(Q21108440)

DNA (cytosine-5)-methyltransferase 3A

1 reference

PWWP domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

ADD domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

DNA methylase, C-5 cytosine-specific, active site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

25 May 2022

1 reference

25 May 2022

methyltransferase activity

3 references

14 February 2019

Dnmt3L cooperates with the Dnmt3 family of de novo DNA methyltransferases to establish maternal imprints in mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88508

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88508

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88508

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88508

5 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88508

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88508

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88508

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88508

14 February 2019

Enzymatic properties of recombinant Dnmt3a DNA methyltransferase from mouse: the enzyme modifies DNA in a non-processive manner and also methylates non-CpG [correction of non-CpA] sites

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88508

DNA-methyltransferase activity

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88508

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88508

6 references

14 February 2019

Modification of de novo DNA methyltransferase 3a (Dnmt3a) by SUMO-1 modulates its interaction with histone deacetylases (HDACs) and its capacity to repress transcription

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88508

14 February 2019

Roles of Mis18α in epigenetic regulation of centromeric chromatin and CENP-A loading

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88508

14 February 2019

Synergistic function of DNA methyltransferases Dnmt3a and Dnmt3b in the methylation of Oct4 and Nanog

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88508

14 February 2019

Physical and functional interaction of DNA methyltransferase 3A with Mbd3 and Brg1 in mouse lymphosarcoma cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88508

14 February 2019

Dnmt3L antagonizes DNA methylation at bivalent promoters and favors DNA methylation at gene bodies in ESCs

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88508

14 February 2019

Lsh is involved in de novo methylation of DNA

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88508

DNA (cytosine-5-)-methyltransferase activity

IPI

7 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88508

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88508

14 February 2019

Synergistic function of DNA methyltransferases Dnmt3a and Dnmt3b in the methylation of Oct4 and Nanog

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88508

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88508

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88508

14 February 2019

Enzymatic properties of recombinant Dnmt3a DNA methyltransferase from mouse: the enzyme modifies DNA in a non-processive manner and also methylates non-CpG [correction of non-CpA] sites

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88508

14 February 2019

Cloning and characterization of a family of novel mammalian DNA (cytosine-5) methyltransferases

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88508

DNA (cytosine-5-)-methyltransferase activity, acting on CpN substrates

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88508

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88508

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88508

14 February 2019

Physical and functional interaction of DNA methyltransferase 3A with Mbd3 and Brg1 in mouse lymphosarcoma cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88508

RNA polymerase II cis-regulatory region sequence-specific DNA binding

1 reference

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O88508&geneProductId=UniProtKB:O88508

transcription factor binding

1 reference

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O88508&geneProductId=UniProtKB:O88508

5 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88508

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88508

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88508

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88508

14 February 2019

DNA methyltransferase expression in the mouse germ line during periods of de novo methylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88508

3 references

3 references

3 references

1 reference

14 February 2019

Physical and functional interaction of DNA methyltransferase 3A with Mbd3 and Brg1 in mouse lymphosarcoma cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88508

1 reference

14 February 2019

Defective imprint resetting in carriers of Robertsonian translocation Rb (8.12)

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88508

chromosome, centromeric region

1 reference

14 February 2019

The PWWP domain of Dnmt3a and Dnmt3b is required for directing DNA methylation to the major satellite repeats at pericentric heterochromatin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88508

6 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88508

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88508

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88508

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88508

14 February 2019

Modification of de novo DNA methyltransferase 3a (Dnmt3a) by SUMO-1 modulates its interaction with histone deacetylases (HDACs) and its capacity to repress transcription

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88508

14 February 2019

Defective imprint resetting in carriers of Robertsonian translocation Rb (8.12)

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88508

regulation of gene expression by genetic imprinting

biological process

3 references

24 April 2018

Dnmt3L cooperates with the Dnmt3 family of de novo DNA methyltransferases to establish maternal imprints in mice

http://www.ebi.ac.uk/QuickGO/annotations?protein=O88508&geneProductId=UniProtKB:O88508

