP00000394897
1 reference
stated in
Ensembl Release 99
Ensembl protein ID
ENSP00000394897
ENSP00000432540
1 reference
stated in
Ensembl Release 99
Ensembl protein ID
ENSP00000432540
ENSP00000431544
1 reference
stated in
Ensembl Release 99
Ensembl protein ID
ENSP00000431544
ENSP00000432865
1 reference
stated in
Ensembl Release 99
Ensembl protein ID
ENSP00000432865
ENSP00000433559
1 reference
stated in
Ensembl Release 99
Ensembl protein ID
ENSP00000433559
ENSP00000434944
1 reference
stated in
Ensembl Release 99
Ensembl protein ID
ENSP00000434944
PDB structure ID
2D86
1 reference
stated in
UniProt
UniProt protein ID
Q9UKW4
retrieved
4 August 2016
language of work or name
English
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