Wikidata

(Q21109354)

English

SRC proto-oncogene, non-receptor tyrosine kinase

mammalian protein found in Homo sapiens

  • pp60c-src
  • tyrosine kinase pp60c-src
  • SRC
  • v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog
  • tyrosine-protein kinase SRC-1
  • p60-Src
  • proto-oncogene c-Src
  • proto-oncogene tyrosine-protein kinase Src
  • protooncogene SRC, Rous sarcoma
In more languages

Statements

image
PBB Protein SRC image.jpg
500 × 500; 38 KB
0 references
molecular function
protein binding
determination method
IPI
103 references
retrieved
8 April 2019
stated in
Molecular chaperone TRAP1 regulates a metabolic switch between mitochondrial respiration and aerobic glycolysis
UniProt-GOA
curator
UniProt
UniProt protein ID
P12931
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931
determination method
IPI
retrieved
8 April 2019
stated in
Reversion-induced LIM interaction with Src reveals a novel Src inactivation cycle
UniProt-GOA
curator
UniProt
UniProt protein ID
P12931
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931
determination method
IPI
retrieved
8 April 2019
stated in
The adaptor protein Tom1L1 is a negative regulator of Src mitogenic signaling induced by growth factors
UniProt-GOA
curator
UniProt
UniProt protein ID
P12931
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931
determination method
IPI
retrieved
8 April 2019
stated in
LPS induces pp60c-src-mediated tyrosine phosphorylation of Hsp90 in lung vascular endothelial cells and mouse lung
UniProt-GOA
curator
UniProt
UniProt protein ID
P12931
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931
determination method
IPI
retrieved
8 April 2019
stated in
PRR7 is a transmembrane adaptor protein expressed in activated T cells involved in regulation of T cell receptor signaling and apoptosis
UniProt-GOA
curator
UniProt
UniProt protein ID
P12931
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931
determination method
IPI
retrieved
8 April 2019
stated in
Src kinase phosphorylates RUNX3 at tyrosine residues and localizes the protein in the cytoplasm
UniProt-GOA
curator
UniProt
UniProt protein ID
P12931
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931
determination method
IPI
retrieved
8 April 2019
stated in
Leptin enhances the potency of circulating angiogenic cells via src kinase and integrin (alpha)vbeta5: implications for angiogenesis in human obesity
UniProt-GOA
curator
UniProt
UniProt protein ID
P12931
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931
determination method
IPI
retrieved
8 April 2019
stated in
The tyrosine kinase c-Src enhances RIG-I (retinoic acid-inducible gene I)-elicited antiviral signaling
UniProt-GOA
curator
UniProt
UniProt protein ID
P12931
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931
determination method
IPI
retrieved
8 April 2019
stated in
A novel signaling molecule, p130, forms stable complexes in vivo with v-Crk and v-Src in a tyrosine phosphorylation-dependent manner
UniProt-GOA
curator
UniProt
UniProt protein ID
P12931
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931
determination method
IPI
retrieved
8 April 2019
stated in
Tau interacts with src-family non-receptor tyrosine kinases
UniProt-GOA
curator
UniProt
UniProt protein ID
P12931
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931
determination method
IPI
retrieved
8 April 2019
stated in
Crystal structure of the conserved core of HIV-1 Nef complexed with a Src family SH3 domain
UniProt-GOA
curator
UniProt
UniProt protein ID
P12931
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931
determination method
IPI
retrieved
8 April 2019
stated in
Association of pp60c-src with biliary glycoprotein (CD66a), an adhesion molecule of the carcinoembryonic antigen family downregulated in colorectal carcinomas
UniProt-GOA
curator
UniProt
UniProt protein ID
P12931
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931
determination method
IPI
retrieved
8 April 2019
stated in
The PDZ protein MPP2 interacts with c-Src in epithelial cells
UniProt-GOA
curator
UniProt
UniProt protein ID
P12931
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931
determination method
IPI
retrieved
8 April 2019
stated in
c-Src regulates Akt signaling in response to ghrelin via beta-arrestin signaling-independent and -dependent mechanisms
UniProt-GOA
curator
UniProt
UniProt protein ID
P12931
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931
determination method
IPI
retrieved
8 April 2019
stated in
Src homology 2 (SH2) domain containing protein tyrosine phosphatase-1 (SHP-1) dephosphorylates VEGF Receptor-2 and attenuates endothelial DNA synthesis, but not migration
UniProt-GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931
determination method
IPI
retrieved
8 April 2019
stated in
Nuclear PKM2 regulates β-catenin transactivation upon EGFR activation
UniProt-GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931
determination method
IPI
retrieved
8 April 2019
stated in
NKX2-1/TITF1/TTF-1-Induced ROR1 is required to sustain EGFR survival signaling in lung adenocarcinoma
