(Q21114040)

http://www.ebi.ac.uk/interpro/protein/Q9Y2R2

Protein-tyrosine phosphatase-like

1 reference

stated in

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9Y2R2

Tyrosine specific protein phosphatases domain, protein family

1 reference

PTP type protein phosphatase domain, protein family

1 reference

Protein-tyrosine phosphatase, catalytic domain, protein family

1 reference

Protein-tyrosine phosphatase, active site, protein family

1 reference

phosphoprotein phosphatase activity

1 reference

13 November 2019

1 reference

13 November 2019

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y2R2

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y2R2

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y2R2

8 references

8 April 2019

Large-scale structural analysis of the classical human protein tyrosine phosphatome

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y2R2

8 April 2019

Proline-serine-threonine phosphatase interacting protein 1 inhibition of T-cell receptor signaling depends on its SH3 domain

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y2R2

8 April 2019

The autoimmunity-associated gene PTPN22 potentiates toll-like receptor-driven, type 1 interferon-dependent immunity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y2R2

8 April 2019

Substrate specificity of lymphoid-specific tyrosine phosphatase (Lyp) and identification of Src kinase-associated protein of 55 kDa homolog (SKAP-HOM) as a Lyp substrate

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y2R2

8 April 2019

The lymphoid protein tyrosine phosphatase Lyp interacts with the adaptor molecule Grb2 and functions as a negative regulator of T-cell activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y2R2

8 April 2019

The mammalian-membrane two-hybrid assay (MaMTH) for probing membrane-protein interactions in human cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y2R2

8 April 2019

Identification of substrates of human protein-tyrosine phosphatase PTPN22

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y2R2

8 April 2019

Cloning and characterization of a lymphoid-specific, inducible human protein tyrosine phosphatase, Lyp

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y2R2

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y2R2

ubiquitin protein ligase binding

1 reference

8 April 2019

The autoimmunity-associated gene PTPN22 potentiates toll-like receptor-driven, type 1 interferon-dependent immunity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y2R2

protein tyrosine phosphatase activity

IPI

6 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y2R2

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y2R2

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y2R2

8 April 2019

Structure, inhibitor, and regulatory mechanism of Lyp, a lymphoid-specific tyrosine phosphatase implicated in autoimmune diseases

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y2R2

8 April 2019

Cloning and characterization of a lymphoid-specific, inducible human protein tyrosine phosphatase, Lyp

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y2R2

8 April 2019

Identification of substrates of human protein-tyrosine phosphatase PTPN22

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y2R2

4 references

8 April 2019

Research progress of several protein tyrosine phosphatases in diabetes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y2R2

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y2R2

8 April 2019

Subcellular localization of intracellular protein tyrosine phosphatases in T cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y2R2

8 April 2019

Cloning and characterization of a lymphoid-specific, inducible human protein tyrosine phosphatase, Lyp

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y2R2

perinuclear region of cytoplasm

1 reference

8 April 2019

Cloning and characterization of a lymphoid-specific, inducible human protein tyrosine phosphatase, Lyp

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y2R2

cytoplasmic side of plasma membrane

1 reference

8 April 2019

Subcellular localization of intracellular protein tyrosine phosphatases in T cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y2R2

1 reference

8 April 2019

Subcellular localization of intracellular protein tyrosine phosphatases in T cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y2R2

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y2R2

positive regulation of protein K63-linked ubiquitination

TAS

biological process

1 reference

8 April 2019

The autoimmunity-associated gene PTPN22 potentiates toll-like receptor-driven, type 1 interferon-dependent immunity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y2R2

regulation of NIK/NF-kappaB signaling

1 reference

8 April 2019

Protein tyrosine phosphatase non-receptor type 22 modulates NOD2-induced cytokine release and autophagy

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y2R2

regulation of innate immune response

1 reference

8 April 2019

PTPN22 gene regulates natural killer cell proliferation during in vitro expansion

