Wikidata

(Q21109354)

English

SRC proto-oncogene, non-receptor tyrosine kinase

mammalian protein found in Homo sapiens

  • pp60c-src
  • tyrosine kinase pp60c-src
  • SRC
  • v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog
  • tyrosine-protein kinase SRC-1
  • p60-Src
  • proto-oncogene c-Src
  • proto-oncogene tyrosine-protein kinase Src
  • protooncogene SRC, Rous sarcoma
In more languages

Statements

image
PBB Protein SRC image.jpg
500 × 500; 38 KB
0 references
molecular function
protein binding
determination method
IPI
103 references
retrieved
8 April 2019
stated in
Molecular chaperone TRAP1 regulates a metabolic switch between mitochondrial respiration and aerobic glycolysis
GOA
curator
UniProt
UniProt protein ID
P12931
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931
determination method
IPI
retrieved
8 April 2019
stated in
Reversion-induced LIM interaction with Src reveals a novel Src inactivation cycle
GOA
curator
UniProt
UniProt protein ID
P12931
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931
determination method
IPI
retrieved
8 April 2019
stated in
The adaptor protein Tom1L1 is a negative regulator of Src mitogenic signaling induced by growth factors
GOA
curator
UniProt
UniProt protein ID
P12931
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931
determination method
IPI
retrieved
8 April 2019
stated in
LPS induces pp60c-src-mediated tyrosine phosphorylation of Hsp90 in lung vascular endothelial cells and mouse lung
GOA
curator
UniProt
UniProt protein ID
P12931
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931
determination method
IPI
retrieved
8 April 2019
stated in
PRR7 is a transmembrane adaptor protein expressed in activated T cells involved in regulation of T cell receptor signaling and apoptosis
GOA
curator
UniProt
UniProt protein ID
P12931
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931
determination method
IPI
retrieved
8 April 2019
stated in
Src kinase phosphorylates RUNX3 at tyrosine residues and localizes the protein in the cytoplasm
GOA
curator
UniProt
UniProt protein ID
P12931
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931
determination method
IPI
retrieved
8 April 2019
stated in
Leptin enhances the potency of circulating angiogenic cells via src kinase and integrin (alpha)vbeta5: implications for angiogenesis in human obesity
GOA
curator
UniProt
UniProt protein ID
P12931
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931
determination method
IPI
retrieved
8 April 2019
stated in
The tyrosine kinase c-Src enhances RIG-I (retinoic acid-inducible gene I)-elicited antiviral signaling
GOA
curator
UniProt
UniProt protein ID
P12931
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931
determination method
IPI
retrieved
8 April 2019
stated in
A novel signaling molecule, p130, forms stable complexes in vivo with v-Crk and v-Src in a tyrosine phosphorylation-dependent manner
GOA
curator
UniProt
UniProt protein ID
P12931
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931
determination method
IPI
retrieved
8 April 2019
stated in
Tau interacts with src-family non-receptor tyrosine kinases
GOA
curator
UniProt
UniProt protein ID
P12931
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931
determination method
IPI
retrieved
8 April 2019
stated in
Crystal structure of the conserved core of HIV-1 Nef complexed with a Src family SH3 domain
GOA
curator
UniProt
UniProt protein ID
P12931
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931
determination method
IPI
retrieved
8 April 2019
stated in
Association of pp60c-src with biliary glycoprotein (CD66a), an adhesion molecule of the carcinoembryonic antigen family downregulated in colorectal carcinomas
GOA
curator
UniProt
UniProt protein ID
P12931
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931
determination method
IPI
retrieved
8 April 2019
stated in
The PDZ protein MPP2 interacts with c-Src in epithelial cells
GOA
curator
UniProt
UniProt protein ID
P12931
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931
determination method
IPI
retrieved
8 April 2019
stated in
c-Src regulates Akt signaling in response to ghrelin via beta-arrestin signaling-independent and -dependent mechanisms
GOA
curator
UniProt
UniProt protein ID
P12931
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931
determination method
IPI
retrieved
8 April 2019
stated in
Src homology 2 (SH2) domain containing protein tyrosine phosphatase-1 (SHP-1) dephosphorylates VEGF Receptor-2 and attenuates endothelial DNA synthesis, but not migration
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931
determination method
IPI
retrieved
8 April 2019
stated in
Nuclear PKM2 regulates β-catenin transactivation upon EGFR activation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931
determination method
IPI
retrieved
8 April 2019
stated in
NKX2-1/TITF1/TTF-1-Induced ROR1 is required to sustain EGFR survival signaling in lung adenocarcinoma
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931
determination method
IPI
retrieved
8 April 2019
stated in
VHL loss in renal cell carcinoma leads to up-regulation of CUB domain-containing protein 1 to stimulate PKC{delta}-driven migration
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931
determination method
IPI
retrieved
8 April 2019
stated in
c-Src is a PDZ interaction partner and substrate of the E3 ubiquitin ligase Ligand-of-Numb protein X1
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931