UniProt-GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931
determination method
IPI
retrieved
8 April 2019
stated in
VHL loss in renal cell carcinoma leads to up-regulation of CUB domain-containing protein 1 to stimulate PKC{delta}-driven migration
UniProt-GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931
determination method
IPI
retrieved
8 April 2019
stated in
c-Src is a PDZ interaction partner and substrate of the E3 ubiquitin ligase Ligand-of-Numb protein X1
UniProt-GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931
determination method
IPI
retrieved
8 April 2019
stated in
Recombinant human erythropoietin antagonizes trastuzumab treatment of breast cancer cells via Jak2-mediated Src activation and PTEN inactivation
UniProt-GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931
determination method
IPI
retrieved
8 April 2019
stated in
Functional interaction between c-Src and its mitotic target, Sam 68
UniProt-GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931
determination method
IPI
retrieved
8 April 2019
stated in
Oncogenic association of the Cbp/PAG adaptor protein with the Lyn tyrosine kinase in human B-NHL rafts
UniProt-GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931
determination method
IPI
retrieved
8 April 2019
stated in
Involvement of Src tyrosine kinase in Escherichia coli invasion of human brain microvascular endothelial cells
UniProt-GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931
determination method
IPI
retrieved
8 April 2019
stated in
A human protein-protein interaction network: a resource for annotating the proteome
UniProt-GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931
determination method
IPI
retrieved
8 April 2019
stated in
Platelet endothelial cell adhesion molecule-1 is phosphorylatable by c-Src, binds Src-Src homology 2 domain, and exhibits immunoreceptor tyrosine-based activation motif-like properties
UniProt-GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931
determination method
IPI
retrieved
8 April 2019
stated in
The mammalian-membrane two-hybrid assay (MaMTH) for probing membrane-protein interactions in human cells
UniProt-GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931
determination method
IPI
retrieved
8 April 2019
stated in
Cbl associates with Pyk2 and Src to regulate Src kinase activity, alpha(v)beta(3) integrin-mediated signaling, cell adhesion, and osteoclast motility
UniProt-GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931
determination method
IPI
retrieved
8 April 2019
stated in
The SRC-associated protein CUB Domain-Containing Protein-1 regulates adhesion and motility
UniProt-GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931
determination method
IPI
retrieved
8 April 2019
stated in
Identification of preferred protein interactions by phage-display of the human Src homology-3 proteome
UniProt-GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931
determination method
IPI
retrieved
8 April 2019
stated in
An inherent role of microtubule network in the action of nuclear receptor
UniProt-GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931
determination method
IPI
retrieved
8 April 2019
stated in
The neurotransmitter dopamine modulates vascular permeability in the endothelium
UniProt-GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931
determination method
IPI
retrieved
8 April 2019
stated in
Magicin associates with the Src-family kinases and is phosphorylated upon CD3 stimulation
UniProt-GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931
determination method
IPI
retrieved
8 April 2019
stated in
Mitochondrial AKAP121 binds and targets protein tyrosine phosphatase D1, a novel positive regulator of src signaling
UniProt-GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931
determination method
IPI
retrieved
8 April 2019
stated in
Translationally controlled tumor protein induces human breast epithelial cell transformation through the activation of Src
UniProt-GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931
determination method
IPI
retrieved
8 April 2019
stated in
Functional role of c-Src in IL-1-induced NF-kappa B activation: c-Src is a component of the IKK complex
UniProt-GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931
determination method
IPI
retrieved
8 April 2019
stated in
Rack1 promotes epithelial cell-cell adhesion by regulating E-cadherin endocytosis
UniProt-GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931
determination method
IPI
retrieved
8 April 2019
stated in
Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network
UniProt-GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931
determination method
IPI
retrieved
8 April 2019
stated in
ErbB2-mediated Src and signal transducer and activator of transcription 3 activation leads to transcriptional up-regulation of p21Cip1 and chemoresistance in breast cancer cells
UniProt-GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931
determination method
IPI
retrieved
8 April 2019
stated in
JMJD6 regulates ERα methylation on arginine.