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y2R2

regulation of natural killer cell proliferation

IC

1 reference

8 April 2019

PTPN22 gene regulates natural killer cell proliferation during in vitro expansion

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y2R2

positive regulation of toll-like receptor 3 signaling pathway

1 reference

8 April 2019

The autoimmunity-associated gene PTPN22 potentiates toll-like receptor-driven, type 1 interferon-dependent immunity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y2R2

regulation of T cell receptor signaling pathway

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y2R2

regulation of B cell receptor signaling pathway

1 reference

8 April 2019

Cutting edge: the PTPN22 allelic variant associated with autoimmunity impairs B cell signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y2R2

phosphoanandamide dephosphorylation

NAS

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y2R2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y2R2

ISS

immune system process

1 reference

8 April 2019

negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway

1 reference

8 April 2019

Protein tyrosine phosphatase non-receptor type 22 modulates NOD2-induced cytokine release and autophagy

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y2R2

negative regulation of p38MAPK cascade

1 reference

8 April 2019

Protein tyrosine phosphatase non-receptor type 22 modulates NOD2-induced cytokine release and autophagy

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y2R2

protein dephosphorylation

3 references

8 April 2019

Identification of a variant form of tyrosine phosphatase LYP

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y2R2

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y2R2

8 April 2019

Cloning and characterization of a lymphoid-specific, inducible human protein tyrosine phosphatase, Lyp

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y2R2

negative regulation of gene expression

1 reference

8 April 2019

Protein tyrosine phosphatase non-receptor type 22 modulates NOD2-induced cytokine release and autophagy

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y2R2

negative regulation of T cell receptor signaling pathway

1 reference

8 April 2019

Structure, inhibitor, and regulatory mechanism of Lyp, a lymphoid-specific tyrosine phosphatase implicated in autoimmune diseases

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y2R2

cellular response to muramyl dipeptide

1 reference

8 April 2019

Protein tyrosine phosphatase non-receptor type 22 modulates NOD2-induced cytokine release and autophagy

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y2R2

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y2R2

response to lipopolysaccharide

1 reference

8 April 2019

The autoimmunity-associated gene PTPN22 potentiates toll-like receptor-driven, type 1 interferon-dependent immunity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y2R2

T cell differentiation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y2R2

positive regulation of gene expression

ISS

positive regulation of ERK1 and ERK2 cascade

1 reference

8 April 2019

Protein tyrosine phosphatase non-receptor type 22 modulates NOD2-induced cytokine release and autophagy

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y2R2

positive regulation of toll-like receptor 4 signaling pathway

1 reference

8 April 2019

The autoimmunity-associated gene PTPN22 potentiates toll-like receptor-driven, type 1 interferon-dependent immunity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y2R2

negative regulation of tumor necrosis factor production

1 reference

8 April 2019

Protein tyrosine phosphatase non-receptor type 22 modulates NOD2-induced cytokine release and autophagy

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y2R2

negative regulation of autophagy

1 reference

8 April 2019

Protein tyrosine phosphatase non-receptor type 22 modulates NOD2-induced cytokine release and autophagy

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y2R2

negative regulation of JUN kinase activity

1 reference

8 April 2019

Protein tyrosine phosphatase non-receptor type 22 modulates NOD2-induced cytokine release and autophagy

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y2R2

negative regulation of T cell activation

1 reference

8 April 2019

Reduced CD4+T cell activation in children with type 1 diabetes carrying the PTPN22/Lyp 620Trp variant

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y2R2

positive regulation of type I interferon production

1 reference

8 April 2019

The autoimmunity-associated gene PTPN22 potentiates toll-like receptor-driven, type 1 interferon-dependent immunity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y2R2

lipopolysaccharide-mediated signaling pathway

1 reference

8 April 2019

Protein tyrosine phosphatase non-receptor type 22 modulates NOD2-induced cytokine release and autophagy

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y2R2

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y2R2

peptidyl-tyrosine dephosphorylation

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y2R2

T cell receptor signaling pathway

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y2R2

TAS

Identifiers

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

13 November 2019

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016