determination method
IPI
retrieved
8 April 2019
stated in
Recombinant human erythropoietin antagonizes trastuzumab treatment of breast cancer cells via Jak2-mediated Src activation and PTEN inactivation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931
determination method
IPI
retrieved
8 April 2019
stated in
Functional interaction between c-Src and its mitotic target, Sam 68
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931
determination method
IPI
retrieved
8 April 2019
stated in
Oncogenic association of the Cbp/PAG adaptor protein with the Lyn tyrosine kinase in human B-NHL rafts
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931
determination method
IPI
retrieved
8 April 2019
stated in
Involvement of Src tyrosine kinase in Escherichia coli invasion of human brain microvascular endothelial cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931
determination method
IPI
retrieved
8 April 2019
stated in
A human protein-protein interaction network: a resource for annotating the proteome
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931
determination method
IPI
retrieved
8 April 2019
stated in
Platelet endothelial cell adhesion molecule-1 is phosphorylatable by c-Src, binds Src-Src homology 2 domain, and exhibits immunoreceptor tyrosine-based activation motif-like properties
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931
determination method
IPI
retrieved
8 April 2019
stated in
The mammalian-membrane two-hybrid assay (MaMTH) for probing membrane-protein interactions in human cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931
determination method
IPI
retrieved
8 April 2019
stated in
Cbl associates with Pyk2 and Src to regulate Src kinase activity, alpha(v)beta(3) integrin-mediated signaling, cell adhesion, and osteoclast motility
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931
determination method
IPI
retrieved
8 April 2019
stated in
The SRC-associated protein CUB Domain-Containing Protein-1 regulates adhesion and motility
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931
determination method
IPI
retrieved
8 April 2019
stated in
Identification of preferred protein interactions by phage-display of the human Src homology-3 proteome
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931
determination method
IPI
retrieved
8 April 2019
stated in
An inherent role of microtubule network in the action of nuclear receptor
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931
determination method
IPI
retrieved
8 April 2019
stated in
The neurotransmitter dopamine modulates vascular permeability in the endothelium
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931
determination method
IPI
retrieved
8 April 2019
stated in
Magicin associates with the Src-family kinases and is phosphorylated upon CD3 stimulation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931
determination method
IPI
retrieved
8 April 2019
stated in
Mitochondrial AKAP121 binds and targets protein tyrosine phosphatase D1, a novel positive regulator of src signaling
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931
determination method
IPI
retrieved
8 April 2019
stated in
Translationally controlled tumor protein induces human breast epithelial cell transformation through the activation of Src
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931
determination method
IPI
retrieved
8 April 2019
stated in
Functional role of c-Src in IL-1-induced NF-kappa B activation: c-Src is a component of the IKK complex
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931
determination method
IPI
retrieved
8 April 2019
stated in
Rack1 promotes epithelial cell-cell adhesion by regulating E-cadherin endocytosis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931
determination method
IPI
retrieved
8 April 2019
stated in
Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931
determination method
IPI
retrieved
8 April 2019
stated in
ErbB2-mediated Src and signal transducer and activator of transcription 3 activation leads to transcriptional up-regulation of p21Cip1 and chemoresistance in breast cancer cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931
determination method
IPI
retrieved
8 April 2019
stated in
JMJD6 regulates ERα methylation on arginine
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931
determination method
IPI
retrieved
8 April 2019
stated in
Role of beta-arrestin 1 in the metastatic progression of colorectal cancer
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931
determination method
IPI
retrieved
8 April 2019
stated in
Structural basis for a novel intrapeptidyl H-bond and reverse binding of c-Cbl-TKB domain substrates
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931
determination method
IPI
retrieved
8 April 2019
stated in
Variant estrogen receptor-c-Src molecular interdependence and c-Src structural requirements for endothelial NO synthase activation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931
determination method
IPI
retrieved
8 April 2019
stated in
Deficiency of a beta-arrestin-2 signal complex contributes to insulin resistance.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931
determination method
IPI
retrieved
8 April 2019
stated in
The role of protein-tyrosine phosphatase 1B in integrin signaling
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931
determination method
IPI
retrieved
8 April 2019
stated in