UniProt-GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931
determination method
IPI
retrieved
8 April 2019
stated in
Role of beta-arrestin 1 in the metastatic progression of colorectal cancer
UniProt-GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931
determination method
IPI
retrieved
8 April 2019
stated in
Structural basis for a novel intrapeptidyl H-bond and reverse binding of c-Cbl-TKB domain substrates
UniProt-GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931
determination method
IPI
retrieved
8 April 2019
stated in
Variant estrogen receptor-c-Src molecular interdependence and c-Src structural requirements for endothelial NO synthase activation.
UniProt-GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931
determination method
IPI
retrieved
8 April 2019
stated in
Deficiency of a beta-arrestin-2 signal complex contributes to insulin resistance.
UniProt-GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931
determination method
IPI
retrieved
8 April 2019
stated in
The role of protein-tyrosine phosphatase 1B in integrin signaling
UniProt-GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931
determination method
IPI
retrieved
8 April 2019
stated in
Targeting AMAP1 and cortactin binding bearing an atypical src homology 3/proline interface for prevention of breast cancer invasion and metastasis
UniProt-GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931
determination method
IPI
retrieved
8 April 2019
stated in
FAK-MAPK-dependent adhesion disassembly downstream of L1 contributes to semaphorin3A-induced collapse
UniProt-GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931
determination method
IPI
retrieved
8 April 2019
stated in
PI3-kinase/Akt-dependent antiapoptotic signaling by the PDGF alpha receptor is negatively regulated by Src family kinases
UniProt-GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931
determination method
IPI
retrieved
8 April 2019
stated in
Identification and functional characterization of an Src homology domain 3 domain-binding site on Cbl
UniProt-GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931
determination method
IPI
retrieved
8 April 2019
stated in
Phosphorylation of Tyr1214 within VEGFR-2 triggers the recruitment of Nck and activation of Fyn leading to SAPK2/p38 activation and endothelial cell migration in response to VEGF
UniProt-GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931
determination method
IPI
retrieved
8 April 2019
stated in
Dosage-dependent switch from G protein-coupled to G protein-independent signaling by a GPCR
UniProt-GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931
determination method
IPI
retrieved
8 April 2019
stated in
Metalloproteinase/Presenilin1 processing of ephrinB regulates EphB-induced Src phosphorylation and signaling
UniProt-GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931
determination method
IPI
retrieved
8 April 2019
stated in
Multiple phosphorylation of chicken protein tyrosine phosphatase 1 and human protein tyrosine phosphatase 1B by casein kinase II and p60c-src in vitro
UniProt-GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931
determination method
IPI
retrieved
8 April 2019
stated in
ErbB-2 activates Stat3 alpha in a Src- and JAK2-dependent manner
UniProt-GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931
determination method
IPI
retrieved
8 April 2019
stated in
Phosphorylation of ETS1 by Src family kinases prevents its recognition by the COP1 tumor suppressor
UniProt-GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931
determination method
IPI
retrieved
8 April 2019
stated in
Bcr-Abl stabilizes beta-catenin in chronic myeloid leukemia through its tyrosine phosphorylation
UniProt-GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931
determination method
IPI
retrieved
8 April 2019
stated in
EGFR-mediated Beclin 1 phosphorylation in autophagy suppression, tumor progression, and tumor chemoresistance
UniProt-GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931
determination method
IPI
retrieved
8 April 2019
stated in
Cysteine mutations cause defective tyrosine phosphorylation in MEGF10 myopathy
UniProt-GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931
determination method
IPI
retrieved
8 April 2019
stated in
A quantitative protein interaction network for the ErbB receptors using protein microarrays
UniProt-GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931
determination method
IPI
retrieved
8 April 2019
stated in
Simultaneous assay of Src SH3 and SH2 domain binding using different wavelength fluorescence polarization probes
UniProt-GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931
determination method
IPI
retrieved
8 April 2019
stated in
Cyanidin-3-glucoside inhibits ethanol-induced invasion of breast cancer cells overexpressing ErbB2
UniProt-GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931
determination method
IPI
retrieved
8 April 2019
stated in
