Wikidata

(Q21119777)

English

Heat shock protein family A (Hsp70) member 1B

mammalian protein found in Homo sapiens

  • HSPA1B
  • heat shock 70 kDa protein 1/2
  • HSP70-1/HSP70-2
  • heat shock 70 kDa protein 2
  • Heat shock 70 kDa protein 1
  • heat shock 70 kDa protein 1A/1B
  • HSP70.1
  • Heat shock 70 kDa protein 1A
  • heat shock 70kD protein 1B
  • heat shock 70 kDa protein 1B
  • HSP70.1/HSP70.2
  • heat shock 70kDa protein 1B
  • HSP70-1
In more languages

Statements

molecular function
protein binding
determination method
IPI
28 references
retrieved
8 April 2019
stated in
ARD1-mediated Hsp70 acetylation balances stress-induced protein refolding and degradation
GOA
curator
UniProt
UniProt protein ID
P0DMV8
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P0DMV8
determination method
IPI
retrieved
8 April 2019
stated in
Binding of human nucleotide exchange factors to heat shock protein 70 (Hsp70) generates functionally distinct complexes in vitro
GOA
curator
UniProt
UniProt protein ID
P0DMV8
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P0DMV8
determination method
IPI
retrieved
8 April 2019
stated in
Interactions between Hsp70 and the hydrophobic core of alpha-synuclein inhibit fibril assembly
GOA
curator
UniProt
UniProt protein ID
P0DMV8
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P0DMV8
determination method
IPI
retrieved
8 April 2019
stated in
A newly uncovered group of distantly related lysine methyltransferases preferentially interact with molecular chaperones to regulate their activity
GOA
curator
UniProt
UniProt protein ID
P0DMV8
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P0DMV8
determination method
IPI
retrieved
8 April 2019
stated in
The C-terminal helices of heat shock protein 70 are essential for J-domain binding and ATPase activation
GOA
curator
UniProt
UniProt protein ID
P0DMV8
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P0DMV8
determination method
IPI
retrieved
8 April 2019
stated in
Hsp70 and Hsp90 oppositely regulate TGF-β signaling through CHIP/Stub1
GOA
curator
UniProt
UniProt protein ID
P0DMV8
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P0DMV8
determination method
IPI
retrieved
8 April 2019
stated in
Evidence for a role of Hsp70 in the regulation of the heat shock response in mammalian cells
GOA
curator
UniProt
UniProt protein ID
P0DMV8
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P0DMV8
determination method
IPI
retrieved
8 April 2019
stated in
A novel nuclear DnaJ protein, DNAJC8, can suppress the formation of spinocerebellar ataxia 3 polyglutamine aggregation in a J-domain independent manner.
GOA
curator
UniProt
UniProt protein ID
P0DMV8
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P0DMV8
determination method
IPI
retrieved
8 April 2019
stated in
HSP70 regulates the function of mitotic centrosomes
GOA
curator
UniProt
UniProt protein ID
P0DMV8
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P0DMV8
determination method
IPI
retrieved
8 April 2019
stated in
Heat shock protein 70 inhibits alpha-synuclein fibril formation via preferential binding to prefibrillar species
GOA
curator
UniProt
UniProt protein ID
P0DMV8
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P0DMV8
determination method
IPI
retrieved
8 April 2019
stated in
ChChd3, an inner mitochondrial membrane protein, is essential for maintaining crista integrity and mitochondrial function
GOA
curator
UniProt
UniProt protein ID
P0DMV8
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P0DMV8
determination method
IPI
retrieved
8 April 2019
stated in
Cofactor Tpr2 combines two TPR domains and a J domain to regulate the Hsp70/Hsp90 chaperone system
GOA
curator
UniProt
UniProt protein ID
P0DMV8
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P0DMV8
determination method
IPI
retrieved
8 April 2019
stated in
Nucleophosmin (NPM1/B23) interacts with activating transcription factor 5 (ATF5) protein and promotes proteasome- and caspase-dependent ATF5 degradation in hepatocellular carcinoma cells
GOA
curator
UniProt
UniProt protein ID
P0DMV8
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P0DMV8
determination method
IPI
retrieved
8 April 2019
stated in
Molecular chaperones as HSF1-specific transcriptional repressors
GOA
curator
UniProt
UniProt protein ID
P0DMV8
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P0DMV8
determination method
IPI
retrieved
8 April 2019
stated in
HSP72 protects cells from ER stress-induced apoptosis via enhancement of IRE1alpha-XBP1 signaling through a physical interaction
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P0DMV8
determination method
IPI
retrieved
8 April 2019
stated in
Genome-wide YFP fluorescence complementation screen identifies new regulators for telomere signaling in human cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P0DMV8
determination method
IPI
retrieved
8 April 2019
stated in
HSP70 sequestration by free α-globin promotes ineffective erythropoiesis in β-thalassaemia
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P0DMV8
determination method
IPI
retrieved
8 April 2019
stated in
70-kDa heat shock proteins: specific interactions with HLA-DR molecules and their peptide fragments
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P0DMV8
determination method
IPI
retrieved
8 April 2019
stated in
Mutations in the substrate binding site of human heat-shock protein 70 indicate specific interaction with HLA-DR outside the peptide binding groove
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P0DMV8
determination method
IPI
retrieved
8 April 2019
stated in
Human respiratory syncytial virus N, P and M protein interactions in HEK-293T cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P0DMV8
determination method
IPI
retrieved
8 April 2019
stated in
HSP72 protects cells from ER stress-induced apoptosis via enhancement of IRE1alpha-XBP1 signaling through a physical interaction