Targeting AMAP1 and cortactin binding bearing an atypical src homology 3/proline interface for prevention of breast cancer invasion and metastasis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931
determination method
IPI
retrieved
8 April 2019
stated in
FAK-MAPK-dependent adhesion disassembly downstream of L1 contributes to semaphorin3A-induced collapse
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931
determination method
IPI
retrieved
8 April 2019
stated in
PI3-kinase/Akt-dependent antiapoptotic signaling by the PDGF alpha receptor is negatively regulated by Src family kinases
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931
determination method
IPI
retrieved
8 April 2019
stated in
Identification and functional characterization of an Src homology domain 3 domain-binding site on Cbl
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931
determination method
IPI
retrieved
8 April 2019
stated in
Phosphorylation of Tyr1214 within VEGFR-2 triggers the recruitment of Nck and activation of Fyn leading to SAPK2/p38 activation and endothelial cell migration in response to VEGF
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931
determination method
IPI
retrieved
8 April 2019
stated in
Dosage-dependent switch from G protein-coupled to G protein-independent signaling by a GPCR
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931
determination method
IPI
retrieved
8 April 2019
stated in
Metalloproteinase/Presenilin1 processing of ephrinB regulates EphB-induced Src phosphorylation and signaling
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931
determination method
IPI
retrieved
8 April 2019
stated in
Multiple phosphorylation of chicken protein tyrosine phosphatase 1 and human protein tyrosine phosphatase 1B by casein kinase II and p60c-src in vitro
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931
determination method
IPI
retrieved
8 April 2019
stated in
ErbB-2 activates Stat3 alpha in a Src- and JAK2-dependent manner
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931
determination method
IPI
retrieved
8 April 2019
stated in
Phosphorylation of ETS1 by Src family kinases prevents its recognition by the COP1 tumor suppressor
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931
determination method
IPI
retrieved
8 April 2019
stated in
Bcr-Abl stabilizes beta-catenin in chronic myeloid leukemia through its tyrosine phosphorylation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931
determination method
IPI
retrieved
8 April 2019
stated in
EGFR-mediated Beclin 1 phosphorylation in autophagy suppression, tumor progression, and tumor chemoresistance
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931
determination method
IPI
retrieved
8 April 2019
stated in
Cysteine mutations cause defective tyrosine phosphorylation in MEGF10 myopathy
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931
determination method
IPI
retrieved
8 April 2019
stated in
A quantitative protein interaction network for the ErbB receptors using protein microarrays
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931
determination method
IPI
retrieved
8 April 2019
stated in
Simultaneous assay of Src SH3 and SH2 domain binding using different wavelength fluorescence polarization probes
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931
determination method
IPI
retrieved
8 April 2019
stated in
Cyanidin-3-glucoside inhibits ethanol-induced invasion of breast cancer cells overexpressing ErbB2
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931
determination method
IPI
retrieved
8 April 2019
stated in
Negative regulation of PYK2/related adhesion focal tyrosine kinase signal transduction by hematopoietic tyrosine phosphatase SHPTP1
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931
determination method
IPI
retrieved
8 April 2019
stated in
The tyrosine phosphatase 1B regulates linker for activation of T-cell phosphorylation and platelet aggregation upon FcgammaRIIa cross-linking
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931
determination method
IPI
retrieved
8 April 2019
stated in
Beta-arrestin1 phosphorylation by GRK5 regulates G protein-independent 5-HT4 receptor signalling
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931
determination method
IPI
retrieved
8 April 2019
stated in
Integrin/Fak/Src-mediated regulation of cell survival and anoikis in human intestinal epithelial crypt cells: selective engagement and roles of PI3-K isoform complexes
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931
determination method
IPI
retrieved
8 April 2019
stated in
Identification of protein-tyrosine phosphatase 1B as the major tyrosine phosphatase activity capable of dephosphorylating and activating c-Src in several human breast cancer cell lines
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931
determination method
IPI
retrieved
8 April 2019
stated in
Phosphorylation-dependent interactions between ADAM15 cytoplasmic domain and Src family protein-tyrosine kinases
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931
determination method
IPI
retrieved
8 April 2019
stated in
Phospho-tyrosine dependent protein-protein interaction network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931
determination method
IPI
retrieved
8 April 2019
stated in
The rat tyrosine phosphatase eta increases cell adhesion by activating c-Src through dephosphorylation of its inhibitory phosphotyrosine residue