Negative regulation of PYK2/related adhesion focal tyrosine kinase signal transduction by hematopoietic tyrosine phosphatase SHPTP1
UniProt-GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931
determination method
IPI
retrieved
8 April 2019
stated in
The tyrosine phosphatase 1B regulates linker for activation of T-cell phosphorylation and platelet aggregation upon FcgammaRIIa cross-linking
UniProt-GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931
determination method
IPI
retrieved
8 April 2019
stated in
Beta-arrestin1 phosphorylation by GRK5 regulates G protein-independent 5-HT4 receptor signalling
UniProt-GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931
determination method
IPI
retrieved
8 April 2019
stated in
Integrin/Fak/Src-mediated regulation of cell survival and anoikis in human intestinal epithelial crypt cells: selective engagement and roles of PI3-K isoform complexes
UniProt-GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931
determination method
IPI
retrieved
8 April 2019
stated in
Identification of protein-tyrosine phosphatase 1B as the major tyrosine phosphatase activity capable of dephosphorylating and activating c-Src in several human breast cancer cell lines
UniProt-GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931
determination method
IPI
retrieved
8 April 2019
stated in
Phosphorylation-dependent interactions between ADAM15 cytoplasmic domain and Src family protein-tyrosine kinases
UniProt-GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931
determination method
IPI
retrieved
8 April 2019
stated in
Phospho-tyrosine dependent protein-protein interaction network
UniProt-GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931
determination method
IPI
retrieved
8 April 2019
stated in
The rat tyrosine phosphatase eta increases cell adhesion by activating c-Src through dephosphorylation of its inhibitory phosphotyrosine residue
UniProt-GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931
determination method
IPI
retrieved
8 April 2019
stated in
Ribosomal protein L10 interacts with the SH3 domain and regulates GDNF-induced neurite growth in SH-SY-5y cells
UniProt-GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931
determination method
IPI
retrieved
8 April 2019
stated in
Characterization of the interactions of estrogen receptor and MNAR in the activation of cSrc
UniProt-GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931
determination method
IPI
retrieved
8 April 2019
stated in
Activation of rapid oestrogen signalling in aggressive human breast cancers
UniProt-GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931
determination method
IPI
retrieved
8 April 2019
stated in
Catalytically active membrane-distal phosphatase domain of receptor protein-tyrosine phosphatase alpha is required for Src activation
UniProt-GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931
determination method
IPI
retrieved
8 April 2019
stated in
Small proline-rich proteins (SPRR) function as SH3 domain ligands, increase resistance to injury and are associated with epithelial-mesenchymal transition (EMT) in cholangiocytes
UniProt-GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931
determination method
IPI
retrieved
8 April 2019
stated in
Enhanced prediction of Src homology 2 (SH2) domain binding potentials using a fluorescence polarization-derived c-Met, c-Kit, ErbB, and androgen receptor interactome
UniProt-GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931
determination method
IPI
retrieved
8 April 2019
stated in
Ack1 mediates Cdc42-dependent cell migration and signaling to p130Cas
UniProt-GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931
determination method
IPI
retrieved
8 April 2019
stated in
Focal adhesion kinase overexpression enhances ras-dependent integrin signaling to ERK2/mitogen-activated protein kinase through interactions with and activation of c-Src
UniProt-GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931
determination method
IPI
retrieved
8 April 2019
stated in
A phosphotyrosine displacement mechanism for activation of Src by PTPalpha
UniProt-GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931
determination method
IPI
retrieved
8 April 2019
stated in
PTP1B contributes to the oncogenic properties of colon cancer cells through Src activation
UniProt-GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931
determination method
IPI
retrieved
8 April 2019
stated in
Direct interaction between ER membrane-bound PTP1B and its plasma membrane-anchored targets
UniProt-GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931
determination method
IPI
retrieved
8 April 2019
stated in
Src kinase becomes preferentially associated with the VEGFR, KDR/Flk-1, following VEGF stimulation of vascular endothelial cells
UniProt-GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931
determination method
IPI
retrieved
8 April 2019
stated in
mda-9/Syntenin promotes metastasis in human melanoma cells by activating c-Src.
