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SH2B adaptor protein 1
mammalian protein found in Homo sapiens
PSM
SH2B1
SH2B adapter protein 1
pro-rich, PH and SH2 domain-containing signaling mediator
SH2-B signaling protein
SH2 domain-containing protein 1B
SH2 domain-containing putative adapter SH2-B
In more languages
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Statements
instance of
protein
1 reference
stated in
UniProt
retrieved
13 November 2019
UniProt protein ID
Q9NRF2
part of
SH2B adapter protein 1
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/Q9NRF2
SH2 domain superfamily
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/Q9NRF2
PH-like domain superfamily
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/Q9NRF2
Phenylalanine zipper superfamily
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/Q9NRF2
pleckstrin homology domain, protein family
1 reference
based on heuristic
inferred from protein domain or family
SH2 domain, protein family
1 reference
based on heuristic
inferred from protein domain or family
SH2B1, SH2 domain, protein family
1 reference
based on heuristic
inferred from protein domain or family
Phenylalanine zipper, protein family
1 reference
based on heuristic
inferred from protein domain or family
found in taxon
Homo sapiens
1 reference
stated in
UniProt
retrieved
13 November 2019
UniProt protein ID
Q9NRF2
encoded by
SH2B1
1 reference
stated in
UniProt
retrieved
13 November 2019
UniProt protein ID
Q9NRF2
molecular function
signaling adaptor activity
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NRF2
determination method
IEA
protein binding
determination method
IPI
4 references
retrieved
8 April 2019
stated in
SH2-Balpha is an insulin-receptor adapter protein and substrate that interacts with the activation loop of the insulin-receptor kinase
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NRF2
determination method
IPI
retrieved
8 April 2019
stated in
SH2B1β interacts with STAT3 and enhances fibroblast growth factor 1-induced gene expression during neuronal differentiation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NRF2
determination method
IPI
retrieved
8 April 2019
stated in
A quantitative protein interaction network for the ErbB receptors using protein microarrays
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NRF2
determination method
IPI
retrieved
8 April 2019
stated in
The mammalian-membrane two-hybrid assay (MaMTH) for probing membrane-protein interactions in human cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NRF2
determination method
IPI
transmembrane receptor protein tyrosine kinase adaptor activity
determination method
IBA
1 reference
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NRF2
determination method
IBA
cell component
cytosol
determination method
TAS
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NRF2
determination method
TAS
nucleus
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q9NRF2
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NRF2
determination method
IEA
membrane
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q9NRF2
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NRF2
determination method
IEA
cytoplasm
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q9NRF2
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NRF2
determination method
IEA
plasma membrane
determination method
IBA
1 reference
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NRF2
determination method
IBA
biological process
positive regulation of signal transduction
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Gene Ontology Consortium
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NRF2
determination method
IEA
positive regulation of mitotic nuclear division
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NRF2
determination method
IEA
blood coagulation
determination method
TAS
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NRF2
determination method
TAS
lamellipodium assembly
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NRF2
determination method
IEA
signal transduction
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NRF2
determination method
IEA
regulation of DNA biosynthetic process
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NRF2
determination method
IEA
transmembrane receptor protein tyrosine kinase signaling pathway
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Gene Ontology Consortium
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NRF2
determination method
IEA
intracellular signal transduction
determination method
IBA
1 reference
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NRF2
determination method
IBA
exact match
https://identifiers.org/uniprot:Q9NRF2
1 reference
stated in
Identifiers.org
UniProt protein ID
Q9NRF2
reference URL
https://registry.identifiers.org/registry/uniprot
http://purl.uniprot.org/uniprot/Q9NRF2
1 reference
stated in
Identifiers.org
UniProt protein ID
Q9NRF2
reference URL
https://registry.identifiers.org/registry/uniprot
https://www.ncbi.nlm.nih.gov/protein/Q9NRF2
1 reference
stated in
Identifiers.org
UniProt protein ID
Q9NRF2
reference URL
https://registry.identifiers.org/registry/uniprot
has part(s)
Phenylalanine zipper
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/Q9NRF2
pleckstrin homology domain
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/Q9NRF2
SH2 domain
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/Q9NRF2
SH2B1, SH2 domain
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/Q9NRF2
Identifiers
RefSeq protein ID
NP_001139267
1 reference
stated in
NCBI Gene
retrieved
30 May 2020
Entrez Gene ID
25970
NP_001139268
1 reference
stated in
NCBI Gene
retrieved
30 May 2020
Entrez Gene ID
25970
NP_001139269
1 reference
stated in
NCBI Gene
retrieved
30 May 2020
Entrez Gene ID
25970
NP_001139284
1 reference
stated in
NCBI Gene
retrieved
30 May 2020
Entrez Gene ID
25970
NP_001295222
1 reference
stated in
NCBI Gene
retrieved
30 May 2020
Entrez Gene ID
25970
NP_001295223
1 reference
stated in
NCBI Gene
retrieved
30 May 2020
Entrez Gene ID
25970
NP_056318
1 reference
stated in
NCBI Gene
retrieved
30 May 2020
Entrez Gene ID
25970
UniProt protein ID
Q9NRF2
1 reference
stated in
UniProt
retrieved
13 November 2019
UniProt protein ID
Q9NRF2
Ensembl protein ID
ENSP00000321221
1 reference
stated in
Ensembl Release 99
Ensembl protein ID
ENSP00000321221
ENSP00000337163
1 reference
stated in
Ensembl Release 99
Ensembl protein ID
ENSP00000337163
ENSP00000352232
1 reference
stated in
Ensembl Release 99
Ensembl protein ID
ENSP00000352232
ENSP00000378903
1 reference
stated in
Ensembl Release 99
Ensembl protein ID
ENSP00000378903
ENSP00000481709
1 reference
stated in
Ensembl Release 99
Ensembl protein ID
ENSP00000481709
ENSP00000438784
1 reference
stated in
Ensembl Release 99
Ensembl protein ID
ENSP00000438784
ENSP00000440354
1 reference
stated in
Ensembl Release 99
Ensembl protein ID
ENSP00000440354
ENSP00000454601
1 reference
stated in
Ensembl Release 99
Ensembl protein ID
ENSP00000454601
ENSP00000455236
1 reference
stated in
Ensembl Release 99
Ensembl protein ID
ENSP00000455236
ENSP00000455534
1 reference
stated in
Ensembl Release 99
Ensembl protein ID
ENSP00000455534
ENSP00000457214
1 reference
stated in
Ensembl Release 99
Ensembl protein ID
ENSP00000457214
ENSP00000457315
1 reference
stated in
Ensembl Release 99
Ensembl protein ID
ENSP00000457315
ENSP00000457724
1 reference
stated in
Ensembl Release 99
Ensembl protein ID
ENSP00000457724
ENSP00000458097
1 reference
stated in
Ensembl Release 99
Ensembl protein ID
ENSP00000458097
PDB structure ID
2HDV
1 reference
stated in
Swiss-Prot
UniProt
retrieved
10 November 2015
reference URL
http://www.uniprot.org/uniprot/Q91ZM2.txt?version=105
2HDX
1 reference
stated in
Swiss-Prot
UniProt
retrieved
10 November 2015
reference URL
http://www.uniprot.org/uniprot/Q91ZM2.txt?version=105
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