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931
determination method
IPI
retrieved
8 April 2019
stated in
Ribosomal protein L10 interacts with the SH3 domain and regulates GDNF-induced neurite growth in SH-SY-5y cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931
determination method
IPI
retrieved
8 April 2019
stated in
Characterization of the interactions of estrogen receptor and MNAR in the activation of cSrc
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931
determination method
IPI
retrieved
8 April 2019
stated in
Activation of rapid oestrogen signalling in aggressive human breast cancers
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931
determination method
IPI
retrieved
8 April 2019
stated in
Catalytically active membrane-distal phosphatase domain of receptor protein-tyrosine phosphatase alpha is required for Src activation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931
determination method
IPI
retrieved
8 April 2019
stated in
Small proline-rich proteins (SPRR) function as SH3 domain ligands, increase resistance to injury and are associated with epithelial-mesenchymal transition (EMT) in cholangiocytes
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931
determination method
IPI
retrieved
8 April 2019
stated in
Enhanced prediction of Src homology 2 (SH2) domain binding potentials using a fluorescence polarization-derived c-Met, c-Kit, ErbB, and androgen receptor interactome
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931
determination method
IPI
retrieved
8 April 2019
stated in
Ack1 mediates Cdc42-dependent cell migration and signaling to p130Cas
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931
determination method
IPI
retrieved
8 April 2019
stated in
Focal adhesion kinase overexpression enhances ras-dependent integrin signaling to ERK2/mitogen-activated protein kinase through interactions with and activation of c-Src
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931
determination method
IPI
retrieved
8 April 2019
stated in
A phosphotyrosine displacement mechanism for activation of Src by PTPalpha
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931
determination method
IPI
retrieved
8 April 2019
stated in
PTP1B contributes to the oncogenic properties of colon cancer cells through Src activation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931
determination method
IPI
retrieved
8 April 2019
stated in
Direct interaction between ER membrane-bound PTP1B and its plasma membrane-anchored targets
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931
determination method
IPI
retrieved
8 April 2019
stated in
Src kinase becomes preferentially associated with the VEGFR, KDR/Flk-1, following VEGF stimulation of vascular endothelial cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931
determination method
IPI
retrieved
8 April 2019
stated in
mda-9/Syntenin promotes metastasis in human melanoma cells by activating c-Src
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931
determination method
IPI
retrieved
8 April 2019
stated in
The Tensin-3 protein, including its SH2 domain, is phosphorylated by Src and contributes to tumorigenesis and metastasis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931
determination method
IPI
retrieved
8 April 2019
stated in
Yes and PI3K bind CD95 to signal invasion of glioblastoma
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931
determination method
IPI
retrieved
8 April 2019
stated in
Regulation of c-Src by binding to the PDZ domain of AF-6
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931
determination method
IPI
retrieved
8 April 2019
stated in
Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931
determination method
IPI
retrieved
8 April 2019
stated in
ARAP3 is transiently tyrosine phosphorylated in cells attaching to fibronectin and inhibits cell spreading in a RhoGAP-dependent manner
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931
determination method
IPI
retrieved
8 April 2019
stated in
A role for Pyk2 and Src in linking G-protein-coupled receptors with MAP kinase activation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931
determination method
IPI
retrieved
8 April 2019
stated in
EG-1 interacts with c-Src and activates its signaling pathway
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931
determination method
IPI
retrieved
8 April 2019
stated in
c-Src phosphorylation and activation of hexokinase promotes tumorigenesis and metastasis.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931
determination method
IPI
retrieved
8 April 2019
stated in
Platelet-endothelial cell adhesion molecule-1 (CD31), a scaffolding molecule for selected catenin family members whose binding is mediated by different tyrosine and serine/threonine phosphorylation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931
determination method
IPI
retrieved
8 April 2019
stated in
p140Cap protein suppresses tumour cell properties, regulating Csk and Src kinase activity
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931
determination method
IPI
retrieved
8 April 2019
stated in
Phosphorylated alpha-actinin and protein-tyrosine phosphatase 1B coregulate the disassembly of the focal adhesion kinase x Src complex and promote cell migration
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931
determination method
IPI
retrieved
8 April 2019
stated in
PTP-1B is an essential positive regulator of platelet integrin signaling