UniProt-GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931
determination method
IPI
retrieved
8 April 2019
stated in
The Tensin-3 protein, including its SH2 domain, is phosphorylated by Src and contributes to tumorigenesis and metastasis
UniProt-GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931
determination method
IPI
retrieved
8 April 2019
stated in
Yes and PI3K bind CD95 to signal invasion of glioblastoma
UniProt-GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931
determination method
IPI
retrieved
8 April 2019
stated in
Regulation of c-Src by binding to the PDZ domain of AF-6
UniProt-GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931
determination method
IPI
retrieved
8 April 2019
stated in
Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening
UniProt-GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931
determination method
IPI
retrieved
8 April 2019
stated in
ARAP3 is transiently tyrosine phosphorylated in cells attaching to fibronectin and inhibits cell spreading in a RhoGAP-dependent manner
UniProt-GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931
determination method
IPI
retrieved
8 April 2019
stated in
A role for Pyk2 and Src in linking G-protein-coupled receptors with MAP kinase activation
UniProt-GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931
determination method
IPI
retrieved
8 April 2019
stated in
EG-1 interacts with c-Src and activates its signaling pathway
UniProt-GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931
determination method
IPI
retrieved
8 April 2019
stated in
c-Src phosphorylation and activation of hexokinase promotes tumorigenesis and metastasis.
UniProt-GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931
determination method
IPI
retrieved
8 April 2019
stated in
Platelet-endothelial cell adhesion molecule-1 (CD31), a scaffolding molecule for selected catenin family members whose binding is mediated by different tyrosine and serine/threonine phosphorylation
UniProt-GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931
determination method
IPI
retrieved
8 April 2019
stated in
p140Cap protein suppresses tumour cell properties, regulating Csk and Src kinase activity
UniProt-GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931
determination method
IPI
retrieved
8 April 2019
stated in
Phosphorylated alpha-actinin and protein-tyrosine phosphatase 1B coregulate the disassembly of the focal adhesion kinase x Src complex and promote cell migration
UniProt-GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931
determination method
IPI
retrieved
8 April 2019
stated in
PTP-1B is an essential positive regulator of platelet integrin signaling
UniProt-GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931
determination method
IPI
retrieved
8 April 2019
stated in
Epidermal growth factor directs sex-specific steroid signaling through Src activation
UniProt-GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931
determination method
IPI
retrieved
8 April 2019
stated in
Analysis of protein-protein interactions in cross-talk pathways reveals CRKL protein as a novel prognostic marker in hepatocellular carcinoma
UniProt-GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931
determination method
IPI
retrieved
8 April 2019
stated in
Beta-arrestin links endothelin A receptor to beta-catenin signaling to induce ovarian cancer cell invasion and metastasis.
