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(Q21119623)
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English
NUMB like endocytic adaptor protein
mammalian protein found in Homo sapiens
numb-related protein
NUMBL
numb-like protein
numb homolog-like
Numb-R
In more languages
edit
Statements
instance of
protein
1 reference
stated in
UniProt
retrieved
13 November 2019
UniProt protein ID
Q9Y6R0
part of
PH-like domain superfamily
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/Q9Y6R0
Numb/numb-like
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/Q9Y6R0
NUMB domain, protein family
1 reference
based on heuristic
inferred from protein domain or family
PTB/PI domain, protein family
1 reference
based on heuristic
inferred from protein domain or family
found in taxon
Homo sapiens
1 reference
stated in
UniProt
retrieved
13 November 2019
UniProt protein ID
Q9Y6R0
encoded by
NUMBL
1 reference
stated in
UniProt
retrieved
13 November 2019
UniProt protein ID
Q9Y6R0
molecular function
protein binding
determination method
IPI
2 references
retrieved
9 May 2019
stated in
NUMBL interacts with TRAF6 and promotes the degradation of TRAF6
GOA
curator
UniProt
UniProt protein ID
Q9Y6R0
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6R0
determination method
IPI
retrieved
9 May 2019
stated in
A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6R0
determination method
IPI
cell component
cytoplasm
determination method
IEA
2 references
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q9Y6R0
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6R0
determination method
IEA
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6R0
determination method
IEA
cytoplasm
determination method
IBA
IEA
3 references
retrieved
9 May 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q9Y6R0
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6R0
determination method
IEA
retrieved
9 May 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6R0
determination method
IEA
retrieved
9 May 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6R0
determination method
IBA
biological process
multicellular organism development
determination method
IEA
1 reference
retrieved
9 May 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q9Y6R0
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6R0
determination method
IEA
positive regulation of neurogenesis
determination method
ISS
IEA
2 references
retrieved
9 May 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q9Y6R0
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6R0
determination method
ISS
retrieved
9 May 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6R0
determination method
IEA
neuroblast proliferation
determination method
IEA
1 reference
retrieved
9 May 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6R0
determination method
IEA
forebrain development
determination method
IEA
1 reference
retrieved
9 May 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6R0
determination method
IEA
protein metabolic process
determination method
IDA
1 reference
retrieved
9 May 2019
stated in
NUMBL interacts with TRAF6 and promotes the degradation of TRAF6
GOA
curator
UniProt
UniProt protein ID
Q9Y6R0
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6R0
determination method
IDA
adherens junction organization
determination method
IEA
1 reference
retrieved
9 May 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6R0
determination method
IEA
neuroblast division in subventricular zone
determination method
ISS
IEA
2 references
retrieved
9 May 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q9Y6R0
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6R0
determination method
ISS
retrieved
9 May 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6R0
determination method
IEA
axonogenesis
determination method
IEA
1 reference
retrieved
9 May 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6R0
determination method
IEA
lateral ventricle development
determination method
ISS
IEA
2 references
retrieved
9 May 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q9Y6R0
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6R0
determination method
ISS
retrieved
9 May 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6R0
determination method
IEA
nervous system development
determination method
TAS
IEA
3 references
retrieved
9 May 2019
stated in
Binding specificity and in vivo targets of the EH domain, a novel protein-protein interaction module
GOA
curator
Proteome Inc.
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6R0
determination method
TAS
retrieved
9 May 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q9Y6R0
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6R0
determination method
IEA
retrieved
9 May 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6R0
determination method
IEA
cytokine-mediated signaling pathway
determination method
IDA
1 reference
retrieved
9 May 2019
stated in
NUMBL interacts with TAB2 and inhibits TNFalpha and IL-1beta-induced NF-kappaB activation
GOA
curator
UniProt
UniProt protein ID
Q9Y6R0
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6R0
determination method
IDA
has part(s)
NUMB domain
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/Q9Y6R0
PTB/PI domain
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/Q9Y6R0
Identifiers
RefSeq protein ID
NP_001276908
1 reference
stated in
NCBI Gene
retrieved
30 May 2020
Entrez Gene ID
9253
NP_001276909
1 reference
stated in
NCBI Gene
retrieved
30 May 2020
Entrez Gene ID
9253
NP_004747
1 reference
stated in
NCBI Gene
retrieved
30 May 2020
Entrez Gene ID
9253
UniProt protein ID
Q9Y6R0
1 reference
stated in
UniProt
retrieved
13 November 2019
UniProt protein ID
Q9Y6R0
Ensembl protein ID
ENSP00000252891
1 reference
stated in
Ensembl Release 99
Ensembl protein ID
ENSP00000252891
ENSP00000442759
1 reference
stated in
Ensembl Release 99
Ensembl protein ID
ENSP00000442759
ENSP00000469310
1 reference
stated in
Ensembl Release 99
Ensembl protein ID
ENSP00000469310
ENSP00000469736
1 reference
stated in
Ensembl Release 99
Ensembl protein ID
ENSP00000469736
ENSP00000470794
1 reference
stated in
Ensembl Release 99
Ensembl protein ID
ENSP00000470794
ENSP00000471376
1 reference
stated in
Ensembl Release 99
Ensembl protein ID
ENSP00000471376
ENSP00000472400
1 reference
stated in
Ensembl Release 99
Ensembl protein ID
ENSP00000472400
PDB structure ID
3F0W
1 reference
stated in
UniProt
UniProt protein ID
Q9Y6R0
retrieved
4 August 2016
language of work or name
English
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