24 April 2018

Essential role for de novo DNA methyltransferase Dnmt3a in paternal and maternal imprinting

http://www.ebi.ac.uk/QuickGO/annotations?protein=O88508&geneProductId=UniProtKB:O88508

24 April 2018

Phosphatidylinositol 3-kinase (PI3K) signaling via glycogen synthase kinase-3 (Gsk-3) regulates DNA methylation of imprinted loci

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=O88508&geneProductId=UniProtKB:O88508

response to ionizing radiation

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88508

response to estradiol

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88508

regulation of transcription, DNA-templated

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O88508&geneProductId=UniProtKB:O88508

maintenance of DNA methylation

1 reference

24 April 2018

Phosphatidylinositol 3-kinase (PI3K) signaling via glycogen synthase kinase-3 (Gsk-3) regulates DNA methylation of imprinted loci

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=O88508&geneProductId=UniProtKB:O88508

cellular response to ethanol

TAS

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88508

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88508

negative regulation of transcription by RNA polymerase II

1 reference

24 April 2018

Physical and functional interaction of DNA methyltransferase 3A with Mbd3 and Brg1 in mouse lymphosarcoma cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=O88508&geneProductId=UniProtKB:O88508

DNA methylation involved in gamete generation

1 reference

14 February 2019

Essential role for de novo DNA methyltransferase Dnmt3a in paternal and maternal imprinting

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88508

transcription, DNA-templated

IMP

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O88508&geneProductId=UniProtKB:O88508

response to vitamin A

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88508

7 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88508

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88508

14 February 2019

Synergistic function of DNA methyltransferases Dnmt3a and Dnmt3b in the methylation of Oct4 and Nanog

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88508

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88508

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88508

14 February 2019

Enzymatic properties of recombinant Dnmt3a DNA methyltransferase from mouse: the enzyme modifies DNA in a non-processive manner and also methylates non-CpG [correction of non-CpA] sites

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88508

14 February 2019

Dnmt3L cooperates with the Dnmt3 family of de novo DNA methyltransferases to establish maternal imprints in mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88508

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88508

response to nutrient levels

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88508

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88508

DNA methylation-dependent heterochromatin assembly

1 reference

14 February 2019

Dnmt3L cooperates with the Dnmt3 family of de novo DNA methyltransferases to establish maternal imprints in mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88508

IMP

neuron differentiation

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88508

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88508

cellular response to amino acid stimulus

1 reference

14 February 2019

Difference in expression of hepatic microRNAs miR-29c, miR-34a, miR-155, and miR-200b is associated with strain-specific susceptibility to dietary nonalcoholic steatohepatitis in mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88508

regulation of gene expression

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88508

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88508

response to toxic substance

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88508

cellular response to hypoxia

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88508

hepatocyte apoptotic process

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88508

hypermethylation of CpG island

1 reference

24 April 2018

Phosphatidylinositol 3-kinase (PI3K) signaling via glycogen synthase kinase-3 (Gsk-3) regulates DNA methylation of imprinted loci

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=O88508&geneProductId=UniProtKB:O88508

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88508

DNA methylation involved in embryo development

3 references

14 February 2019

Essential role for de novo DNA methyltransferase Dnmt3a in paternal and maternal imprinting

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88508

14 February 2019

A tripartite paternally methylated region within the Gpr1-Zdbf2 imprinted domain on mouse chromosome 1 identified by meDIP-on-chip

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88508

14 February 2019

DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88508

C-5 methylation of cytosine

IGI

1 reference

14 February 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88508

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88508

chromatin organization

1 reference

14 February 2019

negative regulation of transcription by RNA polymerase II

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88508

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88508

14 February 2019

Physical and functional interaction of DNA methyltransferase 3A with Mbd3 and Brg1 in mouse lymphosarcoma cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88508

1 reference

ADD domain

1 reference

DNA methylase, C-5 cytosine-specific, active site

1 reference