(Q21114212)

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75807

8 April 2019

Functional proteomics mapping of a human signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75807

8 April 2019

Chronic oxidative stress promotes GADD34-mediated phosphorylation of the TAR DNA-binding protein TDP-43, a modification linked to neurodegeneration.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75807

8 April 2019

Toward an understanding of the protein interaction network of the human liver

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75807

Interaction between growth arrest-DNA damage protein 34 and Src kinase Lyn negatively regulates genotoxic apoptosis

IPI

protein kinase binding

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75807

protein phosphatase 1 binding

IPI

3 references

8 April 2019

Growth arrest and DNA damage-inducible protein GADD34 targets protein phosphatase 1 alpha to the endoplasmic reticulum and promotes dephosphorylation of the alpha subunit of eukaryotic translation initiation factor 2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75807

8 April 2019

Association with endoplasmic reticulum promotes proteasomal degradation of GADD34 protein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75807

8 April 2019

Growth arrest and DNA damage-inducible protein GADD34 assembles a novel signaling complex containing protein phosphatase 1 and inhibitor 1.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75807

protein phosphatase activator activity

1 reference

8 April 2019

Association with endoplasmic reticulum promotes proteasomal degradation of GADD34 protein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75807

protein phosphatase regulator activity

IC

2 references

5 June 2018

Growth arrest and DNA damage-inducible protein GADD34 assembles a novel signaling complex containing protein phosphatase 1 and inhibitor 1.

http://www.ebi.ac.uk/QuickGO/annotations?protein=O75807&geneProductId=UniProtKB:O75807

5 June 2018

Growth arrest and DNA damage-inducible protein GADD34 targets protein phosphatase 1 alpha to the endoplasmic reticulum and promotes dephosphorylation of the alpha subunit of eukaryotic translation initiation factor 2

http://www.ebi.ac.uk/QuickGO/annotations?protein=O75807&geneProductId=UniProtKB:O75807

protein phosphatase regulator activity

IC

3 references

8 April 2019

Growth arrest and DNA damage-inducible protein GADD34 assembles a novel signaling complex containing protein phosphatase 1 and inhibitor 1.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75807

8 April 2019

Growth arrest and DNA damage-inducible protein GADD34 targets protein phosphatase 1 alpha to the endoplasmic reticulum and promotes dephosphorylation of the alpha subunit of eukaryotic translation initiation factor 2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75807

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75807

1 reference

8 April 2019

Association with endoplasmic reticulum promotes proteasomal degradation of GADD34 protein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75807

mitochondrial outer membrane

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75807

protein phosphatase type 1 complex

IEA

2 references

5 June 2018

Growth arrest and DNA damage-inducible protein GADD34 assembles a novel signaling complex containing protein phosphatase 1 and inhibitor 1.

http://www.ebi.ac.uk/QuickGO/annotations?protein=O75807&geneProductId=UniProtKB:O75807

5 June 2018

Growth arrest and DNA damage-inducible protein GADD34 targets protein phosphatase 1 alpha to the endoplasmic reticulum and promotes dephosphorylation of the alpha subunit of eukaryotic translation initiation factor 2

http://www.ebi.ac.uk/QuickGO/annotations?protein=O75807&geneProductId=UniProtKB:O75807

http://www.ebi.ac.uk/QuickGO/annotations?protein=O75807&geneProductId=UniProtKB:O75807

endoplasmic reticulum

3 references

5 June 2018

5 June 2018

Growth arrest and DNA damage-inducible protein GADD34 targets protein phosphatase 1 alpha to the endoplasmic reticulum and promotes dephosphorylation of the alpha subunit of eukaryotic translation initiation factor 2

http://www.ebi.ac.uk/QuickGO/annotations?protein=O75807&geneProductId=UniProtKB:O75807

5 June 2018

Association with endoplasmic reticulum promotes proteasomal degradation of GADD34 protein

http://www.ebi.ac.uk/QuickGO/annotations?protein=O75807&geneProductId=UniProtKB:O75807

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75807

1 reference

5 June 2018

Association with endoplasmic reticulum promotes proteasomal degradation of GADD34 protein

http://www.ebi.ac.uk/QuickGO/annotations?protein=O75807&geneProductId=UniProtKB:O75807

protein phosphatase type 1 complex

3 references

8 April 2019

Growth arrest and DNA damage-inducible protein GADD34 assembles a novel signaling complex containing protein phosphatase 1 and inhibitor 1.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75807