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P0DMV8
determination method
IPI
retrieved
8 April 2019
stated in
Discovery of multiple interacting partners of gankyrin, a proteasomal chaperone and an oncoprotein--evidence for a common hot spot site at the interface and its functional relevance.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P0DMV8
determination method
IPI
retrieved
8 April 2019
stated in
Structure and function of Hip, an attenuator of the Hsp70 chaperone cycle
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P0DMV8
determination method
IPI
retrieved
8 April 2019
stated in
Regulation of Hsp90 client proteins by a Cullin5-RING E3 ubiquitin ligase
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P0DMV8
determination method
IPI
retrieved
8 April 2019
stated in
The ubiquitin ligase Stub1 negatively modulates regulatory T cell suppressive activity by promoting degradation of the transcription factor Foxp3
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P0DMV8
determination method
IPI
retrieved
8 April 2019
stated in
The C-terminal BAG domain of BAG5 induces conformational changes of the Hsp70 nucleotide-binding domain for ADP-ATP exchange
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P0DMV8
determination method
IPI
retrieved
8 April 2019
stated in
BAG5 inhibits parkin and enhances dopaminergic neuron degeneration
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P0DMV8
determination method
IPI
retrieved
8 April 2019
stated in
Cellular cofactors affecting hepatitis C virus infection and replication
GOA
curator
AgBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P0DMV8
determination method
IPI
cell component
cytoplasm
determination method
IDA
IEA
TAS
7 references
retrieved
26 September 2017
stated in
Proteomics of human umbilical vein endothelial cells applied to etoposide-induced apoptosis
GOA
curator
UniProt
UniProt protein ID
P0DMV8
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P0DMV8&geneProductId=UniProtKB:P0DMV8
determination method
TAS
retrieved
26 September 2017
stated in
GOA
curator
UniProt
UniProt protein ID
P0DMV8
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P0DMV8&geneProductId=UniProtKB:P0DMV8
determination method
IEA
retrieved
26 September 2017
stated in
Inhibition of cellular proliferation by the Wilms tumor suppressor WT1 requires association with the inducible chaperone Hsp70
GOA
curator
UniProt
UniProt protein ID
P0DMV8
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P0DMV8&geneProductId=UniProtKB:P0DMV8
determination method
IDA
retrieved
26 September 2017
stated in
Chaperone hsp27 inhibits translation during heat shock by binding eIF4G and facilitating dissociation of cap-initiation complexes
GOA
curator
UniProt
UniProt protein ID
P0DMV8
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P0DMV8&geneProductId=UniProtKB:P0DMV8
determination method
IDA
retrieved
26 September 2017
stated in
The molecular chaperone HSP70 binds to and stabilizes NOD2, an important protein involved in Crohn disease
GOA
curator
UniProt
UniProt protein ID
P0DMV8
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P0DMV8&geneProductId=UniProtKB:P0DMV8
determination method
IDA
retrieved
26 September 2017
stated in
Stress-induced localization of HSPA6 (HSP70B') and HSPA1A (HSP70-1) proteins to centrioles in human neuronal cells
GOA
curator
UniProt
UniProt protein ID
P0DMV8
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P0DMV8&geneProductId=UniProtKB:P0DMV8
determination method
IDA
retrieved
26 September 2017
stated in
HSP90, HSP70, and GAPDH directly interact with the cytoplasmic domain of macrophage scavenger receptors
GOA
curator
Critical Assessment of Protein Function Annotation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P0DMV8&geneProductId=UniProtKB:P0DMV8
determination method
IDA
cytoplasm
determination method
IBA
IDA
IEA
TAS
8 references
retrieved
8 April 2019
stated in
Proteomics of human umbilical vein endothelial cells applied to etoposide-induced apoptosis
GOA
curator
UniProt
UniProt protein ID
P0DMV8
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P0DMV8
determination method
TAS
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
P0DMV8
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P0DMV8
determination method
IEA
retrieved
8 April 2019
stated in
Inhibition of cellular proliferation by the Wilms tumor suppressor WT1 requires association with the inducible chaperone Hsp70
GOA
curator
UniProt
UniProt protein ID
P0DMV8
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P0DMV8
determination method
IDA
retrieved
8 April 2019
stated in
Stress-induced localization of HSPA6 (HSP70B') and HSPA1A (HSP70-1) proteins to centrioles in human neuronal cells
GOA
curator
UniProt
UniProt protein ID
P0DMV8
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P0DMV8
determination method
IDA
retrieved
8 April 2019
stated in
Chaperone hsp27 inhibits translation during heat shock by binding eIF4G and facilitating dissociation of cap-initiation complexes
GOA
curator
UniProt
UniProt protein ID
P0DMV8
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P0DMV8
determination method
IDA
retrieved
8 April 2019
stated in
The molecular chaperone HSP70 binds to and stabilizes NOD2, an important protein involved in Crohn disease
GOA
curator
UniProt
UniProt protein ID
P0DMV8
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P0DMV8
determination method
IDA
retrieved
8 April 2019
stated in
HSP90, HSP70, and GAPDH directly interact with the cytoplasmic domain of macrophage scavenger receptors
GOA
curator
Critical Assessment of Protein Function Annotation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P0DMV8
determination method
IDA
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P0DMV8
determination method
IBA
biological process

Identifiers

Ensembl protein ID
Freebase ID
/m/04f72gh
0 references
PDB structure ID
 
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