(Q21112251)

English

Dickkopf WNT signaling pathway inhibitor 2

mammalian protein found in Homo sapiens

dickkopf homolog 2
dickkopf-related protein 2
dickkopf-2
DKK2
dickkopf 2 homolog
hDkk-2

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Statements

1 reference

13 November 2019

1 reference

13 November 2019

1 reference

13 November 2019

1 reference

27 March 2018

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UBU2&geneProductId=UniProtKB:Q9UBU2

determination method

IEA

receptor antagonist activity

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBU2

3 references

8 April 2019

Functional and structural diversity of the human Dickkopf gene family

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBU2

8 April 2019

Second cysteine-rich domain of Dickkopf-2 activates canonical Wnt signaling pathway via LRP-6 independently of dishevelled

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBU2

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBU2

determination method

IBA

biological process

positive regulation of canonical Wnt signaling pathway

determination method

NAS

IDA

Wnt signaling pathway

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBU2

determination method

IEA

negative regulation of canonical Wnt signaling pathway

3 references

27 March 2018

Wnt signaling in midbrain dopaminergic neuron development and regenerative medicine for Parkinson's disease

GOA

curator

Parkinsons Disease Gene Ontology Initiative

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UBU2&geneProductId=UniProtKB:Q9UBU2

27 March 2018

MicroRNA-222 promotes tumorigenesis via targeting DKK2 and activating the Wnt/β-catenin signaling pathway

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UBU2&geneProductId=UniProtKB:Q9UBU2

27 March 2018

Second cysteine-rich domain of Dickkopf-2 activates canonical Wnt signaling pathway via LRP-6 independently of dishevelled

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UBU2&geneProductId=UniProtKB:Q9UBU2

determination method

IDA

negative regulation of canonical Wnt signaling pathway

4 references

8 April 2019

Wnt signaling in midbrain dopaminergic neuron development and regenerative medicine for Parkinson's disease

GOA

curator

Parkinsons Disease Gene Ontology Initiative

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBU2

8 April 2019

MicroRNA-222 promotes tumorigenesis via targeting DKK2 and activating the Wnt/β-catenin signaling pathway

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBU2

8 April 2019

Second cysteine-rich domain of Dickkopf-2 activates canonical Wnt signaling pathway via LRP-6 independently of dishevelled

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBU2

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBU2

determination method

IBA

extracellular negative regulation of signal transduction

1 reference

10 September 2018

Gene Ontology Consortium

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UBU2&geneProductId=UniProtKB:Q9UBU2

determination method

IEA

negative regulation of signaling receptor activity

1 reference

8 April 2019

Gene Ontology Consortium

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBU2

determination method

IEA

Identifiers

1 reference

30 May 2020

1 reference

13 November 2019

1 reference

1 reference

1 reference

1 reference

9 November 2015

http://www.uniprot.org/uniprot/Q9QYZ8.txt?version=97

(Q21112251)

Dickkopf WNT signaling pathway inhibitor 2

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