8 April 2019

Growth arrest and DNA damage-inducible protein GADD34 targets protein phosphatase 1 alpha to the endoplasmic reticulum and promotes dephosphorylation of the alpha subunit of eukaryotic translation initiation factor 2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75807

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75807

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75807

endoplasmic reticulum

4 references

8 April 2019

8 April 2019

Growth arrest and DNA damage-inducible protein GADD34 targets protein phosphatase 1 alpha to the endoplasmic reticulum and promotes dephosphorylation of the alpha subunit of eukaryotic translation initiation factor 2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75807

8 April 2019

Association with endoplasmic reticulum promotes proteasomal degradation of GADD34 protein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75807

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75807

negative regulation of protein dephosphorylation

biological process

1 reference

8 April 2019

Growth arrest and DNA damage-inducible protein GADD34 assembles a novel signaling complex containing protein phosphatase 1 and inhibitor 1.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75807

cellular response to DNA damage stimulus

1 reference

8 April 2019

Mammalian GADD34, an apoptosis- and DNA damage-inducible gene

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75807

positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation

positive regulation of translational initiation in response to stress

1 reference

8 April 2019

Growth arrest and DNA damage-inducible protein GADD34 targets protein phosphatase 1 alpha to the endoplasmic reticulum and promotes dephosphorylation of the alpha subunit of eukaryotic translation initiation factor 2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75807

positive regulation of phosphoprotein phosphatase activity

IC

1 reference

5 June 2018

Growth arrest and DNA damage-inducible protein GADD34 assembles a novel signaling complex containing protein phosphatase 1 and inhibitor 1.

http://www.ebi.ac.uk/QuickGO/annotations?protein=O75807&geneProductId=UniProtKB:O75807

intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress

1 reference

8 April 2019

The endoplasmic reticulum stress response in aging and age-related diseases

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75807

negative regulation of phosphoprotein phosphatase activity

1 reference

8 April 2019

Growth arrest and DNA damage-inducible protein GADD34 assembles a novel signaling complex containing protein phosphatase 1 and inhibitor 1.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75807

protein localization to endoplasmic reticulum

1 reference

8 April 2019

Growth arrest and DNA damage-inducible protein GADD34 targets protein phosphatase 1 alpha to the endoplasmic reticulum and promotes dephosphorylation of the alpha subunit of eukaryotic translation initiation factor 2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75807

regulation of translational initiation by eIF2 alpha dephosphorylation

IMP

1 reference

8 April 2019

Growth arrest and DNA damage-inducible protein GADD34 targets protein phosphatase 1 alpha to the endoplasmic reticulum and promotes dephosphorylation of the alpha subunit of eukaryotic translation initiation factor 2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75807

negative regulation of PERK-mediated unfolded protein response

1 reference

8 April 2019

The unfolded protein response: integrating stress signals through the stress sensor IRE1α

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75807

regulation of translation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75807

response to endoplasmic reticulum stress

IEA

1 reference

5 June 2018

Growth arrest and DNA damage-inducible protein GADD34 targets protein phosphatase 1 alpha to the endoplasmic reticulum and promotes dephosphorylation of the alpha subunit of eukaryotic translation initiation factor 2

http://www.ebi.ac.uk/QuickGO/annotations?protein=O75807&geneProductId=UniProtKB:O75807

positive regulation of peptidyl-serine dephosphorylation

3 references

8 April 2019

Growth arrest and DNA damage-inducible protein GADD34 assembles a novel signaling complex containing protein phosphatase 1 and inhibitor 1.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75807

8 April 2019

Growth arrest and DNA damage-inducible protein GADD34 targets protein phosphatase 1 alpha to the endoplasmic reticulum and promotes dephosphorylation of the alpha subunit of eukaryotic translation initiation factor 2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75807

8 April 2019

Association with endoplasmic reticulum promotes proteasomal degradation of GADD34 protein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75807

positive regulation of phosphoprotein phosphatase activity

response to endoplasmic reticulum stress

2 references

8 April 2019

Growth arrest and DNA damage-inducible protein GADD34 targets protein phosphatase 1 alpha to the endoplasmic reticulum and promotes dephosphorylation of the alpha subunit of eukaryotic translation initiation factor 2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75807

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75807

Protein phosphatase 1, regulatory subunit 15A/B, C-terminal

has part(s)

1 reference

stated in

InterPro Release 71.0