UniProt-GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931
determination method
IPI
retrieved
8 April 2019
stated in
EGFR/Met association regulates EGFR TKI resistance in breast cancer
UniProt-GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931
determination method
IPI
retrieved
8 April 2019
stated in
Mitotic activation of protein-tyrosine phosphatase alpha and regulation of its Src-mediated transforming activity by its sites of protein kinase C phosphorylation
UniProt-GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931
determination method
IPI
retrieved
8 April 2019
stated in
Structural characterization of autoinhibited c-Met kinase produced by coexpression in bacteria with phosphatase
UniProt-GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931
determination method
IPI
retrieved
8 April 2019
stated in
DOCK8 functions as an adaptor that links TLR-MyD88 signaling to B cell activation
UniProt-GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931
determination method
IPI
retrieved
8 April 2019
stated in
Deciphering the cross talk between hnRNP K and c-Src: the c-Src activation domain in hnRNP K is distinct from a second interaction site
UniProt-GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931
determination method
IPI
retrieved
8 April 2019
stated in
A positive feedback loop of ER-α36/EGFR promotes malignant growth of ER-negative breast cancer cells
UniProt-GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931
determination method
IPI
retrieved
8 April 2019
stated in
XB130, a novel adaptor protein for signal transduction
UniProt-GOA
curator
HUGO Gene Nomenclature Committee
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931
determination method
IPI
protein tyrosine kinase activity
determination method
EXP
IDA
IEA
IMP
TAS
19 references
retrieved
17 October 2017
stated in
UniProt-GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P12931&geneProductId=UniProtKB:P12931
determination method
TAS
retrieved
17 October 2017
stated in
Gbetagamma subunits mediate Src-dependent phosphorylation of the epidermal growth factor receptor. A scaffold for G protein-coupled receptor-mediated Ras activation
UniProt-GOA
curator
Proteome Inc.
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P12931&geneProductId=UniProtKB:P12931
determination method
TAS
retrieved
17 October 2017
stated in
Lipid raft-associated β-adducin is required for PSGL-1-mediated neutrophil rolling on P-selectin
UniProt-GOA
curator
Critical Assessment of Protein Function Annotation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P12931&geneProductId=UniProtKB:P12931
determination method
IMP
retrieved
17 October 2017
stated in
Tarp regulates early Chlamydia-induced host cell survival through interactions with the human adaptor protein SHC1
UniProt-GOA
curator
Critical Assessment of Protein Function Annotation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P12931&geneProductId=UniProtKB:P12931
determination method
IMP
retrieved
17 October 2017
stated in
UniProt-GOA
curator
UniProt
UniProt protein ID
P12931
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P12931&geneProductId=UniProtKB:P12931
determination method
IEA
retrieved
17 October 2017
stated in
UniProt-GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P12931&geneProductId=UniProtKB:P12931
determination method
IEA
retrieved
17 October 2017
stated in
UniProt-GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P12931&geneProductId=UniProtKB:P12931
determination method
IEA
retrieved
17 October 2017
stated in
PKCdelta-dependent functional switch of rpS3 between translation and DNA repair
UniProt-GOA
curator
UniProt
UniProt protein ID
P12931
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P12931&geneProductId=UniProtKB:P12931
determination method
IDA
retrieved
17 October 2017
stated in
Crosstalk between Src and major vault protein in epidermal growth factor-dependent cell signalling
UniProt-GOA
curator
UniProt
UniProt protein ID
P12931
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P12931&geneProductId=UniProtKB:P12931
determination method
IDA
retrieved
17 October 2017
stated in
Steel factor stimulates the tyrosine phosphorylation of the proto-oncogene product, p95vav, in human hemopoietic cells
UniProt-GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P12931&geneProductId=UniProtKB:P12931
determination method
EXP
retrieved
17 October 2017
stated in
Kit signaling through PI 3-kinase and Src kinase pathways: an essential role for Rac1 and JNK activation in mast cell proliferation
UniProt-GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P12931&geneProductId=UniProtKB:P12931
determination method
EXP
retrieved
17 October 2017
stated in
Vav2 is required for cell spreading
UniProt-GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P12931&geneProductId=UniProtKB:P12931
determination method
EXP
retrieved
17 October 2017
stated in
Src kinase phosphorylates RUNX3 at tyrosine residues and localizes the protein in the cytoplasm
UniProt-GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P12931&geneProductId=UniProtKB:P12931
determination method
EXP
retrieved
17 October 2017
stated in
Identification of Src-specific phosphorylation site on focal adhesion kinase: dissection of the role of Src SH2 and catalytic functions and their consequences for tumor cell behavior