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931
determination method
IPI
retrieved
8 April 2019
stated in
Epidermal growth factor directs sex-specific steroid signaling through Src activation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931
determination method
IPI
retrieved
8 April 2019
stated in
Analysis of protein-protein interactions in cross-talk pathways reveals CRKL protein as a novel prognostic marker in hepatocellular carcinoma
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931
determination method
IPI
retrieved
8 April 2019
stated in
Beta-arrestin links endothelin A receptor to beta-catenin signaling to induce ovarian cancer cell invasion and metastasis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931
determination method
IPI
retrieved
8 April 2019
stated in
EGFR/Met association regulates EGFR TKI resistance in breast cancer
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931
determination method
IPI
retrieved
8 April 2019
stated in
Mitotic activation of protein-tyrosine phosphatase alpha and regulation of its Src-mediated transforming activity by its sites of protein kinase C phosphorylation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931
determination method
IPI
retrieved
8 April 2019
stated in
Structural characterization of autoinhibited c-Met kinase produced by coexpression in bacteria with phosphatase
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931
determination method
IPI
retrieved
8 April 2019
stated in
DOCK8 functions as an adaptor that links TLR-MyD88 signaling to B cell activation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931
determination method
IPI
retrieved
8 April 2019
stated in
Deciphering the cross talk between hnRNP K and c-Src: the c-Src activation domain in hnRNP K is distinct from a second interaction site
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931
determination method
IPI
retrieved
8 April 2019
stated in
A positive feedback loop of ER-α36/EGFR promotes malignant growth of ER-negative breast cancer cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931
determination method
IPI
retrieved
8 April 2019
stated in
XB130, a novel adaptor protein for signal transduction
GOA
curator
HUGO Gene Nomenclature Committee
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931
determination method
IPI
protein tyrosine kinase activity
determination method
EXP
IDA
IEA
IMP
TAS
19 references
retrieved
17 October 2017
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P12931&geneProductId=UniProtKB:P12931
determination method
TAS
retrieved
17 October 2017
stated in
Gbetagamma subunits mediate Src-dependent phosphorylation of the epidermal growth factor receptor. A scaffold for G protein-coupled receptor-mediated Ras activation
GOA
curator
Proteome Inc.
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P12931&geneProductId=UniProtKB:P12931
determination method
TAS
retrieved
17 October 2017
stated in
Lipid raft-associated β-adducin is required for PSGL-1-mediated neutrophil rolling on P-selectin
GOA
curator
Critical Assessment of Protein Function Annotation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P12931&geneProductId=UniProtKB:P12931
determination method
IMP
retrieved
17 October 2017
stated in
Tarp regulates early Chlamydia-induced host cell survival through interactions with the human adaptor protein SHC1
GOA
curator
Critical Assessment of Protein Function Annotation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P12931&geneProductId=UniProtKB:P12931
determination method
IMP
retrieved
17 October 2017
stated in
GOA
curator
UniProt
UniProt protein ID
P12931
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P12931&geneProductId=UniProtKB:P12931
determination method
IEA
retrieved
17 October 2017
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P12931&geneProductId=UniProtKB:P12931
determination method
IEA
retrieved
17 October 2017
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P12931&geneProductId=UniProtKB:P12931
determination method
IEA
retrieved
17 October 2017
stated in
PKCdelta-dependent functional switch of rpS3 between translation and DNA repair
GOA
curator
UniProt
UniProt protein ID
P12931
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P12931&geneProductId=UniProtKB:P12931
determination method
IDA
retrieved
17 October 2017
stated in
Crosstalk between Src and major vault protein in epidermal growth factor-dependent cell signalling
GOA
curator
UniProt
UniProt protein ID
P12931
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P12931&geneProductId=UniProtKB:P12931
determination method
IDA
retrieved
17 October 2017
stated in
Steel factor stimulates the tyrosine phosphorylation of the proto-oncogene product, p95vav, in human hemopoietic cells
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P12931&geneProductId=UniProtKB:P12931
determination method
EXP
retrieved
17 October 2017
stated in
Kit signaling through PI 3-kinase and Src kinase pathways: an essential role for Rac1 and JNK activation in mast cell proliferation
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P12931&geneProductId=UniProtKB:P12931
determination method
EXP
retrieved
17 October 2017
stated in
Vav2 is required for cell spreading
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P12931&geneProductId=UniProtKB:P12931
determination method
EXP
retrieved
17 October 2017
stated in
