Wikidata

(Q21114977)

English

Protein phosphatase 2 scaffold subunit Aalpha

mammalian protein found in Homo sapiens

  • protein phosphatase 2A structural subunit A, alpha isoform
  • protein phosphatase 2, regulatory subunit A, alpha
  • serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform
  • serine/threonine protein phosphatase 2A, 65 kDa regulatory subunit A, alpha isoform
  • medium tumor antigen-associated 61 KDA protein
  • PP2A subunit A isoform R1-alpha
  • testicular secretory protein Li 1
  • PPP2R1A
  • protein phosphatase 2 (formerly 2A), regulatory subunit A (PR 65), alpha isoform
  • PP2A subunit A isoform PR65-alpha
In more languages

Statements

molecular function
protein binding
determination method
IPI
37 references
retrieved
8 April 2019
stated in
PP2A is required for centromeric localization of Sgo1 and proper chromosome segregation
GOA
curator
UniProt
UniProt protein ID
P30153
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30153
determination method
IPI
retrieved
8 April 2019
stated in
Oncoprotein CIP2A is stabilized via interaction with tumor suppressor PP2A/B56.
GOA
curator
UniProt
UniProt protein ID
P30153
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30153
determination method
IPI
retrieved
8 April 2019
stated in
A specific PP2A regulatory subunit, B56gamma, mediates DNA damage-induced dephosphorylation of p53 at Thr55
GOA
curator
UniProt
UniProt protein ID
P30153
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30153
determination method
IPI
retrieved
8 April 2019
stated in
Mitogenic Signals Stimulate the CREB Coactivator CRTC3 through PP2A Recruitment
GOA
curator
UniProt
UniProt protein ID
P30153
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30153
determination method
IPI
retrieved
8 April 2019
stated in
FAM122A, a new endogenous inhibitor of protein phosphatase 2A
GOA
curator
UniProt
UniProt protein ID
P30153
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30153
determination method
IPI
retrieved
8 April 2019
stated in
Binding specificity of protein phosphatase 2A core enzyme for regulatory B subunits and T antigens
GOA
curator
UniProt
UniProt protein ID
P30153
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30153
determination method
IPI
retrieved
8 April 2019
stated in
A PP2A phosphatase high density interaction network identifies a novel striatin-interacting phosphatase and kinase complex linked to the cerebral cavernous malformation 3 (CCM3) protein
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30153
determination method
IPI
retrieved
8 April 2019
stated in
A specific PP2A regulatory subunit, B56gamma, mediates DNA damage-induced dephosphorylation of p53 at Thr55
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30153
determination method
IPI
retrieved
8 April 2019
stated in
Structure of protein phosphatase 2A core enzyme bound to tumor-inducing toxins
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30153
determination method
IPI
retrieved
8 April 2019
stated in
Structural and biochemical insights into the regulation of protein phosphatase 2A by small t antigen of SV40
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30153
determination method
IPI
retrieved
8 April 2019
stated in
A human interactome in three quantitative dimensions organized by stoichiometries and abundances
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30153
determination method
IPI
retrieved
8 April 2019
stated in
An integrated workflow for charting the human interaction proteome: insights into the PP2A system
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30153
determination method
IPI
retrieved
8 April 2019
stated in
The tumor suppressor PP2A Abeta regulates the RalA GTPase
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30153
determination method
IPI
retrieved
8 April 2019
stated in
Structural mechanism of demethylation and inactivation of protein phosphatase 2A
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30153
determination method
IPI
retrieved
8 April 2019
stated in
CIP2A inhibits PP2A in human malignancies
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30153
determination method
IPI
retrieved
8 April 2019
stated in
ATM-mediated phosphorylation activates the tumor-suppressive function of B56γ-PP2A
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30153
determination method
IPI
retrieved
8 April 2019
stated in
PME-1 protects extracellular signal-regulated kinase pathway activity from protein phosphatase 2A-mediated inactivation in human malignant glioma
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30153
determination method
IPI
retrieved
8 April 2019
stated in
Mechanisms of the HRSL3 tumor suppressor function in ovarian carcinoma cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30153
determination method
IPI
retrieved
8 April 2019
stated in
Acetylation of Aurora B by TIP60 ensures accurate chromosomal segregation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30153
determination method
IPI
retrieved
8 April 2019
stated in
Protein phosphatase 2A interacts with and directly dephosphorylates RelA
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30153
determination method
IPI
retrieved
8 April 2019
stated in
An organelle-specific protein landscape identifies novel diseases and molecular mechanisms
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30153
determination method
IPI
retrieved
8 April 2019
stated in
PP4R4/KIAA1622 forms a novel stable cytosolic complex with phosphoprotein phosphatase 4
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30153
determination method
IPI
retrieved
8 April 2019
stated in
Identification of structural elements involved in the interaction of simian virus 40 small tumor antigen with protein phosphatase 2A
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30153
determination method
IPI
retrieved
8 April 2019
stated in
AMBRA1 links autophagy to cell proliferation and tumorigenesis by promoting c-Myc dephosphorylation and degradation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30153
determination method
IPI
retrieved
8 April 2019
stated in
Interaction between protein phosphatase 5 and the A subunit of protein phosphatase 2A: evidence for a heterotrimeric form of protein phosphatase 5
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30153
determination method
IPI
retrieved
8 April 2019
stated in
B55β-associated PP2A complex controls PDK1-directed myc signaling and modulates rapamycin sensitivity in colorectal cancer
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30153
determination method
IPI
retrieved
8 April 2019
stated in
Single-step Strep-tag purification for the isolation and identification of protein complexes from mammalian cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30153
determination method
IPI
retrieved
8 April 2019
stated in
Methylation of the C-terminal leucine residue of the PP2A catalytic subunit is unnecessary for the catalytic activity and the binding of regulatory subunit (PR55/B).
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30153
determination method
IPI
retrieved
8 April 2019
stated in
Interaction of nucleoredoxin with protein phosphatase 2A
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30153
determination method
IPI
retrieved
8 April 2019
stated in
An extracellular-matrix-specific GEF-GAP interaction regulates Rho GTPase crosstalk for 3D collagen migration
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30153
determination method
IPI
retrieved
8 April 2019
stated in
Dynamic circadian protein-protein interaction networks predict temporal organization of cellular functions
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30153
determination method
IPI
retrieved
8 April 2019
stated in
Identification of a novel protein phosphatase 2A regulatory subunit highly expressed in muscle
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30153
determination method
IPI
retrieved
8 April 2019
stated in
Activation of the protein kinase B pathway by the HPV-16 E7 oncoprotein occurs through a mechanism involving interaction with PP2A
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30153
determination method
IPI
retrieved
8 April 2019
stated in
Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30153
determination method
IPI
retrieved
8 April 2019
stated in
The chromosomal association of condensin II is regulated by a noncatalytic function of PP2A.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30153
determination method
IPI
retrieved
8 April 2019
stated in
Live-cell imaging RNAi screen identifies PP2A-B55alpha and importin-beta1 as key mitotic exit regulators in human cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30153
determination method
IPI
retrieved
8 April 2019
stated in
Systematic Analysis of Human Protein Phosphatase Interactions and Dynamics.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30153
determination method
IPI
cell component
biological process

Identifiers

PDB structure ID
 
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