UniProt-GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P12931&geneProductId=UniProtKB:P12931
determination method
EXP
retrieved
17 October 2017
stated in
A Src family kinase-Shp2 axis controls RUNX1 activity in megakaryocyte and T-lymphocyte differentiation
UniProt-GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P12931&geneProductId=UniProtKB:P12931
determination method
EXP
retrieved
17 October 2017
stated in
Gab2 is involved in differential phosphoinositide 3-kinase signaling by two splice forms of c-Kit
UniProt-GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P12931&geneProductId=UniProtKB:P12931
determination method
EXP
retrieved
17 October 2017
stated in
Differential involvement of Src family kinases in Fc gamma receptor-mediated phagocytosis
UniProt-GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P12931&geneProductId=UniProtKB:P12931
determination method
EXP
retrieved
17 October 2017
stated in
Differential kinase requirements in human and mouse Fc-gamma receptor phagocytosis and endocytosis
UniProt-GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P12931&geneProductId=UniProtKB:P12931
determination method
EXP
retrieved
17 October 2017
stated in
Tyrosyl phosphorylation of Shp2 is required for normal ERK activation in response to some, but not all, growth factors
UniProt-GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P12931&geneProductId=UniProtKB:P12931
determination method
EXP
protein tyrosine kinase activity
determination method
EXP
IDA
IEA
IMP
NAS
TAS
17 references
retrieved
8 April 2019
stated in
UniProt-GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931
determination method
TAS
retrieved
8 April 2019
stated in
Gbetagamma subunits mediate Src-dependent phosphorylation of the epidermal growth factor receptor. A scaffold for G protein-coupled receptor-mediated Ras activation
UniProt-GOA
curator
Proteome Inc.
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931
determination method
TAS
retrieved
8 April 2019
stated in
Roles of tau protein in health and disease
UniProt-GOA
curator
ARUK-UCL
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931
determination method
NAS
retrieved
8 April 2019
stated in
Tarp regulates early Chlamydia-induced host cell survival through interactions with the human adaptor protein SHC1
UniProt-GOA
curator
Critical Assessment of Protein Function Annotation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931
determination method
IMP
retrieved
8 April 2019
stated in
Lipid raft-associated β-adducin is required for PSGL-1-mediated neutrophil rolling on P-selectin
UniProt-GOA
curator
Critical Assessment of Protein Function Annotation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931
determination method
IMP
retrieved
8 April 2019
stated in
UniProt-GOA
curator
UniProt
UniProt protein ID
P12931
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931
determination method
IEA
retrieved
8 April 2019
stated in
UniProt-GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931
determination method
IEA
retrieved
8 April 2019
stated in
UniProt-GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931
determination method
IEA
retrieved
8 April 2019
stated in
Crosstalk between Src and major vault protein in epidermal growth factor-dependent cell signalling
UniProt-GOA
curator
UniProt
UniProt protein ID
P12931
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931
determination method
IDA
retrieved
8 April 2019
stated in
PKCdelta-dependent functional switch of rpS3 between translation and DNA repair
UniProt-GOA
curator
UniProt
UniProt protein ID
P12931
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931
determination method
IDA
retrieved
8 April 2019
stated in
Tyrosyl phosphorylation of Shp2 is required for normal ERK activation in response to some, but not all, growth factors
UniProt-GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931
determination method
EXP
retrieved
8 April 2019
stated in
Vav2 is required for cell spreading
UniProt-GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931
determination method
EXP
retrieved
8 April 2019
stated in
Src kinase phosphorylates RUNX3 at tyrosine residues and localizes the protein in the cytoplasm
UniProt-GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931
determination method
EXP
retrieved
8 April 2019
stated in
Gab2 is involved in differential phosphoinositide 3-kinase signaling by two splice forms of c-Kit
UniProt-GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931
determination method
EXP
retrieved
8 April 2019
stated in
Kit signaling through PI 3-kinase and Src kinase pathways: an essential role for Rac1 and JNK activation in mast cell proliferation
UniProt-GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931
determination method
EXP
retrieved
8 April 2019
stated in
Identification of Src-specific phosphorylation site on focal adhesion kinase: dissection of the role of Src SH2 and catalytic functions and their consequences for tumor cell behavior
UniProt-GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931
determination method
EXP
retrieved
8 April 2019
stated in
Steel factor stimulates the tyrosine phosphorylation of the proto-oncogene product, p95vav, in human hemopoietic cells
UniProt-GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12931
determination method
EXP