Src kinase phosphorylates RUNX3 at tyrosine residues and localizes the protein in the cytoplasm
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P12931&geneProductId=UniProtKB:P12931
determination method
EXP
retrieved
17 October 2017
stated in
Identification of Src-specific phosphorylation site on focal adhesion kinase: dissection of the role of Src SH2 and catalytic functions and their consequences for tumor cell behavior
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P12931&geneProductId=UniProtKB:P12931
determination method
EXP
retrieved
17 October 2017
stated in
A Src family kinase-Shp2 axis controls RUNX1 activity in megakaryocyte and T-lymphocyte differentiation
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P12931&geneProductId=UniProtKB:P12931
determination method
EXP
retrieved
17 October 2017
stated in
Gab2 is involved in differential phosphoinositide 3-kinase signaling by two splice forms of c-Kit
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P12931&geneProductId=UniProtKB:P12931
determination method
EXP
retrieved
17 October 2017
stated in
Differential involvement of Src family kinases in Fc gamma receptor-mediated phagocytosis
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P12931&geneProductId=UniProtKB:P12931
determination method
EXP
retrieved
17 October 2017
stated in
Differential kinase requirements in human and mouse Fc-gamma receptor phagocytosis and endocytosis
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P12931&geneProductId=UniProtKB:P12931
determination method
EXP
retrieved
17 October 2017
stated in
Tyrosyl phosphorylation of Shp2 is required for normal ERK activation in response to some, but not all, growth factors
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P12931&geneProductId=UniProtKB:P12931
determination method
EXP
protein tyrosine kinase activity
determination method
EXP
IDA
IEA
IMP
NAS
TAS
17 references
retrieved
8 April 2019
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931
determination method
TAS
retrieved
8 April 2019
stated in
Gbetagamma subunits mediate Src-dependent phosphorylation of the epidermal growth factor receptor. A scaffold for G protein-coupled receptor-mediated Ras activation
GOA
curator
Proteome Inc.
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931
determination method
TAS
retrieved
8 April 2019
stated in
Roles of tau protein in health and disease
GOA
curator
ARUK-UCL
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931
determination method
NAS
retrieved
8 April 2019
stated in
Tarp regulates early Chlamydia-induced host cell survival through interactions with the human adaptor protein SHC1
GOA
curator
Critical Assessment of Protein Function Annotation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931
determination method
IMP
retrieved
8 April 2019
stated in
Lipid raft-associated β-adducin is required for PSGL-1-mediated neutrophil rolling on P-selectin
GOA
curator
Critical Assessment of Protein Function Annotation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931
determination method
IMP
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
P12931
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931
determination method
IEA
retrieved
8 April 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931
determination method
IEA
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931
determination method
IEA
retrieved
8 April 2019
stated in
Crosstalk between Src and major vault protein in epidermal growth factor-dependent cell signalling
GOA
curator
UniProt
UniProt protein ID
P12931
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931
determination method
IDA
retrieved
8 April 2019
stated in
PKCdelta-dependent functional switch of rpS3 between translation and DNA repair
GOA
curator
UniProt
UniProt protein ID
P12931
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931
determination method
IDA
retrieved
8 April 2019
stated in
Tyrosyl phosphorylation of Shp2 is required for normal ERK activation in response to some, but not all, growth factors
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931
determination method
EXP
retrieved
8 April 2019
stated in
Vav2 is required for cell spreading
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931
determination method
EXP
retrieved
8 April 2019
stated in
Src kinase phosphorylates RUNX3 at tyrosine residues and localizes the protein in the cytoplasm
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931
determination method
EXP
retrieved
8 April 2019
stated in
Gab2 is involved in differential phosphoinositide 3-kinase signaling by two splice forms of c-Kit
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931
determination method
EXP
retrieved
8 April 2019
stated in
Kit signaling through PI 3-kinase and Src kinase pathways: an essential role for Rac1 and JNK activation in mast cell proliferation
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931
determination method
EXP
retrieved
8 April 2019
stated in
Identification of Src-specific phosphorylation site on focal adhesion kinase: dissection of the role of Src SH2 and catalytic functions and their consequences for tumor cell behavior
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931
determination method
EXP
retrieved
8 April 2019
stated in
Steel factor stimulates the tyrosine phosphorylation of the proto-oncogene product, p95vav, in human hemopoietic cells
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931
determination method
EXP